Amino acid dipepetide frequency for Candidatus Nasuia deltocephalinicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.578AlaAla: 0.578 ± 0.196
0.116AlaCys: 0.116 ± 0.049
0.462AlaAsp: 0.462 ± 0.13
0.347AlaGlu: 0.347 ± 0.121
0.763AlaPhe: 0.763 ± 0.158
0.971AlaGly: 0.971 ± 0.16
0.3AlaHis: 0.3 ± 0.085
1.502AlaIle: 1.502 ± 0.231
1.225AlaLys: 1.225 ± 0.189
1.456AlaLeu: 1.456 ± 0.224
0.231AlaMet: 0.231 ± 0.074
0.462AlaAsn: 0.462 ± 0.087
0.416AlaPro: 0.416 ± 0.106
0.231AlaGln: 0.231 ± 0.072
0.578AlaArg: 0.578 ± 0.112
0.901AlaSer: 0.901 ± 0.149
0.601AlaThr: 0.601 ± 0.154
0.647AlaVal: 0.647 ± 0.146
0.185AlaTrp: 0.185 ± 0.06
0.601AlaTyr: 0.601 ± 0.131
0.0AlaXaa: 0.0 ± 0.0
Cys
0.231CysAla: 0.231 ± 0.062
0.185CysCys: 0.185 ± 0.057
0.508CysAsp: 0.508 ± 0.113
0.324CysGlu: 0.324 ± 0.076
1.155CysPhe: 1.155 ± 0.178
0.693CysGly: 0.693 ± 0.119
0.254CysHis: 0.254 ± 0.099
1.433CysIle: 1.433 ± 0.216
1.433CysLys: 1.433 ± 0.197
1.386CysLeu: 1.386 ± 0.192
0.162CysMet: 0.162 ± 0.063
1.132CysAsn: 1.132 ± 0.149
0.277CysPro: 0.277 ± 0.083
0.208CysGln: 0.208 ± 0.066
0.208CysArg: 0.208 ± 0.066
0.647CysSer: 0.647 ± 0.129
0.347CysThr: 0.347 ± 0.09
0.416CysVal: 0.416 ± 0.105
0.069CysTrp: 0.069 ± 0.035
0.67CysTyr: 0.67 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
0.555AspAla: 0.555 ± 0.167
0.578AspCys: 0.578 ± 0.135
1.502AspAsp: 1.502 ± 0.682
1.641AspGlu: 1.641 ± 0.401
3.397AspPhe: 3.397 ± 0.362
1.502AspGly: 1.502 ± 0.527
0.277AspHis: 0.277 ± 0.068
5.638AspIle: 5.638 ± 0.466
3.281AspLys: 3.281 ± 0.225
4.206AspLeu: 4.206 ± 0.339
0.462AspMet: 0.462 ± 0.121
3.189AspAsn: 3.189 ± 0.451
0.578AspPro: 0.578 ± 0.126
0.439AspGln: 0.439 ± 0.087
0.555AspArg: 0.555 ± 0.123
2.034AspSer: 2.034 ± 0.222
0.901AspThr: 0.901 ± 0.145
0.971AspVal: 0.971 ± 0.167
0.208AspTrp: 0.208 ± 0.088
1.664AspTyr: 1.664 ± 0.211
0.0AspXaa: 0.0 ± 0.0
Glu
0.693GluAla: 0.693 ± 0.159
0.277GluCys: 0.277 ± 0.071
1.525GluAsp: 1.525 ± 0.2
1.386GluGlu: 1.386 ± 0.271
1.895GluPhe: 1.895 ± 0.189
1.34GluGly: 1.34 ± 0.214
0.277GluHis: 0.277 ± 0.097
5.407GluIle: 5.407 ± 0.408
4.806GluLys: 4.806 ± 0.34
2.912GluLeu: 2.912 ± 0.291
0.485GluMet: 0.485 ± 0.107
3.42GluAsn: 3.42 ± 0.4
0.508GluPro: 0.508 ± 0.111
0.277GluGln: 0.277 ± 0.088
0.971GluArg: 0.971 ± 0.187
2.01GluSer: 2.01 ± 0.233
0.832GluThr: 0.832 ± 0.12
1.155GluVal: 1.155 ± 0.168
0.116GluTrp: 0.116 ± 0.052
1.571GluTyr: 1.571 ± 0.191
0.0GluXaa: 0.0 ± 0.0
Phe
0.555PheAla: 0.555 ± 0.097
1.594PheCys: 1.594 ± 0.21
2.981PheAsp: 2.981 ± 0.29
1.941PheGlu: 1.941 ± 0.197
13.772PhePhe: 13.772 ± 1.106
1.849PheGly: 1.849 ± 0.209
0.855PheHis: 0.855 ± 0.143
13.31PheIle: 13.31 ± 0.758
10.791PheLys: 10.791 ± 0.621
13.772PheLeu: 13.772 ± 0.912
1.04PheMet: 1.04 ± 0.17
10.445PheAsn: 10.445 ± 0.625
1.271PhePro: 1.271 ± 0.185
0.578PheGln: 0.578 ± 0.124
1.271PheArg: 1.271 ± 0.207
5.615PheSer: 5.615 ± 0.392
1.733PheThr: 1.733 ± 0.19
1.733PheVal: 1.733 ± 0.194
0.485PheTrp: 0.485 ± 0.116
7.556PheTyr: 7.556 ± 0.7
0.0PheXaa: 0.0 ± 0.0
Gly
0.971GlyAla: 0.971 ± 0.181
0.693GlyCys: 0.693 ± 0.127
1.849GlyAsp: 1.849 ± 0.254
1.086GlyGlu: 1.086 ± 0.191
2.704GlyPhe: 2.704 ± 0.272
2.704GlyGly: 2.704 ± 0.411
0.67GlyHis: 0.67 ± 0.146
5.107GlyIle: 5.107 ± 0.394
3.489GlyLys: 3.489 ± 0.351
3.466GlyLeu: 3.466 ± 0.305
0.624GlyMet: 0.624 ± 0.118
2.912GlyAsn: 2.912 ± 0.923
0.693GlyPro: 0.693 ± 0.125
0.809GlyGln: 0.809 ± 0.152
1.248GlyArg: 1.248 ± 0.194
2.172GlySer: 2.172 ± 0.258
1.109GlyThr: 1.109 ± 0.178
2.057GlyVal: 2.057 ± 0.246
0.347GlyTrp: 0.347 ± 0.088
1.618GlyTyr: 1.618 ± 0.192
0.0GlyXaa: 0.0 ± 0.0
His
0.254HisAla: 0.254 ± 0.067
0.139HisCys: 0.139 ± 0.05
0.254HisAsp: 0.254 ± 0.071
0.277HisGlu: 0.277 ± 0.083
0.716HisPhe: 0.716 ± 0.134
0.508HisGly: 0.508 ± 0.101
0.185HisHis: 0.185 ± 0.083
1.571HisIle: 1.571 ± 0.213
0.855HisLys: 0.855 ± 0.143
0.786HisLeu: 0.786 ± 0.13
0.231HisMet: 0.231 ± 0.063
0.878HisAsn: 0.878 ± 0.158
0.324HisPro: 0.324 ± 0.091
0.092HisGln: 0.092 ± 0.042
0.162HisArg: 0.162 ± 0.067
0.716HisSer: 0.716 ± 0.136
0.347HisThr: 0.347 ± 0.088
0.347HisVal: 0.347 ± 0.098
0.092HisTrp: 0.092 ± 0.046
0.416HisTyr: 0.416 ± 0.094
0.0HisXaa: 0.0 ± 0.0
Ile
1.641IleAla: 1.641 ± 0.25
1.895IleCys: 1.895 ± 0.203
5.315IleAsp: 5.315 ± 0.368
5.384IleGlu: 5.384 ± 0.348
14.882IlePhe: 14.882 ± 0.87
4.159IleGly: 4.159 ± 0.345
1.502IleHis: 1.502 ± 0.172
22.785IleIle: 22.785 ± 1.157
23.917IleLys: 23.917 ± 1.352
15.921IleLeu: 15.921 ± 0.531
1.363IleMet: 1.363 ± 0.199
21.19IleAsn: 21.19 ± 0.886
3.073IlePro: 3.073 ± 0.269
1.456IleGln: 1.456 ± 0.212
2.681IleArg: 2.681 ± 0.239
10.237IleSer: 10.237 ± 0.581
3.489IleThr: 3.489 ± 0.314
2.704IleVal: 2.704 ± 0.304
0.508IleTrp: 0.508 ± 0.119
10.422IleTyr: 10.422 ± 0.608
0.0IleXaa: 0.0 ± 0.0
Lys
1.132LysAla: 1.132 ± 0.192
1.109LysCys: 1.109 ± 0.173
3.397LysAsp: 3.397 ± 0.339
3.859LysGlu: 3.859 ± 0.425
10.653LysPhe: 10.653 ± 0.597
3.536LysGly: 3.536 ± 0.364
0.67LysHis: 0.67 ± 0.128
25.303LysIle: 25.303 ± 1.196
29.37LysLys: 29.37 ± 1.676
11.115LysLeu: 11.115 ± 0.581
1.641LysMet: 1.641 ± 0.204
23.039LysAsn: 23.039 ± 1.287
1.618LysPro: 1.618 ± 0.209
1.155LysGln: 1.155 ± 0.178
2.634LysArg: 2.634 ± 0.236
7.371LysSer: 7.371 ± 0.481
3.004LysThr: 3.004 ± 0.314
2.889LysVal: 2.889 ± 0.312
0.693LysTrp: 0.693 ± 0.153
10.029LysTyr: 10.029 ± 0.7
0.0LysXaa: 0.0 ± 0.0
Leu
1.433LeuAla: 1.433 ± 0.208
0.971LeuCys: 0.971 ± 0.148
3.258LeuAsp: 3.258 ± 0.274
3.813LeuGlu: 3.813 ± 0.29
8.689LeuPhe: 8.689 ± 0.658
4.483LeuGly: 4.483 ± 0.382
0.878LeuHis: 0.878 ± 0.153
15.298LeuIle: 15.298 ± 0.649
16.337LeuLys: 16.337 ± 0.765
10.144LeuLeu: 10.144 ± 0.557
1.179LeuMet: 1.179 ± 0.18
16.222LeuAsn: 16.222 ± 0.755
2.218LeuPro: 2.218 ± 0.221
0.947LeuGln: 0.947 ± 0.143
2.08LeuArg: 2.08 ± 0.218
7.256LeuSer: 7.256 ± 0.583
1.987LeuThr: 1.987 ± 0.252
2.611LeuVal: 2.611 ± 0.334
0.462LeuTrp: 0.462 ± 0.112
5.638LeuTyr: 5.638 ± 0.482
0.0LeuXaa: 0.0 ± 0.0
Met
0.254MetAla: 0.254 ± 0.076
0.139MetCys: 0.139 ± 0.068
0.347MetAsp: 0.347 ± 0.126
0.485MetGlu: 0.485 ± 0.108
0.786MetPhe: 0.786 ± 0.15
0.578MetGly: 0.578 ± 0.113
0.069MetHis: 0.069 ± 0.045
1.594MetIle: 1.594 ± 0.148
1.594MetLys: 1.594 ± 0.173
1.155MetLeu: 1.155 ± 0.169
0.069MetMet: 0.069 ± 0.037
1.271MetAsn: 1.271 ± 0.163
0.37MetPro: 0.37 ± 0.104
0.185MetGln: 0.185 ± 0.051
0.324MetArg: 0.324 ± 0.076
1.063MetSer: 1.063 ± 0.176
0.208MetThr: 0.208 ± 0.064
0.116MetVal: 0.116 ± 0.049
0.023MetTrp: 0.023 ± 0.023
0.716MetTyr: 0.716 ± 0.129
0.0MetXaa: 0.0 ± 0.0
Asn
0.739AsnAla: 0.739 ± 0.143
0.971AsnCys: 0.971 ± 0.138
3.512AsnAsp: 3.512 ± 0.667
3.304AsnGlu: 3.304 ± 0.269
14.304AsnPhe: 14.304 ± 0.97
3.004AsnGly: 3.004 ± 0.5
0.763AsnHis: 0.763 ± 0.143
22.53AsnIle: 22.53 ± 0.92
18.094AsnLys: 18.094 ± 1.026
14.304AsnLeu: 14.304 ± 0.773
1.294AsnMet: 1.294 ± 0.175
17.054AsnAsn: 17.054 ± 1.335
1.294AsnPro: 1.294 ± 0.148
1.202AsnGln: 1.202 ± 0.164
1.849AsnArg: 1.849 ± 0.166
6.678AsnSer: 6.678 ± 0.581
2.704AsnThr: 2.704 ± 0.317
2.311AsnVal: 2.311 ± 0.239
0.878AsnTrp: 0.878 ± 0.193
9.521AsnTyr: 9.521 ± 0.58
0.0AsnXaa: 0.0 ± 0.0
Pro
0.254ProAla: 0.254 ± 0.101
0.277ProCys: 0.277 ± 0.078
0.786ProAsp: 0.786 ± 0.127
0.67ProGlu: 0.67 ± 0.15
1.317ProPhe: 1.317 ± 0.181
1.063ProGly: 1.063 ± 0.164
0.324ProHis: 0.324 ± 0.079
2.704ProIle: 2.704 ± 0.265
1.571ProLys: 1.571 ± 0.194
1.872ProLeu: 1.872 ± 0.213
0.185ProMet: 0.185 ± 0.051
1.294ProAsn: 1.294 ± 0.188
0.347ProPro: 0.347 ± 0.081
0.3ProGln: 0.3 ± 0.096
0.393ProArg: 0.393 ± 0.099
1.34ProSer: 1.34 ± 0.17
0.647ProThr: 0.647 ± 0.122
0.947ProVal: 0.947 ± 0.156
0.116ProTrp: 0.116 ± 0.051
1.109ProTyr: 1.109 ± 0.147
0.0ProXaa: 0.0 ± 0.0
Gln
0.254GlnAla: 0.254 ± 0.078
0.069GlnCys: 0.069 ± 0.035
0.277GlnAsp: 0.277 ± 0.081
0.439GlnGlu: 0.439 ± 0.097
0.462GlnPhe: 0.462 ± 0.106
0.508GlnGly: 0.508 ± 0.117
0.139GlnHis: 0.139 ± 0.066
1.779GlnIle: 1.779 ± 0.215
1.41GlnLys: 1.41 ± 0.199
1.386GlnLeu: 1.386 ± 0.19
0.116GlnMet: 0.116 ± 0.054
1.202GlnAsn: 1.202 ± 0.151
0.231GlnPro: 0.231 ± 0.073
0.185GlnGln: 0.185 ± 0.063
0.416GlnArg: 0.416 ± 0.121
0.924GlnSer: 0.924 ± 0.194
0.254GlnThr: 0.254 ± 0.077
0.37GlnVal: 0.37 ± 0.113
0.139GlnTrp: 0.139 ± 0.05
0.531GlnTyr: 0.531 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
0.37ArgAla: 0.37 ± 0.112
0.277ArgCys: 0.277 ± 0.08
0.994ArgAsp: 0.994 ± 0.176
0.601ArgGlu: 0.601 ± 0.142
1.363ArgPhe: 1.363 ± 0.162
1.155ArgGly: 1.155 ± 0.2
0.324ArgHis: 0.324 ± 0.089
3.027ArgIle: 3.027 ± 0.244
2.865ArgLys: 2.865 ± 0.278
1.849ArgLeu: 1.849 ± 0.226
0.37ArgMet: 0.37 ± 0.089
1.895ArgAsn: 1.895 ± 0.2
0.393ArgPro: 0.393 ± 0.091
0.416ArgGln: 0.416 ± 0.1
0.601ArgArg: 0.601 ± 0.14
1.456ArgSer: 1.456 ± 0.183
0.508ArgThr: 0.508 ± 0.125
0.878ArgVal: 0.878 ± 0.14
0.092ArgTrp: 0.092 ± 0.046
1.248ArgTyr: 1.248 ± 0.169
0.0ArgXaa: 0.0 ± 0.0
Ser
1.063SerAla: 1.063 ± 0.176
0.971SerCys: 0.971 ± 0.121
2.819SerAsp: 2.819 ± 0.316
2.357SerGlu: 2.357 ± 0.235
5.8SerPhe: 5.8 ± 0.438
3.258SerGly: 3.258 ± 0.322
0.716SerHis: 0.716 ± 0.132
8.018SerIle: 8.018 ± 0.537
6.655SerLys: 6.655 ± 0.411
7.533SerLeu: 7.533 ± 0.579
0.485SerMet: 0.485 ± 0.112
6.748SerAsn: 6.748 ± 0.411
1.248SerPro: 1.248 ± 0.178
1.017SerGln: 1.017 ± 0.155
2.103SerArg: 2.103 ± 0.236
5.153SerSer: 5.153 ± 0.428
1.363SerThr: 1.363 ± 0.192
2.241SerVal: 2.241 ± 0.26
0.277SerTrp: 0.277 ± 0.075
3.212SerTyr: 3.212 ± 0.298
0.0SerXaa: 0.0 ± 0.0
Thr
0.462ThrAla: 0.462 ± 0.113
0.231ThrCys: 0.231 ± 0.06
0.647ThrAsp: 0.647 ± 0.121
0.878ThrGlu: 0.878 ± 0.151
1.571ThrPhe: 1.571 ± 0.181
1.525ThrGly: 1.525 ± 0.221
0.254ThrHis: 0.254 ± 0.083
3.281ThrIle: 3.281 ± 0.322
2.565ThrLys: 2.565 ± 0.271
2.149ThrLeu: 2.149 ± 0.218
0.185ThrMet: 0.185 ± 0.079
2.542ThrAsn: 2.542 ± 0.265
0.971ThrPro: 0.971 ± 0.176
0.485ThrGln: 0.485 ± 0.094
0.739ThrArg: 0.739 ± 0.151
1.71ThrSer: 1.71 ± 0.19
1.04ThrThr: 1.04 ± 0.207
0.716ThrVal: 0.716 ± 0.154
0.069ThrTrp: 0.069 ± 0.036
1.063ThrTyr: 1.063 ± 0.149
0.0ThrXaa: 0.0 ± 0.0
Val
0.647ValAla: 0.647 ± 0.129
0.324ValCys: 0.324 ± 0.087
0.994ValAsp: 0.994 ± 0.152
1.248ValGlu: 1.248 ± 0.218
2.057ValPhe: 2.057 ± 0.249
1.363ValGly: 1.363 ± 0.237
0.277ValHis: 0.277 ± 0.084
3.397ValIle: 3.397 ± 0.362
3.004ValLys: 3.004 ± 0.295
3.096ValLeu: 3.096 ± 0.332
0.347ValMet: 0.347 ± 0.09
1.941ValAsn: 1.941 ± 0.24
0.716ValPro: 0.716 ± 0.138
0.393ValGln: 0.393 ± 0.097
0.601ValArg: 0.601 ± 0.115
2.034ValSer: 2.034 ± 0.261
0.647ValThr: 0.647 ± 0.157
0.878ValVal: 0.878 ± 0.16
0.139ValTrp: 0.139 ± 0.056
1.271ValTyr: 1.271 ± 0.19
0.0ValXaa: 0.0 ± 0.0
Trp
0.069TrpAla: 0.069 ± 0.039
0.139TrpCys: 0.139 ± 0.048
0.254TrpAsp: 0.254 ± 0.074
0.116TrpGlu: 0.116 ± 0.047
0.578TrpPhe: 0.578 ± 0.126
0.347TrpGly: 0.347 ± 0.093
0.046TrpHis: 0.046 ± 0.032
0.878TrpIle: 0.878 ± 0.173
0.578TrpLys: 0.578 ± 0.157
0.462TrpLeu: 0.462 ± 0.11
0.116TrpMet: 0.116 ± 0.052
0.485TrpAsn: 0.485 ± 0.1
0.069TrpPro: 0.069 ± 0.045
0.023TrpGln: 0.023 ± 0.024
0.162TrpArg: 0.162 ± 0.064
0.347TrpSer: 0.347 ± 0.084
0.185TrpThr: 0.185 ± 0.068
0.139TrpVal: 0.139 ± 0.061
0.069TrpTrp: 0.069 ± 0.046
0.185TrpTyr: 0.185 ± 0.071
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.416TyrAla: 0.416 ± 0.099
0.786TyrCys: 0.786 ± 0.119
1.895TyrAsp: 1.895 ± 0.227
1.71TyrGlu: 1.71 ± 0.182
6.285TyrPhe: 6.285 ± 0.56
1.779TyrGly: 1.779 ± 0.198
0.37TyrHis: 0.37 ± 0.097
9.96TyrIle: 9.96 ± 0.555
10.399TyrLys: 10.399 ± 0.703
6.932TyrLeu: 6.932 ± 0.498
0.739TyrMet: 0.739 ± 0.118
8.989TyrAsn: 8.989 ± 0.535
0.901TyrPro: 0.901 ± 0.14
0.693TyrGln: 0.693 ± 0.107
1.109TyrArg: 1.109 ± 0.19
3.374TyrSer: 3.374 ± 0.302
1.179TyrThr: 1.179 ± 0.177
1.248TyrVal: 1.248 ± 0.17
0.277TyrTrp: 0.277 ± 0.091
4.252TyrTyr: 4.252 ± 0.425
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 159 proteins (43276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski