Amino acid dipepetide frequency for Acidovorax sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.586AlaAla: 19.586 ± 0.166	1.3AlaCys: 1.3 ± 0.038	6.677AlaAsp: 6.677 ± 0.079	6.413AlaGlu: 6.413 ± 0.078	4.042AlaPhe: 4.042 ± 0.057	11.179AlaGly: 11.179 ± 0.104	2.976AlaHis: 2.976 ± 0.053	4.977AlaIle: 4.977 ± 0.073	3.835AlaLys: 3.835 ± 0.073	15.692AlaLeu: 15.692 ± 0.133	3.484AlaMet: 3.484 ± 0.051	2.775AlaAsn: 2.775 ± 0.062	7.039AlaPro: 7.039 ± 0.102	6.927AlaGln: 6.927 ± 0.081	8.971AlaArg: 8.971 ± 0.086	7.063AlaSer: 7.063 ± 0.081	6.978AlaThr: 6.978 ± 0.087	9.952AlaVal: 9.952 ± 0.09	2.137AlaTrp: 2.137 ± 0.041	2.397AlaTyr: 2.397 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.128CysAla: 1.128 ± 0.028	0.1CysCys: 0.1 ± 0.009	0.499CysAsp: 0.499 ± 0.021	0.439CysGlu: 0.439 ± 0.016	0.281CysPhe: 0.281 ± 0.014	0.944CysGly: 0.944 ± 0.028	0.266CysHis: 0.266 ± 0.015	0.412CysIle: 0.412 ± 0.017	0.209CysLys: 0.209 ± 0.011	0.782CysLeu: 0.782 ± 0.023	0.244CysMet: 0.244 ± 0.013	0.242CysAsn: 0.242 ± 0.014	0.447CysPro: 0.447 ± 0.021	0.259CysGln: 0.259 ± 0.013	0.511CysArg: 0.511 ± 0.02	0.506CysSer: 0.506 ± 0.02	0.521CysThr: 0.521 ± 0.019	0.702CysVal: 0.702 ± 0.026	0.125CysTrp: 0.125 ± 0.01	0.195CysTyr: 0.195 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.55AspAla: 7.55 ± 0.067	0.403AspCys: 0.403 ± 0.019	2.662AspAsp: 2.662 ± 0.062	2.756AspGlu: 2.756 ± 0.043	1.906AspPhe: 1.906 ± 0.038	4.646AspGly: 4.646 ± 0.076	1.212AspHis: 1.212 ± 0.026	2.357AspIle: 2.357 ± 0.039	1.725AspLys: 1.725 ± 0.045	5.216AspLeu: 5.216 ± 0.063	1.191AspMet: 1.191 ± 0.03	1.267AspAsn: 1.267 ± 0.034	2.688AspPro: 2.688 ± 0.05	1.62AspGln: 1.62 ± 0.031	3.121AspArg: 3.121 ± 0.051	2.285AspSer: 2.285 ± 0.037	2.871AspThr: 2.871 ± 0.071	4.145AspVal: 4.145 ± 0.054	0.966AspTrp: 0.966 ± 0.029	1.238AspTyr: 1.238 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.189GluAla: 6.189 ± 0.07	0.329GluCys: 0.329 ± 0.016	2.02GluAsp: 2.02 ± 0.04	2.243GluGlu: 2.243 ± 0.048	1.694GluPhe: 1.694 ± 0.039	3.574GluGly: 3.574 ± 0.053	1.269GluHis: 1.269 ± 0.032	2.289GluIle: 2.289 ± 0.043	1.703GluLys: 1.703 ± 0.041	5.363GluLeu: 5.363 ± 0.07	1.144GluMet: 1.144 ± 0.029	1.138GluAsn: 1.138 ± 0.03	2.466GluPro: 2.466 ± 0.051	2.46GluGln: 2.46 ± 0.044	4.324GluArg: 4.324 ± 0.063	2.475GluSer: 2.475 ± 0.041	2.287GluThr: 2.287 ± 0.043	3.883GluVal: 3.883 ± 0.058	0.673GluTrp: 0.673 ± 0.023	0.929GluTyr: 0.929 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.224PheAla: 4.224 ± 0.066	0.374PheCys: 0.374 ± 0.017	2.377PheAsp: 2.377 ± 0.047	1.85PheGlu: 1.85 ± 0.037	1.261PhePhe: 1.261 ± 0.035	3.172PheGly: 3.172 ± 0.054	0.708PheHis: 0.708 ± 0.022	1.465PheIle: 1.465 ± 0.039	1.165PheLys: 1.165 ± 0.032	2.734PheLeu: 2.734 ± 0.046	0.871PheMet: 0.871 ± 0.026	1.091PheAsn: 1.091 ± 0.031	1.421PhePro: 1.421 ± 0.029	1.071PheGln: 1.071 ± 0.026	1.698PheArg: 1.698 ± 0.032	2.036PheSer: 2.036 ± 0.039	1.958PheThr: 1.958 ± 0.04	2.714PheVal: 2.714 ± 0.048	0.506PheTrp: 0.506 ± 0.02	0.813PheTyr: 0.813 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.778GlyAla: 9.778 ± 0.105	0.905GlyCys: 0.905 ± 0.027	4.087GlyAsp: 4.087 ± 0.063	4.062GlyGlu: 4.062 ± 0.055	3.205GlyPhe: 3.205 ± 0.05	7.195GlyGly: 7.195 ± 0.108	2.018GlyHis: 2.018 ± 0.04	3.736GlyIle: 3.736 ± 0.058	3.139GlyLys: 3.139 ± 0.049	8.852GlyLeu: 8.852 ± 0.076	2.375GlyMet: 2.375 ± 0.042	2.27GlyAsn: 2.27 ± 0.075	3.253GlyPro: 3.253 ± 0.058	3.746GlyGln: 3.746 ± 0.053	5.279GlyArg: 5.279 ± 0.067	4.813GlySer: 4.813 ± 0.076	5.044GlyThr: 5.044 ± 0.082	6.815GlyVal: 6.815 ± 0.079	1.465GlyTrp: 1.465 ± 0.034	2.218GlyTyr: 2.218 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.181HisAla: 3.181 ± 0.054	0.296HisCys: 0.296 ± 0.016	1.217HisAsp: 1.217 ± 0.029	1.158HisGlu: 1.158 ± 0.029	0.885HisPhe: 0.885 ± 0.025	2.246HisGly: 2.246 ± 0.043	0.706HisHis: 0.706 ± 0.028	1.006HisIle: 1.006 ± 0.027	0.613HisLys: 0.613 ± 0.022	2.364HisLeu: 2.364 ± 0.039	0.498HisMet: 0.498 ± 0.018	0.558HisAsn: 0.558 ± 0.023	1.545HisPro: 1.545 ± 0.035	0.833HisGln: 0.833 ± 0.023	1.56HisArg: 1.56 ± 0.037	1.119HisSer: 1.119 ± 0.029	1.269HisThr: 1.269 ± 0.029	1.626HisVal: 1.626 ± 0.034	0.462HisTrp: 0.462 ± 0.017	0.597HisTyr: 0.597 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.928IleAla: 5.928 ± 0.07	0.36IleCys: 0.36 ± 0.017	2.922IleAsp: 2.922 ± 0.045	2.677IleGlu: 2.677 ± 0.049	1.231IlePhe: 1.231 ± 0.033	3.724IleGly: 3.724 ± 0.055	0.859IleHis: 0.859 ± 0.024	1.418IleIle: 1.418 ± 0.042	1.378IleLys: 1.378 ± 0.031	3.112IleLeu: 3.112 ± 0.05	0.712IleMet: 0.712 ± 0.024	1.295IleAsn: 1.295 ± 0.032	1.885IlePro: 1.885 ± 0.039	1.229IleGln: 1.229 ± 0.029	2.298IleArg: 2.298 ± 0.039	2.161IleSer: 2.161 ± 0.04	2.605IleThr: 2.605 ± 0.044	3.297IleVal: 3.297 ± 0.052	0.444IleTrp: 0.444 ± 0.02	0.885IleTyr: 0.885 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.078LysAla: 4.078 ± 0.072	0.137LysCys: 0.137 ± 0.01	1.689LysAsp: 1.689 ± 0.039	1.438LysGlu: 1.438 ± 0.037	0.843LysPhe: 0.843 ± 0.026	2.366LysGly: 2.366 ± 0.044	0.62LysHis: 0.62 ± 0.022	1.383LysIle: 1.383 ± 0.04	1.392LysLys: 1.392 ± 0.047	3.238LysLeu: 3.238 ± 0.057	0.742LysMet: 0.742 ± 0.024	0.899LysAsn: 0.899 ± 0.027	1.915LysPro: 1.915 ± 0.041	1.07LysGln: 1.07 ± 0.028	1.916LysArg: 1.916 ± 0.045	1.756LysSer: 1.756 ± 0.041	1.859LysThr: 1.859 ± 0.044	2.478LysVal: 2.478 ± 0.046	0.318LysTrp: 0.318 ± 0.017	0.595LysTyr: 0.595 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.3LeuAla: 15.3 ± 0.138	1.028LeuCys: 1.028 ± 0.03	5.421LeuAsp: 5.421 ± 0.06	4.679LeuGlu: 4.679 ± 0.063	3.205LeuPhe: 3.205 ± 0.048	8.666LeuGly: 8.666 ± 0.088	2.564LeuHis: 2.564 ± 0.045	4.039LeuIle: 4.039 ± 0.063	3.255LeuLys: 3.255 ± 0.057	11.129LeuLeu: 11.129 ± 0.111	2.577LeuMet: 2.577 ± 0.041	2.676LeuAsn: 2.676 ± 0.048	6.302LeuPro: 6.302 ± 0.07	5.038LeuGln: 5.038 ± 0.063	7.536LeuArg: 7.536 ± 0.095	6.098LeuSer: 6.098 ± 0.075	5.328LeuThr: 5.328 ± 0.066	8.084LeuVal: 8.084 ± 0.084	1.474LeuTrp: 1.474 ± 0.036	2.016LeuTyr: 2.016 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.271MetAla: 3.271 ± 0.046	0.164MetCys: 0.164 ± 0.011	1.203MetAsp: 1.203 ± 0.03	1.069MetGlu: 1.069 ± 0.03	0.649MetPhe: 0.649 ± 0.022	2.029MetGly: 2.029 ± 0.039	0.568MetHis: 0.568 ± 0.022	0.788MetIle: 0.788 ± 0.024	0.908MetLys: 0.908 ± 0.026	2.605MetLeu: 2.605 ± 0.042	0.535MetMet: 0.535 ± 0.019	0.766MetAsn: 0.766 ± 0.025	1.509MetPro: 1.509 ± 0.032	1.15MetGln: 1.15 ± 0.027	1.597MetArg: 1.597 ± 0.036	1.446MetSer: 1.446 ± 0.031	1.523MetThr: 1.523 ± 0.028	1.923MetVal: 1.923 ± 0.04	0.222MetTrp: 0.222 ± 0.013	0.381MetTyr: 0.381 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.482AsnAla: 3.482 ± 0.058	0.216AsnCys: 0.216 ± 0.012	1.385AsnAsp: 1.385 ± 0.056	1.079AsnGlu: 1.079 ± 0.032	0.918AsnPhe: 0.918 ± 0.031	2.122AsnGly: 2.122 ± 0.062	0.53AsnHis: 0.53 ± 0.02	1.182AsnIle: 1.182 ± 0.032	0.761AsnLys: 0.761 ± 0.027	2.582AsnLeu: 2.582 ± 0.046	0.518AsnMet: 0.518 ± 0.02	0.766AsnAsn: 0.766 ± 0.029	1.786AsnPro: 1.786 ± 0.04	0.936AsnGln: 0.936 ± 0.027	1.524AsnArg: 1.524 ± 0.035	1.123AsnSer: 1.123 ± 0.034	1.495AsnThr: 1.495 ± 0.035	1.921AsnVal: 1.921 ± 0.045	0.379AsnTrp: 0.379 ± 0.016	0.647AsnTyr: 0.647 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.941ProAla: 7.941 ± 0.109	0.362ProCys: 0.362 ± 0.017	3.092ProAsp: 3.092 ± 0.049	3.056ProGlu: 3.056 ± 0.048	1.746ProPhe: 1.746 ± 0.039	4.847ProGly: 4.847 ± 0.062	1.341ProHis: 1.341 ± 0.029	1.753ProIle: 1.753 ± 0.035	1.339ProLys: 1.339 ± 0.037	5.554ProLeu: 5.554 ± 0.07	1.234ProMet: 1.234 ± 0.028	1.116ProAsn: 1.116 ± 0.032	2.891ProPro: 2.891 ± 0.066	2.34ProGln: 2.34 ± 0.043	2.994ProArg: 2.994 ± 0.051	2.884ProSer: 2.884 ± 0.041	2.91ProThr: 2.91 ± 0.053	4.45ProVal: 4.45 ± 0.048	0.839ProTrp: 0.839 ± 0.021	1.144ProTyr: 1.144 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	6.333GlnAla: 6.333 ± 0.081	0.308GlnCys: 0.308 ± 0.015	1.871GlnAsp: 1.871 ± 0.037	1.681GlnGlu: 1.681 ± 0.035	1.359GlnPhe: 1.359 ± 0.03	3.642GlnGly: 3.642 ± 0.058	1.104GlnHis: 1.104 ± 0.03	1.686GlnIle: 1.686 ± 0.038	1.147GlnLys: 1.147 ± 0.032	4.466GlnLeu: 4.466 ± 0.062	1.023GlnMet: 1.023 ± 0.028	0.903GlnAsn: 0.903 ± 0.027	2.596GlnPro: 2.596 ± 0.046	2.302GlnGln: 2.302 ± 0.047	3.75GlnArg: 3.75 ± 0.05	2.198GlnSer: 2.198 ± 0.042	2.02GlnThr: 2.02 ± 0.043	3.283GlnVal: 3.283 ± 0.047	0.83GlnTrp: 0.83 ± 0.025	0.872GlnTyr: 0.872 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.777ArgAla: 7.777 ± 0.083	0.578ArgCys: 0.578 ± 0.023	3.386ArgAsp: 3.386 ± 0.05	3.724ArgGlu: 3.724 ± 0.049	2.525ArgPhe: 2.525 ± 0.04	4.513ArgGly: 4.513 ± 0.056	1.857ArgHis: 1.857 ± 0.037	3.134ArgIle: 3.134 ± 0.046	2.032ArgLys: 2.032 ± 0.04	7.386ArgLeu: 7.386 ± 0.088	1.854ArgMet: 1.854 ± 0.039	1.775ArgAsn: 1.775 ± 0.035	3.132ArgPro: 3.132 ± 0.056	2.973ArgGln: 2.973 ± 0.054	4.605ArgArg: 4.605 ± 0.072	3.618ArgSer: 3.618 ± 0.062	3.641ArgThr: 3.641 ± 0.051	4.953ArgVal: 4.953 ± 0.068	1.307ArgTrp: 1.307 ± 0.034	1.725ArgTyr: 1.725 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.033SerAla: 7.033 ± 0.076	0.405SerCys: 0.405 ± 0.016	2.634SerAsp: 2.634 ± 0.046	2.316SerGlu: 2.316 ± 0.044	1.984SerPhe: 1.984 ± 0.045	5.167SerGly: 5.167 ± 0.064	1.255SerHis: 1.255 ± 0.029	2.339SerIle: 2.339 ± 0.041	1.451SerLys: 1.451 ± 0.04	5.596SerLeu: 5.596 ± 0.069	1.315SerMet: 1.315 ± 0.031	1.385SerAsn: 1.385 ± 0.034	3.03SerPro: 3.03 ± 0.049	1.995SerGln: 1.995 ± 0.041	3.32SerArg: 3.32 ± 0.052	3.161SerSer: 3.161 ± 0.053	3.224SerThr: 3.224 ± 0.06	4.102SerVal: 4.102 ± 0.052	0.768SerTrp: 0.768 ± 0.027	1.267SerTyr: 1.267 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	7.002ThrAla: 7.002 ± 0.092	0.391ThrCys: 0.391 ± 0.016	2.737ThrAsp: 2.737 ± 0.059	2.321ThrGlu: 2.321 ± 0.043	1.686ThrPhe: 1.686 ± 0.034	5.202ThrGly: 5.202 ± 0.083	1.33ThrHis: 1.33 ± 0.03	2.077ThrIle: 2.077 ± 0.04	1.238ThrLys: 1.238 ± 0.036	6.6ThrLeu: 6.6 ± 0.075	1.172ThrMet: 1.172 ± 0.029	1.255ThrAsn: 1.255 ± 0.035	3.867ThrPro: 3.867 ± 0.072	2.207ThrGln: 2.207 ± 0.037	3.315ThrArg: 3.315 ± 0.052	2.903ThrSer: 2.903 ± 0.043	3.33ThrThr: 3.33 ± 0.083	4.624ThrVal: 4.624 ± 0.068	0.724ThrTrp: 0.724 ± 0.022	1.074ThrTyr: 1.074 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.408ValAla: 10.408 ± 0.091	0.765ValCys: 0.765 ± 0.024	4.076ValAsp: 4.076 ± 0.057	3.837ValGlu: 3.837 ± 0.057	2.662ValPhe: 2.662 ± 0.044	5.948ValGly: 5.948 ± 0.061	1.748ValHis: 1.748 ± 0.035	3.056ValIle: 3.056 ± 0.054	2.311ValLys: 2.311 ± 0.05	8.795ValLeu: 8.795 ± 0.09	1.953ValMet: 1.953 ± 0.037	2.156ValAsn: 2.156 ± 0.044	4.249ValPro: 4.249 ± 0.057	3.521ValGln: 3.521 ± 0.05	5.331ValArg: 5.331 ± 0.063	4.092ValSer: 4.092 ± 0.048	4.149ValThr: 4.149 ± 0.062	6.829ValVal: 6.829 ± 0.087	1.064ValTrp: 1.064 ± 0.029	1.563ValTyr: 1.563 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.639TrpAla: 1.639 ± 0.042	0.169TrpCys: 0.169 ± 0.011	0.679TrpAsp: 0.679 ± 0.022	0.535TrpGlu: 0.535 ± 0.02	0.57TrpPhe: 0.57 ± 0.022	1.123TrpGly: 1.123 ± 0.033	0.367TrpHis: 0.367 ± 0.017	0.608TrpIle: 0.608 ± 0.022	0.469TrpLys: 0.469 ± 0.017	2.09TrpLeu: 2.09 ± 0.041	0.466TrpMet: 0.466 ± 0.017	0.439TrpAsn: 0.439 ± 0.017	0.759TrpPro: 0.759 ± 0.023	0.823TrpGln: 0.823 ± 0.025	1.238TrpArg: 1.238 ± 0.034	0.853TrpSer: 0.853 ± 0.027	0.795TrpThr: 0.795 ± 0.026	1.157TrpVal: 1.157 ± 0.03	0.318TrpTrp: 0.318 ± 0.017	0.288TrpTyr: 0.288 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.573TyrAla: 2.573 ± 0.042	0.221TyrCys: 0.221 ± 0.012	1.191TyrAsp: 1.191 ± 0.031	1.12TyrGlu: 1.12 ± 0.033	0.857TyrPhe: 0.857 ± 0.024	1.951TyrGly: 1.951 ± 0.034	0.441TyrHis: 0.441 ± 0.016	0.717TyrIle: 0.717 ± 0.023	0.662TyrLys: 0.662 ± 0.025	2.258TyrLeu: 2.258 ± 0.043	0.4TyrMet: 0.4 ± 0.018	0.582TyrAsn: 0.582 ± 0.021	1.052TyrPro: 1.052 ± 0.027	0.875TyrGln: 0.875 ± 0.023	1.606TyrArg: 1.606 ± 0.031	1.153TyrSer: 1.153 ± 0.029	1.249TyrThr: 1.249 ± 0.04	1.572TyrVal: 1.572 ± 0.036	0.362TyrTrp: 0.362 ± 0.017	0.534TyrTyr: 0.534 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5416 proteins (1423572 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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