Amino acid dipepetide frequency for Acinetobacter phage TAC1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.185AlaAla: 4.185 ± 0.397
0.654AlaCys: 0.654 ± 0.139
3.499AlaAsp: 3.499 ± 0.466
3.924AlaGlu: 3.924 ± 0.416
2.714AlaPhe: 2.714 ± 0.316
3.989AlaGly: 3.989 ± 0.531
0.981AlaHis: 0.981 ± 0.174
4.153AlaIle: 4.153 ± 0.351
5.068AlaLys: 5.068 ± 0.366
6.246AlaLeu: 6.246 ± 0.471
2.027AlaMet: 2.027 ± 0.265
3.27AlaAsn: 3.27 ± 0.528
1.733AlaPro: 1.733 ± 0.232
2.289AlaGln: 2.289 ± 0.318
2.878AlaArg: 2.878 ± 0.257
3.695AlaSer: 3.695 ± 0.405
3.433AlaThr: 3.433 ± 0.337
3.499AlaVal: 3.499 ± 0.408
0.752AlaTrp: 0.752 ± 0.131
2.42AlaTyr: 2.42 ± 0.225
0.0AlaXaa: 0.0 ± 0.0
Cys
0.556CysAla: 0.556 ± 0.124
0.163CysCys: 0.163 ± 0.072
0.687CysAsp: 0.687 ± 0.149
1.112CysGlu: 1.112 ± 0.188
0.654CysPhe: 0.654 ± 0.161
1.308CysGly: 1.308 ± 0.187
0.556CysHis: 0.556 ± 0.142
0.785CysIle: 0.785 ± 0.179
0.883CysLys: 0.883 ± 0.174
0.817CysLeu: 0.817 ± 0.171
0.262CysMet: 0.262 ± 0.102
0.687CysAsn: 0.687 ± 0.133
0.36CysPro: 0.36 ± 0.114
0.425CysGln: 0.425 ± 0.108
0.589CysArg: 0.589 ± 0.142
0.425CysSer: 0.425 ± 0.116
0.621CysThr: 0.621 ± 0.152
0.556CysVal: 0.556 ± 0.141
0.098CysTrp: 0.098 ± 0.057
0.687CysTyr: 0.687 ± 0.166
0.0CysXaa: 0.0 ± 0.0
Asp
3.957AspAla: 3.957 ± 0.329
0.752AspCys: 0.752 ± 0.157
4.905AspAsp: 4.905 ± 0.572
5.036AspGlu: 5.036 ± 0.485
3.63AspPhe: 3.63 ± 0.312
4.872AspGly: 4.872 ± 0.385
0.785AspHis: 0.785 ± 0.17
4.316AspIle: 4.316 ± 0.341
4.218AspLys: 4.218 ± 0.434
5.624AspLeu: 5.624 ± 0.462
2.027AspMet: 2.027 ± 0.23
3.139AspAsn: 3.139 ± 0.324
2.747AspPro: 2.747 ± 0.399
1.995AspGln: 1.995 ± 0.256
2.322AspArg: 2.322 ± 0.294
3.826AspSer: 3.826 ± 0.356
2.943AspThr: 2.943 ± 0.357
5.363AspVal: 5.363 ± 0.454
1.308AspTrp: 1.308 ± 0.214
3.041AspTyr: 3.041 ± 0.331
0.0AspXaa: 0.0 ± 0.0
Glu
5.166GluAla: 5.166 ± 0.403
1.471GluCys: 1.471 ± 0.24
5.363GluAsp: 5.363 ± 0.449
5.363GluGlu: 5.363 ± 0.6
3.368GluPhe: 3.368 ± 0.413
3.989GluGly: 3.989 ± 0.377
1.7GluHis: 1.7 ± 0.241
4.676GluIle: 4.676 ± 0.36
4.578GluLys: 4.578 ± 0.439
6.442GluLeu: 6.442 ± 0.479
2.354GluMet: 2.354 ± 0.262
3.466GluAsn: 3.466 ± 0.306
1.733GluPro: 1.733 ± 0.313
2.616GluGln: 2.616 ± 0.281
2.845GluArg: 2.845 ± 0.374
3.957GluSer: 3.957 ± 0.346
3.008GluThr: 3.008 ± 0.35
5.526GluVal: 5.526 ± 0.44
1.144GluTrp: 1.144 ± 0.187
3.074GluTyr: 3.074 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
2.387PheAla: 2.387 ± 0.3
0.523PheCys: 0.523 ± 0.145
3.139PheAsp: 3.139 ± 0.314
3.564PheGlu: 3.564 ± 0.36
1.243PhePhe: 1.243 ± 0.226
3.564PheGly: 3.564 ± 0.373
0.916PheHis: 0.916 ± 0.193
3.106PheIle: 3.106 ± 0.325
3.793PheLys: 3.793 ± 0.342
2.943PheLeu: 2.943 ± 0.273
1.897PheMet: 1.897 ± 0.272
2.354PheAsn: 2.354 ± 0.27
1.602PhePro: 1.602 ± 0.267
1.504PheGln: 1.504 ± 0.231
1.897PheArg: 1.897 ± 0.204
3.303PheSer: 3.303 ± 0.342
2.452PheThr: 2.452 ± 0.296
2.878PheVal: 2.878 ± 0.328
0.458PheTrp: 0.458 ± 0.123
1.864PheTyr: 1.864 ± 0.263
0.0PheXaa: 0.0 ± 0.0
Gly
3.76GlyAla: 3.76 ± 0.329
1.079GlyCys: 1.079 ± 0.216
4.578GlyAsp: 4.578 ± 0.455
4.447GlyGlu: 4.447 ± 0.363
3.531GlyPhe: 3.531 ± 0.331
4.807GlyGly: 4.807 ± 0.409
1.21GlyHis: 1.21 ± 0.208
4.741GlyIle: 4.741 ± 0.38
5.232GlyLys: 5.232 ± 0.401
4.872GlyLeu: 4.872 ± 0.406
1.798GlyMet: 1.798 ± 0.231
3.695GlyAsn: 3.695 ± 0.406
0.817GlyPro: 0.817 ± 0.138
2.289GlyGln: 2.289 ± 0.371
2.616GlyArg: 2.616 ± 0.344
4.022GlySer: 4.022 ± 0.381
4.741GlyThr: 4.741 ± 0.438
4.839GlyVal: 4.839 ± 0.422
1.341GlyTrp: 1.341 ± 0.221
3.074GlyTyr: 3.074 ± 0.32
0.0GlyXaa: 0.0 ± 0.0
His
0.981HisAla: 0.981 ± 0.155
0.229HisCys: 0.229 ± 0.079
1.668HisAsp: 1.668 ± 0.258
1.014HisGlu: 1.014 ± 0.241
0.948HisPhe: 0.948 ± 0.169
1.537HisGly: 1.537 ± 0.25
0.425HisHis: 0.425 ± 0.13
1.406HisIle: 1.406 ± 0.196
1.439HisLys: 1.439 ± 0.256
1.57HisLeu: 1.57 ± 0.2
0.523HisMet: 0.523 ± 0.129
0.981HisAsn: 0.981 ± 0.212
0.654HisPro: 0.654 ± 0.157
0.49HisGln: 0.49 ± 0.134
1.014HisArg: 1.014 ± 0.232
1.21HisSer: 1.21 ± 0.211
0.916HisThr: 0.916 ± 0.148
1.537HisVal: 1.537 ± 0.261
0.458HisTrp: 0.458 ± 0.12
0.589HisTyr: 0.589 ± 0.122
0.0HisXaa: 0.0 ± 0.0
Ile
3.891IleAla: 3.891 ± 0.372
0.719IleCys: 0.719 ± 0.166
5.853IleAsp: 5.853 ± 0.399
5.722IleGlu: 5.722 ± 0.407
2.452IlePhe: 2.452 ± 0.301
3.989IleGly: 3.989 ± 0.352
1.373IleHis: 1.373 ± 0.207
3.695IleIle: 3.695 ± 0.262
5.657IleLys: 5.657 ± 0.403
4.709IleLeu: 4.709 ± 0.43
1.602IleMet: 1.602 ± 0.231
3.368IleAsn: 3.368 ± 0.322
2.125IlePro: 2.125 ± 0.269
2.551IleGln: 2.551 ± 0.347
2.583IleArg: 2.583 ± 0.275
3.728IleSer: 3.728 ± 0.374
3.891IleThr: 3.891 ± 0.435
3.957IleVal: 3.957 ± 0.393
0.948IleTrp: 0.948 ± 0.173
2.322IleTyr: 2.322 ± 0.258
0.0IleXaa: 0.0 ± 0.0
Lys
6.115LysAla: 6.115 ± 0.558
0.621LysCys: 0.621 ± 0.147
4.251LysAsp: 4.251 ± 0.365
4.741LysGlu: 4.741 ± 0.479
3.728LysPhe: 3.728 ± 0.366
4.97LysGly: 4.97 ± 0.442
1.929LysHis: 1.929 ± 0.299
4.839LysIle: 4.839 ± 0.45
5.69LysLys: 5.69 ± 0.539
7.292LysLeu: 7.292 ± 0.556
2.027LysMet: 2.027 ± 0.277
3.27LysAsn: 3.27 ± 0.344
1.897LysPro: 1.897 ± 0.272
2.878LysGln: 2.878 ± 0.351
3.074LysArg: 3.074 ± 0.348
5.265LysSer: 5.265 ± 0.387
4.545LysThr: 4.545 ± 0.395
6.54LysVal: 6.54 ± 0.53
0.981LysTrp: 0.981 ± 0.162
4.087LysTyr: 4.087 ± 0.37
0.0LysXaa: 0.0 ± 0.0
Leu
5.428LeuAla: 5.428 ± 0.494
0.883LeuCys: 0.883 ± 0.185
5.265LeuAsp: 5.265 ± 0.415
6.572LeuGlu: 6.572 ± 0.551
3.368LeuPhe: 3.368 ± 0.357
4.774LeuGly: 4.774 ± 0.453
1.439LeuHis: 1.439 ± 0.22
4.709LeuIle: 4.709 ± 0.416
6.409LeuLys: 6.409 ± 0.491
5.886LeuLeu: 5.886 ± 0.41
1.831LeuMet: 1.831 ± 0.248
5.003LeuAsn: 5.003 ± 0.446
2.125LeuPro: 2.125 ± 0.241
2.616LeuGln: 2.616 ± 0.303
3.303LeuArg: 3.303 ± 0.351
5.395LeuSer: 5.395 ± 0.451
5.003LeuThr: 5.003 ± 0.377
5.33LeuVal: 5.33 ± 0.379
1.014LeuTrp: 1.014 ± 0.223
2.91LeuTyr: 2.91 ± 0.333
0.0LeuXaa: 0.0 ± 0.0
Met
1.668MetAla: 1.668 ± 0.219
0.327MetCys: 0.327 ± 0.116
1.929MetAsp: 1.929 ± 0.289
1.995MetGlu: 1.995 ± 0.29
1.177MetPhe: 1.177 ± 0.205
1.471MetGly: 1.471 ± 0.256
0.327MetHis: 0.327 ± 0.092
2.027MetIle: 2.027 ± 0.303
3.139MetLys: 3.139 ± 0.331
1.733MetLeu: 1.733 ± 0.249
0.621MetMet: 0.621 ± 0.167
1.373MetAsn: 1.373 ± 0.233
0.785MetPro: 0.785 ± 0.173
0.719MetGln: 0.719 ± 0.164
1.177MetArg: 1.177 ± 0.197
2.42MetSer: 2.42 ± 0.279
1.439MetThr: 1.439 ± 0.212
1.668MetVal: 1.668 ± 0.263
0.262MetTrp: 0.262 ± 0.098
0.981MetTyr: 0.981 ± 0.179
0.0MetXaa: 0.0 ± 0.0
Asn
3.204AsnAla: 3.204 ± 0.492
0.621AsnCys: 0.621 ± 0.147
3.041AsnAsp: 3.041 ± 0.28
3.008AsnGlu: 3.008 ± 0.352
2.583AsnPhe: 2.583 ± 0.277
4.48AsnGly: 4.48 ± 0.335
0.883AsnHis: 0.883 ± 0.181
4.284AsnIle: 4.284 ± 0.408
3.63AsnLys: 3.63 ± 0.343
4.349AsnLeu: 4.349 ± 0.419
1.341AsnMet: 1.341 ± 0.231
2.518AsnAsn: 2.518 ± 0.4
1.929AsnPro: 1.929 ± 0.238
1.57AsnGln: 1.57 ± 0.235
1.929AsnArg: 1.929 ± 0.261
3.041AsnSer: 3.041 ± 0.311
3.106AsnThr: 3.106 ± 0.428
3.466AsnVal: 3.466 ± 0.424
0.589AsnTrp: 0.589 ± 0.14
1.929AsnTyr: 1.929 ± 0.259
0.0AsnXaa: 0.0 ± 0.0
Pro
1.341ProAla: 1.341 ± 0.235
0.262ProCys: 0.262 ± 0.098
2.191ProAsp: 2.191 ± 0.333
2.649ProGlu: 2.649 ± 0.365
1.177ProPhe: 1.177 ± 0.176
0.0ProGly: 0.0 ± 0.0
0.654ProHis: 0.654 ± 0.134
1.766ProIle: 1.766 ± 0.236
2.551ProLys: 2.551 ± 0.329
1.7ProLeu: 1.7 ± 0.251
0.817ProMet: 0.817 ± 0.19
2.125ProAsn: 2.125 ± 0.274
1.046ProPro: 1.046 ± 0.199
0.916ProGln: 0.916 ± 0.154
1.177ProArg: 1.177 ± 0.195
2.289ProSer: 2.289 ± 0.289
1.766ProThr: 1.766 ± 0.222
2.191ProVal: 2.191 ± 0.245
0.294ProTrp: 0.294 ± 0.1
1.504ProTyr: 1.504 ± 0.251
0.0ProXaa: 0.0 ± 0.0
Gln
2.91GlnAla: 2.91 ± 0.388
0.49GlnCys: 0.49 ± 0.134
2.06GlnAsp: 2.06 ± 0.243
2.649GlnGlu: 2.649 ± 0.291
1.373GlnPhe: 1.373 ± 0.18
2.747GlnGly: 2.747 ± 0.314
0.654GlnHis: 0.654 ± 0.148
2.158GlnIle: 2.158 ± 0.243
2.289GlnLys: 2.289 ± 0.272
2.976GlnLeu: 2.976 ± 0.327
1.308GlnMet: 1.308 ± 0.248
1.243GlnAsn: 1.243 ± 0.209
0.817GlnPro: 0.817 ± 0.157
1.177GlnGln: 1.177 ± 0.257
1.995GlnArg: 1.995 ± 0.258
1.766GlnSer: 1.766 ± 0.311
1.537GlnThr: 1.537 ± 0.237
2.322GlnVal: 2.322 ± 0.263
0.458GlnTrp: 0.458 ± 0.129
1.635GlnTyr: 1.635 ± 0.246
0.0GlnXaa: 0.0 ± 0.0
Arg
1.897ArgAla: 1.897 ± 0.283
0.425ArgCys: 0.425 ± 0.108
3.008ArgAsp: 3.008 ± 0.296
3.237ArgGlu: 3.237 ± 0.373
2.452ArgPhe: 2.452 ± 0.293
2.779ArgGly: 2.779 ± 0.339
0.883ArgHis: 0.883 ± 0.192
3.368ArgIle: 3.368 ± 0.342
3.63ArgLys: 3.63 ± 0.366
2.91ArgLeu: 2.91 ± 0.301
0.85ArgMet: 0.85 ± 0.196
2.485ArgAsn: 2.485 ± 0.314
1.014ArgPro: 1.014 ± 0.171
1.439ArgGln: 1.439 ± 0.234
2.452ArgArg: 2.452 ± 0.226
2.191ArgSer: 2.191 ± 0.279
2.191ArgThr: 2.191 ± 0.241
3.564ArgVal: 3.564 ± 0.335
0.523ArgTrp: 0.523 ± 0.113
1.962ArgTyr: 1.962 ± 0.242
0.0ArgXaa: 0.0 ± 0.0
Ser
3.466SerAla: 3.466 ± 0.378
0.85SerCys: 0.85 ± 0.19
3.433SerAsp: 3.433 ± 0.307
4.185SerGlu: 4.185 ± 0.392
2.747SerPhe: 2.747 ± 0.312
5.068SerGly: 5.068 ± 0.482
1.308SerHis: 1.308 ± 0.22
3.989SerIle: 3.989 ± 0.44
5.428SerLys: 5.428 ± 0.34
4.643SerLeu: 4.643 ± 0.449
1.21SerMet: 1.21 ± 0.201
3.303SerAsn: 3.303 ± 0.352
1.602SerPro: 1.602 ± 0.315
2.551SerGln: 2.551 ± 0.328
2.878SerArg: 2.878 ± 0.298
3.858SerSer: 3.858 ± 0.618
3.401SerThr: 3.401 ± 0.451
4.774SerVal: 4.774 ± 0.488
0.752SerTrp: 0.752 ± 0.161
2.878SerTyr: 2.878 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
3.662ThrAla: 3.662 ± 0.494
0.621ThrCys: 0.621 ± 0.143
2.943ThrAsp: 2.943 ± 0.368
3.564ThrGlu: 3.564 ± 0.307
2.779ThrPhe: 2.779 ± 0.331
5.003ThrGly: 5.003 ± 0.583
1.275ThrHis: 1.275 ± 0.237
3.27ThrIle: 3.27 ± 0.369
3.924ThrLys: 3.924 ± 0.435
4.512ThrLeu: 4.512 ± 0.347
1.144ThrMet: 1.144 ± 0.192
2.551ThrAsn: 2.551 ± 0.42
2.125ThrPro: 2.125 ± 0.27
1.897ThrGln: 1.897 ± 0.313
2.681ThrArg: 2.681 ± 0.284
3.401ThrSer: 3.401 ± 0.326
3.531ThrThr: 3.531 ± 0.398
4.153ThrVal: 4.153 ± 0.569
0.883ThrTrp: 0.883 ± 0.158
2.06ThrTyr: 2.06 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
3.924ValAla: 3.924 ± 0.352
0.621ValCys: 0.621 ± 0.153
4.643ValAsp: 4.643 ± 0.411
5.265ValGlu: 5.265 ± 0.443
2.779ValPhe: 2.779 ± 0.309
4.839ValGly: 4.839 ± 0.453
0.981ValHis: 0.981 ± 0.204
4.316ValIle: 4.316 ± 0.407
6.54ValLys: 6.54 ± 0.455
5.624ValLeu: 5.624 ± 0.425
1.962ValMet: 1.962 ± 0.23
4.316ValAsn: 4.316 ± 0.407
1.798ValPro: 1.798 ± 0.267
2.224ValGln: 2.224 ± 0.313
3.172ValArg: 3.172 ± 0.301
4.774ValSer: 4.774 ± 0.456
4.382ValThr: 4.382 ± 0.481
5.919ValVal: 5.919 ± 0.52
0.883ValTrp: 0.883 ± 0.146
3.074ValTyr: 3.074 ± 0.314
0.0ValXaa: 0.0 ± 0.0
Trp
0.687TrpAla: 0.687 ± 0.154
0.294TrpCys: 0.294 ± 0.083
1.046TrpAsp: 1.046 ± 0.205
1.112TrpGlu: 1.112 ± 0.199
0.817TrpPhe: 0.817 ± 0.193
0.425TrpGly: 0.425 ± 0.114
0.327TrpHis: 0.327 ± 0.107
0.948TrpIle: 0.948 ± 0.159
1.144TrpLys: 1.144 ± 0.236
0.948TrpLeu: 0.948 ± 0.165
0.49TrpMet: 0.49 ± 0.114
0.589TrpAsn: 0.589 ± 0.126
0.196TrpPro: 0.196 ± 0.071
0.458TrpGln: 0.458 ± 0.103
0.687TrpArg: 0.687 ± 0.132
0.883TrpSer: 0.883 ± 0.149
0.785TrpThr: 0.785 ± 0.156
1.144TrpVal: 1.144 ± 0.186
0.131TrpTrp: 0.131 ± 0.059
0.948TrpTyr: 0.948 ± 0.184
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.224TyrAla: 2.224 ± 0.267
0.621TyrCys: 0.621 ± 0.145
3.303TyrAsp: 3.303 ± 0.28
2.681TyrGlu: 2.681 ± 0.295
1.897TyrPhe: 1.897 ± 0.252
2.878TyrGly: 2.878 ± 0.293
0.981TyrHis: 0.981 ± 0.224
2.583TyrIle: 2.583 ± 0.345
3.499TyrLys: 3.499 ± 0.274
3.466TyrLeu: 3.466 ± 0.438
1.112TyrMet: 1.112 ± 0.167
1.766TyrAsn: 1.766 ± 0.192
1.308TyrPro: 1.308 ± 0.236
1.962TyrGln: 1.962 ± 0.269
1.995TyrArg: 1.995 ± 0.281
2.878TyrSer: 2.878 ± 0.331
2.289TyrThr: 2.289 ± 0.24
2.812TyrVal: 2.812 ± 0.265
0.785TyrTrp: 0.785 ± 0.145
1.7TyrTyr: 1.7 ± 0.351
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 163 proteins (30583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski