Amino acid dipepetide frequency for Arcobacter anaerophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.724AlaAla: 3.724 ± 0.089
0.658AlaCys: 0.658 ± 0.031
2.638AlaAsp: 2.638 ± 0.061
2.437AlaGlu: 2.437 ± 0.064
2.989AlaPhe: 2.989 ± 0.069
3.552AlaGly: 3.552 ± 0.076
0.983AlaHis: 0.983 ± 0.033
5.677AlaIle: 5.677 ± 0.077
5.826AlaLys: 5.826 ± 0.085
6.389AlaLeu: 6.389 ± 0.092
1.633AlaMet: 1.633 ± 0.047
3.183AlaAsn: 3.183 ± 0.065
1.424AlaPro: 1.424 ± 0.043
2.004AlaGln: 2.004 ± 0.053
1.758AlaArg: 1.758 ± 0.045
3.762AlaSer: 3.762 ± 0.072
3.028AlaThr: 3.028 ± 0.074
3.956AlaVal: 3.956 ± 0.084
0.443AlaTrp: 0.443 ± 0.023
2.295AlaTyr: 2.295 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.027
0.103CysCys: 0.103 ± 0.011
0.62CysAsp: 0.62 ± 0.024
0.707CysGlu: 0.707 ± 0.03
0.41CysPhe: 0.41 ± 0.025
0.712CysGly: 0.712 ± 0.033
0.244CysHis: 0.244 ± 0.021
0.691CysIle: 0.691 ± 0.03
0.816CysLys: 0.816 ± 0.035
0.625CysLeu: 0.625 ± 0.029
0.189CysMet: 0.189 ± 0.015
0.493CysAsn: 0.493 ± 0.022
0.383CysPro: 0.383 ± 0.025
0.229CysGln: 0.229 ± 0.016
0.246CysArg: 0.246 ± 0.015
0.739CysSer: 0.739 ± 0.028
0.45CysThr: 0.45 ± 0.022
0.5CysVal: 0.5 ± 0.026
0.061CysTrp: 0.061 ± 0.008
0.309CysTyr: 0.309 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
2.908AspAla: 2.908 ± 0.067
0.448AspCys: 0.448 ± 0.025
3.077AspAsp: 3.077 ± 0.084
5.243AspGlu: 5.243 ± 0.076
3.558AspPhe: 3.558 ± 0.071
2.88AspGly: 2.88 ± 0.083
0.566AspHis: 0.566 ± 0.025
6.241AspIle: 6.241 ± 0.097
5.557AspLys: 5.557 ± 0.092
5.369AspLeu: 5.369 ± 0.077
1.282AspMet: 1.282 ± 0.033
3.094AspAsn: 3.094 ± 0.07
1.266AspPro: 1.266 ± 0.04
0.903AspGln: 0.903 ± 0.031
1.614AspArg: 1.614 ± 0.047
3.545AspSer: 3.545 ± 0.072
2.735AspThr: 2.735 ± 0.079
3.057AspVal: 3.057 ± 0.068
0.397AspTrp: 0.397 ± 0.019
2.557AspTyr: 2.557 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.357GluAla: 4.357 ± 0.078
0.501GluCys: 0.501 ± 0.023
4.503GluAsp: 4.503 ± 0.067
6.509GluGlu: 6.509 ± 0.106
3.706GluPhe: 3.706 ± 0.075
3.223GluGly: 3.223 ± 0.06
1.162GluHis: 1.162 ± 0.035
6.895GluIle: 6.895 ± 0.093
8.39GluLys: 8.39 ± 0.099
7.303GluLeu: 7.303 ± 0.102
1.6GluMet: 1.6 ± 0.044
5.473GluAsn: 5.473 ± 0.094
1.564GluPro: 1.564 ± 0.043
2.256GluGln: 2.256 ± 0.058
1.778GluArg: 1.778 ± 0.049
3.577GluSer: 3.577 ± 0.062
3.049GluThr: 3.049 ± 0.052
4.498GluVal: 4.498 ± 0.067
0.42GluTrp: 0.42 ± 0.023
3.221GluTyr: 3.221 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.082PheAla: 3.082 ± 0.063
0.565PheCys: 0.565 ± 0.025
3.431PheAsp: 3.431 ± 0.058
3.986PheGlu: 3.986 ± 0.077
3.14PhePhe: 3.14 ± 0.084
2.973PheGly: 2.973 ± 0.061
0.765PheHis: 0.765 ± 0.031
5.027PheIle: 5.027 ± 0.097
4.381PheLys: 4.381 ± 0.07
5.231PheLeu: 5.231 ± 0.099
1.182PheMet: 1.182 ± 0.035
2.925PheAsn: 2.925 ± 0.063
1.288PhePro: 1.288 ± 0.037
1.135PheGln: 1.135 ± 0.032
1.427PheArg: 1.427 ± 0.041
4.003PheSer: 4.003 ± 0.075
2.605PheThr: 2.605 ± 0.048
2.981PheVal: 2.981 ± 0.06
0.461PheTrp: 0.461 ± 0.027
2.262PheTyr: 2.262 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
3.539GlyAla: 3.539 ± 0.075
0.683GlyCys: 0.683 ± 0.028
2.626GlyAsp: 2.626 ± 0.061
3.508GlyGlu: 3.508 ± 0.063
3.333GlyPhe: 3.333 ± 0.054
3.461GlyGly: 3.461 ± 0.078
1.021GlyHis: 1.021 ± 0.039
5.04GlyIle: 5.04 ± 0.083
4.6GlyLys: 4.6 ± 0.069
5.028GlyLeu: 5.028 ± 0.087
1.374GlyMet: 1.374 ± 0.042
2.44GlyAsn: 2.44 ± 0.056
0.905GlyPro: 0.905 ± 0.034
1.378GlyGln: 1.378 ± 0.044
1.743GlyArg: 1.743 ± 0.046
3.243GlySer: 3.243 ± 0.071
2.871GlyThr: 2.871 ± 0.065
3.875GlyVal: 3.875 ± 0.084
0.5GlyTrp: 0.5 ± 0.026
2.517GlyTyr: 2.517 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
0.775HisAla: 0.775 ± 0.033
0.184HisCys: 0.184 ± 0.015
0.768HisAsp: 0.768 ± 0.026
1.028HisGlu: 1.028 ± 0.035
0.877HisPhe: 0.877 ± 0.034
0.987HisGly: 0.987 ± 0.037
0.349HisHis: 0.349 ± 0.022
1.445HisIle: 1.445 ± 0.045
1.379HisLys: 1.379 ± 0.043
1.484HisLeu: 1.484 ± 0.042
0.374HisMet: 0.374 ± 0.022
0.883HisAsn: 0.883 ± 0.034
0.685HisPro: 0.685 ± 0.03
0.495HisGln: 0.495 ± 0.021
0.571HisArg: 0.571 ± 0.024
1.007HisSer: 1.007 ± 0.029
0.839HisThr: 0.839 ± 0.033
0.612HisVal: 0.612 ± 0.025
0.147HisTrp: 0.147 ± 0.013
0.646HisTyr: 0.646 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.756IleAla: 5.756 ± 0.09
0.825IleCys: 0.825 ± 0.03
5.901IleAsp: 5.901 ± 0.08
7.12IleGlu: 7.12 ± 0.107
4.827IlePhe: 4.827 ± 0.097
4.98IleGly: 4.98 ± 0.08
1.289IleHis: 1.289 ± 0.043
7.762IleIle: 7.762 ± 0.117
9.214IleLys: 9.214 ± 0.118
8.876IleLeu: 8.876 ± 0.115
1.693IleMet: 1.693 ± 0.042
5.578IleAsn: 5.578 ± 0.08
2.902IlePro: 2.902 ± 0.062
2.268IleGln: 2.268 ± 0.047
2.353IleArg: 2.353 ± 0.049
6.762IleSer: 6.762 ± 0.09
4.692IleThr: 4.692 ± 0.087
5.434IleVal: 5.434 ± 0.082
0.557IleTrp: 0.557 ± 0.025
3.51IleTyr: 3.51 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
5.428LysAla: 5.428 ± 0.087
0.552LysCys: 0.552 ± 0.024
6.299LysAsp: 6.299 ± 0.094
10.332LysGlu: 10.332 ± 0.119
3.707LysPhe: 3.707 ± 0.057
4.363LysGly: 4.363 ± 0.072
1.391LysHis: 1.391 ± 0.039
9.002LysIle: 9.002 ± 0.109
10.793LysLys: 10.793 ± 0.152
8.333LysLeu: 8.333 ± 0.112
2.369LysMet: 2.369 ± 0.051
7.428LysAsn: 7.428 ± 0.128
2.428LysPro: 2.428 ± 0.053
2.843LysGln: 2.843 ± 0.066
3.583LysArg: 3.583 ± 0.073
5.631LysSer: 5.631 ± 0.092
4.779LysThr: 4.779 ± 0.07
5.497LysVal: 5.497 ± 0.082
0.594LysTrp: 0.594 ± 0.03
4.142LysTyr: 4.142 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
5.584LeuAla: 5.584 ± 0.094
0.897LeuCys: 0.897 ± 0.028
5.587LeuAsp: 5.587 ± 0.084
7.49LeuGlu: 7.49 ± 0.094
5.351LeuPhe: 5.351 ± 0.094
5.487LeuGly: 5.487 ± 0.088
1.38LeuHis: 1.38 ± 0.04
8.195LeuIle: 8.195 ± 0.119
10.274LeuLys: 10.274 ± 0.122
9.458LeuLeu: 9.458 ± 0.135
2.057LeuMet: 2.057 ± 0.048
6.402LeuAsn: 6.402 ± 0.089
2.988LeuPro: 2.988 ± 0.056
2.729LeuGln: 2.729 ± 0.06
2.666LeuArg: 2.666 ± 0.059
7.059LeuSer: 7.059 ± 0.105
4.742LeuThr: 4.742 ± 0.067
5.05LeuVal: 5.05 ± 0.083
0.628LeuTrp: 0.628 ± 0.03
3.588LeuTyr: 3.588 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.564MetAla: 1.564 ± 0.043
0.194MetCys: 0.194 ± 0.014
1.188MetAsp: 1.188 ± 0.033
1.29MetGlu: 1.29 ± 0.039
1.088MetPhe: 1.088 ± 0.039
1.413MetGly: 1.413 ± 0.042
0.374MetHis: 0.374 ± 0.02
1.994MetIle: 1.994 ± 0.047
2.23MetLys: 2.23 ± 0.055
2.163MetLeu: 2.163 ± 0.054
0.581MetMet: 0.581 ± 0.029
1.379MetAsn: 1.379 ± 0.041
0.89MetPro: 0.89 ± 0.032
0.934MetGln: 0.934 ± 0.032
0.685MetArg: 0.685 ± 0.026
1.563MetSer: 1.563 ± 0.04
1.091MetThr: 1.091 ± 0.032
1.285MetVal: 1.285 ± 0.038
0.157MetTrp: 0.157 ± 0.015
0.656MetTyr: 0.656 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.15AsnAla: 3.15 ± 0.063
0.58AsnCys: 0.58 ± 0.029
3.063AsnAsp: 3.063 ± 0.068
4.509AsnGlu: 4.509 ± 0.079
3.155AsnPhe: 3.155 ± 0.066
2.976AsnGly: 2.976 ± 0.063
0.912AsnHis: 0.912 ± 0.031
6.63AsnIle: 6.63 ± 0.087
5.806AsnLys: 5.806 ± 0.086
6.093AsnLeu: 6.093 ± 0.093
1.328AsnMet: 1.328 ± 0.039
3.623AsnAsn: 3.623 ± 0.072
2.206AsnPro: 2.206 ± 0.05
1.785AsnGln: 1.785 ± 0.052
2.249AsnArg: 2.249 ± 0.052
4.538AsnSer: 4.538 ± 0.08
2.756AsnThr: 2.756 ± 0.066
2.843AsnVal: 2.843 ± 0.053
0.449AsnTrp: 0.449 ± 0.021
2.451AsnTyr: 2.451 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
1.407ProAla: 1.407 ± 0.044
0.246ProCys: 0.246 ± 0.016
1.439ProAsp: 1.439 ± 0.039
1.782ProGlu: 1.782 ± 0.051
1.692ProPhe: 1.692 ± 0.045
1.253ProGly: 1.253 ± 0.044
0.543ProHis: 0.543 ± 0.024
2.365ProIle: 2.365 ± 0.048
2.779ProLys: 2.779 ± 0.058
2.837ProLeu: 2.837 ± 0.052
0.636ProMet: 0.636 ± 0.027
1.656ProAsn: 1.656 ± 0.04
0.573ProPro: 0.573 ± 0.027
0.883ProGln: 0.883 ± 0.031
0.768ProArg: 0.768 ± 0.029
1.816ProSer: 1.816 ± 0.048
1.573ProThr: 1.573 ± 0.046
1.758ProVal: 1.758 ± 0.046
0.248ProTrp: 0.248 ± 0.018
1.306ProTyr: 1.306 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.563GlnAla: 1.563 ± 0.047
0.188GlnCys: 0.188 ± 0.015
1.25GlnAsp: 1.25 ± 0.032
2.335GlnGlu: 2.335 ± 0.05
1.112GlnPhe: 1.112 ± 0.037
1.312GlnGly: 1.312 ± 0.037
0.389GlnHis: 0.389 ± 0.021
2.634GlnIle: 2.634 ± 0.054
3.346GlnLys: 3.346 ± 0.068
2.375GlnLeu: 2.375 ± 0.05
0.786GlnMet: 0.786 ± 0.032
2.172GlnAsn: 2.172 ± 0.055
0.64GlnPro: 0.64 ± 0.027
0.753GlnGln: 0.753 ± 0.038
1.18GlnArg: 1.18 ± 0.036
1.715GlnSer: 1.715 ± 0.043
1.566GlnThr: 1.566 ± 0.044
1.385GlnVal: 1.385 ± 0.035
0.314GlnTrp: 0.314 ± 0.018
0.929GlnTyr: 0.929 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
1.888ArgAla: 1.888 ± 0.053
0.294ArgCys: 0.294 ± 0.019
1.832ArgAsp: 1.832 ± 0.046
2.279ArgGlu: 2.279 ± 0.054
1.597ArgPhe: 1.597 ± 0.041
1.633ArgGly: 1.633 ± 0.037
0.489ArgHis: 0.489 ± 0.021
2.437ArgIle: 2.437 ± 0.051
2.653ArgLys: 2.653 ± 0.058
2.818ArgLeu: 2.818 ± 0.057
0.686ArgMet: 0.686 ± 0.026
1.596ArgAsn: 1.596 ± 0.044
0.808ArgPro: 0.808 ± 0.03
0.79ArgGln: 0.79 ± 0.027
1.188ArgArg: 1.188 ± 0.035
1.467ArgSer: 1.467 ± 0.041
1.348ArgThr: 1.348 ± 0.038
2.572ArgVal: 2.572 ± 0.053
0.25ArgTrp: 0.25 ± 0.018
1.338ArgTyr: 1.338 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
3.501SerAla: 3.501 ± 0.065
0.662SerCys: 0.662 ± 0.031
3.182SerAsp: 3.182 ± 0.074
3.421SerGlu: 3.421 ± 0.057
4.186SerPhe: 4.186 ± 0.075
3.592SerGly: 3.592 ± 0.083
1.08SerHis: 1.08 ± 0.034
6.278SerIle: 6.278 ± 0.093
6.726SerLys: 6.726 ± 0.087
7.219SerLeu: 7.219 ± 0.096
1.617SerMet: 1.617 ± 0.039
3.988SerAsn: 3.988 ± 0.077
1.492SerPro: 1.492 ± 0.042
2.044SerGln: 2.044 ± 0.049
1.859SerArg: 1.859 ± 0.043
5.175SerSer: 5.175 ± 0.098
3.257SerThr: 3.257 ± 0.075
3.529SerVal: 3.529 ± 0.058
0.527SerTrp: 0.527 ± 0.026
2.696SerTyr: 2.696 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
3.146ThrAla: 3.146 ± 0.07
0.37ThrCys: 0.37 ± 0.022
2.291ThrAsp: 2.291 ± 0.059
2.079ThrGlu: 2.079 ± 0.052
2.546ThrPhe: 2.546 ± 0.053
2.838ThrGly: 2.838 ± 0.06
0.874ThrHis: 0.874 ± 0.035
4.803ThrIle: 4.803 ± 0.082
4.859ThrLys: 4.859 ± 0.08
5.456ThrLeu: 5.456 ± 0.084
1.044ThrMet: 1.044 ± 0.031
2.77ThrAsn: 2.77 ± 0.066
1.983ThrPro: 1.983 ± 0.052
1.707ThrGln: 1.707 ± 0.05
1.26ThrArg: 1.26 ± 0.04
3.284ThrSer: 3.284 ± 0.068
2.855ThrThr: 2.855 ± 0.082
3.006ThrVal: 3.006 ± 0.076
0.322ThrTrp: 0.322 ± 0.021
2.015ThrTyr: 2.015 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
3.848ValAla: 3.848 ± 0.076
0.661ValCys: 0.661 ± 0.031
3.666ValAsp: 3.666 ± 0.071
4.299ValGlu: 4.299 ± 0.07
2.822ValPhe: 2.822 ± 0.06
3.363ValGly: 3.363 ± 0.075
0.865ValHis: 0.865 ± 0.035
5.054ValIle: 5.054 ± 0.085
5.058ValLys: 5.058 ± 0.074
5.658ValLeu: 5.658 ± 0.091
1.244ValMet: 1.244 ± 0.042
3.226ValAsn: 3.226 ± 0.063
1.786ValPro: 1.786 ± 0.052
1.479ValGln: 1.479 ± 0.037
1.559ValArg: 1.559 ± 0.044
3.95ValSer: 3.95 ± 0.075
2.944ValThr: 2.944 ± 0.077
3.836ValVal: 3.836 ± 0.08
0.448ValTrp: 0.448 ± 0.022
2.176ValTyr: 2.176 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.438TrpAla: 0.438 ± 0.022
0.081TrpCys: 0.081 ± 0.009
0.432TrpAsp: 0.432 ± 0.022
0.487TrpGlu: 0.487 ± 0.023
0.412TrpPhe: 0.412 ± 0.023
0.486TrpGly: 0.486 ± 0.022
0.183TrpHis: 0.183 ± 0.015
0.65TrpIle: 0.65 ± 0.026
0.521TrpLys: 0.521 ± 0.028
0.769TrpLeu: 0.769 ± 0.034
0.224TrpMet: 0.224 ± 0.015
0.383TrpAsn: 0.383 ± 0.019
0.157TrpPro: 0.157 ± 0.014
0.289TrpGln: 0.289 ± 0.016
0.254TrpArg: 0.254 ± 0.016
0.436TrpSer: 0.436 ± 0.022
0.303TrpThr: 0.303 ± 0.02
0.432TrpVal: 0.432 ± 0.025
0.071TrpTrp: 0.071 ± 0.01
0.315TrpTyr: 0.315 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.141TyrAla: 2.141 ± 0.053
0.4TyrCys: 0.4 ± 0.023
2.5TyrAsp: 2.5 ± 0.053
3.145TyrGlu: 3.145 ± 0.063
2.341TyrPhe: 2.341 ± 0.056
2.201TyrGly: 2.201 ± 0.056
0.675TyrHis: 0.675 ± 0.03
3.482TyrIle: 3.482 ± 0.069
4.287TyrLys: 4.287 ± 0.079
4.128TyrLeu: 4.128 ± 0.077
0.818TyrMet: 0.818 ± 0.029
2.408TyrAsn: 2.408 ± 0.05
1.19TyrPro: 1.19 ± 0.041
1.042TyrGln: 1.042 ± 0.035
1.222TyrArg: 1.222 ± 0.042
2.761TyrSer: 2.761 ± 0.054
2.025TyrThr: 2.025 ± 0.053
1.837TyrVal: 1.837 ± 0.045
0.329TyrTrp: 0.329 ± 0.02
1.772TyrTyr: 1.772 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2919 proteins (924466 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski