Amino acid dipepetide frequency for Hydrogenophaga sp. IBVHS2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.903AlaAla: 17.903 ± 0.213
1.279AlaCys: 1.279 ± 0.041
7.083AlaAsp: 7.083 ± 0.093
6.593AlaGlu: 6.593 ± 0.097
4.023AlaPhe: 4.023 ± 0.068
11.211AlaGly: 11.211 ± 0.143
2.784AlaHis: 2.784 ± 0.067
4.721AlaIle: 4.721 ± 0.074
2.813AlaLys: 2.813 ± 0.078
15.374AlaLeu: 15.374 ± 0.179
3.477AlaMet: 3.477 ± 0.056
2.28AlaAsn: 2.28 ± 0.053
6.67AlaPro: 6.67 ± 0.116
5.771AlaGln: 5.771 ± 0.085
10.022AlaArg: 10.022 ± 0.116
6.509AlaSer: 6.509 ± 0.098
6.112AlaThr: 6.112 ± 0.088
9.447AlaVal: 9.447 ± 0.123
2.224AlaTrp: 2.224 ± 0.049
2.265AlaTyr: 2.265 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.082CysAla: 1.082 ± 0.033
0.1CysCys: 0.1 ± 0.009
0.488CysAsp: 0.488 ± 0.023
0.514CysGlu: 0.514 ± 0.019
0.297CysPhe: 0.297 ± 0.019
0.99CysGly: 0.99 ± 0.033
0.285CysHis: 0.285 ± 0.018
0.409CysIle: 0.409 ± 0.02
0.2CysLys: 0.2 ± 0.014
0.872CysLeu: 0.872 ± 0.03
0.233CysMet: 0.233 ± 0.015
0.236CysAsn: 0.236 ± 0.015
0.528CysPro: 0.528 ± 0.027
0.27CysGln: 0.27 ± 0.016
0.63CysArg: 0.63 ± 0.026
0.495CysSer: 0.495 ± 0.022
0.522CysThr: 0.522 ± 0.024
0.676CysVal: 0.676 ± 0.03
0.12CysTrp: 0.12 ± 0.011
0.172CysTyr: 0.172 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.276AspAla: 7.276 ± 0.099
0.428AspCys: 0.428 ± 0.022
2.885AspAsp: 2.885 ± 0.062
3.119AspGlu: 3.119 ± 0.056
1.882AspPhe: 1.882 ± 0.045
4.778AspGly: 4.778 ± 0.08
1.312AspHis: 1.312 ± 0.04
2.508AspIle: 2.508 ± 0.06
1.455AspLys: 1.455 ± 0.046
5.798AspLeu: 5.798 ± 0.08
1.276AspMet: 1.276 ± 0.034
1.118AspAsn: 1.118 ± 0.037
3.365AspPro: 3.365 ± 0.062
1.744AspGln: 1.744 ± 0.049
4.006AspArg: 4.006 ± 0.068
2.112AspSer: 2.112 ± 0.052
2.73AspThr: 2.73 ± 0.059
4.049AspVal: 4.049 ± 0.069
0.992AspTrp: 0.992 ± 0.032
1.128AspTyr: 1.128 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.028GluAla: 7.028 ± 0.092
0.356GluCys: 0.356 ± 0.022
2.026GluAsp: 2.026 ± 0.048
2.189GluGlu: 2.189 ± 0.059
1.604GluPhe: 1.604 ± 0.043
3.743GluGly: 3.743 ± 0.066
1.287GluHis: 1.287 ± 0.035
2.35GluIle: 2.35 ± 0.05
1.716GluLys: 1.716 ± 0.046
5.861GluLeu: 5.861 ± 0.084
1.128GluMet: 1.128 ± 0.029
1.078GluAsn: 1.078 ± 0.036
2.769GluPro: 2.769 ± 0.058
2.621GluGln: 2.621 ± 0.06
4.854GluArg: 4.854 ± 0.088
2.289GluSer: 2.289 ± 0.057
2.291GluThr: 2.291 ± 0.046
4.221GluVal: 4.221 ± 0.058
0.71GluTrp: 0.71 ± 0.029
0.883GluTyr: 0.883 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.791PheAla: 3.791 ± 0.07
0.39PheCys: 0.39 ± 0.02
2.461PheAsp: 2.461 ± 0.051
2.074PheGlu: 2.074 ± 0.046
1.311PhePhe: 1.311 ± 0.045
3.2PheGly: 3.2 ± 0.068
0.782PheHis: 0.782 ± 0.031
1.349PheIle: 1.349 ± 0.038
0.972PheLys: 0.972 ± 0.034
2.905PheLeu: 2.905 ± 0.067
0.836PheMet: 0.836 ± 0.027
1.085PheAsn: 1.085 ± 0.03
1.4PhePro: 1.4 ± 0.039
1.114PheGln: 1.114 ± 0.036
1.963PheArg: 1.963 ± 0.049
1.869PheSer: 1.869 ± 0.044
1.794PheThr: 1.794 ± 0.046
2.646PheVal: 2.646 ± 0.058
0.478PheTrp: 0.478 ± 0.024
0.78PheTyr: 0.78 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.917GlyAla: 8.917 ± 0.132
0.922GlyCys: 0.922 ± 0.028
3.9GlyAsp: 3.9 ± 0.069
4.299GlyGlu: 4.299 ± 0.064
3.254GlyPhe: 3.254 ± 0.062
6.978GlyGly: 6.978 ± 0.114
2.241GlyHis: 2.241 ± 0.054
3.768GlyIle: 3.768 ± 0.063
2.626GlyLys: 2.626 ± 0.067
10.095GlyLeu: 10.095 ± 0.125
2.391GlyMet: 2.391 ± 0.051
1.994GlyAsn: 1.994 ± 0.061
3.565GlyPro: 3.565 ± 0.052
4.011GlyGln: 4.011 ± 0.072
6.36GlyArg: 6.36 ± 0.08
4.561GlySer: 4.561 ± 0.084
4.515GlyThr: 4.515 ± 0.086
6.803GlyVal: 6.803 ± 0.087
1.681GlyTrp: 1.681 ± 0.051
1.918GlyTyr: 1.918 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.997HisAla: 2.997 ± 0.062
0.292HisCys: 0.292 ± 0.018
1.269HisAsp: 1.269 ± 0.04
1.076HisGlu: 1.076 ± 0.034
0.854HisPhe: 0.854 ± 0.034
2.324HisGly: 2.324 ± 0.059
0.769HisHis: 0.769 ± 0.032
0.959HisIle: 0.959 ± 0.032
0.549HisLys: 0.549 ± 0.023
2.462HisLeu: 2.462 ± 0.054
0.517HisMet: 0.517 ± 0.023
0.509HisAsn: 0.509 ± 0.021
1.717HisPro: 1.717 ± 0.048
0.8HisGln: 0.8 ± 0.029
1.854HisArg: 1.854 ± 0.042
0.979HisSer: 0.979 ± 0.03
1.242HisThr: 1.242 ± 0.038
1.556HisVal: 1.556 ± 0.042
0.435HisTrp: 0.435 ± 0.024
0.528HisTyr: 0.528 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.008IleAla: 5.008 ± 0.071
0.383IleCys: 0.383 ± 0.019
3.127IleAsp: 3.127 ± 0.055
3.141IleGlu: 3.141 ± 0.063
1.115IlePhe: 1.115 ± 0.039
3.984IleGly: 3.984 ± 0.069
0.852IleHis: 0.852 ± 0.031
1.38IleIle: 1.38 ± 0.043
1.287IleLys: 1.287 ± 0.042
2.943IleLeu: 2.943 ± 0.065
0.732IleMet: 0.732 ± 0.029
1.336IleAsn: 1.336 ± 0.045
1.897IlePro: 1.897 ± 0.04
1.277IleGln: 1.277 ± 0.036
2.719IleArg: 2.719 ± 0.056
2.04IleSer: 2.04 ± 0.048
2.574IleThr: 2.574 ± 0.057
3.081IleVal: 3.081 ± 0.058
0.484IleTrp: 0.484 ± 0.024
0.843IleTyr: 0.843 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.91LysAla: 3.91 ± 0.099
0.139LysCys: 0.139 ± 0.011
1.509LysAsp: 1.509 ± 0.04
1.204LysGlu: 1.204 ± 0.045
0.738LysPhe: 0.738 ± 0.028
2.239LysGly: 2.239 ± 0.061
0.533LysHis: 0.533 ± 0.024
1.085LysIle: 1.085 ± 0.035
1.134LysLys: 1.134 ± 0.055
2.8LysLeu: 2.8 ± 0.062
0.618LysMet: 0.618 ± 0.023
0.743LysAsn: 0.743 ± 0.03
1.791LysPro: 1.791 ± 0.047
0.969LysGln: 0.969 ± 0.034
1.697LysArg: 1.697 ± 0.048
1.331LysSer: 1.331 ± 0.044
1.602LysThr: 1.602 ± 0.047
2.371LysVal: 2.371 ± 0.055
0.27LysTrp: 0.27 ± 0.019
0.516LysTyr: 0.516 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
14.986LeuAla: 14.986 ± 0.184
1.041LeuCys: 1.041 ± 0.035
6.261LeuAsp: 6.261 ± 0.095
5.02LeuGlu: 5.02 ± 0.079
3.23LeuPhe: 3.23 ± 0.071
9.047LeuGly: 9.047 ± 0.088
2.546LeuHis: 2.546 ± 0.061
4.251LeuIle: 4.251 ± 0.067
3.286LeuLys: 3.286 ± 0.061
11.873LeuLeu: 11.873 ± 0.159
2.794LeuMet: 2.794 ± 0.056
2.617LeuAsn: 2.617 ± 0.052
6.698LeuPro: 6.698 ± 0.096
5.455LeuGln: 5.455 ± 0.081
8.269LeuArg: 8.269 ± 0.105
6.107LeuSer: 6.107 ± 0.092
5.48LeuThr: 5.48 ± 0.076
8.377LeuVal: 8.377 ± 0.118
1.492LeuTrp: 1.492 ± 0.043
1.85LeuTyr: 1.85 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.446MetAla: 3.446 ± 0.062
0.171MetCys: 0.171 ± 0.013
1.29MetAsp: 1.29 ± 0.04
1.097MetGlu: 1.097 ± 0.036
0.646MetPhe: 0.646 ± 0.026
2.081MetGly: 2.081 ± 0.05
0.514MetHis: 0.514 ± 0.024
0.865MetIle: 0.865 ± 0.03
0.988MetLys: 0.988 ± 0.034
2.485MetLeu: 2.485 ± 0.056
0.55MetMet: 0.55 ± 0.024
0.889MetAsn: 0.889 ± 0.028
1.605MetPro: 1.605 ± 0.04
1.039MetGln: 1.039 ± 0.03
1.565MetArg: 1.565 ± 0.041
1.48MetSer: 1.48 ± 0.044
1.542MetThr: 1.542 ± 0.041
1.821MetVal: 1.821 ± 0.047
0.202MetTrp: 0.202 ± 0.015
0.319MetTyr: 0.319 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.026AsnAla: 3.026 ± 0.063
0.226AsnCys: 0.226 ± 0.015
1.243AsnAsp: 1.243 ± 0.042
1.111AsnGlu: 1.111 ± 0.038
0.769AsnPhe: 0.769 ± 0.032
2.036AsnGly: 2.036 ± 0.058
0.493AsnHis: 0.493 ± 0.024
1.089AsnIle: 1.089 ± 0.039
0.647AsnLys: 0.647 ± 0.023
2.486AsnLeu: 2.486 ± 0.063
0.519AsnMet: 0.519 ± 0.023
0.632AsnAsn: 0.632 ± 0.029
1.788AsnPro: 1.788 ± 0.05
0.85AsnGln: 0.85 ± 0.037
1.662AsnArg: 1.662 ± 0.041
0.966AsnSer: 0.966 ± 0.036
1.361AsnThr: 1.361 ± 0.049
1.645AsnVal: 1.645 ± 0.05
0.359AsnTrp: 0.359 ± 0.018
0.532AsnTyr: 0.532 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
8.381ProAla: 8.381 ± 0.125
0.389ProCys: 0.389 ± 0.024
3.681ProAsp: 3.681 ± 0.067
3.284ProGlu: 3.284 ± 0.069
1.757ProPhe: 1.757 ± 0.047
5.389ProGly: 5.389 ± 0.087
1.191ProHis: 1.191 ± 0.037
1.651ProIle: 1.651 ± 0.043
1.265ProLys: 1.265 ± 0.045
5.725ProLeu: 5.725 ± 0.095
1.392ProMet: 1.392 ± 0.037
1.123ProAsn: 1.123 ± 0.034
3.153ProPro: 3.153 ± 0.079
2.311ProGln: 2.311 ± 0.052
3.308ProArg: 3.308 ± 0.062
2.795ProSer: 2.795 ± 0.052
2.718ProThr: 2.718 ± 0.05
5.12ProVal: 5.12 ± 0.084
0.918ProTrp: 0.918 ± 0.032
0.978ProTyr: 0.978 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
6.676GlnAla: 6.676 ± 0.1
0.304GlnCys: 0.304 ± 0.016
1.774GlnAsp: 1.774 ± 0.044
1.569GlnGlu: 1.569 ± 0.04
1.122GlnPhe: 1.122 ± 0.034
3.657GlnGly: 3.657 ± 0.057
0.995GlnHis: 0.995 ± 0.04
1.675GlnIle: 1.675 ± 0.042
1.003GlnLys: 1.003 ± 0.035
4.325GlnLeu: 4.325 ± 0.074
0.962GlnMet: 0.962 ± 0.032
0.855GlnAsn: 0.855 ± 0.033
2.671GlnPro: 2.671 ± 0.058
2.072GlnGln: 2.072 ± 0.049
4.161GlnArg: 4.161 ± 0.072
1.886GlnSer: 1.886 ± 0.05
2.152GlnThr: 2.152 ± 0.052
3.381GlnVal: 3.381 ± 0.066
0.701GlnTrp: 0.701 ± 0.028
0.677GlnTyr: 0.677 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
8.084ArgAla: 8.084 ± 0.11
0.704ArgCys: 0.704 ± 0.028
3.782ArgAsp: 3.782 ± 0.07
4.431ArgGlu: 4.431 ± 0.077
2.938ArgPhe: 2.938 ± 0.066
4.681ArgGly: 4.681 ± 0.07
2.277ArgHis: 2.277 ± 0.057
3.581ArgIle: 3.581 ± 0.064
1.813ArgLys: 1.813 ± 0.053
9.166ArgLeu: 9.166 ± 0.126
2.01ArgMet: 2.01 ± 0.047
1.687ArgAsn: 1.687 ± 0.042
4.027ArgPro: 4.027 ± 0.075
3.679ArgGln: 3.679 ± 0.059
5.86ArgArg: 5.86 ± 0.09
3.92ArgSer: 3.92 ± 0.057
3.561ArgThr: 3.561 ± 0.062
5.519ArgVal: 5.519 ± 0.085
1.424ArgTrp: 1.424 ± 0.04
1.674ArgTyr: 1.674 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.16SerAla: 6.16 ± 0.1
0.42SerCys: 0.42 ± 0.025
2.479SerAsp: 2.479 ± 0.048
2.247SerGlu: 2.247 ± 0.049
1.831SerPhe: 1.831 ± 0.044
4.808SerGly: 4.808 ± 0.083
1.161SerHis: 1.161 ± 0.034
2.039SerIle: 2.039 ± 0.05
1.185SerLys: 1.185 ± 0.04
5.719SerLeu: 5.719 ± 0.093
1.22SerMet: 1.22 ± 0.041
1.139SerAsn: 1.139 ± 0.033
2.93SerPro: 2.93 ± 0.056
1.796SerGln: 1.796 ± 0.047
3.758SerArg: 3.758 ± 0.059
2.627SerSer: 2.627 ± 0.069
2.821SerThr: 2.821 ± 0.061
3.997SerVal: 3.997 ± 0.087
0.719SerTrp: 0.719 ± 0.028
1.052SerTyr: 1.052 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
6.309ThrAla: 6.309 ± 0.088
0.42ThrCys: 0.42 ± 0.021
2.884ThrAsp: 2.884 ± 0.064
2.631ThrGlu: 2.631 ± 0.057
1.656ThrPhe: 1.656 ± 0.043
4.978ThrGly: 4.978 ± 0.076
1.162ThrHis: 1.162 ± 0.032
1.862ThrIle: 1.862 ± 0.05
1.001ThrLys: 1.001 ± 0.034
6.387ThrLeu: 6.387 ± 0.086
0.984ThrMet: 0.984 ± 0.033
1.075ThrAsn: 1.075 ± 0.039
3.804ThrPro: 3.804 ± 0.074
1.819ThrGln: 1.819 ± 0.045
3.531ThrArg: 3.531 ± 0.062
2.438ThrSer: 2.438 ± 0.06
2.839ThrThr: 2.839 ± 0.06
4.483ThrVal: 4.483 ± 0.09
0.691ThrTrp: 0.691 ± 0.028
0.992ThrTyr: 0.992 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.745ValAla: 9.745 ± 0.104
0.747ValCys: 0.747 ± 0.03
4.198ValAsp: 4.198 ± 0.071
3.916ValGlu: 3.916 ± 0.067
2.84ValPhe: 2.84 ± 0.054
5.865ValGly: 5.865 ± 0.096
1.753ValHis: 1.753 ± 0.055
3.287ValIle: 3.287 ± 0.061
2.325ValLys: 2.325 ± 0.06
8.901ValLeu: 8.901 ± 0.108
2.062ValMet: 2.062 ± 0.052
2.107ValAsn: 2.107 ± 0.063
4.325ValPro: 4.325 ± 0.075
3.425ValGln: 3.425 ± 0.065
5.651ValArg: 5.651 ± 0.083
3.887ValSer: 3.887 ± 0.073
4.116ValThr: 4.116 ± 0.07
6.957ValVal: 6.957 ± 0.104
1.168ValTrp: 1.168 ± 0.036
1.38ValTyr: 1.38 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.56TrpAla: 1.56 ± 0.04
0.207TrpCys: 0.207 ± 0.015
0.646TrpAsp: 0.646 ± 0.026
0.549TrpGlu: 0.549 ± 0.023
0.546TrpPhe: 0.546 ± 0.024
1.039TrpGly: 1.039 ± 0.038
0.351TrpHis: 0.351 ± 0.02
0.638TrpIle: 0.638 ± 0.027
0.386TrpLys: 0.386 ± 0.021
2.37TrpLeu: 2.37 ± 0.058
0.474TrpMet: 0.474 ± 0.023
0.407TrpAsn: 0.407 ± 0.021
0.86TrpPro: 0.86 ± 0.036
0.852TrpGln: 0.852 ± 0.03
1.391TrpArg: 1.391 ± 0.04
0.839TrpSer: 0.839 ± 0.032
0.851TrpThr: 0.851 ± 0.027
1.141TrpVal: 1.141 ± 0.034
0.346TrpTrp: 0.346 ± 0.02
0.264TrpTyr: 0.264 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.275TyrAla: 2.275 ± 0.05
0.201TyrCys: 0.201 ± 0.015
0.974TyrAsp: 0.974 ± 0.033
0.942TyrGlu: 0.942 ± 0.031
0.788TyrPhe: 0.788 ± 0.03
1.771TyrGly: 1.771 ± 0.048
0.397TyrHis: 0.397 ± 0.019
0.737TyrIle: 0.737 ± 0.027
0.551TyrLys: 0.551 ± 0.028
2.135TyrLeu: 2.135 ± 0.053
0.418TyrMet: 0.418 ± 0.02
0.531TyrAsn: 0.531 ± 0.028
0.969TyrPro: 0.969 ± 0.032
0.74TyrGln: 0.74 ± 0.027
1.558TyrArg: 1.558 ± 0.042
0.977TyrSer: 0.977 ± 0.032
1.124TyrThr: 1.124 ± 0.035
1.362TyrVal: 1.362 ± 0.036
0.301TyrTrp: 0.301 ± 0.019
0.419TyrTyr: 0.419 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2952 proteins (976957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski