Amino acid dipepetide frequency for Burkholderia glumae (strain BGR1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.78AlaAla: 22.78 ± 0.197	1.408AlaCys: 1.408 ± 0.028	7.091AlaAsp: 7.091 ± 0.067	6.498AlaGlu: 6.498 ± 0.066	4.396AlaPhe: 4.396 ± 0.048	12.358AlaGly: 12.358 ± 0.111	2.989AlaHis: 2.989 ± 0.047	5.723AlaIle: 5.723 ± 0.056	3.417AlaLys: 3.417 ± 0.054	15.741AlaLeu: 15.741 ± 0.136	3.224AlaMet: 3.224 ± 0.044	3.204AlaAsn: 3.204 ± 0.044	7.344AlaPro: 7.344 ± 0.084	5.316AlaGln: 5.316 ± 0.064	11.317AlaArg: 11.317 ± 0.111	7.767AlaSer: 7.767 ± 0.092	6.535AlaThr: 6.535 ± 0.072	8.948AlaVal: 8.948 ± 0.067	1.916AlaTrp: 1.916 ± 0.033	2.768AlaTyr: 2.768 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.296CysAla: 1.296 ± 0.027	0.133CysCys: 0.133 ± 0.008	0.533CysAsp: 0.533 ± 0.019	0.527CysGlu: 0.527 ± 0.017	0.325CysPhe: 0.325 ± 0.012	1.013CysGly: 1.013 ± 0.024	0.247CysHis: 0.247 ± 0.012	0.337CysIle: 0.337 ± 0.014	0.186CysLys: 0.186 ± 0.01	0.85CysLeu: 0.85 ± 0.024	0.189CysMet: 0.189 ± 0.009	0.207CysAsn: 0.207 ± 0.011	0.447CysPro: 0.447 ± 0.015	0.216CysGln: 0.216 ± 0.011	0.695CysArg: 0.695 ± 0.022	0.517CysSer: 0.517 ± 0.018	0.456CysThr: 0.456 ± 0.016	0.734CysVal: 0.734 ± 0.022	0.14CysTrp: 0.14 ± 0.009	0.22CysTyr: 0.22 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.789AspAla: 8.789 ± 0.091	0.463AspCys: 0.463 ± 0.017	3.306AspAsp: 3.306 ± 0.051	3.406AspGlu: 3.406 ± 0.047	1.797AspPhe: 1.797 ± 0.03	5.304AspGly: 5.304 ± 0.064	1.183AspHis: 1.183 ± 0.027	2.154AspIle: 2.154 ± 0.035	1.297AspLys: 1.297 ± 0.033	5.148AspLeu: 5.148 ± 0.053	0.98AspMet: 0.98 ± 0.023	1.163AspAsn: 1.163 ± 0.03	3.187AspPro: 3.187 ± 0.035	1.557AspGln: 1.557 ± 0.029	3.566AspArg: 3.566 ± 0.045	2.369AspSer: 2.369 ± 0.037	2.914AspThr: 2.914 ± 0.05	3.849AspVal: 3.849 ± 0.043	0.992AspTrp: 0.992 ± 0.026	1.56AspTyr: 1.56 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.178GluAla: 7.178 ± 0.084	0.41GluCys: 0.41 ± 0.014	1.883GluAsp: 1.883 ± 0.04	1.931GluGlu: 1.931 ± 0.041	1.646GluPhe: 1.646 ± 0.032	3.013GluGly: 3.013 ± 0.043	1.443GluHis: 1.443 ± 0.028	2.783GluIle: 2.783 ± 0.048	1.423GluLys: 1.423 ± 0.033	5.514GluLeu: 5.514 ± 0.062	1.104GluMet: 1.104 ± 0.025	1.115GluAsn: 1.115 ± 0.023	2.748GluPro: 2.748 ± 0.045	2.428GluGln: 2.428 ± 0.037	5.369GluArg: 5.369 ± 0.064	2.34GluSer: 2.34 ± 0.042	2.689GluThr: 2.689 ± 0.039	3.462GluVal: 3.462 ± 0.05	0.712GluTrp: 0.712 ± 0.023	1.052GluTyr: 1.052 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.687PheAla: 4.687 ± 0.054	0.387PheCys: 0.387 ± 0.016	2.659PheAsp: 2.659 ± 0.038	2.044PheGlu: 2.044 ± 0.035	1.282PhePhe: 1.282 ± 0.029	3.553PheGly: 3.553 ± 0.046	0.748PheHis: 0.748 ± 0.02	1.312PheIle: 1.312 ± 0.028	0.794PheLys: 0.794 ± 0.021	2.666PheLeu: 2.666 ± 0.041	0.699PheMet: 0.699 ± 0.019	0.983PheAsn: 0.983 ± 0.021	1.454PhePro: 1.454 ± 0.028	0.938PheGln: 0.938 ± 0.022	2.105PheArg: 2.105 ± 0.036	2.101PheSer: 2.101 ± 0.035	1.754PheThr: 1.754 ± 0.033	3.107PheVal: 3.107 ± 0.04	0.458PheTrp: 0.458 ± 0.016	0.888PheTyr: 0.888 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.936GlyAla: 10.936 ± 0.104	0.899GlyCys: 0.899 ± 0.024	4.153GlyAsp: 4.153 ± 0.056	4.591GlyGlu: 4.591 ± 0.057	3.36GlyPhe: 3.36 ± 0.049	7.376GlyGly: 7.376 ± 0.109	1.867GlyHis: 1.867 ± 0.035	4.045GlyIle: 4.045 ± 0.052	2.797GlyLys: 2.797 ± 0.044	7.962GlyLeu: 7.962 ± 0.081	2.03GlyMet: 2.03 ± 0.031	2.209GlyAsn: 2.209 ± 0.052	3.186GlyPro: 3.186 ± 0.045	2.739GlyGln: 2.739 ± 0.037	6.124GlyArg: 6.124 ± 0.069	4.666GlySer: 4.666 ± 0.069	4.831GlyThr: 4.831 ± 0.077	6.546GlyVal: 6.546 ± 0.067	1.473GlyTrp: 1.473 ± 0.029	2.435GlyTyr: 2.435 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	3.344HisAla: 3.344 ± 0.047	0.251HisCys: 0.251 ± 0.012	1.502HisAsp: 1.502 ± 0.034	1.205HisGlu: 1.205 ± 0.029	0.873HisPhe: 0.873 ± 0.023	2.383HisGly: 2.383 ± 0.038	0.662HisHis: 0.662 ± 0.019	0.719HisIle: 0.719 ± 0.019	0.403HisLys: 0.403 ± 0.016	2.234HisLeu: 2.234 ± 0.038	0.412HisMet: 0.412 ± 0.015	0.458HisAsn: 0.458 ± 0.015	1.476HisPro: 1.476 ± 0.029	0.668HisGln: 0.668 ± 0.021	1.707HisArg: 1.707 ± 0.03	0.978HisSer: 0.978 ± 0.021	1.023HisThr: 1.023 ± 0.023	1.64HisVal: 1.64 ± 0.027	0.407HisTrp: 0.407 ± 0.015	0.717HisTyr: 0.717 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.758IleAla: 6.758 ± 0.069	0.414IleCys: 0.414 ± 0.015	3.397IleAsp: 3.397 ± 0.046	3.206IleGlu: 3.206 ± 0.044	1.145IlePhe: 1.145 ± 0.026	4.556IleGly: 4.556 ± 0.053	0.889IleHis: 0.889 ± 0.02	1.278IleIle: 1.278 ± 0.031	1.148IleLys: 1.148 ± 0.03	3.006IleLeu: 3.006 ± 0.041	0.62IleMet: 0.62 ± 0.019	1.207IleAsn: 1.207 ± 0.03	1.881IlePro: 1.881 ± 0.037	1.142IleGln: 1.142 ± 0.024	2.851IleArg: 2.851 ± 0.035	2.172IleSer: 2.172 ± 0.039	2.246IleThr: 2.246 ± 0.035	4.013IleVal: 4.013 ± 0.057	0.507IleTrp: 0.507 ± 0.016	0.93IleTyr: 0.93 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.151LysAla: 3.151 ± 0.049	0.154LysCys: 0.154 ± 0.009	1.179LysAsp: 1.179 ± 0.029	1.111LysGlu: 1.111 ± 0.031	0.769LysPhe: 0.769 ± 0.021	1.82LysGly: 1.82 ± 0.035	0.597LysHis: 0.597 ± 0.018	1.333LysIle: 1.333 ± 0.032	0.93LysLys: 0.93 ± 0.032	3.055LysLeu: 3.055 ± 0.045	0.632LysMet: 0.632 ± 0.019	0.688LysAsn: 0.688 ± 0.021	1.78LysPro: 1.78 ± 0.037	1.085LysGln: 1.085 ± 0.029	2.136LysArg: 2.136 ± 0.035	1.476LysSer: 1.476 ± 0.034	1.586LysThr: 1.586 ± 0.032	1.86LysVal: 1.86 ± 0.037	0.296LysTrp: 0.296 ± 0.013	0.621LysTyr: 0.621 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.857LeuAla: 15.857 ± 0.136	0.968LeuCys: 0.968 ± 0.023	6.612LeuAsp: 6.612 ± 0.072	4.779LeuGlu: 4.779 ± 0.052	3.35LeuPhe: 3.35 ± 0.048	8.449LeuGly: 8.449 ± 0.084	2.265LeuHis: 2.265 ± 0.036	4.269LeuIle: 4.269 ± 0.058	2.91LeuLys: 2.91 ± 0.045	9.985LeuLeu: 9.985 ± 0.118	2.091LeuMet: 2.091 ± 0.036	2.558LeuAsn: 2.558 ± 0.038	6.083LeuPro: 6.083 ± 0.064	3.133LeuGln: 3.133 ± 0.047	7.708LeuArg: 7.708 ± 0.075	6.117LeuSer: 6.117 ± 0.113	5.329LeuThr: 5.329 ± 0.061	7.566LeuVal: 7.566 ± 0.078	1.134LeuTrp: 1.134 ± 0.028	2.168LeuTyr: 2.168 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.248MetAla: 2.248 ± 0.033	0.142MetCys: 0.142 ± 0.01	0.83MetAsp: 0.83 ± 0.02	0.81MetGlu: 0.81 ± 0.022	0.679MetPhe: 0.679 ± 0.019	1.295MetGly: 1.295 ± 0.032	0.486MetHis: 0.486 ± 0.015	0.973MetIle: 0.973 ± 0.024	0.905MetLys: 0.905 ± 0.024	2.509MetLeu: 2.509 ± 0.041	0.529MetMet: 0.529 ± 0.016	0.8MetAsn: 0.8 ± 0.022	1.424MetPro: 1.424 ± 0.027	0.915MetGln: 0.915 ± 0.021	1.753MetArg: 1.753 ± 0.033	1.6MetSer: 1.6 ± 0.028	1.533MetThr: 1.533 ± 0.028	1.328MetVal: 1.328 ± 0.029	0.177MetTrp: 0.177 ± 0.01	0.338MetTyr: 0.338 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.055	0.235AsnCys: 0.235 ± 0.011	1.351AsnAsp: 1.351 ± 0.031	1.087AsnGlu: 1.087 ± 0.027	0.889AsnPhe: 0.889 ± 0.022	2.477AsnGly: 2.477 ± 0.048	0.535AsnHis: 0.535 ± 0.017	1.011AsnIle: 1.011 ± 0.027	0.529AsnLys: 0.529 ± 0.018	2.67AsnLeu: 2.67 ± 0.04	0.479AsnMet: 0.479 ± 0.016	0.68AsnAsn: 0.68 ± 0.024	1.73AsnPro: 1.73 ± 0.034	0.868AsnGln: 0.868 ± 0.024	1.749AsnArg: 1.749 ± 0.029	1.234AsnSer: 1.234 ± 0.051	1.33AsnThr: 1.33 ± 0.036	2.013AsnVal: 2.013 ± 0.049	0.384AsnTrp: 0.384 ± 0.016	0.665AsnTyr: 0.665 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.436ProAla: 8.436 ± 0.089	0.408ProCys: 0.408 ± 0.015	3.489ProAsp: 3.489 ± 0.05	2.906ProGlu: 2.906 ± 0.038	1.912ProPhe: 1.912 ± 0.032	4.595ProGly: 4.595 ± 0.055	1.227ProHis: 1.227 ± 0.025	2.026ProIle: 2.026 ± 0.035	1.308ProLys: 1.308 ± 0.032	5.426ProLeu: 5.426 ± 0.063	1.05ProMet: 1.05 ± 0.025	1.369ProAsn: 1.369 ± 0.027	2.948ProPro: 2.948 ± 0.052	1.784ProGln: 1.784 ± 0.035	3.395ProArg: 3.395 ± 0.045	2.88ProSer: 2.88 ± 0.043	2.522ProThr: 2.522 ± 0.055	4.298ProVal: 4.298 ± 0.061	0.662ProTrp: 0.662 ± 0.02	1.183ProTyr: 1.183 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.053GlnAla: 5.053 ± 0.074	0.263GlnCys: 0.263 ± 0.012	1.334GlnAsp: 1.334 ± 0.029	1.173GlnGlu: 1.173 ± 0.027	1.208GlnPhe: 1.208 ± 0.026	2.382GlnGly: 2.382 ± 0.039	0.851GlnHis: 0.851 ± 0.021	1.831GlnIle: 1.831 ± 0.034	0.908GlnLys: 0.908 ± 0.022	3.733GlnLeu: 3.733 ± 0.048	0.896GlnMet: 0.896 ± 0.023	0.84GlnAsn: 0.84 ± 0.026	2.08GlnPro: 2.08 ± 0.035	1.834GlnGln: 1.834 ± 0.042	2.988GlnArg: 2.988 ± 0.042	1.834GlnSer: 1.834 ± 0.036	1.868GlnThr: 1.868 ± 0.032	2.466GlnVal: 2.466 ± 0.039	0.551GlnTrp: 0.551 ± 0.018	0.893GlnTyr: 0.893 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.867ArgAla: 9.867 ± 0.104	0.671ArgCys: 0.671 ± 0.019	4.276ArgAsp: 4.276 ± 0.051	4.694ArgGlu: 4.694 ± 0.057	3.131ArgPhe: 3.131 ± 0.042	5.313ArgGly: 5.313 ± 0.061	2.254ArgHis: 2.254 ± 0.041	3.752ArgIle: 3.752 ± 0.045	1.775ArgLys: 1.775 ± 0.038	8.221ArgLeu: 8.221 ± 0.094	1.782ArgMet: 1.782 ± 0.027	1.811ArgAsn: 1.811 ± 0.032	3.689ArgPro: 3.689 ± 0.052	2.796ArgGln: 2.796 ± 0.041	6.626ArgArg: 6.626 ± 0.077	3.487ArgSer: 3.487 ± 0.036	3.445ArgThr: 3.445 ± 0.048	5.567ArgVal: 5.567 ± 0.064	1.129ArgTrp: 1.129 ± 0.026	2.237ArgTyr: 2.237 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.874SerAla: 6.874 ± 0.077	0.462SerCys: 0.462 ± 0.016	2.615SerAsp: 2.615 ± 0.04	2.353SerGlu: 2.353 ± 0.045	1.981SerPhe: 1.981 ± 0.03	5.211SerGly: 5.211 ± 0.076	1.2SerHis: 1.2 ± 0.028	2.538SerIle: 2.538 ± 0.035	1.343SerLys: 1.343 ± 0.032	5.758SerLeu: 5.758 ± 0.078	1.199SerMet: 1.199 ± 0.024	1.563SerAsn: 1.563 ± 0.051	2.89SerPro: 2.89 ± 0.049	1.792SerGln: 1.792 ± 0.031	3.781SerArg: 3.781 ± 0.052	3.271SerSer: 3.271 ± 0.095	3.075SerThr: 3.075 ± 0.108	4.092SerVal: 4.092 ± 0.053	0.719SerTrp: 0.719 ± 0.019	1.314SerTyr: 1.314 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.144ThrAla: 6.144 ± 0.065	0.409ThrCys: 0.409 ± 0.016	2.67ThrAsp: 2.67 ± 0.04	2.116ThrGlu: 2.116 ± 0.031	1.792ThrPhe: 1.792 ± 0.031	4.748ThrGly: 4.748 ± 0.071	1.248ThrHis: 1.248 ± 0.026	2.473ThrIle: 2.473 ± 0.043	1.112ThrLys: 1.112 ± 0.026	6.552ThrLeu: 6.552 ± 0.082	1.062ThrMet: 1.062 ± 0.025	1.298ThrAsn: 1.298 ± 0.043	3.469ThrPro: 3.469 ± 0.054	1.809ThrGln: 1.809 ± 0.034	3.784ThrArg: 3.784 ± 0.047	2.824ThrSer: 2.824 ± 0.059	2.794ThrThr: 2.794 ± 0.064	4.165ThrVal: 4.165 ± 0.052	0.612ThrTrp: 0.612 ± 0.021	1.17ThrTyr: 1.17 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.916ValAla: 9.916 ± 0.08	0.759ValCys: 0.759 ± 0.019	4.11ValAsp: 4.11 ± 0.061	4.155ValGlu: 4.155 ± 0.059	2.581ValPhe: 2.581 ± 0.039	5.447ValGly: 5.447 ± 0.064	1.386ValHis: 1.386 ± 0.029	3.397ValIle: 3.397 ± 0.044	2.205ValLys: 2.205 ± 0.041	7.625ValLeu: 7.625 ± 0.078	1.617ValMet: 1.617 ± 0.027	2.028ValAsn: 2.028 ± 0.04	4.119ValPro: 4.119 ± 0.054	2.323ValGln: 2.323 ± 0.038	5.309ValArg: 5.309 ± 0.063	4.466ValSer: 4.466 ± 0.06	4.381ValThr: 4.381 ± 0.051	5.947ValVal: 5.947 ± 0.066	0.919ValTrp: 0.919 ± 0.021	1.593ValTyr: 1.593 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.242TrpAla: 1.242 ± 0.03	0.172TrpCys: 0.172 ± 0.009	0.563TrpAsp: 0.563 ± 0.015	0.51TrpGlu: 0.51 ± 0.019	0.561TrpPhe: 0.561 ± 0.017	0.817TrpGly: 0.817 ± 0.022	0.415TrpHis: 0.415 ± 0.014	0.682TrpIle: 0.682 ± 0.019	0.368TrpLys: 0.368 ± 0.015	2.037TrpLeu: 2.037 ± 0.034	0.315TrpMet: 0.315 ± 0.011	0.443TrpAsn: 0.443 ± 0.016	0.671TrpPro: 0.671 ± 0.018	0.726TrpGln: 0.726 ± 0.021	1.42TrpArg: 1.42 ± 0.033	0.786TrpSer: 0.786 ± 0.02	0.648TrpThr: 0.648 ± 0.018	0.886TrpVal: 0.886 ± 0.022	0.222TrpTrp: 0.222 ± 0.01	0.317TrpTyr: 0.317 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.876TyrAla: 2.876 ± 0.037	0.26TyrCys: 0.26 ± 0.011	1.433TyrAsp: 1.433 ± 0.033	1.145TyrGlu: 1.145 ± 0.026	0.94TyrPhe: 0.94 ± 0.022	2.113TyrGly: 2.113 ± 0.034	0.567TyrHis: 0.567 ± 0.018	0.732TyrIle: 0.732 ± 0.021	0.502TyrLys: 0.502 ± 0.019	2.639TyrLeu: 2.639 ± 0.042	0.362TyrMet: 0.362 ± 0.015	0.6TyrAsn: 0.6 ± 0.02	1.219TyrPro: 1.219 ± 0.03	0.916TyrGln: 0.916 ± 0.023	2.14TyrArg: 2.14 ± 0.033	1.144TyrSer: 1.144 ± 0.025	1.291TyrThr: 1.291 ± 0.028	1.797TyrVal: 1.797 ± 0.035	0.393TyrTrp: 0.393 ± 0.016	0.638TyrTyr: 0.638 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5660 proteins (1927278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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