Amino acid dipepetide frequency for Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.132AlaAla: 14.132 ± 0.184
1.662AlaCys: 1.662 ± 0.042
6.202AlaAsp: 6.202 ± 0.072
6.592AlaGlu: 6.592 ± 0.091
4.03AlaPhe: 4.03 ± 0.066
10.018AlaGly: 10.018 ± 0.11
2.661AlaHis: 2.661 ± 0.063
4.69AlaIle: 4.69 ± 0.078
3.115AlaLys: 3.115 ± 0.065
12.693AlaLeu: 12.693 ± 0.117
3.418AlaMet: 3.418 ± 0.059
2.241AlaAsn: 2.241 ± 0.045
5.408AlaPro: 5.408 ± 0.102
3.458AlaGln: 3.458 ± 0.063
8.7AlaArg: 8.7 ± 0.091
6.546AlaSer: 6.546 ± 0.086
6.374AlaThr: 6.374 ± 0.095
8.536AlaVal: 8.536 ± 0.108
1.538AlaTrp: 1.538 ± 0.044
2.375AlaTyr: 2.375 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.512CysAla: 1.512 ± 0.041
0.312CysCys: 0.312 ± 0.02
0.78CysAsp: 0.78 ± 0.026
0.715CysGlu: 0.715 ± 0.028
0.434CysPhe: 0.434 ± 0.02
1.563CysGly: 1.563 ± 0.045
0.555CysHis: 0.555 ± 0.031
0.77CysIle: 0.77 ± 0.028
0.382CysLys: 0.382 ± 0.019
1.395CysLeu: 1.395 ± 0.035
0.371CysMet: 0.371 ± 0.021
0.407CysAsn: 0.407 ± 0.023
0.999CysPro: 0.999 ± 0.037
0.281CysGln: 0.281 ± 0.017
1.17CysArg: 1.17 ± 0.038
0.776CysSer: 0.776 ± 0.031
0.833CysThr: 0.833 ± 0.029
1.03CysVal: 1.03 ± 0.031
0.144CysTrp: 0.144 ± 0.012
0.286CysTyr: 0.286 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.62AspAla: 7.62 ± 0.101
0.686AspCys: 0.686 ± 0.028
3.6AspAsp: 3.6 ± 0.078
3.605AspGlu: 3.605 ± 0.061
2.114AspPhe: 2.114 ± 0.047
5.038AspGly: 5.038 ± 0.086
1.095AspHis: 1.095 ± 0.031
3.447AspIle: 3.447 ± 0.066
1.723AspLys: 1.723 ± 0.05
5.479AspLeu: 5.479 ± 0.077
1.849AspMet: 1.849 ± 0.043
1.298AspAsn: 1.298 ± 0.037
2.77AspPro: 2.77 ± 0.051
0.98AspGln: 0.98 ± 0.032
3.714AspArg: 3.714 ± 0.066
2.241AspSer: 2.241 ± 0.05
3.134AspThr: 3.134 ± 0.066
4.688AspVal: 4.688 ± 0.074
0.716AspTrp: 0.716 ± 0.026
1.466AspTyr: 1.466 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
7.782GluAla: 7.782 ± 0.09
0.639GluCys: 0.639 ± 0.022
3.036GluAsp: 3.036 ± 0.061
3.73GluGlu: 3.73 ± 0.072
1.558GluPhe: 1.558 ± 0.048
5.273GluGly: 5.273 ± 0.085
1.531GluHis: 1.531 ± 0.038
2.345GluIle: 2.345 ± 0.051
2.296GluLys: 2.296 ± 0.055
5.4GluLeu: 5.4 ± 0.085
1.74GluMet: 1.74 ± 0.039
1.533GluAsn: 1.533 ± 0.04
2.122GluPro: 2.122 ± 0.049
2.287GluGln: 2.287 ± 0.054
5.258GluArg: 5.258 ± 0.076
2.707GluSer: 2.707 ± 0.048
3.262GluThr: 3.262 ± 0.059
4.714GluVal: 4.714 ± 0.077
0.594GluTrp: 0.594 ± 0.022
1.211GluTyr: 1.211 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.827PheAla: 3.827 ± 0.068
0.617PheCys: 0.617 ± 0.024
2.35PheAsp: 2.35 ± 0.049
2.023PheGlu: 2.023 ± 0.047
1.528PhePhe: 1.528 ± 0.042
3.207PheGly: 3.207 ± 0.055
0.765PheHis: 0.765 ± 0.029
1.751PheIle: 1.751 ± 0.047
1.031PheLys: 1.031 ± 0.036
3.29PheLeu: 3.29 ± 0.06
1.091PheMet: 1.091 ± 0.034
0.996PheAsn: 0.996 ± 0.032
1.598PhePro: 1.598 ± 0.035
0.775PheGln: 0.775 ± 0.027
2.457PheArg: 2.457 ± 0.055
2.238PheSer: 2.238 ± 0.041
2.23PheThr: 2.23 ± 0.048
2.683PheVal: 2.683 ± 0.056
0.53PheTrp: 0.53 ± 0.023
0.92PheTyr: 0.92 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.307GlyAla: 8.307 ± 0.107
1.491GlyCys: 1.491 ± 0.045
4.755GlyAsp: 4.755 ± 0.077
4.849GlyGlu: 4.849 ± 0.077
3.195GlyPhe: 3.195 ± 0.056
7.553GlyGly: 7.553 ± 0.119
2.14GlyHis: 2.14 ± 0.053
4.504GlyIle: 4.504 ± 0.061
3.322GlyLys: 3.322 ± 0.063
8.815GlyLeu: 8.815 ± 0.118
2.915GlyMet: 2.915 ± 0.05
2.191GlyAsn: 2.191 ± 0.049
3.194GlyPro: 3.194 ± 0.067
2.67GlyGln: 2.67 ± 0.057
6.46GlyArg: 6.46 ± 0.097
4.109GlySer: 4.109 ± 0.073
5.219GlyThr: 5.219 ± 0.079
7.07GlyVal: 7.07 ± 0.095
1.157GlyTrp: 1.157 ± 0.033
2.322GlyTyr: 2.322 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
2.638HisAla: 2.638 ± 0.06
0.412HisCys: 0.412 ± 0.02
1.634HisAsp: 1.634 ± 0.045
1.501HisGlu: 1.501 ± 0.038
0.954HisPhe: 0.954 ± 0.033
2.384HisGly: 2.384 ± 0.051
0.663HisHis: 0.663 ± 0.029
1.196HisIle: 1.196 ± 0.035
0.696HisLys: 0.696 ± 0.025
2.504HisLeu: 2.504 ± 0.048
0.646HisMet: 0.646 ± 0.023
0.539HisAsn: 0.539 ± 0.022
1.599HisPro: 1.599 ± 0.049
0.551HisGln: 0.551 ± 0.023
1.667HisArg: 1.667 ± 0.044
1.109HisSer: 1.109 ± 0.033
1.242HisThr: 1.242 ± 0.038
1.768HisVal: 1.768 ± 0.043
0.273HisTrp: 0.273 ± 0.014
0.551HisTyr: 0.551 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.117IleAla: 5.117 ± 0.08
0.606IleCys: 0.606 ± 0.02
2.78IleAsp: 2.78 ± 0.052
2.813IleGlu: 2.813 ± 0.06
1.466IlePhe: 1.466 ± 0.04
3.531IleGly: 3.531 ± 0.064
0.97IleHis: 0.97 ± 0.032
2.387IleIle: 2.387 ± 0.049
1.374IleLys: 1.374 ± 0.043
4.146IleLeu: 4.146 ± 0.069
1.199IleMet: 1.199 ± 0.037
1.223IleAsn: 1.223 ± 0.035
2.49IlePro: 2.49 ± 0.05
0.972IleGln: 0.972 ± 0.032
3.218IleArg: 3.218 ± 0.054
2.445IleSer: 2.445 ± 0.052
2.469IleThr: 2.469 ± 0.05
3.649IleVal: 3.649 ± 0.072
0.396IleTrp: 0.396 ± 0.021
0.946IleTyr: 0.946 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.033LysAla: 4.033 ± 0.068
0.315LysCys: 0.315 ± 0.019
1.704LysAsp: 1.704 ± 0.054
1.863LysGlu: 1.863 ± 0.055
0.788LysPhe: 0.788 ± 0.033
3.014LysGly: 3.014 ± 0.058
0.646LysHis: 0.646 ± 0.025
1.178LysIle: 1.178 ± 0.044
1.395LysLys: 1.395 ± 0.049
2.894LysLeu: 2.894 ± 0.066
0.822LysMet: 0.822 ± 0.03
0.883LysAsn: 0.883 ± 0.034
1.789LysPro: 1.789 ± 0.047
0.988LysGln: 0.988 ± 0.037
2.202LysArg: 2.202 ± 0.052
1.496LysSer: 1.496 ± 0.044
1.767LysThr: 1.767 ± 0.044
2.589LysVal: 2.589 ± 0.06
0.304LysTrp: 0.304 ± 0.017
0.69LysTyr: 0.69 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
12.911LeuAla: 12.911 ± 0.135
1.685LeuCys: 1.685 ± 0.04
6.32LeuAsp: 6.32 ± 0.076
6.064LeuGlu: 6.064 ± 0.082
3.948LeuPhe: 3.948 ± 0.068
8.171LeuGly: 8.171 ± 0.116
2.747LeuHis: 2.747 ± 0.06
3.34LeuIle: 3.34 ± 0.06
3.132LeuLys: 3.132 ± 0.069
10.972LeuLeu: 10.972 ± 0.136
2.438LeuMet: 2.438 ± 0.052
2.192LeuAsn: 2.192 ± 0.049
6.115LeuPro: 6.115 ± 0.082
2.941LeuGln: 2.941 ± 0.053
8.512LeuArg: 8.512 ± 0.113
5.75LeuSer: 5.75 ± 0.082
5.292LeuThr: 5.292 ± 0.079
7.823LeuVal: 7.823 ± 0.087
1.149LeuTrp: 1.149 ± 0.039
2.244LeuTyr: 2.244 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.133MetAla: 3.133 ± 0.063
0.293MetCys: 0.293 ± 0.017
1.485MetAsp: 1.485 ± 0.036
1.567MetGlu: 1.567 ± 0.044
0.778MetPhe: 0.778 ± 0.03
2.261MetGly: 2.261 ± 0.056
0.745MetHis: 0.745 ± 0.028
0.775MetIle: 0.775 ± 0.028
0.926MetLys: 0.926 ± 0.03
3.052MetLeu: 3.052 ± 0.061
0.589MetMet: 0.589 ± 0.026
0.791MetAsn: 0.791 ± 0.028
1.913MetPro: 1.913 ± 0.042
1.138MetGln: 1.138 ± 0.031
2.212MetArg: 2.212 ± 0.049
1.645MetSer: 1.645 ± 0.04
1.728MetThr: 1.728 ± 0.041
1.98MetVal: 1.98 ± 0.047
0.273MetTrp: 0.273 ± 0.017
0.493MetTyr: 0.493 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.813AsnAla: 2.813 ± 0.055
0.332AsnCys: 0.332 ± 0.018
1.282AsnAsp: 1.282 ± 0.041
1.198AsnGlu: 1.198 ± 0.036
0.778AsnPhe: 0.778 ± 0.03
2.072AsnGly: 2.072 ± 0.049
0.487AsnHis: 0.487 ± 0.021
1.432AsnIle: 1.432 ± 0.04
0.698AsnLys: 0.698 ± 0.026
2.598AsnLeu: 2.598 ± 0.056
0.713AsnMet: 0.713 ± 0.027
0.646AsnAsn: 0.646 ± 0.029
1.626AsnPro: 1.626 ± 0.039
0.533AsnGln: 0.533 ± 0.021
1.686AsnArg: 1.686 ± 0.041
0.959AsnSer: 0.959 ± 0.029
1.275AsnThr: 1.275 ± 0.034
1.984AsnVal: 1.984 ± 0.05
0.288AsnTrp: 0.288 ± 0.018
0.605AsnTyr: 0.605 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.29ProAla: 6.29 ± 0.112
0.879ProCys: 0.879 ± 0.033
3.702ProAsp: 3.702 ± 0.072
3.959ProGlu: 3.959 ± 0.061
2.045ProPhe: 2.045 ± 0.054
4.827ProGly: 4.827 ± 0.074
1.348ProHis: 1.348 ± 0.043
1.472ProIle: 1.472 ± 0.037
1.297ProLys: 1.297 ± 0.044
5.085ProLeu: 5.085 ± 0.075
1.13ProMet: 1.13 ± 0.032
0.931ProAsn: 0.931 ± 0.028
2.648ProPro: 2.648 ± 0.062
1.73ProGln: 1.73 ± 0.042
3.279ProArg: 3.279 ± 0.069
2.764ProSer: 2.764 ± 0.055
2.229ProThr: 2.229 ± 0.047
4.807ProVal: 4.807 ± 0.075
0.746ProTrp: 0.746 ± 0.025
1.198ProTyr: 1.198 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
3.414GlnAla: 3.414 ± 0.059
0.403GlnCys: 0.403 ± 0.021
1.425GlnAsp: 1.425 ± 0.038
1.721GlnGlu: 1.721 ± 0.042
0.847GlnPhe: 0.847 ± 0.03
2.786GlnGly: 2.786 ± 0.067
0.809GlnHis: 0.809 ± 0.027
1.067GlnIle: 1.067 ± 0.035
1.092GlnLys: 1.092 ± 0.037
2.687GlnLeu: 2.687 ± 0.05
0.819GlnMet: 0.819 ± 0.025
0.758GlnAsn: 0.758 ± 0.03
1.589GlnPro: 1.589 ± 0.04
1.265GlnGln: 1.265 ± 0.046
2.551GlnArg: 2.551 ± 0.054
1.484GlnSer: 1.484 ± 0.039
1.575GlnThr: 1.575 ± 0.044
2.158GlnVal: 2.158 ± 0.052
0.37GlnTrp: 0.37 ± 0.019
0.636GlnTyr: 0.636 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.263ArgAla: 7.263 ± 0.097
1.108ArgCys: 1.108 ± 0.034
4.406ArgAsp: 4.406 ± 0.073
5.18ArgGlu: 5.18 ± 0.08
2.892ArgPhe: 2.892 ± 0.058
5.055ArgGly: 5.055 ± 0.067
2.351ArgHis: 2.351 ± 0.05
4.064ArgIle: 4.064 ± 0.072
2.92ArgLys: 2.92 ± 0.066
8.532ArgLeu: 8.532 ± 0.109
2.29ArgMet: 2.29 ± 0.044
2.16ArgAsn: 2.16 ± 0.044
3.639ArgPro: 3.639 ± 0.075
2.688ArgGln: 2.688 ± 0.06
6.111ArgArg: 6.111 ± 0.095
3.494ArgSer: 3.494 ± 0.065
3.766ArgThr: 3.766 ± 0.059
5.171ArgVal: 5.171 ± 0.075
0.882ArgTrp: 0.882 ± 0.031
1.89ArgTyr: 1.89 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
5.134SerAla: 5.134 ± 0.071
0.813SerCys: 0.813 ± 0.029
2.519SerAsp: 2.519 ± 0.052
2.409SerGlu: 2.409 ± 0.044
2.107SerPhe: 2.107 ± 0.042
5.383SerGly: 5.383 ± 0.083
1.167SerHis: 1.167 ± 0.033
2.555SerIle: 2.555 ± 0.055
1.364SerLys: 1.364 ± 0.037
5.868SerLeu: 5.868 ± 0.081
1.423SerMet: 1.423 ± 0.037
1.085SerAsn: 1.085 ± 0.037
3.134SerPro: 3.134 ± 0.058
1.412SerGln: 1.412 ± 0.046
3.809SerArg: 3.809 ± 0.061
2.984SerSer: 2.984 ± 0.065
2.742SerThr: 2.742 ± 0.048
3.822SerVal: 3.822 ± 0.061
0.65SerTrp: 0.65 ± 0.027
1.202SerTyr: 1.202 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.099ThrAla: 6.099 ± 0.087
0.725ThrCys: 0.725 ± 0.028
2.737ThrAsp: 2.737 ± 0.063
2.635ThrGlu: 2.635 ± 0.054
2.096ThrPhe: 2.096 ± 0.046
5.545ThrGly: 5.545 ± 0.085
1.211ThrHis: 1.211 ± 0.037
2.384ThrIle: 2.384 ± 0.052
1.289ThrLys: 1.289 ± 0.042
6.286ThrLeu: 6.286 ± 0.069
1.373ThrMet: 1.373 ± 0.035
1.122ThrAsn: 1.122 ± 0.04
3.916ThrPro: 3.916 ± 0.067
1.408ThrGln: 1.408 ± 0.037
3.668ThrArg: 3.668 ± 0.05
2.827ThrSer: 2.827 ± 0.053
3.183ThrThr: 3.183 ± 0.065
4.417ThrVal: 4.417 ± 0.068
0.609ThrTrp: 0.609 ± 0.022
1.229ThrTyr: 1.229 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.758ValAla: 8.758 ± 0.101
1.179ValCys: 1.179 ± 0.039
4.418ValAsp: 4.418 ± 0.07
4.747ValGlu: 4.747 ± 0.067
2.955ValPhe: 2.955 ± 0.058
5.543ValGly: 5.543 ± 0.08
1.747ValHis: 1.747 ± 0.038
3.452ValIle: 3.452 ± 0.058
2.183ValLys: 2.183 ± 0.056
8.372ValLeu: 8.372 ± 0.105
2.056ValMet: 2.056 ± 0.049
1.97ValAsn: 1.97 ± 0.048
4.068ValPro: 4.068 ± 0.067
2.255ValGln: 2.255 ± 0.049
6.129ValArg: 6.129 ± 0.077
4.331ValSer: 4.331 ± 0.063
4.641ValThr: 4.641 ± 0.067
6.692ValVal: 6.692 ± 0.084
0.88ValTrp: 0.88 ± 0.033
1.628ValTyr: 1.628 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.104TrpAla: 1.104 ± 0.04
0.203TrpCys: 0.203 ± 0.014
0.645TrpAsp: 0.645 ± 0.023
0.609TrpGlu: 0.609 ± 0.024
0.489TrpPhe: 0.489 ± 0.02
0.905TrpGly: 0.905 ± 0.032
0.357TrpHis: 0.357 ± 0.019
0.43TrpIle: 0.43 ± 0.02
0.452TrpLys: 0.452 ± 0.019
1.44TrpLeu: 1.44 ± 0.043
0.364TrpMet: 0.364 ± 0.02
0.409TrpAsn: 0.409 ± 0.021
0.596TrpPro: 0.596 ± 0.022
0.551TrpGln: 0.551 ± 0.021
1.114TrpArg: 1.114 ± 0.035
0.539TrpSer: 0.539 ± 0.021
0.577TrpThr: 0.577 ± 0.022
0.769TrpVal: 0.769 ± 0.029
0.193TrpTrp: 0.193 ± 0.015
0.27TrpTyr: 0.27 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.505TyrAla: 2.505 ± 0.053
0.356TyrCys: 0.356 ± 0.021
1.483TyrAsp: 1.483 ± 0.041
1.239TyrGlu: 1.239 ± 0.032
0.902TyrPhe: 0.902 ± 0.031
2.113TyrGly: 2.113 ± 0.043
0.533TyrHis: 0.533 ± 0.026
0.958TyrIle: 0.958 ± 0.028
0.672TyrLys: 0.672 ± 0.027
2.241TyrLeu: 2.241 ± 0.049
0.53TyrMet: 0.53 ± 0.023
0.631TyrAsn: 0.631 ± 0.026
1.153TyrPro: 1.153 ± 0.034
0.573TyrGln: 0.573 ± 0.027
1.944TyrArg: 1.944 ± 0.044
1.137TyrSer: 1.137 ± 0.036
1.219TyrThr: 1.219 ± 0.037
1.654TyrVal: 1.654 ± 0.039
0.324TyrTrp: 0.324 ± 0.017
0.632TyrTyr: 0.632 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3518 proteins (1075623 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski