Amino acid dipepetide frequency for Thermothielavioides terrestris (strain ATCC 38088 / NRRL 8126) (Thielavia terrestris)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.853AlaAla: 14.853 ± 0.098	1.165AlaCys: 1.165 ± 0.019	5.277AlaAsp: 5.277 ± 0.036	6.341AlaGlu: 6.341 ± 0.051	3.242AlaPhe: 3.242 ± 0.03	8.077AlaGly: 8.077 ± 0.055	2.075AlaHis: 2.075 ± 0.023	3.848AlaIle: 3.848 ± 0.033	4.208AlaLys: 4.208 ± 0.04	9.026AlaLeu: 9.026 ± 0.058	2.015AlaMet: 2.015 ± 0.022	2.996AlaAsn: 2.996 ± 0.024	6.47AlaPro: 6.47 ± 0.059	3.987AlaGln: 3.987 ± 0.036	6.875AlaArg: 6.875 ± 0.05	8.069AlaSer: 8.069 ± 0.051	5.852AlaThr: 5.852 ± 0.041	6.708AlaVal: 6.708 ± 0.046	1.347AlaTrp: 1.347 ± 0.019	2.225AlaTyr: 2.225 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.016	0.25CysCys: 0.25 ± 0.011	0.612CysAsp: 0.612 ± 0.013	0.57CysGlu: 0.57 ± 0.011	0.49CysPhe: 0.49 ± 0.011	0.979CysGly: 0.979 ± 0.019	0.305CysHis: 0.305 ± 0.009	0.573CysIle: 0.573 ± 0.011	0.444CysLys: 0.444 ± 0.01	1.226CysLeu: 1.226 ± 0.019	0.245CysMet: 0.245 ± 0.008	0.383CysAsn: 0.383 ± 0.01	0.714CysPro: 0.714 ± 0.014	0.409CysGln: 0.409 ± 0.009	0.831CysArg: 0.831 ± 0.015	0.842CysSer: 0.842 ± 0.017	0.615CysThr: 0.615 ± 0.014	0.8CysVal: 0.8 ± 0.016	0.209CysTrp: 0.209 ± 0.008	0.324CysTyr: 0.324 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.536AspAla: 5.536 ± 0.039	0.601AspCys: 0.601 ± 0.012	4.396AspAsp: 4.396 ± 0.042	4.499AspGlu: 4.499 ± 0.041	2.008AspPhe: 2.008 ± 0.023	4.67AspGly: 4.67 ± 0.037	1.163AspHis: 1.163 ± 0.016	2.43AspIle: 2.43 ± 0.028	2.139AspLys: 2.139 ± 0.023	4.856AspLeu: 4.856 ± 0.035	1.134AspMet: 1.134 ± 0.017	1.569AspAsn: 1.569 ± 0.021	3.597AspPro: 3.597 ± 0.03	1.688AspGln: 1.688 ± 0.022	3.409AspArg: 3.409 ± 0.043	3.68AspSer: 3.68 ± 0.032	2.541AspThr: 2.541 ± 0.024	3.706AspVal: 3.706 ± 0.03	0.878AspTrp: 0.878 ± 0.014	1.438AspTyr: 1.438 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.19GluAla: 6.19 ± 0.045	0.589GluCys: 0.589 ± 0.013	3.995GluAsp: 3.995 ± 0.038	5.637GluGlu: 5.637 ± 0.065	1.819GluPhe: 1.819 ± 0.021	4.017GluGly: 4.017 ± 0.033	1.348GluHis: 1.348 ± 0.02	2.487GluIle: 2.487 ± 0.029	3.256GluLys: 3.256 ± 0.042	5.294GluLeu: 5.294 ± 0.044	1.375GluMet: 1.375 ± 0.018	1.781GluAsn: 1.781 ± 0.023	3.107GluPro: 3.107 ± 0.032	2.475GluGln: 2.475 ± 0.025	4.428GluArg: 4.428 ± 0.04	3.694GluSer: 3.694 ± 0.037	3.205GluThr: 3.205 ± 0.032	3.573GluVal: 3.573 ± 0.028	0.861GluTrp: 0.861 ± 0.013	1.488GluTyr: 1.488 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.273PheAla: 3.273 ± 0.029	0.513PheCys: 0.513 ± 0.011	2.109PheAsp: 2.109 ± 0.022	1.958PheGlu: 1.958 ± 0.021	1.441PhePhe: 1.441 ± 0.023	2.76PheGly: 2.76 ± 0.027	0.83PheHis: 0.83 ± 0.013	1.441PheIle: 1.441 ± 0.02	1.249PheLys: 1.249 ± 0.02	3.273PheLeu: 3.273 ± 0.032	0.659PheMet: 0.659 ± 0.013	1.166PheAsn: 1.166 ± 0.016	1.942PhePro: 1.942 ± 0.021	1.213PheGln: 1.213 ± 0.018	2.085PheArg: 2.085 ± 0.02	2.567PheSer: 2.567 ± 0.026	1.892PheThr: 1.892 ± 0.024	2.374PheVal: 2.374 ± 0.024	0.578PheTrp: 0.578 ± 0.013	0.987PheTyr: 0.987 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	7.04GlyAla: 7.04 ± 0.046	0.913GlyCys: 0.913 ± 0.016	4.012GlyAsp: 4.012 ± 0.034	4.159GlyGlu: 4.159 ± 0.032	2.68GlyPhe: 2.68 ± 0.027	8.012GlyGly: 8.012 ± 0.087	1.683GlyHis: 1.683 ± 0.025	3.058GlyIle: 3.058 ± 0.033	3.264GlyLys: 3.264 ± 0.032	6.3GlyLeu: 6.3 ± 0.044	1.561GlyMet: 1.561 ± 0.02	2.344GlyAsn: 2.344 ± 0.027	4.186GlyPro: 4.186 ± 0.034	2.64GlyGln: 2.64 ± 0.028	5.144GlyArg: 5.144 ± 0.041	6.111GlySer: 6.111 ± 0.052	4.112GlyThr: 4.112 ± 0.036	4.76GlyVal: 4.76 ± 0.04	1.223GlyTrp: 1.223 ± 0.019	2.015GlyTyr: 2.015 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.16HisAla: 2.16 ± 0.026	0.32HisCys: 0.32 ± 0.009	1.247HisAsp: 1.247 ± 0.017	1.204HisGlu: 1.204 ± 0.018	0.828HisPhe: 0.828 ± 0.015	1.83HisGly: 1.83 ± 0.02	0.979HisHis: 0.979 ± 0.024	0.983HisIle: 0.983 ± 0.015	0.781HisLys: 0.781 ± 0.014	2.176HisLeu: 2.176 ± 0.025	0.445HisMet: 0.445 ± 0.008	0.703HisAsn: 0.703 ± 0.013	1.841HisPro: 1.841 ± 0.02	0.997HisGln: 0.997 ± 0.018	1.638HisArg: 1.638 ± 0.023	1.582HisSer: 1.582 ± 0.021	1.12HisThr: 1.12 ± 0.016	1.417HisVal: 1.417 ± 0.017	0.325HisTrp: 0.325 ± 0.009	0.65HisTyr: 0.65 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.802IleAla: 3.802 ± 0.033	0.597IleCys: 0.597 ± 0.013	2.339IleAsp: 2.339 ± 0.021	2.367IleGlu: 2.367 ± 0.027	1.558IlePhe: 1.558 ± 0.021	2.634IleGly: 2.634 ± 0.027	0.977IleHis: 0.977 ± 0.014	1.844IleIle: 1.844 ± 0.025	1.76IleLys: 1.76 ± 0.023	3.768IleLeu: 3.768 ± 0.035	0.802IleMet: 0.802 ± 0.013	1.362IleAsn: 1.362 ± 0.02	2.609IlePro: 2.609 ± 0.024	1.479IleGln: 1.479 ± 0.021	2.597IleArg: 2.597 ± 0.028	2.868IleSer: 2.868 ± 0.031	2.283IleThr: 2.283 ± 0.027	2.768IleVal: 2.768 ± 0.03	0.6IleTrp: 0.6 ± 0.012	1.147IleTyr: 1.147 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.249LysAla: 4.249 ± 0.044	0.397LysCys: 0.397 ± 0.009	2.278LysAsp: 2.278 ± 0.028	2.912LysGlu: 2.912 ± 0.039	1.191LysPhe: 1.191 ± 0.018	2.751LysGly: 2.751 ± 0.031	0.995LysHis: 0.995 ± 0.014	1.79LysIle: 1.79 ± 0.025	2.965LysLys: 2.965 ± 0.049	3.649LysLeu: 3.649 ± 0.033	0.852LysMet: 0.852 ± 0.014	1.312LysAsn: 1.312 ± 0.02	2.706LysPro: 2.706 ± 0.028	1.655LysGln: 1.655 ± 0.021	3.241LysArg: 3.241 ± 0.033	2.697LysSer: 2.697 ± 0.027	2.479LysThr: 2.479 ± 0.027	2.47LysVal: 2.47 ± 0.028	0.585LysTrp: 0.585 ± 0.011	1.168LysTyr: 1.168 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	9.507LeuAla: 9.507 ± 0.054	1.158LeuCys: 1.158 ± 0.02	5.132LeuAsp: 5.132 ± 0.033	5.319LeuGlu: 5.319 ± 0.042	3.156LeuPhe: 3.156 ± 0.027	6.261LeuGly: 6.261 ± 0.044	2.09LeuHis: 2.09 ± 0.025	3.22LeuIle: 3.22 ± 0.032	3.685LeuLys: 3.685 ± 0.036	8.654LeuLeu: 8.654 ± 0.065	1.648LeuMet: 1.648 ± 0.02	2.686LeuAsn: 2.686 ± 0.023	5.962LeuPro: 5.962 ± 0.041	3.577LeuGln: 3.577 ± 0.034	6.678LeuArg: 6.678 ± 0.044	6.784LeuSer: 6.784 ± 0.041	4.578LeuThr: 4.578 ± 0.034	5.742LeuVal: 5.742 ± 0.046	1.22LeuTrp: 1.22 ± 0.02	2.142LeuTyr: 2.142 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.377MetAla: 2.377 ± 0.023	0.222MetCys: 0.222 ± 0.008	1.125MetAsp: 1.125 ± 0.015	1.139MetGlu: 1.139 ± 0.016	0.63MetPhe: 0.63 ± 0.01	1.346MetGly: 1.346 ± 0.018	0.422MetHis: 0.422 ± 0.011	0.73MetIle: 0.73 ± 0.015	0.776MetLys: 0.776 ± 0.015	1.79MetLeu: 1.79 ± 0.019	0.503MetMet: 0.503 ± 0.012	0.577MetAsn: 0.577 ± 0.013	1.248MetPro: 1.248 ± 0.017	0.763MetGln: 0.763 ± 0.014	1.314MetArg: 1.314 ± 0.016	1.54MetSer: 1.54 ± 0.018	1.114MetThr: 1.114 ± 0.016	1.249MetVal: 1.249 ± 0.015	0.24MetTrp: 0.24 ± 0.008	0.454MetTyr: 0.454 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.935AsnAla: 2.935 ± 0.025	0.385AsnCys: 0.385 ± 0.01	1.549AsnAsp: 1.549 ± 0.02	1.55AsnGlu: 1.55 ± 0.022	1.119AsnPhe: 1.119 ± 0.017	2.747AsnGly: 2.747 ± 0.025	0.707AsnHis: 0.707 ± 0.012	1.511AsnIle: 1.511 ± 0.021	1.231AsnLys: 1.231 ± 0.018	2.815AsnLeu: 2.815 ± 0.027	0.626AsnMet: 0.626 ± 0.01	1.292AsnAsn: 1.292 ± 0.031	2.34AsnPro: 2.34 ± 0.024	1.089AsnGln: 1.089 ± 0.017	1.817AsnArg: 1.817 ± 0.019	2.138AsnSer: 2.138 ± 0.022	1.713AsnThr: 1.713 ± 0.021	1.902AsnVal: 1.902 ± 0.023	0.491AsnTrp: 0.491 ± 0.013	0.846AsnTyr: 0.846 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.804ProAla: 7.804 ± 0.064	0.565ProCys: 0.565 ± 0.014	3.588ProAsp: 3.588 ± 0.031	3.88ProGlu: 3.88 ± 0.036	2.036ProPhe: 2.036 ± 0.023	4.988ProGly: 4.988 ± 0.039	1.452ProHis: 1.452 ± 0.018	2.172ProIle: 2.172 ± 0.024	2.466ProLys: 2.466 ± 0.028	5.157ProLeu: 5.157 ± 0.036	1.014ProMet: 1.014 ± 0.016	1.993ProAsn: 1.993 ± 0.025	7.278ProPro: 7.278 ± 0.093	2.649ProGln: 2.649 ± 0.044	4.257ProArg: 4.257 ± 0.04	6.406ProSer: 6.406 ± 0.054	4.199ProThr: 4.199 ± 0.039	4.018ProVal: 4.018 ± 0.033	0.803ProTrp: 0.803 ± 0.014	1.442ProTyr: 1.442 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.91GlnAla: 3.91 ± 0.035	0.416GlnCys: 0.416 ± 0.011	1.867GlnAsp: 1.867 ± 0.021	2.184GlnGlu: 2.184 ± 0.026	1.167GlnPhe: 1.167 ± 0.018	2.463GlnGly: 2.463 ± 0.024	1.134GlnHis: 1.134 ± 0.019	1.544GlnIle: 1.544 ± 0.02	1.605GlnLys: 1.605 ± 0.021	3.492GlnLeu: 3.492 ± 0.034	0.775GlnMet: 0.775 ± 0.016	1.188GlnAsn: 1.188 ± 0.014	3.038GlnPro: 3.038 ± 0.037	3.033GlnGln: 3.033 ± 0.061	2.823GlnArg: 2.823 ± 0.025	2.632GlnSer: 2.632 ± 0.028	2.151GlnThr: 2.151 ± 0.025	2.096GlnVal: 2.096 ± 0.022	0.518GlnTrp: 0.518 ± 0.01	1.012GlnTyr: 1.012 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.446ArgAla: 6.446 ± 0.044	0.837ArgCys: 0.837 ± 0.016	3.858ArgAsp: 3.858 ± 0.047	4.473ArgGlu: 4.473 ± 0.041	2.315ArgPhe: 2.315 ± 0.021	4.541ArgGly: 4.541 ± 0.039	1.793ArgHis: 1.793 ± 0.022	2.743ArgIle: 2.743 ± 0.026	3.301ArgLys: 3.301 ± 0.037	6.275ArgLeu: 6.275 ± 0.041	1.373ArgMet: 1.373 ± 0.019	2.044ArgAsn: 2.044 ± 0.022	4.408ArgPro: 4.408 ± 0.043	2.855ArgGln: 2.855 ± 0.027	6.627ArgArg: 6.627 ± 0.051	5.022ArgSer: 5.022 ± 0.049	3.413ArgThr: 3.413 ± 0.029	3.856ArgVal: 3.856 ± 0.033	1.088ArgTrp: 1.088 ± 0.016	1.697ArgTyr: 1.697 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.662SerAla: 7.662 ± 0.047	0.818SerCys: 0.818 ± 0.017	3.803SerAsp: 3.803 ± 0.038	3.662SerGlu: 3.662 ± 0.035	2.619SerPhe: 2.619 ± 0.025	5.784SerGly: 5.784 ± 0.046	1.716SerHis: 1.716 ± 0.02	2.99SerIle: 2.99 ± 0.025	2.967SerLys: 2.967 ± 0.03	6.583SerLeu: 6.583 ± 0.043	1.451SerMet: 1.451 ± 0.02	2.303SerAsn: 2.303 ± 0.022	5.975SerPro: 5.975 ± 0.058	2.912SerGln: 2.912 ± 0.033	5.174SerArg: 5.174 ± 0.043	8.611SerSer: 8.611 ± 0.082	4.926SerThr: 4.926 ± 0.045	4.329SerVal: 4.329 ± 0.039	1.029SerTrp: 1.029 ± 0.017	1.728SerTyr: 1.728 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.126ThrAla: 6.126 ± 0.045	0.684ThrCys: 0.684 ± 0.014	2.578ThrAsp: 2.578 ± 0.025	2.707ThrGlu: 2.707 ± 0.026	1.965ThrPhe: 1.965 ± 0.022	4.187ThrGly: 4.187 ± 0.038	1.146ThrHis: 1.146 ± 0.016	2.429ThrIle: 2.429 ± 0.023	2.11ThrLys: 2.11 ± 0.023	4.888ThrLeu: 4.888 ± 0.04	0.992ThrMet: 0.992 ± 0.015	1.73ThrAsn: 1.73 ± 0.022	4.566ThrPro: 4.566 ± 0.04	1.847ThrGln: 1.847 ± 0.023	3.21ThrArg: 3.21 ± 0.027	4.696ThrSer: 4.696 ± 0.042	4.59ThrThr: 4.59 ± 0.06	3.76ThrVal: 3.76 ± 0.035	0.815ThrTrp: 0.815 ± 0.015	1.379ThrTyr: 1.379 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	6.266ValAla: 6.266 ± 0.044	0.862ValCys: 0.862 ± 0.017	3.758ValAsp: 3.758 ± 0.029	3.827ValGlu: 3.827 ± 0.035	2.475ValPhe: 2.475 ± 0.03	4.298ValGly: 4.298 ± 0.037	1.397ValHis: 1.397 ± 0.018	2.508ValIle: 2.508 ± 0.026	2.559ValLys: 2.559 ± 0.027	6.062ValLeu: 6.062 ± 0.041	1.231ValMet: 1.231 ± 0.017	1.923ValAsn: 1.923 ± 0.023	4.05ValPro: 4.05 ± 0.031	2.255ValGln: 2.255 ± 0.024	4.092ValArg: 4.092 ± 0.031	4.443ValSer: 4.443 ± 0.036	3.373ValThr: 3.373 ± 0.033	4.875ValVal: 4.875 ± 0.044	0.94ValTrp: 0.94 ± 0.015	1.712ValTyr: 1.712 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.286TrpAla: 1.286 ± 0.02	0.205TrpCys: 0.205 ± 0.007	0.922TrpAsp: 0.922 ± 0.016	0.869TrpGlu: 0.869 ± 0.015	0.517TrpPhe: 0.517 ± 0.011	0.954TrpGly: 0.954 ± 0.015	0.348TrpHis: 0.348 ± 0.011	0.64TrpIle: 0.64 ± 0.014	0.668TrpLys: 0.668 ± 0.013	1.379TrpLeu: 1.379 ± 0.022	0.342TrpMet: 0.342 ± 0.01	0.536TrpAsn: 0.536 ± 0.01	0.685TrpPro: 0.685 ± 0.014	0.552TrpGln: 0.552 ± 0.009	1.096TrpArg: 1.096 ± 0.016	0.971TrpSer: 0.971 ± 0.014	0.879TrpThr: 0.879 ± 0.014	0.907TrpVal: 0.907 ± 0.017	0.295TrpTrp: 0.295 ± 0.009	0.395TrpTyr: 0.395 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.179TyrAla: 2.179 ± 0.022	0.38TyrCys: 0.38 ± 0.01	1.493TyrAsp: 1.493 ± 0.02	1.362TyrGlu: 1.362 ± 0.015	1.055TyrPhe: 1.055 ± 0.015	1.918TyrGly: 1.918 ± 0.023	0.665TyrHis: 0.665 ± 0.013	1.22TyrIle: 1.22 ± 0.022	0.906TyrLys: 0.906 ± 0.017	2.538TyrLeu: 2.538 ± 0.027	0.514TyrMet: 0.514 ± 0.011	0.918TyrAsn: 0.918 ± 0.014	1.443TyrPro: 1.443 ± 0.019	0.97TyrGln: 0.97 ± 0.017	1.631TyrArg: 1.631 ± 0.019	1.689TyrSer: 1.689 ± 0.02	1.371TyrThr: 1.371 ± 0.019	1.598TyrVal: 1.598 ± 0.019	0.402TyrTrp: 0.402 ± 0.011	0.859TyrTyr: 0.859 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9760 proteins (4525313 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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