Amino acid dipepetide frequency for Streptococcus satellite phage Javan735

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.546AlaAla: 0.546 ± 0.343
0.273AlaCys: 0.273 ± 0.266
2.458AlaAsp: 2.458 ± 0.904
3.551AlaGlu: 3.551 ± 0.736
3.824AlaPhe: 3.824 ± 0.8
1.912AlaGly: 1.912 ± 0.62
0.819AlaHis: 0.819 ± 0.526
3.824AlaIle: 3.824 ± 1.159
6.829AlaLys: 6.829 ± 1.583
3.824AlaLeu: 3.824 ± 0.893
1.912AlaMet: 1.912 ± 0.863
3.551AlaAsn: 3.551 ± 0.998
1.093AlaPro: 1.093 ± 0.479
3.005AlaGln: 3.005 ± 0.83
2.731AlaArg: 2.731 ± 0.793
1.366AlaSer: 1.366 ± 0.557
4.37AlaThr: 4.37 ± 1.024
1.639AlaVal: 1.639 ± 0.634
0.0AlaTrp: 0.0 ± 0.0
3.824AlaTyr: 3.824 ± 0.974
0.0AlaXaa: 0.0 ± 0.0
Cys
0.546CysAla: 0.546 ± 0.32
0.0CysCys: 0.0 ± 0.0
0.273CysAsp: 0.273 ± 0.285
0.273CysGlu: 0.273 ± 0.257
0.273CysPhe: 0.273 ± 0.253
0.546CysGly: 0.546 ± 0.343
0.273CysHis: 0.273 ± 0.257
0.273CysIle: 0.273 ± 0.241
0.546CysLys: 0.546 ± 0.332
1.093CysLeu: 1.093 ± 0.472
0.273CysMet: 0.273 ± 0.307
0.0CysAsn: 0.0 ± 0.0
0.819CysPro: 0.819 ± 0.393
0.0CysGln: 0.0 ± 0.0
0.546CysArg: 0.546 ± 0.322
0.273CysSer: 0.273 ± 0.266
0.0CysThr: 0.0 ± 0.0
0.273CysVal: 0.273 ± 0.285
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.366AspAla: 1.366 ± 0.541
1.093AspCys: 1.093 ± 0.408
4.917AspAsp: 4.917 ± 1.017
3.278AspGlu: 3.278 ± 0.788
3.824AspPhe: 3.824 ± 0.934
3.278AspGly: 3.278 ± 0.859
0.0AspHis: 0.0 ± 0.0
6.009AspIle: 6.009 ± 1.092
5.19AspLys: 5.19 ± 0.989
7.648AspLeu: 7.648 ± 1.287
0.819AspMet: 0.819 ± 0.49
3.824AspAsn: 3.824 ± 0.981
1.093AspPro: 1.093 ± 0.459
0.546AspGln: 0.546 ± 0.408
2.185AspArg: 2.185 ± 0.926
4.097AspSer: 4.097 ± 1.268
4.097AspThr: 4.097 ± 1.055
3.551AspVal: 3.551 ± 0.817
0.273AspTrp: 0.273 ± 0.239
1.912AspTyr: 1.912 ± 0.651
0.0AspXaa: 0.0 ± 0.0
Glu
3.824GluAla: 3.824 ± 1.001
0.819GluCys: 0.819 ± 0.439
4.644GluAsp: 4.644 ± 1.278
4.097GluGlu: 4.097 ± 1.263
3.005GluPhe: 3.005 ± 0.98
3.278GluGly: 3.278 ± 0.79
1.366GluHis: 1.366 ± 0.89
7.648GluIle: 7.648 ± 1.264
9.833GluLys: 9.833 ± 1.455
7.921GluLeu: 7.921 ± 1.495
1.366GluMet: 1.366 ± 0.559
4.917GluAsn: 4.917 ± 0.824
1.093GluPro: 1.093 ± 0.81
5.463GluGln: 5.463 ± 0.975
3.824GluArg: 3.824 ± 1.31
4.917GluSer: 4.917 ± 0.925
4.917GluThr: 4.917 ± 0.915
1.912GluVal: 1.912 ± 0.795
0.273GluTrp: 0.273 ± 0.241
3.551GluTyr: 3.551 ± 1.334
0.0GluXaa: 0.0 ± 0.0
Phe
1.912PheAla: 1.912 ± 0.811
0.273PheCys: 0.273 ± 0.285
3.005PheAsp: 3.005 ± 0.861
3.005PheGlu: 3.005 ± 0.786
2.185PhePhe: 2.185 ± 0.689
1.912PheGly: 1.912 ± 0.574
1.093PheHis: 1.093 ± 0.493
2.458PheIle: 2.458 ± 0.712
5.19PheLys: 5.19 ± 1.173
4.644PheLeu: 4.644 ± 1.04
0.819PheMet: 0.819 ± 0.446
1.639PheAsn: 1.639 ± 0.679
0.819PhePro: 0.819 ± 0.52
1.093PheGln: 1.093 ± 0.544
1.366PheArg: 1.366 ± 0.412
4.37PheSer: 4.37 ± 0.935
1.639PheThr: 1.639 ± 0.707
1.912PheVal: 1.912 ± 0.855
1.093PheTrp: 1.093 ± 0.476
1.912PheTyr: 1.912 ± 0.745
0.0PheXaa: 0.0 ± 0.0
Gly
2.185GlyAla: 2.185 ± 0.678
0.0GlyCys: 0.0 ± 0.0
1.912GlyAsp: 1.912 ± 0.741
2.185GlyGlu: 2.185 ± 0.763
2.731GlyPhe: 2.731 ± 0.866
2.731GlyGly: 2.731 ± 1.071
1.366GlyHis: 1.366 ± 0.453
3.551GlyIle: 3.551 ± 0.667
5.463GlyLys: 5.463 ± 1.144
4.097GlyLeu: 4.097 ± 1.004
1.093GlyMet: 1.093 ± 0.672
2.185GlyAsn: 2.185 ± 0.726
0.0GlyPro: 0.0 ± 0.0
2.458GlyGln: 2.458 ± 0.786
2.731GlyArg: 2.731 ± 0.725
3.278GlySer: 3.278 ± 0.849
2.185GlyThr: 2.185 ± 0.63
2.458GlyVal: 2.458 ± 0.737
0.273GlyTrp: 0.273 ± 0.239
3.278GlyTyr: 3.278 ± 0.949
0.0GlyXaa: 0.0 ± 0.0
His
2.185HisAla: 2.185 ± 0.86
0.0HisCys: 0.0 ± 0.0
0.546HisAsp: 0.546 ± 0.342
0.819HisGlu: 0.819 ± 0.446
0.546HisPhe: 0.546 ± 0.505
0.819HisGly: 0.819 ± 0.436
0.273HisHis: 0.273 ± 0.253
1.366HisIle: 1.366 ± 0.673
1.093HisLys: 1.093 ± 0.432
2.731HisLeu: 2.731 ± 0.817
0.273HisMet: 0.273 ± 0.244
1.366HisAsn: 1.366 ± 0.599
0.273HisPro: 0.273 ± 0.251
0.819HisGln: 0.819 ± 0.401
0.819HisArg: 0.819 ± 0.591
1.093HisSer: 1.093 ± 0.444
1.366HisThr: 1.366 ± 0.625
0.273HisVal: 0.273 ± 0.257
0.0HisTrp: 0.0 ± 0.0
1.093HisTyr: 1.093 ± 0.572
0.0HisXaa: 0.0 ± 0.0
Ile
2.731IleAla: 2.731 ± 0.776
0.0IleCys: 0.0 ± 0.0
4.917IleAsp: 4.917 ± 1.054
5.736IleGlu: 5.736 ± 1.245
2.458IlePhe: 2.458 ± 0.848
1.639IleGly: 1.639 ± 0.505
1.093IleHis: 1.093 ± 0.511
5.736IleIle: 5.736 ± 1.256
10.107IleLys: 10.107 ± 1.482
9.287IleLeu: 9.287 ± 1.099
0.273IleMet: 0.273 ± 0.266
4.097IleAsn: 4.097 ± 0.952
2.731IlePro: 2.731 ± 0.832
3.005IleGln: 3.005 ± 0.679
2.185IleArg: 2.185 ± 0.658
4.917IleSer: 4.917 ± 1.239
4.917IleThr: 4.917 ± 1.17
3.005IleVal: 3.005 ± 0.551
0.0IleTrp: 0.0 ± 0.0
2.731IleTyr: 2.731 ± 0.832
0.0IleXaa: 0.0 ± 0.0
Lys
6.829LysAla: 6.829 ± 1.51
0.546LysCys: 0.546 ± 0.356
6.009LysAsp: 6.009 ± 1.273
10.38LysGlu: 10.38 ± 1.391
4.37LysPhe: 4.37 ± 1.19
5.463LysGly: 5.463 ± 1.142
2.458LysHis: 2.458 ± 1.079
6.556LysIle: 6.556 ± 1.392
9.287LysLys: 9.287 ± 1.519
6.009LysLeu: 6.009 ± 1.57
2.185LysMet: 2.185 ± 0.84
6.009LysAsn: 6.009 ± 1.124
2.458LysPro: 2.458 ± 0.667
4.917LysGln: 4.917 ± 0.968
6.282LysArg: 6.282 ± 1.157
6.556LysSer: 6.556 ± 0.888
7.102LysThr: 7.102 ± 1.624
4.097LysVal: 4.097 ± 0.833
0.819LysTrp: 0.819 ± 0.393
4.097LysTyr: 4.097 ± 0.925
0.0LysXaa: 0.0 ± 0.0
Leu
7.375LeuAla: 7.375 ± 1.556
0.546LeuCys: 0.546 ± 0.39
7.648LeuAsp: 7.648 ± 1.422
9.833LeuGlu: 9.833 ± 1.433
2.731LeuPhe: 2.731 ± 0.889
5.736LeuGly: 5.736 ± 0.904
1.093LeuHis: 1.093 ± 0.606
5.463LeuIle: 5.463 ± 1.499
7.648LeuLys: 7.648 ± 1.389
9.014LeuLeu: 9.014 ± 2.058
3.278LeuMet: 3.278 ± 0.816
7.102LeuAsn: 7.102 ± 1.392
3.005LeuPro: 3.005 ± 0.801
3.824LeuGln: 3.824 ± 1.11
5.463LeuArg: 5.463 ± 0.888
8.194LeuSer: 8.194 ± 1.309
6.829LeuThr: 6.829 ± 1.483
4.917LeuVal: 4.917 ± 1.215
0.819LeuTrp: 0.819 ± 0.619
3.551LeuTyr: 3.551 ± 0.856
0.0LeuXaa: 0.0 ± 0.0
Met
0.819MetAla: 0.819 ± 0.405
0.0MetCys: 0.0 ± 0.0
1.912MetAsp: 1.912 ± 0.617
1.639MetGlu: 1.639 ± 0.593
0.273MetPhe: 0.273 ± 0.304
0.273MetGly: 0.273 ± 0.234
0.0MetHis: 0.0 ± 0.0
1.093MetIle: 1.093 ± 0.619
2.185MetLys: 2.185 ± 0.669
1.912MetLeu: 1.912 ± 0.645
0.273MetMet: 0.273 ± 0.241
1.912MetAsn: 1.912 ± 0.788
0.546MetPro: 0.546 ± 0.35
0.273MetGln: 0.273 ± 0.26
1.366MetArg: 1.366 ± 0.614
2.185MetSer: 2.185 ± 0.742
1.912MetThr: 1.912 ± 0.891
0.546MetVal: 0.546 ± 0.318
0.0MetTrp: 0.0 ± 0.0
0.819MetTyr: 0.819 ± 0.412
0.0MetXaa: 0.0 ± 0.0
Asn
3.278AsnAla: 3.278 ± 0.706
0.273AsnCys: 0.273 ± 0.257
1.366AsnAsp: 1.366 ± 0.452
3.005AsnGlu: 3.005 ± 0.992
2.185AsnPhe: 2.185 ± 0.702
3.824AsnGly: 3.824 ± 0.939
1.912AsnHis: 1.912 ± 0.968
3.551AsnIle: 3.551 ± 1.294
5.736AsnLys: 5.736 ± 1.227
5.19AsnLeu: 5.19 ± 0.992
1.639AsnMet: 1.639 ± 0.719
4.917AsnAsn: 4.917 ± 1.78
1.912AsnPro: 1.912 ± 0.68
2.731AsnGln: 2.731 ± 0.908
3.005AsnArg: 3.005 ± 0.694
4.644AsnSer: 4.644 ± 1.018
4.37AsnThr: 4.37 ± 1.273
2.185AsnVal: 2.185 ± 0.684
1.093AsnTrp: 1.093 ± 0.429
3.824AsnTyr: 3.824 ± 0.9
0.0AsnXaa: 0.0 ± 0.0
Pro
1.366ProAla: 1.366 ± 0.66
0.273ProCys: 0.273 ± 0.303
1.639ProAsp: 1.639 ± 0.653
2.458ProGlu: 2.458 ± 0.908
2.185ProPhe: 2.185 ± 0.827
0.546ProGly: 0.546 ± 0.375
0.819ProHis: 0.819 ± 0.468
1.093ProIle: 1.093 ± 0.394
3.551ProLys: 3.551 ± 1.146
1.093ProLeu: 1.093 ± 0.554
0.273ProMet: 0.273 ± 0.26
1.366ProAsn: 1.366 ± 0.498
0.546ProPro: 0.546 ± 0.373
0.546ProGln: 0.546 ± 0.368
1.639ProArg: 1.639 ± 0.612
1.366ProSer: 1.366 ± 0.603
1.912ProThr: 1.912 ± 0.571
0.819ProVal: 0.819 ± 0.403
0.0ProTrp: 0.0 ± 0.0
1.093ProTyr: 1.093 ± 0.427
0.0ProXaa: 0.0 ± 0.0
Gln
3.551GlnAla: 3.551 ± 0.777
0.546GlnCys: 0.546 ± 0.332
2.458GlnAsp: 2.458 ± 0.971
3.005GlnGlu: 3.005 ± 0.774
1.639GlnPhe: 1.639 ± 0.786
0.819GlnGly: 0.819 ± 0.585
0.819GlnHis: 0.819 ± 0.389
3.278GlnIle: 3.278 ± 0.874
3.551GlnLys: 3.551 ± 0.763
3.551GlnLeu: 3.551 ± 1.195
0.0GlnMet: 0.0 ± 0.0
2.458GlnAsn: 2.458 ± 0.76
0.819GlnPro: 0.819 ± 0.5
1.093GlnGln: 1.093 ± 0.619
1.912GlnArg: 1.912 ± 0.882
1.639GlnSer: 1.639 ± 0.625
1.912GlnThr: 1.912 ± 0.622
3.005GlnVal: 3.005 ± 0.809
0.546GlnTrp: 0.546 ± 0.321
0.819GlnTyr: 0.819 ± 0.45
0.0GlnXaa: 0.0 ± 0.0
Arg
1.366ArgAla: 1.366 ± 0.578
0.273ArgCys: 0.273 ± 0.241
3.005ArgAsp: 3.005 ± 0.793
4.917ArgGlu: 4.917 ± 1.298
2.185ArgPhe: 2.185 ± 0.792
1.366ArgGly: 1.366 ± 0.476
0.819ArgHis: 0.819 ± 0.342
3.551ArgIle: 3.551 ± 0.892
4.917ArgLys: 4.917 ± 1.029
6.282ArgLeu: 6.282 ± 1.364
1.093ArgMet: 1.093 ± 0.503
3.278ArgAsn: 3.278 ± 0.968
1.912ArgPro: 1.912 ± 0.904
1.912ArgGln: 1.912 ± 0.682
1.366ArgArg: 1.366 ± 0.674
1.912ArgSer: 1.912 ± 0.786
2.731ArgThr: 2.731 ± 0.66
0.819ArgVal: 0.819 ± 0.388
0.546ArgTrp: 0.546 ± 0.391
3.824ArgTyr: 3.824 ± 1.164
0.0ArgXaa: 0.0 ± 0.0
Ser
3.278SerAla: 3.278 ± 1.823
0.546SerCys: 0.546 ± 0.375
4.644SerAsp: 4.644 ± 1.343
6.829SerGlu: 6.829 ± 1.541
3.278SerPhe: 3.278 ± 0.967
3.551SerGly: 3.551 ± 0.658
0.819SerHis: 0.819 ± 0.368
4.097SerIle: 4.097 ± 1.193
7.102SerLys: 7.102 ± 1.259
7.648SerLeu: 7.648 ± 1.258
1.366SerMet: 1.366 ± 0.611
3.278SerAsn: 3.278 ± 0.84
1.912SerPro: 1.912 ± 0.544
1.093SerGln: 1.093 ± 0.566
2.731SerArg: 2.731 ± 0.65
5.19SerSer: 5.19 ± 1.176
4.37SerThr: 4.37 ± 1.045
2.731SerVal: 2.731 ± 0.802
1.093SerTrp: 1.093 ± 0.49
0.819SerTyr: 0.819 ± 0.536
0.0SerXaa: 0.0 ± 0.0
Thr
2.458ThrAla: 2.458 ± 0.941
0.0ThrCys: 0.0 ± 0.0
1.639ThrAsp: 1.639 ± 0.719
4.644ThrGlu: 4.644 ± 1.07
1.639ThrPhe: 1.639 ± 0.479
4.917ThrGly: 4.917 ± 0.764
1.912ThrHis: 1.912 ± 0.557
4.644ThrIle: 4.644 ± 0.932
5.19ThrLys: 5.19 ± 1.107
8.741ThrLeu: 8.741 ± 1.383
1.366ThrMet: 1.366 ± 0.485
3.278ThrAsn: 3.278 ± 0.911
1.639ThrPro: 1.639 ± 0.548
1.639ThrGln: 1.639 ± 0.659
2.731ThrArg: 2.731 ± 0.883
3.278ThrSer: 3.278 ± 0.833
2.731ThrThr: 2.731 ± 0.869
6.829ThrVal: 6.829 ± 1.322
0.546ThrTrp: 0.546 ± 0.331
3.005ThrTyr: 3.005 ± 1.188
0.0ThrXaa: 0.0 ± 0.0
Val
2.731ValAla: 2.731 ± 0.809
0.273ValCys: 0.273 ± 0.285
3.005ValAsp: 3.005 ± 1.022
3.824ValGlu: 3.824 ± 1.017
1.366ValPhe: 1.366 ± 0.513
1.639ValGly: 1.639 ± 0.631
0.0ValHis: 0.0 ± 0.0
4.37ValIle: 4.37 ± 1.212
3.824ValLys: 3.824 ± 0.869
4.37ValLeu: 4.37 ± 0.808
0.273ValMet: 0.273 ± 0.293
3.005ValAsn: 3.005 ± 0.593
0.819ValPro: 0.819 ± 0.379
1.366ValGln: 1.366 ± 0.743
1.912ValArg: 1.912 ± 0.644
4.097ValSer: 4.097 ± 1.028
2.731ValThr: 2.731 ± 0.756
3.005ValVal: 3.005 ± 0.849
0.546ValTrp: 0.546 ± 0.468
3.551ValTyr: 3.551 ± 0.977
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.379
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.912TrpGlu: 1.912 ± 0.693
0.0TrpPhe: 0.0 ± 0.0
0.273TrpGly: 0.273 ± 0.283
0.0TrpHis: 0.0 ± 0.0
0.546TrpIle: 0.546 ± 0.388
0.273TrpLys: 0.273 ± 0.241
1.093TrpLeu: 1.093 ± 0.564
0.0TrpMet: 0.0 ± 0.0
0.273TrpAsn: 0.273 ± 0.252
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.273TrpArg: 0.273 ± 0.257
0.819TrpSer: 0.819 ± 0.388
0.546TrpThr: 0.546 ± 0.375
1.093TrpVal: 1.093 ± 0.536
0.0TrpTrp: 0.0 ± 0.0
0.273TrpTyr: 0.273 ± 0.253
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.185TyrAla: 2.185 ± 0.71
0.546TyrCys: 0.546 ± 0.368
3.005TyrAsp: 3.005 ± 0.802
3.278TyrGlu: 3.278 ± 0.704
1.639TyrPhe: 1.639 ± 0.753
1.639TyrGly: 1.639 ± 0.693
0.819TyrHis: 0.819 ± 0.442
2.458TyrIle: 2.458 ± 0.662
4.917TyrLys: 4.917 ± 1.523
7.921TyrLeu: 7.921 ± 1.478
1.093TyrMet: 1.093 ± 0.481
2.458TyrAsn: 2.458 ± 1.047
1.093TyrPro: 1.093 ± 0.517
1.639TyrGln: 1.639 ± 0.652
3.005TyrArg: 3.005 ± 0.885
2.185TyrSer: 2.185 ± 0.645
2.185TyrThr: 2.185 ± 0.634
1.639TyrVal: 1.639 ± 0.654
0.273TyrTrp: 0.273 ± 0.285
1.639TyrTyr: 1.639 ± 0.818
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 25 proteins (3662 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski