Amino acid dipepetide frequency for Moraxella phage Mcat12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.261AlaAla: 5.261 ± 0.868
0.837AlaCys: 0.837 ± 0.394
4.903AlaAsp: 4.903 ± 0.976
4.185AlaGlu: 4.185 ± 0.77
4.424AlaPhe: 4.424 ± 0.725
5.381AlaGly: 5.381 ± 1.04
2.033AlaHis: 2.033 ± 0.4
7.533AlaIle: 7.533 ± 1.086
7.772AlaLys: 7.772 ± 1.347
9.446AlaLeu: 9.446 ± 1.022
2.631AlaMet: 2.631 ± 0.669
5.381AlaAsn: 5.381 ± 0.941
1.794AlaPro: 1.794 ± 0.449
4.544AlaGln: 4.544 ± 0.818
2.989AlaArg: 2.989 ± 0.465
6.816AlaSer: 6.816 ± 0.852
7.294AlaThr: 7.294 ± 1.558
5.5AlaVal: 5.5 ± 0.867
1.674AlaTrp: 1.674 ± 0.46
2.152AlaTyr: 2.152 ± 0.455
0.0AlaXaa: 0.0 ± 0.0
Cys
0.598CysAla: 0.598 ± 0.335
0.239CysCys: 0.239 ± 0.155
0.598CysAsp: 0.598 ± 0.247
0.598CysGlu: 0.598 ± 0.326
0.239CysPhe: 0.239 ± 0.159
0.478CysGly: 0.478 ± 0.304
0.478CysHis: 0.478 ± 0.214
0.12CysIle: 0.12 ± 0.149
0.239CysLys: 0.239 ± 0.184
0.957CysLeu: 0.957 ± 0.334
0.12CysMet: 0.12 ± 0.133
0.239CysAsn: 0.239 ± 0.148
0.598CysPro: 0.598 ± 0.31
0.837CysGln: 0.837 ± 0.364
0.957CysArg: 0.957 ± 0.314
0.239CysSer: 0.239 ± 0.167
0.478CysThr: 0.478 ± 0.254
0.478CysVal: 0.478 ± 0.243
0.0CysTrp: 0.0 ± 0.0
0.478CysTyr: 0.478 ± 0.294
0.0CysXaa: 0.0 ± 0.0
Asp
5.381AspAla: 5.381 ± 0.713
0.717AspCys: 0.717 ± 0.251
4.424AspAsp: 4.424 ± 0.829
3.587AspGlu: 3.587 ± 0.513
2.87AspPhe: 2.87 ± 0.453
6.577AspGly: 6.577 ± 0.923
1.076AspHis: 1.076 ± 0.365
3.587AspIle: 3.587 ± 0.676
4.305AspLys: 4.305 ± 0.847
4.424AspLeu: 4.424 ± 0.677
0.837AspMet: 0.837 ± 0.226
4.663AspAsn: 4.663 ± 0.658
1.794AspPro: 1.794 ± 0.44
1.076AspGln: 1.076 ± 0.345
2.272AspArg: 2.272 ± 0.56
2.989AspSer: 2.989 ± 0.592
2.272AspThr: 2.272 ± 0.506
3.826AspVal: 3.826 ± 0.519
0.717AspTrp: 0.717 ± 0.335
2.511AspTyr: 2.511 ± 0.543
0.0AspXaa: 0.0 ± 0.0
Glu
3.587GluAla: 3.587 ± 0.752
0.598GluCys: 0.598 ± 0.256
2.391GluAsp: 2.391 ± 0.642
1.674GluGlu: 1.674 ± 0.449
3.229GluPhe: 3.229 ± 0.65
2.511GluGly: 2.511 ± 0.616
1.794GluHis: 1.794 ± 0.372
3.946GluIle: 3.946 ± 0.757
3.946GluLys: 3.946 ± 0.924
6.098GluLeu: 6.098 ± 0.979
1.674GluMet: 1.674 ± 0.562
2.631GluAsn: 2.631 ± 0.64
2.152GluPro: 2.152 ± 0.665
3.348GluGln: 3.348 ± 0.666
3.229GluArg: 3.229 ± 0.64
2.272GluSer: 2.272 ± 0.415
2.272GluThr: 2.272 ± 0.448
3.109GluVal: 3.109 ± 0.834
0.717GluTrp: 0.717 ± 0.341
2.391GluTyr: 2.391 ± 0.559
0.0GluXaa: 0.0 ± 0.0
Phe
2.631PheAla: 2.631 ± 0.692
0.717PheCys: 0.717 ± 0.289
3.109PheAsp: 3.109 ± 0.705
3.229PheGlu: 3.229 ± 0.636
1.435PhePhe: 1.435 ± 0.494
3.707PheGly: 3.707 ± 0.825
0.957PheHis: 0.957 ± 0.286
2.272PheIle: 2.272 ± 0.454
1.674PheLys: 1.674 ± 0.478
3.587PheLeu: 3.587 ± 0.99
1.913PheMet: 1.913 ± 0.446
1.674PheAsn: 1.674 ± 0.443
0.957PhePro: 0.957 ± 0.277
0.717PheGln: 0.717 ± 0.325
1.315PheArg: 1.315 ± 0.352
2.272PheSer: 2.272 ± 0.554
2.631PheThr: 2.631 ± 0.511
2.033PheVal: 2.033 ± 0.444
0.478PheTrp: 0.478 ± 0.268
1.794PheTyr: 1.794 ± 0.385
0.0PheXaa: 0.0 ± 0.0
Gly
5.5GlyAla: 5.5 ± 0.764
0.478GlyCys: 0.478 ± 0.224
3.946GlyAsp: 3.946 ± 0.955
5.261GlyGlu: 5.261 ± 0.739
4.066GlyPhe: 4.066 ± 0.619
5.022GlyGly: 5.022 ± 0.956
0.957GlyHis: 0.957 ± 0.378
4.305GlyIle: 4.305 ± 0.601
6.935GlyLys: 6.935 ± 0.957
8.49GlyLeu: 8.49 ± 1.389
2.152GlyMet: 2.152 ± 0.495
2.511GlyAsn: 2.511 ± 0.574
0.0GlyPro: 0.0 ± 0.0
2.152GlyGln: 2.152 ± 0.574
3.348GlyArg: 3.348 ± 0.53
2.87GlySer: 2.87 ± 0.575
3.348GlyThr: 3.348 ± 0.747
6.098GlyVal: 6.098 ± 0.708
0.837GlyTrp: 0.837 ± 0.285
2.391GlyTyr: 2.391 ± 0.754
0.0GlyXaa: 0.0 ± 0.0
His
2.87HisAla: 2.87 ± 0.486
0.239HisCys: 0.239 ± 0.171
1.913HisAsp: 1.913 ± 0.404
1.315HisGlu: 1.315 ± 0.374
0.957HisPhe: 0.957 ± 0.344
2.989HisGly: 2.989 ± 0.521
1.435HisHis: 1.435 ± 0.617
1.315HisIle: 1.315 ± 0.393
1.674HisLys: 1.674 ± 0.357
2.272HisLeu: 2.272 ± 0.649
0.239HisMet: 0.239 ± 0.17
0.957HisAsn: 0.957 ± 0.393
1.196HisPro: 1.196 ± 0.494
1.196HisGln: 1.196 ± 0.327
1.196HisArg: 1.196 ± 0.447
0.717HisSer: 0.717 ± 0.432
1.315HisThr: 1.315 ± 0.417
0.598HisVal: 0.598 ± 0.227
0.478HisTrp: 0.478 ± 0.231
0.837HisTyr: 0.837 ± 0.34
0.0HisXaa: 0.0 ± 0.0
Ile
7.055IleAla: 7.055 ± 1.073
0.598IleCys: 0.598 ± 0.318
4.424IleAsp: 4.424 ± 0.678
3.826IleGlu: 3.826 ± 0.619
1.794IlePhe: 1.794 ± 0.472
5.381IleGly: 5.381 ± 0.709
1.076IleHis: 1.076 ± 0.362
6.098IleIle: 6.098 ± 0.752
4.783IleLys: 4.783 ± 0.706
5.022IleLeu: 5.022 ± 0.747
2.033IleMet: 2.033 ± 0.519
4.424IleAsn: 4.424 ± 0.866
2.511IlePro: 2.511 ± 0.551
1.913IleGln: 1.913 ± 0.591
1.794IleArg: 1.794 ± 0.39
3.348IleSer: 3.348 ± 0.745
4.544IleThr: 4.544 ± 0.87
2.87IleVal: 2.87 ± 0.55
0.359IleTrp: 0.359 ± 0.228
2.511IleTyr: 2.511 ± 0.563
0.0IleXaa: 0.0 ± 0.0
Lys
7.533LysAla: 7.533 ± 1.071
0.598LysCys: 0.598 ± 0.221
3.826LysAsp: 3.826 ± 0.69
3.946LysGlu: 3.946 ± 0.94
2.511LysPhe: 2.511 ± 0.633
4.903LysGly: 4.903 ± 0.64
1.435LysHis: 1.435 ± 0.453
3.468LysIle: 3.468 ± 0.76
3.946LysLys: 3.946 ± 0.683
6.218LysLeu: 6.218 ± 0.757
2.391LysMet: 2.391 ± 0.689
3.468LysAsn: 3.468 ± 0.675
1.913LysPro: 1.913 ± 0.515
4.424LysGln: 4.424 ± 0.885
3.826LysArg: 3.826 ± 0.704
4.066LysSer: 4.066 ± 0.732
4.663LysThr: 4.663 ± 0.797
4.185LysVal: 4.185 ± 0.806
0.598LysTrp: 0.598 ± 0.274
1.913LysTyr: 1.913 ± 0.456
0.0LysXaa: 0.0 ± 0.0
Leu
10.044LeuAla: 10.044 ± 1.764
0.837LeuCys: 0.837 ± 0.42
7.414LeuAsp: 7.414 ± 0.835
4.783LeuGlu: 4.783 ± 1.083
2.75LeuPhe: 2.75 ± 0.77
7.174LeuGly: 7.174 ± 1.001
2.511LeuHis: 2.511 ± 0.564
5.979LeuIle: 5.979 ± 0.717
6.935LeuLys: 6.935 ± 0.815
6.337LeuLeu: 6.337 ± 0.959
2.631LeuMet: 2.631 ± 0.553
4.424LeuAsn: 4.424 ± 0.728
3.348LeuPro: 3.348 ± 0.666
4.066LeuGln: 4.066 ± 0.525
3.707LeuArg: 3.707 ± 0.669
6.935LeuSer: 6.935 ± 0.803
5.381LeuThr: 5.381 ± 0.847
5.381LeuVal: 5.381 ± 0.986
1.196LeuTrp: 1.196 ± 0.339
2.989LeuTyr: 2.989 ± 0.525
0.0LeuXaa: 0.0 ± 0.0
Met
3.229MetAla: 3.229 ± 0.608
0.359MetCys: 0.359 ± 0.205
1.435MetAsp: 1.435 ± 0.312
0.598MetGlu: 0.598 ± 0.296
0.837MetPhe: 0.837 ± 0.341
2.033MetGly: 2.033 ± 0.54
0.598MetHis: 0.598 ± 0.258
1.554MetIle: 1.554 ± 0.449
1.674MetLys: 1.674 ± 0.422
2.75MetLeu: 2.75 ± 0.576
0.717MetMet: 0.717 ± 0.328
1.315MetAsn: 1.315 ± 0.485
1.196MetPro: 1.196 ± 0.311
1.913MetGln: 1.913 ± 0.48
1.076MetArg: 1.076 ± 0.308
2.272MetSer: 2.272 ± 0.601
1.554MetThr: 1.554 ± 0.466
2.033MetVal: 2.033 ± 0.672
0.239MetTrp: 0.239 ± 0.152
0.359MetTyr: 0.359 ± 0.218
0.0MetXaa: 0.0 ± 0.0
Asn
4.424AsnAla: 4.424 ± 1.088
0.0AsnCys: 0.0 ± 0.0
2.272AsnAsp: 2.272 ± 0.54
3.109AsnGlu: 3.109 ± 0.418
1.913AsnPhe: 1.913 ± 0.445
2.75AsnGly: 2.75 ± 0.413
1.554AsnHis: 1.554 ± 0.509
2.75AsnIle: 2.75 ± 0.439
2.87AsnLys: 2.87 ± 0.697
3.946AsnLeu: 3.946 ± 1.005
2.033AsnMet: 2.033 ± 0.513
2.87AsnAsn: 2.87 ± 0.578
3.109AsnPro: 3.109 ± 0.894
2.75AsnGln: 2.75 ± 0.578
1.913AsnArg: 1.913 ± 0.408
2.989AsnSer: 2.989 ± 0.616
2.511AsnThr: 2.511 ± 0.569
2.631AsnVal: 2.631 ± 0.616
0.478AsnTrp: 0.478 ± 0.307
2.152AsnTyr: 2.152 ± 0.558
0.0AsnXaa: 0.0 ± 0.0
Pro
2.391ProAla: 2.391 ± 0.783
0.12ProCys: 0.12 ± 0.13
1.435ProAsp: 1.435 ± 0.414
1.554ProGlu: 1.554 ± 0.433
1.554ProPhe: 1.554 ± 0.382
0.478ProGly: 0.478 ± 0.24
0.598ProHis: 0.598 ± 0.275
2.511ProIle: 2.511 ± 0.591
3.229ProLys: 3.229 ± 0.593
3.109ProLeu: 3.109 ± 0.812
0.837ProMet: 0.837 ± 0.304
2.511ProAsn: 2.511 ± 0.698
1.196ProPro: 1.196 ± 0.428
0.957ProGln: 0.957 ± 0.346
0.717ProArg: 0.717 ± 0.297
3.229ProSer: 3.229 ± 0.729
1.674ProThr: 1.674 ± 0.39
2.272ProVal: 2.272 ± 0.561
0.239ProTrp: 0.239 ± 0.165
0.478ProTyr: 0.478 ± 0.216
0.0ProXaa: 0.0 ± 0.0
Gln
4.903GlnAla: 4.903 ± 0.803
0.239GlnCys: 0.239 ± 0.189
2.391GlnAsp: 2.391 ± 0.513
1.435GlnGlu: 1.435 ± 0.385
1.196GlnPhe: 1.196 ± 0.34
2.391GlnGly: 2.391 ± 0.526
1.554GlnHis: 1.554 ± 0.416
3.587GlnIle: 3.587 ± 0.592
4.663GlnLys: 4.663 ± 0.645
5.74GlnLeu: 5.74 ± 0.741
1.196GlnMet: 1.196 ± 0.279
1.913GlnAsn: 1.913 ± 0.453
1.196GlnPro: 1.196 ± 0.37
1.674GlnGln: 1.674 ± 0.57
2.272GlnArg: 2.272 ± 0.477
2.272GlnSer: 2.272 ± 0.508
2.152GlnThr: 2.152 ± 0.542
2.631GlnVal: 2.631 ± 0.573
0.598GlnTrp: 0.598 ± 0.311
1.315GlnTyr: 1.315 ± 0.349
0.0GlnXaa: 0.0 ± 0.0
Arg
4.066ArgAla: 4.066 ± 0.633
0.478ArgCys: 0.478 ± 0.225
2.631ArgAsp: 2.631 ± 0.516
2.75ArgGlu: 2.75 ± 0.593
2.152ArgPhe: 2.152 ± 0.652
2.511ArgGly: 2.511 ± 0.505
1.913ArgHis: 1.913 ± 0.42
2.033ArgIle: 2.033 ± 0.466
2.033ArgLys: 2.033 ± 0.602
5.74ArgLeu: 5.74 ± 1.104
0.598ArgMet: 0.598 ± 0.211
1.315ArgAsn: 1.315 ± 0.377
0.717ArgPro: 0.717 ± 0.279
2.391ArgGln: 2.391 ± 0.406
1.435ArgArg: 1.435 ± 0.46
2.75ArgSer: 2.75 ± 0.573
2.989ArgThr: 2.989 ± 0.564
2.272ArgVal: 2.272 ± 0.451
0.239ArgTrp: 0.239 ± 0.152
2.75ArgTyr: 2.75 ± 0.571
0.0ArgXaa: 0.0 ± 0.0
Ser
5.859SerAla: 5.859 ± 1.053
0.359SerCys: 0.359 ± 0.195
3.468SerAsp: 3.468 ± 0.713
3.468SerGlu: 3.468 ± 0.675
2.033SerPhe: 2.033 ± 0.572
2.631SerGly: 2.631 ± 0.497
2.152SerHis: 2.152 ± 0.405
5.62SerIle: 5.62 ± 1.001
3.468SerLys: 3.468 ± 0.667
6.577SerLeu: 6.577 ± 1.035
1.196SerMet: 1.196 ± 0.352
3.587SerAsn: 3.587 ± 0.671
1.196SerPro: 1.196 ± 0.572
3.229SerGln: 3.229 ± 0.607
2.87SerArg: 2.87 ± 0.513
3.468SerSer: 3.468 ± 0.848
2.152SerThr: 2.152 ± 0.483
4.424SerVal: 4.424 ± 0.774
0.478SerTrp: 0.478 ± 0.26
1.674SerTyr: 1.674 ± 0.349
0.0SerXaa: 0.0 ± 0.0
Thr
7.294ThrAla: 7.294 ± 1.02
0.239ThrCys: 0.239 ± 0.163
3.707ThrAsp: 3.707 ± 0.61
3.468ThrGlu: 3.468 ± 0.572
1.794ThrPhe: 1.794 ± 0.493
4.663ThrGly: 4.663 ± 0.877
1.435ThrHis: 1.435 ± 0.444
3.229ThrIle: 3.229 ± 0.661
4.544ThrLys: 4.544 ± 1.216
4.903ThrLeu: 4.903 ± 0.672
1.674ThrMet: 1.674 ± 0.398
1.674ThrAsn: 1.674 ± 0.407
2.152ThrPro: 2.152 ± 0.533
1.554ThrGln: 1.554 ± 0.444
1.794ThrArg: 1.794 ± 0.453
3.348ThrSer: 3.348 ± 0.61
2.391ThrThr: 2.391 ± 0.543
3.229ThrVal: 3.229 ± 0.553
0.837ThrTrp: 0.837 ± 0.275
1.315ThrTyr: 1.315 ± 0.516
0.0ThrXaa: 0.0 ± 0.0
Val
5.74ValAla: 5.74 ± 0.991
0.598ValCys: 0.598 ± 0.263
2.631ValAsp: 2.631 ± 0.543
2.272ValGlu: 2.272 ± 0.601
2.152ValPhe: 2.152 ± 0.603
5.261ValGly: 5.261 ± 0.866
0.957ValHis: 0.957 ± 0.293
4.185ValIle: 4.185 ± 0.82
2.87ValLys: 2.87 ± 0.68
4.903ValLeu: 4.903 ± 0.688
1.913ValMet: 1.913 ± 0.511
1.554ValAsn: 1.554 ± 0.493
2.391ValPro: 2.391 ± 0.615
3.348ValGln: 3.348 ± 0.599
4.185ValArg: 4.185 ± 0.719
4.783ValSer: 4.783 ± 0.863
3.109ValThr: 3.109 ± 0.696
4.544ValVal: 4.544 ± 0.836
1.315ValTrp: 1.315 ± 0.43
2.152ValTyr: 2.152 ± 0.404
0.0ValXaa: 0.0 ± 0.0
Trp
1.674TrpAla: 1.674 ± 0.378
0.12TrpCys: 0.12 ± 0.133
0.837TrpAsp: 0.837 ± 0.339
0.478TrpGlu: 0.478 ± 0.233
0.239TrpPhe: 0.239 ± 0.2
0.598TrpGly: 0.598 ± 0.333
0.12TrpHis: 0.12 ± 0.15
0.359TrpIle: 0.359 ± 0.175
0.359TrpLys: 0.359 ± 0.228
1.076TrpLeu: 1.076 ± 0.381
0.359TrpMet: 0.359 ± 0.208
0.359TrpAsn: 0.359 ± 0.168
0.12TrpPro: 0.12 ± 0.099
1.554TrpGln: 1.554 ± 0.49
0.598TrpArg: 0.598 ± 0.255
0.957TrpSer: 0.957 ± 0.355
0.598TrpThr: 0.598 ± 0.223
0.957TrpVal: 0.957 ± 0.293
0.239TrpTrp: 0.239 ± 0.178
0.359TrpTyr: 0.359 ± 0.231
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.511TyrAla: 2.511 ± 0.653
0.598TyrCys: 0.598 ± 0.258
2.152TyrAsp: 2.152 ± 0.474
2.033TyrGlu: 2.033 ± 0.593
1.076TyrPhe: 1.076 ± 0.383
3.229TyrGly: 3.229 ± 0.454
1.076TyrHis: 1.076 ± 0.471
1.913TyrIle: 1.913 ± 0.352
1.913TyrLys: 1.913 ± 0.546
3.229TyrLeu: 3.229 ± 0.877
0.478TyrMet: 0.478 ± 0.205
1.554TyrAsn: 1.554 ± 0.539
1.554TyrPro: 1.554 ± 0.473
1.674TyrGln: 1.674 ± 0.389
2.272TyrArg: 2.272 ± 0.569
1.315TyrSer: 1.315 ± 0.326
1.913TyrThr: 1.913 ± 0.464
1.794TyrVal: 1.794 ± 0.448
0.239TyrTrp: 0.239 ± 0.166
1.076TyrTyr: 1.076 ± 0.379
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (8364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski