Amino acid dipepetide frequency for Limihaloglobus sulfuriphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.508AlaAla: 9.508 ± 0.132	0.996AlaCys: 0.996 ± 0.033	5.194AlaAsp: 5.194 ± 0.079	5.166AlaGlu: 5.166 ± 0.077	3.009AlaPhe: 3.009 ± 0.059	7.461AlaGly: 7.461 ± 0.107	1.097AlaHis: 1.097 ± 0.036	4.681AlaIle: 4.681 ± 0.075	3.998AlaLys: 3.998 ± 0.069	6.167AlaLeu: 6.167 ± 0.083	2.182AlaMet: 2.182 ± 0.046	2.963AlaAsn: 2.963 ± 0.053	2.407AlaPro: 2.407 ± 0.057	2.696AlaGln: 2.696 ± 0.054	3.719AlaArg: 3.719 ± 0.066	4.512AlaSer: 4.512 ± 0.068	2.805AlaThr: 2.805 ± 0.064	6.62AlaVal: 6.62 ± 0.095	0.929AlaTrp: 0.929 ± 0.03	2.447AlaTyr: 2.447 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.764CysAla: 0.764 ± 0.028	0.278CysCys: 0.278 ± 0.018	0.872CysAsp: 0.872 ± 0.027	0.78CysGlu: 0.78 ± 0.026	0.678CysPhe: 0.678 ± 0.027	1.572CysGly: 1.572 ± 0.047	0.3CysHis: 0.3 ± 0.02	0.921CysIle: 0.921 ± 0.028	0.733CysLys: 0.733 ± 0.03	1.144CysLeu: 1.144 ± 0.034	0.296CysMet: 0.296 ± 0.016	0.515CysAsn: 0.515 ± 0.024	0.756CysPro: 0.756 ± 0.027	0.439CysGln: 0.439 ± 0.02	0.905CysArg: 0.905 ± 0.032	1.095CysSer: 1.095 ± 0.033	0.617CysThr: 0.617 ± 0.022	0.92CysVal: 0.92 ± 0.033	0.181CysTrp: 0.181 ± 0.012	0.601CysTyr: 0.601 ± 0.029	0.0CysXaa: 0.0 ± 0.0
Asp	4.194AspAla: 4.194 ± 0.066	0.983AspCys: 0.983 ± 0.03	3.504AspAsp: 3.504 ± 0.066	3.965AspGlu: 3.965 ± 0.071	3.271AspPhe: 3.271 ± 0.054	5.061AspGly: 5.061 ± 0.097	0.99AspHis: 0.99 ± 0.027	5.034AspIle: 5.034 ± 0.072	3.758AspLys: 3.758 ± 0.071	4.652AspLeu: 4.652 ± 0.07	1.806AspMet: 1.806 ± 0.038	3.065AspAsn: 3.065 ± 0.056	2.771AspPro: 2.771 ± 0.057	1.633AspGln: 1.633 ± 0.047	2.593AspArg: 2.593 ± 0.051	3.996AspSer: 3.996 ± 0.072	3.243AspThr: 3.243 ± 0.055	3.917AspVal: 3.917 ± 0.056	1.117AspTrp: 1.117 ± 0.04	2.91AspTyr: 2.91 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	4.471GluAla: 4.471 ± 0.073	0.745GluCys: 0.745 ± 0.029	3.425GluAsp: 3.425 ± 0.055	3.537GluGlu: 3.537 ± 0.063	2.755GluPhe: 2.755 ± 0.051	3.737GluGly: 3.737 ± 0.062	1.25GluHis: 1.25 ± 0.031	4.645GluIle: 4.645 ± 0.07	4.826GluLys: 4.826 ± 0.087	6.415GluLeu: 6.415 ± 0.085	1.922GluMet: 1.922 ± 0.045	3.585GluAsn: 3.585 ± 0.057	2.729GluPro: 2.729 ± 0.052	2.575GluGln: 2.575 ± 0.052	2.675GluArg: 2.675 ± 0.055	3.721GluSer: 3.721 ± 0.058	3.742GluThr: 3.742 ± 0.058	3.462GluVal: 3.462 ± 0.057	0.799GluTrp: 0.799 ± 0.03	2.617GluTyr: 2.617 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.5PheAla: 3.5 ± 0.063	0.787PheCys: 0.787 ± 0.026	3.25PheAsp: 3.25 ± 0.06	3.035PheGlu: 3.035 ± 0.058	1.934PhePhe: 1.934 ± 0.047	3.242PheGly: 3.242 ± 0.051	0.739PheHis: 0.739 ± 0.028	2.802PheIle: 2.802 ± 0.052	2.149PheLys: 2.149 ± 0.052	3.253PheLeu: 3.253 ± 0.065	1.063PheMet: 1.063 ± 0.033	2.017PheAsn: 2.017 ± 0.044	1.404PhePro: 1.404 ± 0.03	1.029PheGln: 1.029 ± 0.032	1.927PheArg: 1.927 ± 0.037	3.219PheSer: 3.219 ± 0.06	2.618PheThr: 2.618 ± 0.05	2.866PheVal: 2.866 ± 0.059	0.637PheTrp: 0.637 ± 0.022	1.697PheTyr: 1.697 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.794GlyAla: 4.794 ± 0.083	1.224GlyCys: 1.224 ± 0.038	4.335GlyAsp: 4.335 ± 0.075	4.336GlyGlu: 4.336 ± 0.067	3.605GlyPhe: 3.605 ± 0.062	6.458GlyGly: 6.458 ± 0.163	1.458GlyHis: 1.458 ± 0.033	5.44GlyIle: 5.44 ± 0.079	4.534GlyLys: 4.534 ± 0.078	6.41GlyLeu: 6.41 ± 0.1	2.063GlyMet: 2.063 ± 0.054	3.16GlyAsn: 3.16 ± 0.071	2.308GlyPro: 2.308 ± 0.05	2.328GlyGln: 2.328 ± 0.05	4.157GlyArg: 4.157 ± 0.067	5.65GlySer: 5.65 ± 0.092	4.283GlyThr: 4.283 ± 0.081	4.73GlyVal: 4.73 ± 0.07	1.415GlyTrp: 1.415 ± 0.044	3.207GlyTyr: 3.207 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.113HisAla: 1.113 ± 0.035	0.314HisCys: 0.314 ± 0.017	0.967HisAsp: 0.967 ± 0.028	1.006HisGlu: 1.006 ± 0.028	0.87HisPhe: 0.87 ± 0.028	1.387HisGly: 1.387 ± 0.035	0.435HisHis: 0.435 ± 0.022	1.411HisIle: 1.411 ± 0.035	1.017HisLys: 1.017 ± 0.031	1.589HisLeu: 1.589 ± 0.043	0.397HisMet: 0.397 ± 0.02	0.846HisAsn: 0.846 ± 0.028	0.928HisPro: 0.928 ± 0.036	0.56HisGln: 0.56 ± 0.021	0.937HisArg: 0.937 ± 0.029	1.121HisSer: 1.121 ± 0.033	0.92HisThr: 0.92 ± 0.031	1.047HisVal: 1.047 ± 0.031	0.321HisTrp: 0.321 ± 0.016	0.746HisTyr: 0.746 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.7IleAla: 5.7 ± 0.081	1.024IleCys: 1.024 ± 0.032	4.966IleAsp: 4.966 ± 0.07	5.028IleGlu: 5.028 ± 0.066	2.712IlePhe: 2.712 ± 0.048	4.548IleGly: 4.548 ± 0.071	1.131IleHis: 1.131 ± 0.034	4.676IleIle: 4.676 ± 0.068	4.034IleLys: 4.034 ± 0.061	5.569IleLeu: 5.569 ± 0.081	1.427IleMet: 1.427 ± 0.042	3.274IleAsn: 3.274 ± 0.052	2.845IlePro: 2.845 ± 0.052	1.861IleGln: 1.861 ± 0.042	3.253IleArg: 3.253 ± 0.06	5.254IleSer: 5.254 ± 0.068	4.095IleThr: 4.095 ± 0.069	4.228IleVal: 4.228 ± 0.07	0.797IleTrp: 0.797 ± 0.03	2.356IleTyr: 2.356 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.355LysAla: 4.355 ± 0.073	0.711LysCys: 0.711 ± 0.031	3.522LysAsp: 3.522 ± 0.062	3.523LysGlu: 3.523 ± 0.071	1.977LysPhe: 1.977 ± 0.042	3.444LysGly: 3.444 ± 0.071	1.133LysHis: 1.133 ± 0.032	4.209LysIle: 4.209 ± 0.076	4.157LysLys: 4.157 ± 0.084	4.962LysLeu: 4.962 ± 0.08	1.599LysMet: 1.599 ± 0.042	2.829LysAsn: 2.829 ± 0.052	2.698LysPro: 2.698 ± 0.051	2.065LysGln: 2.065 ± 0.049	2.772LysArg: 2.772 ± 0.064	3.584LysSer: 3.584 ± 0.063	3.715LysThr: 3.715 ± 0.065	3.253LysVal: 3.253 ± 0.051	0.813LysTrp: 0.813 ± 0.029	2.303LysTyr: 2.303 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	7.367LeuAla: 7.367 ± 0.096	1.376LeuCys: 1.376 ± 0.035	5.229LeuAsp: 5.229 ± 0.077	6.214LeuGlu: 6.214 ± 0.081	3.561LeuPhe: 3.561 ± 0.062	5.968LeuGly: 5.968 ± 0.082	1.513LeuHis: 1.513 ± 0.037	5.713LeuIle: 5.713 ± 0.09	5.501LeuLys: 5.501 ± 0.083	7.653LeuLeu: 7.653 ± 0.119	2.186LeuMet: 2.186 ± 0.05	3.923LeuAsn: 3.923 ± 0.067	3.772LeuPro: 3.772 ± 0.064	2.265LeuGln: 2.265 ± 0.048	4.27LeuArg: 4.27 ± 0.071	6.329LeuSer: 6.329 ± 0.086	4.62LeuThr: 4.62 ± 0.058	5.176LeuVal: 5.176 ± 0.082	1.131LeuTrp: 1.131 ± 0.035	2.788LeuTyr: 2.788 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.233MetAla: 2.233 ± 0.053	0.284MetCys: 0.284 ± 0.017	1.43MetAsp: 1.43 ± 0.033	1.225MetGlu: 1.225 ± 0.034	1.063MetPhe: 1.063 ± 0.034	1.69MetGly: 1.69 ± 0.042	0.469MetHis: 0.469 ± 0.021	1.669MetIle: 1.669 ± 0.042	1.603MetLys: 1.603 ± 0.036	2.573MetLeu: 2.573 ± 0.052	0.639MetMet: 0.639 ± 0.024	1.196MetAsn: 1.196 ± 0.032	1.516MetPro: 1.516 ± 0.038	0.94MetGln: 0.94 ± 0.033	1.283MetArg: 1.283 ± 0.033	1.714MetSer: 1.714 ± 0.042	1.41MetThr: 1.41 ± 0.034	1.531MetVal: 1.531 ± 0.041	0.267MetTrp: 0.267 ± 0.016	0.8MetTyr: 0.8 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.221AsnAla: 3.221 ± 0.058	0.748AsnCys: 0.748 ± 0.031	2.442AsnAsp: 2.442 ± 0.048	2.487AsnGlu: 2.487 ± 0.051	1.845AsnPhe: 1.845 ± 0.043	3.554AsnGly: 3.554 ± 0.068	0.79AsnHis: 0.79 ± 0.027	3.606AsnIle: 3.606 ± 0.058	2.28AsnLys: 2.28 ± 0.047	3.752AsnLeu: 3.752 ± 0.053	1.15AsnMet: 1.15 ± 0.028	2.18AsnAsn: 2.18 ± 0.059	2.536AsnPro: 2.536 ± 0.044	1.397AsnGln: 1.397 ± 0.038	2.266AsnArg: 2.266 ± 0.054	3.079AsnSer: 3.079 ± 0.059	2.549AsnThr: 2.549 ± 0.048	2.867AsnVal: 2.867 ± 0.053	0.838AsnTrp: 0.838 ± 0.034	1.876AsnTyr: 1.876 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.991ProAla: 3.991 ± 0.076	0.459ProCys: 0.459 ± 0.02	3.373ProAsp: 3.373 ± 0.056	3.807ProGlu: 3.807 ± 0.068	1.79ProPhe: 1.79 ± 0.044	3.354ProGly: 3.354 ± 0.06	0.816ProHis: 0.816 ± 0.031	1.973ProIle: 1.973 ± 0.04	1.9ProLys: 1.9 ± 0.051	3.451ProLeu: 3.451 ± 0.062	0.848ProMet: 0.848 ± 0.027	1.564ProAsn: 1.564 ± 0.038	1.404ProPro: 1.404 ± 0.04	1.731ProGln: 1.731 ± 0.042	1.712ProArg: 1.712 ± 0.041	2.467ProSer: 2.467 ± 0.047	1.711ProThr: 1.711 ± 0.04	3.426ProVal: 3.426 ± 0.059	0.628ProTrp: 0.628 ± 0.022	1.497ProTyr: 1.497 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.611GlnAla: 2.611 ± 0.051	0.34GlnCys: 0.34 ± 0.018	1.754GlnAsp: 1.754 ± 0.04	1.781GlnGlu: 1.781 ± 0.042	1.181GlnPhe: 1.181 ± 0.035	2.092GlnGly: 2.092 ± 0.043	0.557GlnHis: 0.557 ± 0.023	2.534GlnIle: 2.534 ± 0.051	2.087GlnLys: 2.087 ± 0.051	2.912GlnLeu: 2.912 ± 0.06	1.058GlnMet: 1.058 ± 0.03	1.581GlnAsn: 1.581 ± 0.031	1.236GlnPro: 1.236 ± 0.037	1.416GlnGln: 1.416 ± 0.049	1.811GlnArg: 1.811 ± 0.046	2.068GlnSer: 2.068 ± 0.048	1.86GlnThr: 1.86 ± 0.043	1.884GlnVal: 1.884 ± 0.041	0.621GlnTrp: 0.621 ± 0.025	1.138GlnTyr: 1.138 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.095ArgAla: 3.095 ± 0.052	0.692ArgCys: 0.692 ± 0.026	2.861ArgAsp: 2.861 ± 0.05	3.099ArgGlu: 3.099 ± 0.054	2.23ArgPhe: 2.23 ± 0.046	3.197ArgGly: 3.197 ± 0.062	0.983ArgHis: 0.983 ± 0.03	3.659ArgIle: 3.659 ± 0.064	3.133ArgLys: 3.133 ± 0.055	4.935ArgLeu: 4.935 ± 0.081	1.3ArgMet: 1.3 ± 0.034	2.135ArgAsn: 2.135 ± 0.045	2.014ArgPro: 2.014 ± 0.044	1.867ArgGln: 1.867 ± 0.04	2.932ArgArg: 2.932 ± 0.068	2.71ArgSer: 2.71 ± 0.059	2.175ArgThr: 2.175 ± 0.049	2.978ArgVal: 2.978 ± 0.054	0.715ArgTrp: 0.715 ± 0.029	2.004ArgTyr: 2.004 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.973SerAla: 4.973 ± 0.079	0.932SerCys: 0.932 ± 0.027	4.257SerAsp: 4.257 ± 0.067	4.069SerGlu: 4.069 ± 0.058	3.064SerPhe: 3.064 ± 0.063	6.342SerGly: 6.342 ± 0.099	1.132SerHis: 1.132 ± 0.032	4.323SerIle: 4.323 ± 0.068	3.204SerLys: 3.204 ± 0.058	6.042SerLeu: 6.042 ± 0.078	1.594SerMet: 1.594 ± 0.04	2.731SerAsn: 2.731 ± 0.06	2.914SerPro: 2.914 ± 0.059	2.347SerGln: 2.347 ± 0.048	3.652SerArg: 3.652 ± 0.059	4.822SerSer: 4.822 ± 0.091	2.936SerThr: 2.936 ± 0.06	4.41SerVal: 4.41 ± 0.067	1.027SerTrp: 1.027 ± 0.035	2.408SerTyr: 2.408 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.031ThrAla: 5.031 ± 0.089	0.614ThrCys: 0.614 ± 0.025	3.509ThrAsp: 3.509 ± 0.062	3.185ThrGlu: 3.185 ± 0.051	2.078ThrPhe: 2.078 ± 0.046	5.088ThrGly: 5.088 ± 0.086	0.889ThrHis: 0.889 ± 0.029	3.462ThrIle: 3.462 ± 0.067	2.196ThrLys: 2.196 ± 0.05	4.67ThrLeu: 4.67 ± 0.071	1.118ThrMet: 1.118 ± 0.031	2.053ThrAsn: 2.053 ± 0.046	2.523ThrPro: 2.523 ± 0.062	1.551ThrGln: 1.551 ± 0.04	2.207ThrArg: 2.207 ± 0.046	3.166ThrSer: 3.166 ± 0.057	2.555ThrThr: 2.555 ± 0.061	4.093ThrVal: 4.093 ± 0.072	0.69ThrTrp: 0.69 ± 0.027	1.724ThrTyr: 1.724 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.081ValAla: 4.081 ± 0.076	1.103ValCys: 1.103 ± 0.035	3.977ValAsp: 3.977 ± 0.06	4.389ValGlu: 4.389 ± 0.079	3.162ValPhe: 3.162 ± 0.061	3.934ValGly: 3.934 ± 0.078	1.09ValHis: 1.09 ± 0.03	4.779ValIle: 4.779 ± 0.059	3.757ValLys: 3.757 ± 0.062	5.708ValLeu: 5.708 ± 0.082	1.672ValMet: 1.672 ± 0.043	3.187ValAsn: 3.187 ± 0.054	2.854ValPro: 2.854 ± 0.057	1.683ValGln: 1.683 ± 0.038	2.876ValArg: 2.876 ± 0.051	4.968ValSer: 4.968 ± 0.076	3.775ValThr: 3.775 ± 0.074	4.4ValVal: 4.4 ± 0.085	0.882ValTrp: 0.882 ± 0.028	2.477ValTyr: 2.477 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.974TrpAla: 0.974 ± 0.033	0.166TrpCys: 0.166 ± 0.011	1.002TrpAsp: 1.002 ± 0.032	0.683TrpGlu: 0.683 ± 0.023	0.654TrpPhe: 0.654 ± 0.025	1.008TrpGly: 1.008 ± 0.029	0.433TrpHis: 0.433 ± 0.019	0.793TrpIle: 0.793 ± 0.029	0.796TrpLys: 0.796 ± 0.028	1.524TrpLeu: 1.524 ± 0.044	0.383TrpMet: 0.383 ± 0.02	0.757TrpAsn: 0.757 ± 0.028	0.593TrpPro: 0.593 ± 0.022	0.869TrpGln: 0.869 ± 0.031	0.747TrpArg: 0.747 ± 0.032	0.897TrpSer: 0.897 ± 0.034	0.757TrpThr: 0.757 ± 0.029	0.803TrpVal: 0.803 ± 0.03	0.284TrpTrp: 0.284 ± 0.019	0.588TrpTyr: 0.588 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.581TyrAla: 2.581 ± 0.055	0.594TyrCys: 0.594 ± 0.026	2.596TyrAsp: 2.596 ± 0.057	2.315TyrGlu: 2.315 ± 0.052	1.732TyrPhe: 1.732 ± 0.045	2.757TyrGly: 2.757 ± 0.05	0.727TyrHis: 0.727 ± 0.027	2.447TyrIle: 2.447 ± 0.045	1.961TyrLys: 1.961 ± 0.049	3.173TyrLeu: 3.173 ± 0.052	0.831TyrMet: 0.831 ± 0.025	1.903TyrAsn: 1.903 ± 0.045	1.693TyrPro: 1.693 ± 0.041	1.269TyrGln: 1.269 ± 0.039	2.018TyrArg: 2.018 ± 0.04	2.806TyrSer: 2.806 ± 0.057	2.018TyrThr: 2.018 ± 0.054	2.142TyrVal: 2.142 ± 0.047	0.621TyrTrp: 0.621 ± 0.026	1.662TyrTyr: 1.662 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2870 proteins (1126502 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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