Amino acid dipepetide frequency for Candidatus Symbiobacter mobilis CR

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.132AlaAla: 13.132 ± 0.181
1.427AlaCys: 1.427 ± 0.052
5.759AlaAsp: 5.759 ± 0.079
5.889AlaGlu: 5.889 ± 0.092
3.542AlaPhe: 3.542 ± 0.068
8.061AlaGly: 8.061 ± 0.174
2.927AlaHis: 2.927 ± 0.068
5.251AlaIle: 5.251 ± 0.086
3.616AlaLys: 3.616 ± 0.073
13.687AlaLeu: 13.687 ± 0.171
3.588AlaMet: 3.588 ± 0.074
2.972AlaAsn: 2.972 ± 0.078
5.184AlaPro: 5.184 ± 0.125
6.184AlaGln: 6.184 ± 0.109
7.519AlaArg: 7.519 ± 0.118
6.586AlaSer: 6.586 ± 0.123
6.166AlaThr: 6.166 ± 0.142
8.204AlaVal: 8.204 ± 0.105
1.81AlaTrp: 1.81 ± 0.053
2.404AlaTyr: 2.404 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.504CysAla: 1.504 ± 0.054
0.187CysCys: 0.187 ± 0.015
0.671CysAsp: 0.671 ± 0.031
0.579CysGlu: 0.579 ± 0.022
0.364CysPhe: 0.364 ± 0.023
1.129CysGly: 1.129 ± 0.039
0.351CysHis: 0.351 ± 0.024
0.633CysIle: 0.633 ± 0.028
0.415CysLys: 0.415 ± 0.019
1.093CysLeu: 1.093 ± 0.04
0.292CysMet: 0.292 ± 0.019
0.358CysAsn: 0.358 ± 0.021
0.661CysPro: 0.661 ± 0.033
0.417CysGln: 0.417 ± 0.023
0.661CysArg: 0.661 ± 0.032
0.641CysSer: 0.641 ± 0.028
0.696CysThr: 0.696 ± 0.036
0.851CysVal: 0.851 ± 0.035
0.163CysTrp: 0.163 ± 0.013
0.226CysTyr: 0.226 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.127AspAla: 7.127 ± 0.112
0.598AspCys: 0.598 ± 0.028
2.92AspAsp: 2.92 ± 0.071
2.998AspGlu: 2.998 ± 0.075
2.167AspPhe: 2.167 ± 0.057
4.353AspGly: 4.353 ± 0.089
1.268AspHis: 1.268 ± 0.039
3.281AspIle: 3.281 ± 0.065
1.827AspLys: 1.827 ± 0.043
5.261AspLeu: 5.261 ± 0.076
1.218AspMet: 1.218 ± 0.036
1.379AspAsn: 1.379 ± 0.038
3.028AspPro: 3.028 ± 0.067
1.754AspGln: 1.754 ± 0.056
3.598AspArg: 3.598 ± 0.084
2.627AspSer: 2.627 ± 0.055
3.143AspThr: 3.143 ± 0.067
4.445AspVal: 4.445 ± 0.08
0.923AspTrp: 0.923 ± 0.034
1.468AspTyr: 1.468 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
6.009GluAla: 6.009 ± 0.103
0.587GluCys: 0.587 ± 0.029
2.591GluAsp: 2.591 ± 0.059
3.424GluGlu: 3.424 ± 0.076
1.93GluPhe: 1.93 ± 0.052
3.8GluGly: 3.8 ± 0.088
1.591GluHis: 1.591 ± 0.047
2.742GluIle: 2.742 ± 0.066
1.976GluLys: 1.976 ± 0.048
5.847GluLeu: 5.847 ± 0.096
1.274GluMet: 1.274 ± 0.042
1.278GluAsn: 1.278 ± 0.042
2.428GluPro: 2.428 ± 0.067
2.869GluGln: 2.869 ± 0.066
4.636GluArg: 4.636 ± 0.083
3.085GluSer: 3.085 ± 0.063
2.525GluThr: 2.525 ± 0.056
4.066GluVal: 4.066 ± 0.073
0.829GluTrp: 0.829 ± 0.039
1.286GluTyr: 1.286 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.946PheAla: 3.946 ± 0.077
0.449PheCys: 0.449 ± 0.023
2.622PheAsp: 2.622 ± 0.061
2.002PheGlu: 2.002 ± 0.055
1.303PhePhe: 1.303 ± 0.042
2.828PheGly: 2.828 ± 0.057
0.976PheHis: 0.976 ± 0.036
1.178PheIle: 1.178 ± 0.041
0.814PheLys: 0.814 ± 0.039
3.477PheLeu: 3.477 ± 0.079
0.533PheMet: 0.533 ± 0.026
0.778PheAsn: 0.778 ± 0.029
1.499PhePro: 1.499 ± 0.041
1.251PheGln: 1.251 ± 0.044
2.18PheArg: 2.18 ± 0.058
2.11PheSer: 2.11 ± 0.053
1.758PheThr: 1.758 ± 0.058
2.733PheVal: 2.733 ± 0.063
0.451PheTrp: 0.451 ± 0.029
0.822PheTyr: 0.822 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
7.426GlyAla: 7.426 ± 0.163
1.052GlyCys: 1.052 ± 0.038
3.945GlyAsp: 3.945 ± 0.098
3.92GlyGlu: 3.92 ± 0.072
2.942GlyPhe: 2.942 ± 0.066
5.555GlyGly: 5.555 ± 0.21
1.974GlyHis: 1.974 ± 0.048
4.081GlyIle: 4.081 ± 0.082
3.624GlyLys: 3.624 ± 0.073
7.45GlyLeu: 7.45 ± 0.109
2.338GlyMet: 2.338 ± 0.052
2.392GlyAsn: 2.392 ± 0.093
2.219GlyPro: 2.219 ± 0.057
3.136GlyGln: 3.136 ± 0.063
4.498GlyArg: 4.498 ± 0.095
4.379GlySer: 4.379 ± 0.11
4.605GlyThr: 4.605 ± 0.196
6.266GlyVal: 6.266 ± 0.111
1.331GlyTrp: 1.331 ± 0.046
2.365GlyTyr: 2.365 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
3.306HisAla: 3.306 ± 0.072
0.433HisCys: 0.433 ± 0.023
1.452HisAsp: 1.452 ± 0.041
1.233HisGlu: 1.233 ± 0.041
1.013HisPhe: 1.013 ± 0.042
2.244HisGly: 2.244 ± 0.056
0.88HisHis: 0.88 ± 0.036
1.266HisIle: 1.266 ± 0.049
0.708HisLys: 0.708 ± 0.032
2.646HisLeu: 2.646 ± 0.06
0.427HisMet: 0.427 ± 0.02
0.639HisAsn: 0.639 ± 0.026
1.949HisPro: 1.949 ± 0.056
0.959HisGln: 0.959 ± 0.035
1.921HisArg: 1.921 ± 0.055
1.539HisSer: 1.539 ± 0.041
1.459HisThr: 1.459 ± 0.044
1.666HisVal: 1.666 ± 0.047
0.463HisTrp: 0.463 ± 0.026
0.71HisTyr: 0.71 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.028IleAla: 6.028 ± 0.094
0.432IleCys: 0.432 ± 0.026
3.829IleAsp: 3.829 ± 0.074
3.462IleGlu: 3.462 ± 0.07
1.235IlePhe: 1.235 ± 0.038
3.626IleGly: 3.626 ± 0.065
1.286IleHis: 1.286 ± 0.041
1.657IleIle: 1.657 ± 0.047
1.512IleLys: 1.512 ± 0.042
4.149IleLeu: 4.149 ± 0.076
0.709IleMet: 0.709 ± 0.027
1.344IleAsn: 1.344 ± 0.049
2.5IlePro: 2.5 ± 0.062
1.664IleGln: 1.664 ± 0.052
3.063IleArg: 3.063 ± 0.059
2.51IleSer: 2.51 ± 0.07
2.55IleThr: 2.55 ± 0.081
3.83IleVal: 3.83 ± 0.066
0.495IleTrp: 0.495 ± 0.025
0.853IleTyr: 0.853 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.342LysAla: 3.342 ± 0.082
0.202LysCys: 0.202 ± 0.016
1.651LysAsp: 1.651 ± 0.046
1.732LysGlu: 1.732 ± 0.055
0.948LysPhe: 0.948 ± 0.036
2.195LysGly: 2.195 ± 0.057
0.7LysHis: 0.7 ± 0.03
1.718LysIle: 1.718 ± 0.054
1.501LysLys: 1.501 ± 0.051
3.511LysLeu: 3.511 ± 0.075
0.811LysMet: 0.811 ± 0.031
1.14LysAsn: 1.14 ± 0.039
1.915LysPro: 1.915 ± 0.054
1.352LysGln: 1.352 ± 0.042
1.953LysArg: 1.953 ± 0.049
1.943LysSer: 1.943 ± 0.05
2.047LysThr: 2.047 ± 0.055
2.623LysVal: 2.623 ± 0.064
0.338LysTrp: 0.338 ± 0.019
0.719LysTyr: 0.719 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
12.934LeuAla: 12.934 ± 0.158
1.452LeuCys: 1.452 ± 0.043
6.432LeuAsp: 6.432 ± 0.09
5.69LeuGlu: 5.69 ± 0.092
3.337LeuPhe: 3.337 ± 0.078
8.215LeuGly: 8.215 ± 0.118
3.359LeuHis: 3.359 ± 0.074
4.008LeuIle: 4.008 ± 0.076
2.657LeuLys: 2.657 ± 0.076
11.661LeuLeu: 11.661 ± 0.17
2.126LeuMet: 2.126 ± 0.056
2.262LeuAsn: 2.262 ± 0.05
5.809LeuPro: 5.809 ± 0.091
5.082LeuGln: 5.082 ± 0.092
9.019LeuArg: 9.019 ± 0.124
6.31LeuSer: 6.31 ± 0.083
5.513LeuThr: 5.513 ± 0.161
7.386LeuVal: 7.386 ± 0.115
1.46LeuTrp: 1.46 ± 0.052
2.272LeuTyr: 2.272 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.704MetAla: 2.704 ± 0.06
0.176MetCys: 0.176 ± 0.014
1.323MetAsp: 1.323 ± 0.044
1.296MetGlu: 1.296 ± 0.043
0.633MetPhe: 0.633 ± 0.026
1.861MetGly: 1.861 ± 0.043
0.717MetHis: 0.717 ± 0.026
0.85MetIle: 0.85 ± 0.033
0.778MetLys: 0.778 ± 0.029
2.673MetLeu: 2.673 ± 0.059
0.523MetMet: 0.523 ± 0.027
0.783MetAsn: 0.783 ± 0.029
1.391MetPro: 1.391 ± 0.04
1.347MetGln: 1.347 ± 0.042
1.686MetArg: 1.686 ± 0.043
1.359MetSer: 1.359 ± 0.041
1.323MetThr: 1.323 ± 0.037
1.817MetVal: 1.817 ± 0.054
0.206MetTrp: 0.206 ± 0.016
0.445MetTyr: 0.445 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.288AsnAla: 3.288 ± 0.068
0.254AsnCys: 0.254 ± 0.017
1.547AsnAsp: 1.547 ± 0.045
1.385AsnGlu: 1.385 ± 0.045
0.826AsnPhe: 0.826 ± 0.035
2.083AsnGly: 2.083 ± 0.068
0.641AsnHis: 0.641 ± 0.027
1.414AsnIle: 1.414 ± 0.046
0.953AsnLys: 0.953 ± 0.042
2.868AsnLeu: 2.868 ± 0.052
0.564AsnMet: 0.564 ± 0.03
0.713AsnAsn: 0.713 ± 0.033
1.84AsnPro: 1.84 ± 0.051
1.087AsnGln: 1.087 ± 0.034
1.73AsnArg: 1.73 ± 0.049
1.276AsnSer: 1.276 ± 0.053
1.523AsnThr: 1.523 ± 0.055
1.909AsnVal: 1.909 ± 0.057
0.367AsnTrp: 0.367 ± 0.022
0.634AsnTyr: 0.634 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
5.7ProAla: 5.7 ± 0.12
0.546ProCys: 0.546 ± 0.026
3.105ProAsp: 3.105 ± 0.073
2.956ProGlu: 2.956 ± 0.069
1.655ProPhe: 1.655 ± 0.048
3.869ProGly: 3.869 ± 0.068
1.308ProHis: 1.308 ± 0.039
2.26ProIle: 2.26 ± 0.059
1.501ProLys: 1.501 ± 0.045
4.752ProLeu: 4.752 ± 0.088
1.321ProMet: 1.321 ± 0.036
1.407ProAsn: 1.407 ± 0.042
2.909ProPro: 2.909 ± 0.087
2.32ProGln: 2.32 ± 0.059
2.569ProArg: 2.569 ± 0.055
2.956ProSer: 2.956 ± 0.06
3.174ProThr: 3.174 ± 0.074
4.069ProVal: 4.069 ± 0.077
0.769ProTrp: 0.769 ± 0.03
1.222ProTyr: 1.222 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
5.576GlnAla: 5.576 ± 0.102
0.518GlnCys: 0.518 ± 0.025
2.057GlnAsp: 2.057 ± 0.043
2.493GlnGlu: 2.493 ± 0.061
1.327GlnPhe: 1.327 ± 0.039
3.581GlnGly: 3.581 ± 0.07
1.253GlnHis: 1.253 ± 0.042
2.128GlnIle: 2.128 ± 0.09
1.311GlnLys: 1.311 ± 0.046
3.942GlnLeu: 3.942 ± 0.094
1.004GlnMet: 1.004 ± 0.034
1.093GlnAsn: 1.093 ± 0.036
2.211GlnPro: 2.211 ± 0.057
2.241GlnGln: 2.241 ± 0.058
3.969GlnArg: 3.969 ± 0.073
2.576GlnSer: 2.576 ± 0.058
2.521GlnThr: 2.521 ± 0.063
3.092GlnVal: 3.092 ± 0.085
0.795GlnTrp: 0.795 ± 0.03
1.001GlnTyr: 1.001 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.708ArgAla: 6.708 ± 0.101
0.922ArgCys: 0.922 ± 0.039
3.547ArgAsp: 3.547 ± 0.072
4.152ArgGlu: 4.152 ± 0.078
2.777ArgPhe: 2.777 ± 0.064
4.121ArgGly: 4.121 ± 0.073
1.807ArgHis: 1.807 ± 0.05
4.002ArgIle: 4.002 ± 0.082
2.775ArgLys: 2.775 ± 0.072
7.449ArgLeu: 7.449 ± 0.128
1.986ArgMet: 1.986 ± 0.047
2.375ArgAsn: 2.375 ± 0.059
2.854ArgPro: 2.854 ± 0.062
3.089ArgGln: 3.089 ± 0.07
4.692ArgArg: 4.692 ± 0.118
4.062ArgSer: 4.062 ± 0.071
3.644ArgThr: 3.644 ± 0.068
4.801ArgVal: 4.801 ± 0.087
1.336ArgTrp: 1.336 ± 0.044
2.003ArgTyr: 2.003 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.497SerAla: 6.497 ± 0.115
0.577SerCys: 0.577 ± 0.027
2.843SerAsp: 2.843 ± 0.057
2.741SerGlu: 2.741 ± 0.063
1.849SerPhe: 1.849 ± 0.052
4.763SerGly: 4.763 ± 0.148
1.458SerHis: 1.458 ± 0.043
2.852SerIle: 2.852 ± 0.07
1.786SerLys: 1.786 ± 0.054
6.07SerLeu: 6.07 ± 0.096
1.453SerMet: 1.453 ± 0.043
1.547SerAsn: 1.547 ± 0.045
2.965SerPro: 2.965 ± 0.065
2.346SerGln: 2.346 ± 0.053
3.496SerArg: 3.496 ± 0.07
3.521SerSer: 3.521 ± 0.088
3.55SerThr: 3.55 ± 0.085
4.245SerVal: 4.245 ± 0.088
0.747SerTrp: 0.747 ± 0.031
1.28SerTyr: 1.28 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.186ThrAla: 6.186 ± 0.168
0.496ThrCys: 0.496 ± 0.024
2.795ThrAsp: 2.795 ± 0.067
2.537ThrGlu: 2.537 ± 0.061
1.707ThrPhe: 1.707 ± 0.047
4.67ThrGly: 4.67 ± 0.136
1.496ThrHis: 1.496 ± 0.047
2.608ThrIle: 2.608 ± 0.096
1.545ThrLys: 1.545 ± 0.049
6.832ThrLeu: 6.832 ± 0.144
1.202ThrMet: 1.202 ± 0.035
1.461ThrAsn: 1.461 ± 0.048
3.514ThrPro: 3.514 ± 0.063
2.526ThrGln: 2.526 ± 0.067
3.148ThrArg: 3.148 ± 0.064
2.968ThrSer: 2.968 ± 0.092
3.595ThrThr: 3.595 ± 0.216
4.758ThrVal: 4.758 ± 0.169
0.699ThrTrp: 0.699 ± 0.033
1.107ThrTyr: 1.107 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
8.489ValAla: 8.489 ± 0.129
1.029ValCys: 1.029 ± 0.04
4.336ValAsp: 4.336 ± 0.065
4.35ValGlu: 4.35 ± 0.075
2.566ValPhe: 2.566 ± 0.063
5.722ValGly: 5.722 ± 0.09
1.974ValHis: 1.974 ± 0.045
3.115ValIle: 3.115 ± 0.068
1.79ValLys: 1.79 ± 0.055
9.17ValLeu: 9.17 ± 0.12
1.647ValMet: 1.647 ± 0.038
1.82ValAsn: 1.82 ± 0.066
3.633ValPro: 3.633 ± 0.077
3.311ValGln: 3.311 ± 0.063
5.753ValArg: 5.753 ± 0.091
4.054ValSer: 4.054 ± 0.082
4.128ValThr: 4.128 ± 0.147
6.55ValVal: 6.55 ± 0.108
1.065ValTrp: 1.065 ± 0.034
1.634ValTyr: 1.634 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.377TrpAla: 1.377 ± 0.046
0.203TrpCys: 0.203 ± 0.015
0.664TrpAsp: 0.664 ± 0.04
0.791TrpGlu: 0.791 ± 0.033
0.581TrpPhe: 0.581 ± 0.028
0.969TrpGly: 0.969 ± 0.036
0.399TrpHis: 0.399 ± 0.022
0.784TrpIle: 0.784 ± 0.032
0.585TrpLys: 0.585 ± 0.027
1.913TrpLeu: 1.913 ± 0.06
0.502TrpMet: 0.502 ± 0.026
0.556TrpAsn: 0.556 ± 0.03
0.647TrpPro: 0.647 ± 0.03
0.715TrpGln: 0.715 ± 0.03
1.041TrpArg: 1.041 ± 0.034
0.722TrpSer: 0.722 ± 0.033
0.669TrpThr: 0.669 ± 0.028
1.157TrpVal: 1.157 ± 0.041
0.294TrpTrp: 0.294 ± 0.022
0.358TrpTyr: 0.358 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.629TyrAla: 2.629 ± 0.053
0.353TyrCys: 0.353 ± 0.022
1.293TyrAsp: 1.293 ± 0.037
1.146TyrGlu: 1.146 ± 0.035
1.008TyrPhe: 1.008 ± 0.04
1.856TyrGly: 1.856 ± 0.057
0.547TyrHis: 0.547 ± 0.023
0.907TyrIle: 0.907 ± 0.032
0.667TyrLys: 0.667 ± 0.032
2.533TyrLeu: 2.533 ± 0.059
0.373TyrMet: 0.373 ± 0.021
0.603TyrAsn: 0.603 ± 0.035
1.21TyrPro: 1.21 ± 0.039
1.041TyrGln: 1.041 ± 0.031
1.968TyrArg: 1.968 ± 0.044
1.358TyrSer: 1.358 ± 0.042
1.262TyrThr: 1.262 ± 0.061
1.67TyrVal: 1.67 ± 0.041
0.387TyrTrp: 0.387 ± 0.021
0.602TyrTyr: 0.602 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2609 proteins (902661 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski