Amino acid dipepetide frequency for Burkholderia sp. SRS-W-2-2016

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.623AlaAla: 18.623 ± 0.148	1.251AlaCys: 1.251 ± 0.026	6.781AlaAsp: 6.781 ± 0.062	5.95AlaGlu: 5.95 ± 0.065	4.243AlaPhe: 4.243 ± 0.046	10.979AlaGly: 10.979 ± 0.108	2.88AlaHis: 2.88 ± 0.035	5.682AlaIle: 5.682 ± 0.068	3.657AlaLys: 3.657 ± 0.057	14.621AlaLeu: 14.621 ± 0.114	3.127AlaMet: 3.127 ± 0.039	3.708AlaAsn: 3.708 ± 0.053	6.11AlaPro: 6.11 ± 0.077	5.668AlaGln: 5.668 ± 0.064	8.957AlaArg: 8.957 ± 0.079	7.734AlaSer: 7.734 ± 0.074	6.751AlaThr: 6.751 ± 0.074	8.719AlaVal: 8.719 ± 0.074	1.683AlaTrp: 1.683 ± 0.028	2.677AlaTyr: 2.677 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.245CysAla: 1.245 ± 0.024	0.132CysCys: 0.132 ± 0.008	0.553CysAsp: 0.553 ± 0.016	0.488CysGlu: 0.488 ± 0.016	0.332CysPhe: 0.332 ± 0.013	1.005CysGly: 1.005 ± 0.024	0.244CysHis: 0.244 ± 0.011	0.38CysIle: 0.38 ± 0.015	0.217CysLys: 0.217 ± 0.011	0.741CysLeu: 0.741 ± 0.023	0.184CysMet: 0.184 ± 0.011	0.242CysAsn: 0.242 ± 0.011	0.413CysPro: 0.413 ± 0.015	0.2CysGln: 0.2 ± 0.009	0.57CysArg: 0.57 ± 0.016	0.5CysSer: 0.5 ± 0.014	0.46CysThr: 0.46 ± 0.016	0.801CysVal: 0.801 ± 0.024	0.108CysTrp: 0.108 ± 0.007	0.222CysTyr: 0.222 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.078AspAla: 8.078 ± 0.078	0.453AspCys: 0.453 ± 0.015	3.095AspAsp: 3.095 ± 0.048	3.331AspGlu: 3.331 ± 0.044	1.924AspPhe: 1.924 ± 0.033	4.738AspGly: 4.738 ± 0.062	1.114AspHis: 1.114 ± 0.025	2.357AspIle: 2.357 ± 0.033	1.49AspLys: 1.49 ± 0.031	5.03AspLeu: 5.03 ± 0.05	1.088AspMet: 1.088 ± 0.025	1.381AspAsn: 1.381 ± 0.03	2.867AspPro: 2.867 ± 0.034	1.578AspGln: 1.578 ± 0.027	3.167AspArg: 3.167 ± 0.039	2.671AspSer: 2.671 ± 0.046	2.983AspThr: 2.983 ± 0.039	4.209AspVal: 4.209 ± 0.051	0.911AspTrp: 0.911 ± 0.022	1.501AspTyr: 1.501 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.167GluAla: 6.167 ± 0.074	0.38GluCys: 0.38 ± 0.013	1.979GluAsp: 1.979 ± 0.038	2.202GluGlu: 2.202 ± 0.038	1.794GluPhe: 1.794 ± 0.032	3.048GluGly: 3.048 ± 0.044	1.45GluHis: 1.45 ± 0.029	2.663GluIle: 2.663 ± 0.04	1.684GluLys: 1.684 ± 0.034	5.636GluLeu: 5.636 ± 0.08	1.19GluMet: 1.19 ± 0.025	1.372GluAsn: 1.372 ± 0.03	2.562GluPro: 2.562 ± 0.042	2.633GluGln: 2.633 ± 0.045	4.91GluArg: 4.91 ± 0.061	2.461GluSer: 2.461 ± 0.031	2.659GluThr: 2.659 ± 0.042	3.463GluVal: 3.463 ± 0.047	0.721GluTrp: 0.721 ± 0.016	1.136GluTyr: 1.136 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.788PheAla: 4.788 ± 0.049	0.411PheCys: 0.411 ± 0.015	2.749PheAsp: 2.749 ± 0.039	2.009PheGlu: 2.009 ± 0.035	1.461PhePhe: 1.461 ± 0.034	3.76PheGly: 3.76 ± 0.046	0.735PheHis: 0.735 ± 0.02	1.625PheIle: 1.625 ± 0.028	0.962PheLys: 0.962 ± 0.024	2.893PheLeu: 2.893 ± 0.043	0.808PheMet: 0.808 ± 0.018	1.227PheAsn: 1.227 ± 0.025	1.518PhePro: 1.518 ± 0.03	0.986PheGln: 0.986 ± 0.024	2.016PheArg: 2.016 ± 0.032	2.287PheSer: 2.287 ± 0.033	2.028PheThr: 2.028 ± 0.034	3.184PheVal: 3.184 ± 0.04	0.503PheTrp: 0.503 ± 0.019	0.994PheTyr: 0.994 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.939GlyAla: 9.939 ± 0.115	0.834GlyCys: 0.834 ± 0.021	3.945GlyAsp: 3.945 ± 0.048	4.226GlyGlu: 4.226 ± 0.051	3.503GlyPhe: 3.503 ± 0.043	7.195GlyGly: 7.195 ± 0.11	1.865GlyHis: 1.865 ± 0.029	4.296GlyIle: 4.296 ± 0.052	3.141GlyLys: 3.141 ± 0.045	8.03GlyLeu: 8.03 ± 0.069	2.193GlyMet: 2.193 ± 0.032	2.582GlyAsn: 2.582 ± 0.058	2.873GlyPro: 2.873 ± 0.036	2.775GlyGln: 2.775 ± 0.038	5.087GlyArg: 5.087 ± 0.057	4.949GlySer: 4.949 ± 0.074	4.829GlyThr: 4.829 ± 0.099	6.723GlyVal: 6.723 ± 0.058	1.378GlyTrp: 1.378 ± 0.03	2.421GlyTyr: 2.421 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	3.125HisAla: 3.125 ± 0.042	0.266HisCys: 0.266 ± 0.013	1.358HisAsp: 1.358 ± 0.025	1.222HisGlu: 1.222 ± 0.028	0.908HisPhe: 0.908 ± 0.021	2.17HisGly: 2.17 ± 0.035	0.6HisHis: 0.6 ± 0.021	0.874HisIle: 0.874 ± 0.02	0.518HisLys: 0.518 ± 0.015	2.121HisLeu: 2.121 ± 0.034	0.453HisMet: 0.453 ± 0.015	0.556HisAsn: 0.556 ± 0.017	1.395HisPro: 1.395 ± 0.027	0.646HisGln: 0.646 ± 0.017	1.465HisArg: 1.465 ± 0.027	1.114HisSer: 1.114 ± 0.022	1.075HisThr: 1.075 ± 0.021	1.654HisVal: 1.654 ± 0.03	0.393HisTrp: 0.393 ± 0.014	0.676HisTyr: 0.676 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.993IleAla: 6.993 ± 0.062	0.468IleCys: 0.468 ± 0.013	3.451IleAsp: 3.451 ± 0.043	3.121IleGlu: 3.121 ± 0.038	1.473IlePhe: 1.473 ± 0.029	4.759IleGly: 4.759 ± 0.056	0.893IleHis: 0.893 ± 0.022	1.549IleIle: 1.549 ± 0.033	1.292IleLys: 1.292 ± 0.028	3.189IleLeu: 3.189 ± 0.047	0.725IleMet: 0.725 ± 0.021	1.415IleAsn: 1.415 ± 0.028	2.011IlePro: 2.011 ± 0.029	1.224IleGln: 1.224 ± 0.027	2.722IleArg: 2.722 ± 0.04	2.486IleSer: 2.486 ± 0.035	2.396IleThr: 2.396 ± 0.036	4.36IleVal: 4.36 ± 0.052	0.487IleTrp: 0.487 ± 0.017	1.089IleTyr: 1.089 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.388LysAla: 3.388 ± 0.048	0.149LysCys: 0.149 ± 0.009	1.429LysAsp: 1.429 ± 0.026	1.319LysGlu: 1.319 ± 0.032	0.892LysPhe: 0.892 ± 0.02	2.036LysGly: 2.036 ± 0.031	0.659LysHis: 0.659 ± 0.019	1.502LysIle: 1.502 ± 0.029	1.18LysLys: 1.18 ± 0.033	3.365LysLeu: 3.365 ± 0.048	0.75LysMet: 0.75 ± 0.021	0.89LysAsn: 0.89 ± 0.025	1.967LysPro: 1.967 ± 0.033	1.328LysGln: 1.328 ± 0.027	2.277LysArg: 2.277 ± 0.032	1.662LysSer: 1.662 ± 0.034	1.749LysThr: 1.749 ± 0.029	2.191LysVal: 2.191 ± 0.036	0.383LysTrp: 0.383 ± 0.015	0.684LysTyr: 0.684 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.273LeuAla: 14.273 ± 0.103	1.006LeuCys: 1.006 ± 0.025	5.979LeuAsp: 5.979 ± 0.061	4.941LeuGlu: 4.941 ± 0.064	3.744LeuPhe: 3.744 ± 0.046	8.277LeuGly: 8.277 ± 0.07	2.202LeuHis: 2.202 ± 0.034	4.685LeuIle: 4.685 ± 0.051	3.303LeuLys: 3.303 ± 0.043	10.45LeuLeu: 10.45 ± 0.107	2.207LeuMet: 2.207 ± 0.031	2.989LeuAsn: 2.989 ± 0.047	5.692LeuPro: 5.692 ± 0.058	3.492LeuGln: 3.492 ± 0.044	7.12LeuArg: 7.12 ± 0.062	6.456LeuSer: 6.456 ± 0.081	5.733LeuThr: 5.733 ± 0.059	7.281LeuVal: 7.281 ± 0.06	1.152LeuTrp: 1.152 ± 0.027	2.204LeuTyr: 2.204 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.35MetAla: 2.35 ± 0.037	0.182MetCys: 0.182 ± 0.009	0.884MetAsp: 0.884 ± 0.021	0.844MetGlu: 0.844 ± 0.021	0.776MetPhe: 0.776 ± 0.02	1.469MetGly: 1.469 ± 0.028	0.546MetHis: 0.546 ± 0.016	1.101MetIle: 1.101 ± 0.021	0.995MetLys: 0.995 ± 0.021	2.639MetLeu: 2.639 ± 0.037	0.558MetMet: 0.558 ± 0.015	0.929MetAsn: 0.929 ± 0.022	1.385MetPro: 1.385 ± 0.024	0.991MetGln: 0.991 ± 0.024	1.707MetArg: 1.707 ± 0.029	1.765MetSer: 1.765 ± 0.029	1.553MetThr: 1.553 ± 0.025	1.428MetVal: 1.428 ± 0.028	0.211MetTrp: 0.211 ± 0.009	0.429MetTyr: 0.429 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.891AsnAla: 3.891 ± 0.051	0.259AsnCys: 0.259 ± 0.012	1.6AsnAsp: 1.6 ± 0.031	1.395AsnGlu: 1.395 ± 0.025	1.036AsnPhe: 1.036 ± 0.024	2.834AsnGly: 2.834 ± 0.059	0.58AsnHis: 0.58 ± 0.017	1.231AsnIle: 1.231 ± 0.028	0.677AsnLys: 0.677 ± 0.02	2.857AsnLeu: 2.857 ± 0.034	0.561AsnMet: 0.561 ± 0.016	0.943AsnAsn: 0.943 ± 0.028	1.896AsnPro: 1.896 ± 0.032	0.983AsnGln: 0.983 ± 0.025	1.879AsnArg: 1.879 ± 0.028	1.552AsnSer: 1.552 ± 0.039	1.654AsnThr: 1.654 ± 0.046	2.406AsnVal: 2.406 ± 0.048	0.453AsnTrp: 0.453 ± 0.016	0.796AsnTyr: 0.796 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.993ProAla: 6.993 ± 0.071	0.323ProCys: 0.323 ± 0.014	3.124ProAsp: 3.124 ± 0.044	2.851ProGlu: 2.851 ± 0.044	1.929ProPhe: 1.929 ± 0.034	4.122ProGly: 4.122 ± 0.051	1.243ProHis: 1.243 ± 0.025	1.901ProIle: 1.901 ± 0.031	1.378ProLys: 1.378 ± 0.027	5.377ProLeu: 5.377 ± 0.053	1.015ProMet: 1.015 ± 0.018	1.472ProAsn: 1.472 ± 0.026	2.434ProPro: 2.434 ± 0.052	2.035ProGln: 2.035 ± 0.029	2.965ProArg: 2.965 ± 0.043	2.735ProSer: 2.735 ± 0.035	2.551ProThr: 2.551 ± 0.041	4.288ProVal: 4.288 ± 0.046	0.64ProTrp: 0.64 ± 0.02	1.222ProTyr: 1.222 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.518GlnAla: 4.518 ± 0.052	0.287GlnCys: 0.287 ± 0.012	1.32GlnAsp: 1.32 ± 0.028	1.276GlnGlu: 1.276 ± 0.026	1.379GlnPhe: 1.379 ± 0.025	2.461GlnGly: 2.461 ± 0.037	0.949GlnHis: 0.949 ± 0.023	2.016GlnIle: 2.016 ± 0.032	1.134GlnLys: 1.134 ± 0.027	4.131GlnLeu: 4.131 ± 0.05	1.067GlnMet: 1.067 ± 0.023	0.998GlnAsn: 0.998 ± 0.025	2.211GlnPro: 2.211 ± 0.037	2.117GlnGln: 2.117 ± 0.05	3.07GlnArg: 3.07 ± 0.042	2.147GlnSer: 2.147 ± 0.034	2.099GlnThr: 2.099 ± 0.039	2.533GlnVal: 2.533 ± 0.041	0.58GlnTrp: 0.58 ± 0.017	0.99GlnTyr: 0.99 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.26ArgAla: 8.26 ± 0.074	0.567ArgCys: 0.567 ± 0.017	3.925ArgAsp: 3.925 ± 0.049	4.285ArgGlu: 4.285 ± 0.054	2.918ArgPhe: 2.918 ± 0.043	4.619ArgGly: 4.619 ± 0.048	1.801ArgHis: 1.801 ± 0.031	3.58ArgIle: 3.58 ± 0.044	2.068ArgLys: 2.068 ± 0.035	6.938ArgLeu: 6.938 ± 0.066	1.752ArgMet: 1.752 ± 0.03	2.035ArgAsn: 2.035 ± 0.031	2.957ArgPro: 2.957 ± 0.041	2.511ArgGln: 2.511 ± 0.038	5.11ArgArg: 5.11 ± 0.058	3.534ArgSer: 3.534 ± 0.045	3.311ArgThr: 3.311 ± 0.044	5.151ArgVal: 5.151 ± 0.058	1.053ArgTrp: 1.053 ± 0.024	2.009ArgTyr: 2.009 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	7.42SerAla: 7.42 ± 0.07	0.452SerCys: 0.452 ± 0.014	2.79SerAsp: 2.79 ± 0.035	2.567SerGlu: 2.567 ± 0.045	2.276SerPhe: 2.276 ± 0.034	5.619SerGly: 5.619 ± 0.076	1.218SerHis: 1.218 ± 0.023	2.754SerIle: 2.754 ± 0.038	1.561SerLys: 1.561 ± 0.028	5.859SerLeu: 5.859 ± 0.067	1.353SerMet: 1.353 ± 0.026	1.801SerAsn: 1.801 ± 0.047	2.814SerPro: 2.814 ± 0.041	1.901SerGln: 1.901 ± 0.035	3.571SerArg: 3.571 ± 0.048	3.556SerSer: 3.556 ± 0.066	3.511SerThr: 3.511 ± 0.104	4.495SerVal: 4.495 ± 0.055	0.733SerTrp: 0.733 ± 0.021	1.433SerTyr: 1.433 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.182ThrAla: 6.182 ± 0.079	0.421ThrCys: 0.421 ± 0.013	2.718ThrAsp: 2.718 ± 0.042	2.267ThrGlu: 2.267 ± 0.032	1.925ThrPhe: 1.925 ± 0.033	4.981ThrGly: 4.981 ± 0.086	1.226ThrHis: 1.226 ± 0.026	2.607ThrIle: 2.607 ± 0.04	1.186ThrLys: 1.186 ± 0.025	6.757ThrLeu: 6.757 ± 0.099	1.11ThrMet: 1.11 ± 0.025	1.501ThrAsn: 1.501 ± 0.036	3.576ThrPro: 3.576 ± 0.045	2.045ThrGln: 2.045 ± 0.034	3.643ThrArg: 3.643 ± 0.048	3.239ThrSer: 3.239 ± 0.075	3.121ThrThr: 3.121 ± 0.071	4.463ThrVal: 4.463 ± 0.059	0.69ThrTrp: 0.69 ± 0.019	1.32ThrTyr: 1.32 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.596ValAla: 9.596 ± 0.085	0.79ValCys: 0.79 ± 0.019	4.23ValAsp: 4.23 ± 0.06	4.081ValGlu: 4.081 ± 0.061	2.846ValPhe: 2.846 ± 0.046	5.607ValGly: 5.607 ± 0.054	1.48ValHis: 1.48 ± 0.028	3.759ValIle: 3.759 ± 0.048	2.353ValLys: 2.353 ± 0.038	7.993ValLeu: 7.993 ± 0.07	1.783ValMet: 1.783 ± 0.033	2.32ValAsn: 2.32 ± 0.035	3.965ValPro: 3.965 ± 0.049	2.532ValGln: 2.532 ± 0.033	4.977ValArg: 4.977 ± 0.046	4.657ValSer: 4.657 ± 0.053	4.454ValThr: 4.454 ± 0.056	6.141ValVal: 6.141 ± 0.061	0.943ValTrp: 0.943 ± 0.02	1.783ValTyr: 1.783 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.107TrpAla: 1.107 ± 0.025	0.147TrpCys: 0.147 ± 0.008	0.626TrpAsp: 0.626 ± 0.019	0.492TrpGlu: 0.492 ± 0.016	0.548TrpPhe: 0.548 ± 0.017	0.858TrpGly: 0.858 ± 0.021	0.391TrpHis: 0.391 ± 0.015	0.677TrpIle: 0.677 ± 0.019	0.403TrpLys: 0.403 ± 0.014	1.99TrpLeu: 1.99 ± 0.034	0.349TrpMet: 0.349 ± 0.014	0.459TrpAsn: 0.459 ± 0.014	0.679TrpPro: 0.679 ± 0.018	0.718TrpGln: 0.718 ± 0.019	1.217TrpArg: 1.217 ± 0.025	0.822TrpSer: 0.822 ± 0.02	0.706TrpThr: 0.706 ± 0.019	0.902TrpVal: 0.902 ± 0.023	0.226TrpTrp: 0.226 ± 0.011	0.333TrpTyr: 0.333 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.866TyrAla: 2.866 ± 0.038	0.26TyrCys: 0.26 ± 0.012	1.432TyrAsp: 1.432 ± 0.048	1.242TyrGlu: 1.242 ± 0.026	1.033TyrPhe: 1.033 ± 0.025	2.244TyrGly: 2.244 ± 0.034	0.512TyrHis: 0.512 ± 0.017	0.864TyrIle: 0.864 ± 0.019	0.603TyrLys: 0.603 ± 0.017	2.566TyrLeu: 2.566 ± 0.033	0.469TyrMet: 0.469 ± 0.013	0.663TyrAsn: 0.663 ± 0.021	1.273TyrPro: 1.273 ± 0.029	0.924TyrGln: 0.924 ± 0.022	1.959TyrArg: 1.959 ± 0.029	1.356TyrSer: 1.356 ± 0.033	1.354TyrThr: 1.354 ± 0.029	1.897TyrVal: 1.897 ± 0.034	0.402TyrTrp: 0.402 ± 0.015	0.669TyrTyr: 0.669 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6582 proteins (2176520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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