Amino acid dipepetide frequency for Streptococcus merionis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.026AlaAla: 6.026 ± 0.117
0.551AlaCys: 0.551 ± 0.029
4.438AlaAsp: 4.438 ± 0.101
5.428AlaGlu: 5.428 ± 0.125
3.618AlaPhe: 3.618 ± 0.075
5.672AlaGly: 5.672 ± 0.107
1.399AlaHis: 1.399 ± 0.046
6.185AlaIle: 6.185 ± 0.102
5.291AlaLys: 5.291 ± 0.118
7.896AlaLeu: 7.896 ± 0.134
2.145AlaMet: 2.145 ± 0.063
3.244AlaAsn: 3.244 ± 0.075
2.337AlaPro: 2.337 ± 0.08
3.397AlaGln: 3.397 ± 0.085
3.077AlaArg: 3.077 ± 0.067
4.712AlaSer: 4.712 ± 0.089
4.611AlaThr: 4.611 ± 0.106
5.602AlaVal: 5.602 ± 0.108
0.649AlaTrp: 0.649 ± 0.029
2.932AlaTyr: 2.932 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.365CysAla: 0.365 ± 0.025
0.044CysCys: 0.044 ± 0.008
0.307CysAsp: 0.307 ± 0.023
0.301CysGlu: 0.301 ± 0.021
0.292CysPhe: 0.292 ± 0.02
0.471CysGly: 0.471 ± 0.029
0.177CysHis: 0.177 ± 0.015
0.395CysIle: 0.395 ± 0.027
0.239CysLys: 0.239 ± 0.021
0.718CysLeu: 0.718 ± 0.038
0.147CysMet: 0.147 ± 0.016
0.207CysAsn: 0.207 ± 0.021
0.272CysPro: 0.272 ± 0.02
0.38CysGln: 0.38 ± 0.023
0.26CysArg: 0.26 ± 0.02
0.312CysSer: 0.312 ± 0.022
0.239CysThr: 0.239 ± 0.02
0.354CysVal: 0.354 ± 0.025
0.058CysTrp: 0.058 ± 0.009
0.229CysTyr: 0.229 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.763AspAla: 3.763 ± 0.089
0.38AspCys: 0.38 ± 0.026
3.04AspAsp: 3.04 ± 0.074
3.965AspGlu: 3.965 ± 0.08
3.274AspPhe: 3.274 ± 0.07
3.893AspGly: 3.893 ± 0.126
0.979AspHis: 0.979 ± 0.042
4.078AspIle: 4.078 ± 0.079
3.825AspLys: 3.825 ± 0.1
6.002AspLeu: 6.002 ± 0.12
1.574AspMet: 1.574 ± 0.051
2.304AspAsn: 2.304 ± 0.065
1.674AspPro: 1.674 ± 0.057
2.393AspGln: 2.393 ± 0.071
2.203AspArg: 2.203 ± 0.058
3.031AspSer: 3.031 ± 0.076
2.72AspThr: 2.72 ± 0.068
3.862AspVal: 3.862 ± 0.084
0.662AspTrp: 0.662 ± 0.032
2.84AspTyr: 2.84 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
5.748GluAla: 5.748 ± 0.13
0.303GluCys: 0.303 ± 0.019
3.734GluAsp: 3.734 ± 0.074
5.569GluGlu: 5.569 ± 0.114
2.351GluPhe: 2.351 ± 0.067
3.544GluGly: 3.544 ± 0.079
1.317GluHis: 1.317 ± 0.048
5.039GluIle: 5.039 ± 0.099
5.395GluLys: 5.395 ± 0.109
6.788GluLeu: 6.788 ± 0.117
1.832GluMet: 1.832 ± 0.052
3.51GluAsn: 3.51 ± 0.08
1.838GluPro: 1.838 ± 0.057
3.021GluGln: 3.021 ± 0.071
3.227GluArg: 3.227 ± 0.083
3.404GluSer: 3.404 ± 0.084
4.214GluThr: 4.214 ± 0.087
4.758GluVal: 4.758 ± 0.093
0.581GluTrp: 0.581 ± 0.029
1.789GluTyr: 1.789 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.426PheAla: 3.426 ± 0.076
0.297PheCys: 0.297 ± 0.025
2.926PheAsp: 2.926 ± 0.069
3.043PheGlu: 3.043 ± 0.071
2.187PhePhe: 2.187 ± 0.077
3.242PheGly: 3.242 ± 0.079
0.828PheHis: 0.828 ± 0.035
3.071PheIle: 3.071 ± 0.079
2.507PheLys: 2.507 ± 0.066
4.637PheLeu: 4.637 ± 0.113
1.093PheMet: 1.093 ± 0.045
1.865PheAsn: 1.865 ± 0.055
1.511PhePro: 1.511 ± 0.057
1.632PheGln: 1.632 ± 0.047
1.594PheArg: 1.594 ± 0.053
3.205PheSer: 3.205 ± 0.074
2.57PheThr: 2.57 ± 0.063
3.223PheVal: 3.223 ± 0.073
0.487PheTrp: 0.487 ± 0.032
1.968PheTyr: 1.968 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.882GlyAla: 4.882 ± 0.1
0.466GlyCys: 0.466 ± 0.026
3.414GlyAsp: 3.414 ± 0.098
3.644GlyGlu: 3.644 ± 0.082
3.253GlyPhe: 3.253 ± 0.068
4.323GlyGly: 4.323 ± 0.095
1.356GlyHis: 1.356 ± 0.05
5.325GlyIle: 5.325 ± 0.097
4.248GlyLys: 4.248 ± 0.111
7.219GlyLeu: 7.219 ± 0.114
1.86GlyMet: 1.86 ± 0.063
2.619GlyAsn: 2.619 ± 0.068
1.403GlyPro: 1.403 ± 0.044
3.332GlyGln: 3.332 ± 0.083
2.8GlyArg: 2.8 ± 0.077
3.663GlySer: 3.663 ± 0.074
3.748GlyThr: 3.748 ± 0.094
4.876GlyVal: 4.876 ± 0.083
0.678GlyTrp: 0.678 ± 0.032
2.734GlyTyr: 2.734 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.176HisAla: 1.176 ± 0.044
0.151HisCys: 0.151 ± 0.014
0.978HisAsp: 0.978 ± 0.039
1.041HisGlu: 1.041 ± 0.041
1.234HisPhe: 1.234 ± 0.049
1.237HisGly: 1.237 ± 0.046
0.566HisHis: 0.566 ± 0.029
1.341HisIle: 1.341 ± 0.041
0.913HisLys: 0.913 ± 0.037
2.293HisLeu: 2.293 ± 0.06
0.457HisMet: 0.457 ± 0.022
0.671HisAsn: 0.671 ± 0.03
0.954HisPro: 0.954 ± 0.043
0.916HisGln: 0.916 ± 0.034
0.884HisArg: 0.884 ± 0.041
1.044HisSer: 1.044 ± 0.041
0.922HisThr: 0.922 ± 0.037
1.173HisVal: 1.173 ± 0.042
0.18HisTrp: 0.18 ± 0.016
0.955HisTyr: 0.955 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.318IleAla: 6.318 ± 0.12
0.572IleCys: 0.572 ± 0.033
4.237IleAsp: 4.237 ± 0.086
4.797IleGlu: 4.797 ± 0.096
3.339IlePhe: 3.339 ± 0.084
5.038IleGly: 5.038 ± 0.096
1.228IleHis: 1.228 ± 0.047
5.113IleIle: 5.113 ± 0.105
4.102IleLys: 4.102 ± 0.086
7.505IleLeu: 7.505 ± 0.135
1.691IleMet: 1.691 ± 0.057
3.0IleAsn: 3.0 ± 0.07
2.737IlePro: 2.737 ± 0.064
2.51IleGln: 2.51 ± 0.068
2.893IleArg: 2.893 ± 0.069
4.861IleSer: 4.861 ± 0.111
4.049IleThr: 4.049 ± 0.091
5.073IleVal: 5.073 ± 0.082
0.663IleTrp: 0.663 ± 0.037
2.517IleTyr: 2.517 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.294LysAla: 5.294 ± 0.115
0.23LysCys: 0.23 ± 0.019
3.647LysAsp: 3.647 ± 0.09
5.176LysGlu: 5.176 ± 0.115
1.798LysPhe: 1.798 ± 0.054
3.674LysGly: 3.674 ± 0.081
1.211LysHis: 1.211 ± 0.05
4.381LysIle: 4.381 ± 0.086
4.46LysLys: 4.46 ± 0.096
5.506LysLeu: 5.506 ± 0.107
1.818LysMet: 1.818 ± 0.046
3.061LysAsn: 3.061 ± 0.088
2.14LysPro: 2.14 ± 0.066
2.507LysGln: 2.507 ± 0.077
2.997LysArg: 2.997 ± 0.073
3.519LysSer: 3.519 ± 0.075
4.005LysThr: 4.005 ± 0.1
4.344LysVal: 4.344 ± 0.089
0.556LysTrp: 0.556 ± 0.029
2.051LysTyr: 2.051 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
9.255LeuAla: 9.255 ± 0.137
0.58LeuCys: 0.58 ± 0.031
5.855LeuAsp: 5.855 ± 0.107
6.951LeuGlu: 6.951 ± 0.126
4.46LeuPhe: 4.46 ± 0.102
6.795LeuGly: 6.795 ± 0.121
1.614LeuHis: 1.614 ± 0.045
6.925LeuIle: 6.925 ± 0.121
6.102LeuLys: 6.102 ± 0.101
10.619LeuLeu: 10.619 ± 0.187
2.67LeuMet: 2.67 ± 0.065
4.072LeuAsn: 4.072 ± 0.08
4.235LeuPro: 4.235 ± 0.076
3.509LeuGln: 3.509 ± 0.078
3.877LeuArg: 3.877 ± 0.075
7.752LeuSer: 7.752 ± 0.119
6.62LeuThr: 6.62 ± 0.113
7.237LeuVal: 7.237 ± 0.141
0.83LeuTrp: 0.83 ± 0.038
3.326LeuTyr: 3.326 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
2.39MetAla: 2.39 ± 0.061
0.111MetCys: 0.111 ± 0.014
1.384MetAsp: 1.384 ± 0.047
1.458MetGlu: 1.458 ± 0.045
0.86MetPhe: 0.86 ± 0.04
1.665MetGly: 1.665 ± 0.057
0.341MetHis: 0.341 ± 0.023
1.989MetIle: 1.989 ± 0.063
1.76MetLys: 1.76 ± 0.055
2.381MetLeu: 2.381 ± 0.061
0.778MetMet: 0.778 ± 0.036
1.149MetAsn: 1.149 ± 0.044
0.89MetPro: 0.89 ± 0.037
0.866MetGln: 0.866 ± 0.039
1.028MetArg: 1.028 ± 0.041
1.635MetSer: 1.635 ± 0.048
2.14MetThr: 2.14 ± 0.059
1.901MetVal: 1.901 ± 0.062
0.188MetTrp: 0.188 ± 0.016
0.562MetTyr: 0.562 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.859AsnAla: 2.859 ± 0.069
0.239AsnCys: 0.239 ± 0.019
2.172AsnAsp: 2.172 ± 0.052
2.345AsnGlu: 2.345 ± 0.063
1.815AsnPhe: 1.815 ± 0.049
3.215AsnGly: 3.215 ± 0.105
1.091AsnHis: 1.091 ± 0.043
3.114AsnIle: 3.114 ± 0.075
2.299AsnLys: 2.299 ± 0.06
4.429AsnLeu: 4.429 ± 0.089
1.041AsnMet: 1.041 ± 0.041
1.744AsnAsn: 1.744 ± 0.06
2.233AsnPro: 2.233 ± 0.055
2.183AsnGln: 2.183 ± 0.063
1.966AsnArg: 1.966 ± 0.059
2.352AsnSer: 2.352 ± 0.063
2.181AsnThr: 2.181 ± 0.06
2.626AsnVal: 2.626 ± 0.062
0.518AsnTrp: 0.518 ± 0.025
1.785AsnTyr: 1.785 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.638ProAla: 2.638 ± 0.064
0.13ProCys: 0.13 ± 0.017
2.337ProAsp: 2.337 ± 0.06
3.091ProGlu: 3.091 ± 0.069
1.727ProPhe: 1.727 ± 0.058
1.876ProGly: 1.876 ± 0.058
0.675ProHis: 0.675 ± 0.033
2.623ProIle: 2.623 ± 0.066
2.062ProLys: 2.062 ± 0.065
3.183ProLeu: 3.183 ± 0.071
0.792ProMet: 0.792 ± 0.036
1.673ProAsn: 1.673 ± 0.055
0.606ProPro: 0.606 ± 0.041
1.296ProGln: 1.296 ± 0.053
1.097ProArg: 1.097 ± 0.042
2.187ProSer: 2.187 ± 0.061
2.219ProThr: 2.219 ± 0.074
2.652ProVal: 2.652 ± 0.061
0.303ProTrp: 0.303 ± 0.023
1.421ProTyr: 1.421 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.942GlnAla: 3.942 ± 0.097
0.153GlnCys: 0.153 ± 0.012
2.118GlnAsp: 2.118 ± 0.062
3.203GlnGlu: 3.203 ± 0.075
1.72GlnPhe: 1.72 ± 0.045
2.377GlnGly: 2.377 ± 0.06
0.778GlnHis: 0.778 ± 0.04
3.074GlnIle: 3.074 ± 0.07
2.884GlnLys: 2.884 ± 0.087
4.718GlnLeu: 4.718 ± 0.096
1.075GlnMet: 1.075 ± 0.045
1.733GlnAsn: 1.733 ± 0.062
1.426GlnPro: 1.426 ± 0.055
1.653GlnGln: 1.653 ± 0.059
1.524GlnArg: 1.524 ± 0.049
2.334GlnSer: 2.334 ± 0.064
2.511GlnThr: 2.511 ± 0.066
3.23GlnVal: 3.23 ± 0.07
0.365GlnTrp: 0.365 ± 0.023
1.296GlnTyr: 1.296 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.75ArgAla: 2.75 ± 0.071
0.192ArgCys: 0.192 ± 0.019
2.29ArgAsp: 2.29 ± 0.048
3.087ArgGlu: 3.087 ± 0.071
2.15ArgPhe: 2.15 ± 0.059
2.262ArgGly: 2.262 ± 0.058
0.939ArgHis: 0.939 ± 0.034
2.797ArgIle: 2.797 ± 0.073
2.741ArgLys: 2.741 ± 0.067
4.54ArgLeu: 4.54 ± 0.08
1.067ArgMet: 1.067 ± 0.042
1.682ArgAsn: 1.682 ± 0.054
1.303ArgPro: 1.303 ± 0.054
2.268ArgGln: 2.268 ± 0.071
1.922ArgArg: 1.922 ± 0.059
2.044ArgSer: 2.044 ± 0.057
1.994ArgThr: 1.994 ± 0.059
2.764ArgVal: 2.764 ± 0.067
0.328ArgTrp: 0.328 ± 0.025
1.724ArgTyr: 1.724 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.255SerAla: 4.255 ± 0.082
0.309SerCys: 0.309 ± 0.026
3.518SerAsp: 3.518 ± 0.086
3.725SerGlu: 3.725 ± 0.089
2.952SerPhe: 2.952 ± 0.08
4.676SerGly: 4.676 ± 0.094
1.273SerHis: 1.273 ± 0.048
4.182SerIle: 4.182 ± 0.089
3.48SerLys: 3.48 ± 0.074
6.673SerLeu: 6.673 ± 0.112
1.391SerMet: 1.391 ± 0.045
2.464SerAsn: 2.464 ± 0.074
2.045SerPro: 2.045 ± 0.054
3.129SerGln: 3.129 ± 0.079
2.528SerArg: 2.528 ± 0.065
4.152SerSer: 4.152 ± 0.106
3.229SerThr: 3.229 ± 0.09
4.008SerVal: 4.008 ± 0.084
0.602SerTrp: 0.602 ± 0.03
2.611SerTyr: 2.611 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.603ThrAla: 4.603 ± 0.082
0.292ThrCys: 0.292 ± 0.021
3.37ThrAsp: 3.37 ± 0.086
3.769ThrGlu: 3.769 ± 0.095
2.761ThrPhe: 2.761 ± 0.064
4.202ThrGly: 4.202 ± 0.077
1.061ThrHis: 1.061 ± 0.044
4.634ThrIle: 4.634 ± 0.075
3.338ThrLys: 3.338 ± 0.076
5.661ThrLeu: 5.661 ± 0.102
1.275ThrMet: 1.275 ± 0.044
2.339ThrAsn: 2.339 ± 0.065
2.605ThrPro: 2.605 ± 0.082
2.101ThrGln: 2.101 ± 0.063
2.053ThrArg: 2.053 ± 0.055
3.657ThrSer: 3.657 ± 0.075
3.762ThrThr: 3.762 ± 0.219
4.768ThrVal: 4.768 ± 0.109
0.489ThrTrp: 0.489 ± 0.03
2.342ThrTyr: 2.342 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
6.274ValAla: 6.274 ± 0.12
0.45ValCys: 0.45 ± 0.024
3.937ValAsp: 3.937 ± 0.095
4.584ValGlu: 4.584 ± 0.087
3.106ValPhe: 3.106 ± 0.073
4.562ValGly: 4.562 ± 0.106
1.175ValHis: 1.175 ± 0.045
5.107ValIle: 5.107 ± 0.1
4.258ValLys: 4.258 ± 0.084
7.006ValLeu: 7.006 ± 0.124
1.768ValMet: 1.768 ± 0.055
2.923ValAsn: 2.923 ± 0.064
2.717ValPro: 2.717 ± 0.064
2.302ValGln: 2.302 ± 0.066
2.767ValArg: 2.767 ± 0.061
4.599ValSer: 4.599 ± 0.086
4.808ValThr: 4.808 ± 0.122
5.118ValVal: 5.118 ± 0.107
0.549ValTrp: 0.549 ± 0.032
2.343ValTyr: 2.343 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.578TrpAla: 0.578 ± 0.036
0.065TrpCys: 0.065 ± 0.01
0.484TrpAsp: 0.484 ± 0.029
0.584TrpGlu: 0.584 ± 0.034
0.424TrpPhe: 0.424 ± 0.024
0.674TrpGly: 0.674 ± 0.031
0.165TrpHis: 0.165 ± 0.015
0.592TrpIle: 0.592 ± 0.032
0.471TrpLys: 0.471 ± 0.026
1.208TrpLeu: 1.208 ± 0.047
0.23TrpMet: 0.23 ± 0.02
0.436TrpAsn: 0.436 ± 0.027
0.233TrpPro: 0.233 ± 0.019
0.51TrpGln: 0.51 ± 0.029
0.386TrpArg: 0.386 ± 0.022
0.592TrpSer: 0.592 ± 0.028
0.554TrpThr: 0.554 ± 0.03
0.534TrpVal: 0.534 ± 0.027
0.103TrpTrp: 0.103 ± 0.013
0.351TrpTyr: 0.351 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.667TyrAla: 2.667 ± 0.062
0.253TyrCys: 0.253 ± 0.02
2.275TyrAsp: 2.275 ± 0.064
2.203TyrGlu: 2.203 ± 0.063
1.991TyrPhe: 1.991 ± 0.061
2.446TyrGly: 2.446 ± 0.064
0.914TyrHis: 0.914 ± 0.044
2.275TyrIle: 2.275 ± 0.055
2.0TyrLys: 2.0 ± 0.063
4.302TyrLeu: 4.302 ± 0.092
0.769TyrMet: 0.769 ± 0.03
1.515TyrAsn: 1.515 ± 0.05
1.429TyrPro: 1.429 ± 0.057
2.21TyrGln: 2.21 ± 0.063
1.759TyrArg: 1.759 ± 0.052
2.148TyrSer: 2.148 ± 0.058
1.985TyrThr: 1.985 ± 0.074
2.249TyrVal: 2.249 ± 0.056
0.386TyrTrp: 0.386 ± 0.025
1.632TyrTyr: 1.632 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2137 proteins (660612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski