Amino acid dipepetide frequency for Mycobacterium virus Fruitloop

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.641AlaAla: 13.641 ± 1.574
0.668AlaCys: 0.668 ± 0.165
7.294AlaAsp: 7.294 ± 0.664
7.628AlaGlu: 7.628 ± 0.72
2.617AlaPhe: 2.617 ± 0.394
9.744AlaGly: 9.744 ± 1.272
2.561AlaHis: 2.561 ± 0.432
4.454AlaIle: 4.454 ± 0.56
3.953AlaLys: 3.953 ± 0.478
8.018AlaLeu: 8.018 ± 0.766
2.339AlaMet: 2.339 ± 0.364
2.617AlaAsn: 2.617 ± 0.35
5.011AlaPro: 5.011 ± 0.619
3.341AlaGln: 3.341 ± 0.436
7.071AlaArg: 7.071 ± 0.656
5.401AlaSer: 5.401 ± 0.557
5.735AlaThr: 5.735 ± 0.603
7.183AlaVal: 7.183 ± 0.592
2.561AlaTrp: 2.561 ± 0.39
2.45AlaTyr: 2.45 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.835CysAla: 0.835 ± 0.248
0.111CysCys: 0.111 ± 0.078
1.448CysAsp: 1.448 ± 0.401
0.835CysGlu: 0.835 ± 0.253
0.167CysPhe: 0.167 ± 0.094
1.225CysGly: 1.225 ± 0.303
0.0CysHis: 0.0 ± 0.0
0.278CysIle: 0.278 ± 0.142
0.334CysLys: 0.334 ± 0.14
0.947CysLeu: 0.947 ± 0.25
0.223CysMet: 0.223 ± 0.118
0.223CysAsn: 0.223 ± 0.11
1.002CysPro: 1.002 ± 0.27
0.167CysGln: 0.167 ± 0.086
0.445CysArg: 0.445 ± 0.171
0.501CysSer: 0.501 ± 0.157
0.724CysThr: 0.724 ± 0.236
0.724CysVal: 0.724 ± 0.171
0.39CysTrp: 0.39 ± 0.136
0.111CysTyr: 0.111 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
6.849AspAla: 6.849 ± 0.656
1.002AspCys: 1.002 ± 0.298
4.844AspAsp: 4.844 ± 0.622
3.062AspGlu: 3.062 ± 0.395
2.171AspPhe: 2.171 ± 0.278
7.016AspGly: 7.016 ± 0.683
1.615AspHis: 1.615 ± 0.297
2.561AspIle: 2.561 ± 0.339
1.503AspLys: 1.503 ± 0.253
5.958AspLeu: 5.958 ± 0.519
1.058AspMet: 1.058 ± 0.287
1.67AspAsn: 1.67 ± 0.334
5.401AspPro: 5.401 ± 0.639
2.227AspGln: 2.227 ± 0.352
5.512AspArg: 5.512 ± 0.648
3.508AspSer: 3.508 ± 0.578
4.232AspThr: 4.232 ± 0.5
4.343AspVal: 4.343 ± 0.509
1.615AspTrp: 1.615 ± 0.281
2.116AspTyr: 2.116 ± 0.341
0.0AspXaa: 0.0 ± 0.0
Glu
6.292GluAla: 6.292 ± 0.639
0.668GluCys: 0.668 ± 0.176
3.396GluAsp: 3.396 ± 0.409
3.007GluGlu: 3.007 ± 0.57
2.227GluPhe: 2.227 ± 0.306
2.728GluGly: 2.728 ± 0.414
1.726GluHis: 1.726 ± 0.408
2.283GluIle: 2.283 ± 0.367
1.67GluLys: 1.67 ± 0.284
5.679GluLeu: 5.679 ± 0.721
1.559GluMet: 1.559 ± 0.28
1.837GluAsn: 1.837 ± 0.26
2.784GluPro: 2.784 ± 0.442
2.951GluGln: 2.951 ± 0.459
5.234GluArg: 5.234 ± 0.67
2.951GluSer: 2.951 ± 0.401
4.232GluThr: 4.232 ± 0.544
3.898GluVal: 3.898 ± 0.563
1.336GluTrp: 1.336 ± 0.257
1.949GluTyr: 1.949 ± 0.385
0.0GluXaa: 0.0 ± 0.0
Phe
3.118PheAla: 3.118 ± 0.438
0.223PheCys: 0.223 ± 0.1
2.394PheAsp: 2.394 ± 0.41
1.615PheGlu: 1.615 ± 0.328
0.78PhePhe: 0.78 ± 0.274
3.118PheGly: 3.118 ± 0.648
0.39PheHis: 0.39 ± 0.146
1.726PheIle: 1.726 ± 0.345
1.114PheLys: 1.114 ± 0.239
1.893PheLeu: 1.893 ± 0.281
0.668PheMet: 0.668 ± 0.231
1.169PheAsn: 1.169 ± 0.338
1.448PhePro: 1.448 ± 0.31
1.002PheGln: 1.002 ± 0.282
1.336PheArg: 1.336 ± 0.263
1.503PheSer: 1.503 ± 0.299
2.339PheThr: 2.339 ± 0.399
2.227PheVal: 2.227 ± 0.279
0.835PheTrp: 0.835 ± 0.188
1.058PheTyr: 1.058 ± 0.274
0.0PheXaa: 0.0 ± 0.0
Gly
9.076GlyAla: 9.076 ± 1.341
0.835GlyCys: 0.835 ± 0.23
6.013GlyAsp: 6.013 ± 0.658
4.009GlyGlu: 4.009 ± 0.533
2.895GlyPhe: 2.895 ± 0.47
11.47GlyGly: 11.47 ± 2.878
1.726GlyHis: 1.726 ± 0.252
4.51GlyIle: 4.51 ± 0.62
2.394GlyLys: 2.394 ± 0.43
6.459GlyLeu: 6.459 ± 0.611
2.506GlyMet: 2.506 ± 0.436
2.895GlyAsn: 2.895 ± 0.403
4.287GlyPro: 4.287 ± 0.584
2.116GlyGln: 2.116 ± 0.545
5.067GlyArg: 5.067 ± 0.661
5.624GlySer: 5.624 ± 0.898
6.125GlyThr: 6.125 ± 0.705
5.624GlyVal: 5.624 ± 0.562
2.45GlyTrp: 2.45 ± 0.446
2.171GlyTyr: 2.171 ± 0.377
0.0GlyXaa: 0.0 ± 0.0
His
1.448HisAla: 1.448 ± 0.346
0.278HisCys: 0.278 ± 0.174
1.559HisAsp: 1.559 ± 0.3
1.281HisGlu: 1.281 ± 0.289
0.501HisPhe: 0.501 ± 0.166
1.837HisGly: 1.837 ± 0.305
1.002HisHis: 1.002 ± 0.263
1.392HisIle: 1.392 ± 0.28
0.668HisLys: 0.668 ± 0.198
1.448HisLeu: 1.448 ± 0.292
0.612HisMet: 0.612 ± 0.151
0.724HisAsn: 0.724 ± 0.173
1.503HisPro: 1.503 ± 0.332
0.78HisGln: 0.78 ± 0.207
2.116HisArg: 2.116 ± 0.355
0.78HisSer: 0.78 ± 0.191
1.615HisThr: 1.615 ± 0.343
1.503HisVal: 1.503 ± 0.32
0.612HisTrp: 0.612 ± 0.163
0.891HisTyr: 0.891 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
5.401IleAla: 5.401 ± 0.551
0.724IleCys: 0.724 ± 0.226
3.953IleAsp: 3.953 ± 0.407
3.508IleGlu: 3.508 ± 0.421
0.835IlePhe: 0.835 ± 0.261
3.675IleGly: 3.675 ± 0.451
1.392IleHis: 1.392 ± 0.273
1.559IleIle: 1.559 ± 0.305
1.225IleLys: 1.225 ± 0.228
2.116IleLeu: 2.116 ± 0.421
0.445IleMet: 0.445 ± 0.135
1.837IleAsn: 1.837 ± 0.277
3.118IlePro: 3.118 ± 0.318
1.169IleGln: 1.169 ± 0.258
3.062IleArg: 3.062 ± 0.493
2.339IleSer: 2.339 ± 0.405
3.396IleThr: 3.396 ± 0.474
2.673IleVal: 2.673 ± 0.346
0.891IleTrp: 0.891 ± 0.246
0.668IleTyr: 0.668 ± 0.189
0.0IleXaa: 0.0 ± 0.0
Lys
3.675LysAla: 3.675 ± 0.401
0.501LysCys: 0.501 ± 0.174
1.559LysAsp: 1.559 ± 0.27
1.392LysGlu: 1.392 ± 0.276
1.169LysPhe: 1.169 ± 0.212
2.617LysGly: 2.617 ± 0.345
1.169LysHis: 1.169 ± 0.309
0.947LysIle: 0.947 ± 0.214
1.281LysLys: 1.281 ± 0.43
2.561LysLeu: 2.561 ± 0.483
0.39LysMet: 0.39 ± 0.124
0.78LysAsn: 0.78 ± 0.226
1.949LysPro: 1.949 ± 0.357
1.726LysGln: 1.726 ± 0.248
2.506LysArg: 2.506 ± 0.477
1.503LysSer: 1.503 ± 0.275
2.116LysThr: 2.116 ± 0.351
2.45LysVal: 2.45 ± 0.42
0.668LysTrp: 0.668 ± 0.181
1.169LysTyr: 1.169 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
7.739LeuAla: 7.739 ± 0.728
0.78LeuCys: 0.78 ± 0.217
5.178LeuAsp: 5.178 ± 0.647
3.842LeuGlu: 3.842 ± 0.565
2.45LeuPhe: 2.45 ± 0.301
5.568LeuGly: 5.568 ± 0.59
1.002LeuHis: 1.002 ± 0.226
3.118LeuIle: 3.118 ± 0.469
1.782LeuLys: 1.782 ± 0.289
4.844LeuLeu: 4.844 ± 0.514
2.004LeuMet: 2.004 ± 0.36
2.283LeuAsn: 2.283 ± 0.389
5.234LeuPro: 5.234 ± 0.669
2.45LeuGln: 2.45 ± 0.446
5.735LeuArg: 5.735 ± 0.766
5.846LeuSer: 5.846 ± 0.572
5.624LeuThr: 5.624 ± 0.616
5.401LeuVal: 5.401 ± 0.526
1.392LeuTrp: 1.392 ± 0.287
2.116LeuTyr: 2.116 ± 0.365
0.0LeuXaa: 0.0 ± 0.0
Met
2.673MetAla: 2.673 ± 0.433
0.111MetCys: 0.111 ± 0.083
1.336MetAsp: 1.336 ± 0.246
1.002MetGlu: 1.002 ± 0.247
0.78MetPhe: 0.78 ± 0.189
1.67MetGly: 1.67 ± 0.288
0.223MetHis: 0.223 ± 0.109
1.002MetIle: 1.002 ± 0.271
0.835MetLys: 0.835 ± 0.239
1.559MetLeu: 1.559 ± 0.263
0.445MetMet: 0.445 ± 0.211
1.114MetAsn: 1.114 ± 0.252
1.169MetPro: 1.169 ± 0.246
0.445MetGln: 0.445 ± 0.147
1.281MetArg: 1.281 ± 0.262
3.118MetSer: 3.118 ± 0.406
2.506MetThr: 2.506 ± 0.325
1.448MetVal: 1.448 ± 0.363
0.334MetTrp: 0.334 ± 0.137
0.334MetTyr: 0.334 ± 0.136
0.0MetXaa: 0.0 ± 0.0
Asn
3.731AsnAla: 3.731 ± 0.415
0.223AsnCys: 0.223 ± 0.109
1.726AsnAsp: 1.726 ± 0.286
1.503AsnGlu: 1.503 ± 0.294
0.835AsnPhe: 0.835 ± 0.278
3.898AsnGly: 3.898 ± 0.565
0.835AsnHis: 0.835 ± 0.186
1.726AsnIle: 1.726 ± 0.447
0.947AsnLys: 0.947 ± 0.217
2.171AsnLeu: 2.171 ± 0.363
0.445AsnMet: 0.445 ± 0.132
2.004AsnAsn: 2.004 ± 0.461
2.561AsnPro: 2.561 ± 0.396
1.058AsnGln: 1.058 ± 0.33
2.171AsnArg: 2.171 ± 0.366
1.281AsnSer: 1.281 ± 0.3
2.004AsnThr: 2.004 ± 0.337
1.782AsnVal: 1.782 ± 0.356
0.724AsnTrp: 0.724 ± 0.154
0.724AsnTyr: 0.724 ± 0.167
0.0AsnXaa: 0.0 ± 0.0
Pro
5.067ProAla: 5.067 ± 0.599
0.612ProCys: 0.612 ± 0.2
4.454ProAsp: 4.454 ± 0.582
4.287ProGlu: 4.287 ± 0.407
1.726ProPhe: 1.726 ± 0.308
6.18ProGly: 6.18 ± 0.697
1.503ProHis: 1.503 ± 0.276
2.116ProIle: 2.116 ± 0.276
2.06ProLys: 2.06 ± 0.339
4.176ProLeu: 4.176 ± 0.582
1.67ProMet: 1.67 ± 0.364
2.339ProAsn: 2.339 ± 0.349
3.563ProPro: 3.563 ± 0.616
2.227ProGln: 2.227 ± 0.37
3.285ProArg: 3.285 ± 0.539
3.174ProSer: 3.174 ± 0.393
3.341ProThr: 3.341 ± 0.502
4.844ProVal: 4.844 ± 0.548
1.114ProTrp: 1.114 ± 0.263
1.615ProTyr: 1.615 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
4.621GlnAla: 4.621 ± 0.632
0.278GlnCys: 0.278 ± 0.13
1.559GlnAsp: 1.559 ± 0.294
1.726GlnGlu: 1.726 ± 0.297
1.114GlnPhe: 1.114 ± 0.223
2.116GlnGly: 2.116 ± 0.475
0.557GlnHis: 0.557 ± 0.225
1.559GlnIle: 1.559 ± 0.278
1.169GlnLys: 1.169 ± 0.219
3.285GlnLeu: 3.285 ± 0.455
0.39GlnMet: 0.39 ± 0.165
0.891GlnAsn: 0.891 ± 0.231
2.339GlnPro: 2.339 ± 0.394
1.002GlnGln: 1.002 ± 0.209
2.45GlnArg: 2.45 ± 0.342
1.949GlnSer: 1.949 ± 0.372
1.782GlnThr: 1.782 ± 0.357
2.339GlnVal: 2.339 ± 0.362
0.724GlnTrp: 0.724 ± 0.21
0.835GlnTyr: 0.835 ± 0.284
0.0GlnXaa: 0.0 ± 0.0
Arg
6.514ArgAla: 6.514 ± 0.588
0.891ArgCys: 0.891 ± 0.238
4.12ArgAsp: 4.12 ± 0.508
4.733ArgGlu: 4.733 ± 0.616
2.116ArgPhe: 2.116 ± 0.419
4.065ArgGly: 4.065 ± 0.474
1.281ArgHis: 1.281 ± 0.287
3.508ArgIle: 3.508 ± 0.466
2.561ArgLys: 2.561 ± 0.431
5.234ArgLeu: 5.234 ± 0.672
3.007ArgMet: 3.007 ± 0.487
2.506ArgAsn: 2.506 ± 0.448
3.396ArgPro: 3.396 ± 0.453
2.06ArgGln: 2.06 ± 0.316
5.791ArgArg: 5.791 ± 0.771
3.953ArgSer: 3.953 ± 0.455
3.563ArgThr: 3.563 ± 0.509
5.624ArgVal: 5.624 ± 0.637
2.116ArgTrp: 2.116 ± 0.426
2.06ArgTyr: 2.06 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
5.568SerAla: 5.568 ± 0.758
0.612SerCys: 0.612 ± 0.188
4.287SerAsp: 4.287 ± 0.49
3.341SerGlu: 3.341 ± 0.461
2.171SerPhe: 2.171 ± 0.444
6.403SerGly: 6.403 ± 0.706
1.448SerHis: 1.448 ± 0.262
2.84SerIle: 2.84 ± 0.42
2.561SerLys: 2.561 ± 0.389
4.009SerLeu: 4.009 ± 0.492
1.336SerMet: 1.336 ± 0.262
2.06SerAsn: 2.06 ± 0.343
3.007SerPro: 3.007 ± 0.395
1.559SerGln: 1.559 ± 0.256
3.174SerArg: 3.174 ± 0.437
3.842SerSer: 3.842 ± 0.515
3.341SerThr: 3.341 ± 0.485
4.733SerVal: 4.733 ± 0.548
1.503SerTrp: 1.503 ± 0.226
1.503SerTyr: 1.503 ± 0.237
0.0SerXaa: 0.0 ± 0.0
Thr
6.125ThrAla: 6.125 ± 0.625
0.724ThrCys: 0.724 ± 0.204
4.176ThrAsp: 4.176 ± 0.541
3.508ThrGlu: 3.508 ± 0.383
1.893ThrPhe: 1.893 ± 0.343
5.958ThrGly: 5.958 ± 0.548
1.726ThrHis: 1.726 ± 0.305
3.619ThrIle: 3.619 ± 0.421
2.227ThrLys: 2.227 ± 0.325
4.733ThrLeu: 4.733 ± 0.451
1.281ThrMet: 1.281 ± 0.251
2.06ThrAsn: 2.06 ± 0.346
5.011ThrPro: 5.011 ± 0.584
2.06ThrGln: 2.06 ± 0.355
4.065ThrArg: 4.065 ± 0.435
4.065ThrSer: 4.065 ± 0.508
4.788ThrThr: 4.788 ± 0.57
5.457ThrVal: 5.457 ± 0.661
0.947ThrTrp: 0.947 ± 0.261
1.837ThrTyr: 1.837 ± 0.328
0.0ThrXaa: 0.0 ± 0.0
Val
7.517ValAla: 7.517 ± 0.52
0.891ValCys: 0.891 ± 0.216
5.457ValAsp: 5.457 ± 0.499
5.067ValGlu: 5.067 ± 0.68
2.171ValPhe: 2.171 ± 0.392
5.735ValGly: 5.735 ± 0.594
1.281ValHis: 1.281 ± 0.32
2.673ValIle: 2.673 ± 0.472
2.227ValLys: 2.227 ± 0.321
5.122ValLeu: 5.122 ± 0.666
1.67ValMet: 1.67 ± 0.256
2.116ValAsn: 2.116 ± 0.35
4.287ValPro: 4.287 ± 0.377
2.561ValGln: 2.561 ± 0.353
4.343ValArg: 4.343 ± 0.588
5.067ValSer: 5.067 ± 0.571
5.067ValThr: 5.067 ± 0.49
6.793ValVal: 6.793 ± 0.634
2.171ValTrp: 2.171 ± 0.443
1.67ValTyr: 1.67 ± 0.359
0.0ValXaa: 0.0 ± 0.0
Trp
2.004TrpAla: 2.004 ± 0.306
0.167TrpCys: 0.167 ± 0.098
1.67TrpAsp: 1.67 ± 0.268
1.169TrpGlu: 1.169 ± 0.33
0.724TrpPhe: 0.724 ± 0.192
1.002TrpGly: 1.002 ± 0.232
0.724TrpHis: 0.724 ± 0.223
1.114TrpIle: 1.114 ± 0.216
0.78TrpLys: 0.78 ± 0.188
1.782TrpLeu: 1.782 ± 0.371
1.002TrpMet: 1.002 ± 0.265
0.612TrpAsn: 0.612 ± 0.218
1.002TrpPro: 1.002 ± 0.303
1.058TrpGln: 1.058 ± 0.278
2.171TrpArg: 2.171 ± 0.469
1.559TrpSer: 1.559 ± 0.305
1.559TrpThr: 1.559 ± 0.294
2.394TrpVal: 2.394 ± 0.485
1.114TrpTrp: 1.114 ± 0.21
0.557TrpTyr: 0.557 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.479
0.39TyrCys: 0.39 ± 0.146
1.837TyrAsp: 1.837 ± 0.366
1.893TyrGlu: 1.893 ± 0.311
0.668TyrPhe: 0.668 ± 0.203
2.227TyrGly: 2.227 ± 0.392
0.39TyrHis: 0.39 ± 0.125
1.002TyrIle: 1.002 ± 0.23
0.835TyrLys: 0.835 ± 0.225
2.394TyrLeu: 2.394 ± 0.343
0.278TyrMet: 0.278 ± 0.113
0.612TyrAsn: 0.612 ± 0.183
1.281TyrPro: 1.281 ± 0.22
0.724TyrGln: 0.724 ± 0.193
2.283TyrArg: 2.283 ± 0.39
1.336TyrSer: 1.336 ± 0.311
2.171TyrThr: 2.171 ± 0.39
2.45TyrVal: 2.45 ± 0.302
0.668TyrTrp: 0.668 ± 0.191
0.78TyrTyr: 0.78 ± 0.187
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 102 proteins (17961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski