Amino acid dipepetide frequency for Streptococcus satellite phage Javan332

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.301AlaAla: 0.301 ± 0.245
0.0AlaCys: 0.0 ± 0.0
4.213AlaAsp: 4.213 ± 1.033
6.621AlaGlu: 6.621 ± 1.38
3.009AlaPhe: 3.009 ± 1.094
3.31AlaGly: 3.31 ± 0.881
0.602AlaHis: 0.602 ± 0.412
4.815AlaIle: 4.815 ± 1.252
6.019AlaLys: 6.019 ± 1.252
4.514AlaLeu: 4.514 ± 1.504
2.407AlaMet: 2.407 ± 1.333
3.31AlaAsn: 3.31 ± 1.013
0.903AlaPro: 0.903 ± 0.45
3.611AlaGln: 3.611 ± 0.863
2.407AlaArg: 2.407 ± 0.585
4.213AlaSer: 4.213 ± 0.967
5.417AlaThr: 5.417 ± 1.049
3.009AlaVal: 3.009 ± 0.703
0.602AlaTrp: 0.602 ± 0.338
1.505AlaTyr: 1.505 ± 0.579
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.204CysAsp: 1.204 ± 0.778
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.301CysIle: 0.301 ± 0.319
0.301CysLys: 0.301 ± 0.28
0.301CysLeu: 0.301 ± 0.278
0.301CysMet: 0.301 ± 0.326
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.602CysGln: 0.602 ± 0.471
0.301CysArg: 0.301 ± 0.28
0.0CysSer: 0.0 ± 0.0
0.602CysThr: 0.602 ± 0.414
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.301CysTyr: 0.301 ± 0.259
0.0CysXaa: 0.0 ± 0.0
Asp
1.505AspAla: 1.505 ± 0.507
0.602AspCys: 0.602 ± 0.367
2.708AspAsp: 2.708 ± 0.827
5.116AspGlu: 5.116 ± 1.385
3.009AspPhe: 3.009 ± 0.647
2.407AspGly: 2.407 ± 0.596
0.602AspHis: 0.602 ± 0.408
5.718AspIle: 5.718 ± 1.294
4.514AspLys: 4.514 ± 1.044
4.514AspLeu: 4.514 ± 0.912
2.107AspMet: 2.107 ± 0.468
3.912AspAsn: 3.912 ± 1.208
1.204AspPro: 1.204 ± 0.499
1.204AspGln: 1.204 ± 0.645
3.009AspArg: 3.009 ± 0.896
3.009AspSer: 3.009 ± 0.818
3.611AspThr: 3.611 ± 0.673
2.708AspVal: 2.708 ± 0.806
0.301AspTrp: 0.301 ± 0.332
5.116AspTyr: 5.116 ± 1.75
0.0AspXaa: 0.0 ± 0.0
Glu
5.116GluAla: 5.116 ± 1.173
0.301GluCys: 0.301 ± 0.31
3.912GluAsp: 3.912 ± 1.008
7.222GluGlu: 7.222 ± 1.239
3.009GluPhe: 3.009 ± 0.893
3.912GluGly: 3.912 ± 1.024
1.806GluHis: 1.806 ± 0.673
5.116GluIle: 5.116 ± 1.212
7.523GluLys: 7.523 ± 1.293
10.232GluLeu: 10.232 ± 1.516
3.009GluMet: 3.009 ± 0.987
4.213GluAsn: 4.213 ± 0.878
3.611GluPro: 3.611 ± 1.085
2.708GluGln: 2.708 ± 1.373
6.921GluArg: 6.921 ± 1.685
3.31GluSer: 3.31 ± 1.191
4.213GluThr: 4.213 ± 1.049
5.116GluVal: 5.116 ± 1.588
0.301GluTrp: 0.301 ± 0.332
4.213GluTyr: 4.213 ± 0.842
0.0GluXaa: 0.0 ± 0.0
Phe
2.107PheAla: 2.107 ± 0.907
0.602PheCys: 0.602 ± 0.52
4.213PheAsp: 4.213 ± 0.86
3.912PheGlu: 3.912 ± 1.283
2.407PhePhe: 2.407 ± 0.885
4.213PheGly: 4.213 ± 0.769
0.602PheHis: 0.602 ± 0.338
1.806PheIle: 1.806 ± 0.664
3.31PheLys: 3.31 ± 0.974
4.514PheLeu: 4.514 ± 1.183
0.602PheMet: 0.602 ± 0.343
1.806PheAsn: 1.806 ± 0.752
0.301PhePro: 0.301 ± 0.349
2.107PheGln: 2.107 ± 0.766
2.107PheArg: 2.107 ± 0.64
1.806PheSer: 1.806 ± 0.561
1.505PheThr: 1.505 ± 0.821
1.505PheVal: 1.505 ± 0.582
0.602PheTrp: 0.602 ± 0.429
3.009PheTyr: 3.009 ± 0.611
0.0PheXaa: 0.0 ± 0.0
Gly
2.107GlyAla: 2.107 ± 0.728
0.301GlyCys: 0.301 ± 0.28
3.009GlyAsp: 3.009 ± 1.108
4.514GlyGlu: 4.514 ± 1.021
3.31GlyPhe: 3.31 ± 1.049
1.505GlyGly: 1.505 ± 0.599
0.903GlyHis: 0.903 ± 0.412
3.009GlyIle: 3.009 ± 0.648
4.514GlyLys: 4.514 ± 1.023
6.019GlyLeu: 6.019 ± 1.245
2.407GlyMet: 2.407 ± 0.745
1.505GlyAsn: 1.505 ± 0.638
0.0GlyPro: 0.0 ± 0.0
3.31GlyGln: 3.31 ± 0.913
2.107GlyArg: 2.107 ± 0.571
1.806GlySer: 1.806 ± 0.788
2.708GlyThr: 2.708 ± 1.118
3.611GlyVal: 3.611 ± 0.881
0.301GlyTrp: 0.301 ± 0.245
3.611GlyTyr: 3.611 ± 1.046
0.0GlyXaa: 0.0 ± 0.0
His
1.505HisAla: 1.505 ± 0.652
0.0HisCys: 0.0 ± 0.0
0.301HisAsp: 0.301 ± 0.31
0.602HisGlu: 0.602 ± 0.338
1.204HisPhe: 1.204 ± 0.643
2.107HisGly: 2.107 ± 0.626
0.602HisHis: 0.602 ± 0.345
0.903HisIle: 0.903 ± 0.595
2.107HisLys: 2.107 ± 0.808
1.806HisLeu: 1.806 ± 0.521
0.0HisMet: 0.0 ± 0.0
0.301HisAsn: 0.301 ± 0.258
0.301HisPro: 0.301 ± 0.267
0.301HisGln: 0.301 ± 0.31
1.204HisArg: 1.204 ± 0.507
1.505HisSer: 1.505 ± 0.6
1.204HisThr: 1.204 ± 0.432
0.301HisVal: 0.301 ± 0.245
0.301HisTrp: 0.301 ± 0.245
1.505HisTyr: 1.505 ± 0.594
0.0HisXaa: 0.0 ± 0.0
Ile
3.611IleAla: 3.611 ± 0.719
0.301IleCys: 0.301 ± 0.364
5.116IleAsp: 5.116 ± 1.123
6.621IleGlu: 6.621 ± 1.772
2.708IlePhe: 2.708 ± 0.842
3.611IleGly: 3.611 ± 0.681
0.903IleHis: 0.903 ± 0.57
3.009IleIle: 3.009 ± 0.73
7.222IleLys: 7.222 ± 1.258
5.116IleLeu: 5.116 ± 1.081
0.903IleMet: 0.903 ± 0.511
2.407IleAsn: 2.407 ± 1.136
2.708IlePro: 2.708 ± 0.712
2.407IleGln: 2.407 ± 0.789
2.708IleArg: 2.708 ± 0.806
5.718IleSer: 5.718 ± 1.451
4.815IleThr: 4.815 ± 0.936
1.204IleVal: 1.204 ± 0.517
1.204IleTrp: 1.204 ± 0.551
1.806IleTyr: 1.806 ± 0.785
0.0IleXaa: 0.0 ± 0.0
Lys
9.63LysAla: 9.63 ± 1.597
0.0LysCys: 0.0 ± 0.0
6.019LysAsp: 6.019 ± 1.477
8.727LysGlu: 8.727 ± 1.418
3.31LysPhe: 3.31 ± 0.689
5.116LysGly: 5.116 ± 1.404
3.912LysHis: 3.912 ± 0.901
6.32LysIle: 6.32 ± 1.11
8.426LysLys: 8.426 ± 1.77
8.125LysLeu: 8.125 ± 2.056
2.107LysMet: 2.107 ± 0.789
3.611LysAsn: 3.611 ± 0.936
4.213LysPro: 4.213 ± 0.822
5.116LysGln: 5.116 ± 0.917
7.222LysArg: 7.222 ± 1.407
5.116LysSer: 5.116 ± 1.406
6.621LysThr: 6.621 ± 1.606
4.213LysVal: 4.213 ± 0.768
1.806LysTrp: 1.806 ± 0.601
1.204LysTyr: 1.204 ± 0.559
0.0LysXaa: 0.0 ± 0.0
Leu
6.921LeuAla: 6.921 ± 1.18
0.301LeuCys: 0.301 ± 0.258
6.019LeuAsp: 6.019 ± 1.78
11.435LeuGlu: 11.435 ± 2.249
3.912LeuPhe: 3.912 ± 0.847
2.708LeuGly: 2.708 ± 0.962
1.204LeuHis: 1.204 ± 0.448
4.815LeuIle: 4.815 ± 1.252
9.931LeuLys: 9.931 ± 1.609
9.028LeuLeu: 9.028 ± 1.712
1.505LeuMet: 1.505 ± 0.626
6.019LeuAsn: 6.019 ± 1.254
3.31LeuPro: 3.31 ± 1.304
4.514LeuGln: 4.514 ± 0.878
3.009LeuArg: 3.009 ± 1.186
4.815LeuSer: 4.815 ± 1.304
7.523LeuThr: 7.523 ± 1.004
4.815LeuVal: 4.815 ± 1.246
0.602LeuTrp: 0.602 ± 0.394
3.611LeuTyr: 3.611 ± 1.016
0.0LeuXaa: 0.0 ± 0.0
Met
2.407MetAla: 2.407 ± 0.586
0.0MetCys: 0.0 ± 0.0
2.708MetAsp: 2.708 ± 0.614
2.407MetGlu: 2.407 ± 0.783
1.204MetPhe: 1.204 ± 0.578
1.204MetGly: 1.204 ± 0.481
0.0MetHis: 0.0 ± 0.0
1.204MetIle: 1.204 ± 0.429
1.806MetLys: 1.806 ± 0.701
1.806MetLeu: 1.806 ± 0.479
0.0MetMet: 0.0 ± 0.0
2.708MetAsn: 2.708 ± 0.666
0.0MetPro: 0.0 ± 0.0
2.407MetGln: 2.407 ± 0.634
1.505MetArg: 1.505 ± 0.5
0.602MetSer: 0.602 ± 0.442
4.213MetThr: 4.213 ± 1.209
1.505MetVal: 1.505 ± 0.65
0.0MetTrp: 0.0 ± 0.0
0.301MetTyr: 0.301 ± 0.292
0.0MetXaa: 0.0 ± 0.0
Asn
1.806AsnAla: 1.806 ± 0.636
0.0AsnCys: 0.0 ± 0.0
1.806AsnAsp: 1.806 ± 0.739
2.407AsnGlu: 2.407 ± 0.523
0.903AsnPhe: 0.903 ± 0.455
3.31AsnGly: 3.31 ± 0.911
0.903AsnHis: 0.903 ± 0.407
1.505AsnIle: 1.505 ± 0.596
5.718AsnLys: 5.718 ± 1.045
4.514AsnLeu: 4.514 ± 0.805
2.107AsnMet: 2.107 ± 0.86
1.806AsnAsn: 1.806 ± 0.828
2.708AsnPro: 2.708 ± 1.164
1.806AsnGln: 1.806 ± 0.747
2.107AsnArg: 2.107 ± 0.649
3.611AsnSer: 3.611 ± 0.866
1.806AsnThr: 1.806 ± 0.942
1.806AsnVal: 1.806 ± 0.647
0.602AsnTrp: 0.602 ± 0.414
2.708AsnTyr: 2.708 ± 0.822
0.0AsnXaa: 0.0 ± 0.0
Pro
1.806ProAla: 1.806 ± 0.482
0.0ProCys: 0.0 ± 0.0
1.505ProAsp: 1.505 ± 0.747
3.912ProGlu: 3.912 ± 1.26
2.407ProPhe: 2.407 ± 0.913
0.903ProGly: 0.903 ± 0.418
0.301ProHis: 0.301 ± 0.258
2.107ProIle: 2.107 ± 0.721
2.407ProLys: 2.407 ± 0.746
2.708ProLeu: 2.708 ± 0.678
0.301ProMet: 0.301 ± 0.364
2.407ProAsn: 2.407 ± 0.884
0.602ProPro: 0.602 ± 0.322
0.903ProGln: 0.903 ± 0.569
2.407ProArg: 2.407 ± 0.606
0.903ProSer: 0.903 ± 0.477
1.806ProThr: 1.806 ± 0.642
1.204ProVal: 1.204 ± 0.625
0.0ProTrp: 0.0 ± 0.0
1.505ProTyr: 1.505 ± 0.555
0.0ProXaa: 0.0 ± 0.0
Gln
5.116GlnAla: 5.116 ± 1.453
0.0GlnCys: 0.0 ± 0.0
1.204GlnAsp: 1.204 ± 0.51
3.31GlnGlu: 3.31 ± 0.981
1.806GlnPhe: 1.806 ± 0.606
2.708GlnGly: 2.708 ± 0.875
0.903GlnHis: 0.903 ± 0.371
3.009GlnIle: 3.009 ± 0.836
7.824GlnLys: 7.824 ± 1.398
4.514GlnLeu: 4.514 ± 1.279
0.903GlnMet: 0.903 ± 0.432
1.806GlnAsn: 1.806 ± 0.868
0.602GlnPro: 0.602 ± 0.728
3.31GlnGln: 3.31 ± 0.956
2.407GlnArg: 2.407 ± 0.802
3.009GlnSer: 3.009 ± 0.884
2.407GlnThr: 2.407 ± 0.692
2.107GlnVal: 2.107 ± 0.771
0.602GlnTrp: 0.602 ± 0.354
1.204GlnTyr: 1.204 ± 0.702
0.0GlnXaa: 0.0 ± 0.0
Arg
3.31ArgAla: 3.31 ± 0.896
0.0ArgCys: 0.0 ± 0.0
2.708ArgAsp: 2.708 ± 1.02
4.514ArgGlu: 4.514 ± 0.837
3.009ArgPhe: 3.009 ± 0.758
2.708ArgGly: 2.708 ± 0.604
0.903ArgHis: 0.903 ± 0.611
3.912ArgIle: 3.912 ± 0.688
5.417ArgLys: 5.417 ± 1.345
6.019ArgLeu: 6.019 ± 1.214
1.204ArgMet: 1.204 ± 0.524
2.107ArgAsn: 2.107 ± 0.876
1.204ArgPro: 1.204 ± 0.544
3.611ArgGln: 3.611 ± 0.864
2.107ArgArg: 2.107 ± 0.842
2.107ArgSer: 2.107 ± 0.627
3.009ArgThr: 3.009 ± 0.819
2.107ArgVal: 2.107 ± 0.852
0.0ArgTrp: 0.0 ± 0.0
2.407ArgTyr: 2.407 ± 1.019
0.0ArgXaa: 0.0 ± 0.0
Ser
1.806SerAla: 1.806 ± 0.687
0.602SerCys: 0.602 ± 0.394
3.009SerAsp: 3.009 ± 0.818
3.31SerGlu: 3.31 ± 0.994
1.204SerPhe: 1.204 ± 0.458
1.505SerGly: 1.505 ± 0.626
0.903SerHis: 0.903 ± 0.49
4.213SerIle: 4.213 ± 0.768
5.718SerLys: 5.718 ± 0.943
5.417SerLeu: 5.417 ± 1.136
2.107SerMet: 2.107 ± 0.904
1.204SerAsn: 1.204 ± 0.549
1.204SerPro: 1.204 ± 0.414
3.009SerGln: 3.009 ± 0.827
3.31SerArg: 3.31 ± 1.677
2.107SerSer: 2.107 ± 0.828
1.505SerThr: 1.505 ± 0.424
4.213SerVal: 4.213 ± 1.106
0.602SerTrp: 0.602 ± 0.373
3.31SerTyr: 3.31 ± 0.963
0.0SerXaa: 0.0 ± 0.0
Thr
3.611ThrAla: 3.611 ± 1.025
0.301ThrCys: 0.301 ± 0.326
3.31ThrAsp: 3.31 ± 1.05
3.912ThrGlu: 3.912 ± 0.705
3.611ThrPhe: 3.611 ± 1.475
4.514ThrGly: 4.514 ± 1.236
0.903ThrHis: 0.903 ± 0.595
4.213ThrIle: 4.213 ± 0.858
5.718ThrLys: 5.718 ± 1.255
7.824ThrLeu: 7.824 ± 1.498
2.107ThrMet: 2.107 ± 0.781
1.505ThrAsn: 1.505 ± 0.566
3.31ThrPro: 3.31 ± 0.749
3.611ThrGln: 3.611 ± 1.036
2.708ThrArg: 2.708 ± 0.543
2.708ThrSer: 2.708 ± 0.756
4.213ThrThr: 4.213 ± 1.319
3.009ThrVal: 3.009 ± 0.9
0.602ThrTrp: 0.602 ± 0.307
2.407ThrTyr: 2.407 ± 1.007
0.0ThrXaa: 0.0 ± 0.0
Val
5.116ValAla: 5.116 ± 1.287
0.0ValCys: 0.0 ± 0.0
1.505ValAsp: 1.505 ± 0.629
3.611ValGlu: 3.611 ± 1.344
0.602ValPhe: 0.602 ± 0.384
3.31ValGly: 3.31 ± 0.748
0.903ValHis: 0.903 ± 0.467
4.213ValIle: 4.213 ± 1.338
5.116ValLys: 5.116 ± 1.245
3.31ValLeu: 3.31 ± 0.893
1.204ValMet: 1.204 ± 0.532
0.903ValAsn: 0.903 ± 0.46
1.505ValPro: 1.505 ± 0.548
1.505ValGln: 1.505 ± 0.598
1.806ValArg: 1.806 ± 0.52
1.806ValSer: 1.806 ± 0.764
3.912ValThr: 3.912 ± 1.186
3.31ValVal: 3.31 ± 0.971
0.301ValTrp: 0.301 ± 0.245
3.31ValTyr: 3.31 ± 0.979
0.0ValXaa: 0.0 ± 0.0
Trp
1.204TrpAla: 1.204 ± 0.591
0.0TrpCys: 0.0 ± 0.0
0.301TrpAsp: 0.301 ± 0.332
1.204TrpGlu: 1.204 ± 0.513
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.602TrpIle: 0.602 ± 0.444
1.505TrpLys: 1.505 ± 0.528
1.505TrpLeu: 1.505 ± 0.822
0.0TrpMet: 0.0 ± 0.0
0.301TrpAsn: 0.301 ± 0.258
0.602TrpPro: 0.602 ± 0.355
0.602TrpGln: 0.602 ± 0.384
0.0TrpArg: 0.0 ± 0.0
0.602TrpSer: 0.602 ± 0.337
0.0TrpThr: 0.0 ± 0.0
0.301TrpVal: 0.301 ± 0.226
0.301TrpTrp: 0.301 ± 0.28
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.806TyrAla: 1.806 ± 0.71
0.903TyrCys: 0.903 ± 0.525
2.107TyrAsp: 2.107 ± 0.85
2.407TyrGlu: 2.407 ± 0.72
2.407TyrPhe: 2.407 ± 1.009
1.505TyrGly: 1.505 ± 0.692
1.204TyrHis: 1.204 ± 0.593
3.31TyrIle: 3.31 ± 0.899
5.718TyrLys: 5.718 ± 1.586
4.213TyrLeu: 4.213 ± 1.221
2.407TyrMet: 2.407 ± 0.776
2.407TyrAsn: 2.407 ± 0.971
1.806TyrPro: 1.806 ± 0.635
2.107TyrGln: 2.107 ± 0.806
3.009TyrArg: 3.009 ± 0.972
1.505TyrSer: 1.505 ± 0.643
3.009TyrThr: 3.009 ± 0.678
1.204TyrVal: 1.204 ± 0.509
0.0TyrTrp: 0.0 ± 0.0
3.009TyrTyr: 3.009 ± 0.7
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (3324 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski