Amino acid dipepetide frequency for Microbacterium mitrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.223AlaAla: 19.223 ± 0.242
0.697AlaCys: 0.697 ± 0.028
8.109AlaAsp: 8.109 ± 0.103
8.564AlaGlu: 8.564 ± 0.133
3.944AlaPhe: 3.944 ± 0.077
11.125AlaGly: 11.125 ± 0.139
2.474AlaHis: 2.474 ± 0.058
6.832AlaIle: 6.832 ± 0.107
3.106AlaLys: 3.106 ± 0.072
13.601AlaLeu: 13.601 ± 0.164
3.121AlaMet: 3.121 ± 0.064
2.776AlaAsn: 2.776 ± 0.056
6.202AlaPro: 6.202 ± 0.113
4.205AlaGln: 4.205 ± 0.085
8.332AlaArg: 8.332 ± 0.133
7.292AlaSer: 7.292 ± 0.1
8.334AlaThr: 8.334 ± 0.128
10.949AlaVal: 10.949 ± 0.147
1.858AlaTrp: 1.858 ± 0.046
2.433AlaTyr: 2.433 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.698CysAla: 0.698 ± 0.031
0.044CysCys: 0.044 ± 0.008
0.321CysAsp: 0.321 ± 0.022
0.265CysGlu: 0.265 ± 0.019
0.184CysPhe: 0.184 ± 0.013
0.551CysGly: 0.551 ± 0.029
0.109CysHis: 0.109 ± 0.012
0.211CysIle: 0.211 ± 0.017
0.057CysLys: 0.057 ± 0.009
0.395CysLeu: 0.395 ± 0.023
0.087CysMet: 0.087 ± 0.011
0.108CysAsn: 0.108 ± 0.012
0.241CysPro: 0.241 ± 0.02
0.134CysGln: 0.134 ± 0.014
0.299CysArg: 0.299 ± 0.019
0.327CysSer: 0.327 ± 0.021
0.355CysThr: 0.355 ± 0.035
0.418CysVal: 0.418 ± 0.025
0.058CysTrp: 0.058 ± 0.009
0.093CysTyr: 0.093 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.639AspAla: 8.639 ± 0.107
0.224AspCys: 0.224 ± 0.015
4.186AspAsp: 4.186 ± 0.092
4.595AspGlu: 4.595 ± 0.092
1.798AspPhe: 1.798 ± 0.048
5.735AspGly: 5.735 ± 0.107
1.115AspHis: 1.115 ± 0.041
2.823AspIle: 2.823 ± 0.053
1.198AspLys: 1.198 ± 0.038
5.671AspLeu: 5.671 ± 0.086
1.009AspMet: 1.009 ± 0.038
1.277AspAsn: 1.277 ± 0.046
3.516AspPro: 3.516 ± 0.072
1.516AspGln: 1.516 ± 0.049
3.836AspArg: 3.836 ± 0.068
2.806AspSer: 2.806 ± 0.056
2.883AspThr: 2.883 ± 0.061
5.533AspVal: 5.533 ± 0.087
0.851AspTrp: 0.851 ± 0.037
1.333AspTyr: 1.333 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
7.456GluAla: 7.456 ± 0.132
0.256GluCys: 0.256 ± 0.023
2.612GluAsp: 2.612 ± 0.059
2.964GluGlu: 2.964 ± 0.086
1.898GluPhe: 1.898 ± 0.055
3.976GluGly: 3.976 ± 0.088
1.436GluHis: 1.436 ± 0.053
3.028GluIle: 3.028 ± 0.067
1.693GluLys: 1.693 ± 0.054
6.415GluLeu: 6.415 ± 0.105
1.143GluMet: 1.143 ± 0.037
1.564GluAsn: 1.564 ± 0.043
2.966GluPro: 2.966 ± 0.06
2.341GluGln: 2.341 ± 0.058
4.84GluArg: 4.84 ± 0.109
3.195GluSer: 3.195 ± 0.066
3.331GluThr: 3.331 ± 0.052
4.659GluVal: 4.659 ± 0.087
0.869GluTrp: 0.869 ± 0.034
1.3GluTyr: 1.3 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
4.584PheAla: 4.584 ± 0.09
0.16PheCys: 0.16 ± 0.014
2.456PheAsp: 2.456 ± 0.057
1.773PheGlu: 1.773 ± 0.049
1.175PhePhe: 1.175 ± 0.045
3.365PheGly: 3.365 ± 0.077
0.594PheHis: 0.594 ± 0.03
1.454PheIle: 1.454 ± 0.053
0.533PheLys: 0.533 ± 0.03
2.724PheLeu: 2.724 ± 0.061
0.579PheMet: 0.579 ± 0.027
0.796PheAsn: 0.796 ± 0.033
1.307PhePro: 1.307 ± 0.044
0.828PheGln: 0.828 ± 0.032
1.79PheArg: 1.79 ± 0.048
1.849PheSer: 1.849 ± 0.05
2.26PheThr: 2.26 ± 0.058
2.949PheVal: 2.949 ± 0.069
0.487PheTrp: 0.487 ± 0.025
0.651PheTyr: 0.651 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
10.135GlyAla: 10.135 ± 0.137
0.477GlyCys: 0.477 ± 0.028
4.935GlyAsp: 4.935 ± 0.089
5.082GlyGlu: 5.082 ± 0.08
3.183GlyPhe: 3.183 ± 0.057
7.055GlyGly: 7.055 ± 0.142
1.644GlyHis: 1.644 ± 0.051
4.823GlyIle: 4.823 ± 0.079
2.451GlyLys: 2.451 ± 0.061
7.757GlyLeu: 7.757 ± 0.106
1.936GlyMet: 1.936 ± 0.053
1.882GlyAsn: 1.882 ± 0.047
3.129GlyPro: 3.129 ± 0.069
2.427GlyGln: 2.427 ± 0.056
5.024GlyArg: 5.024 ± 0.091
5.243GlySer: 5.243 ± 0.101
5.656GlyThr: 5.656 ± 0.112
7.549GlyVal: 7.549 ± 0.123
1.517GlyTrp: 1.517 ± 0.048
2.26GlyTyr: 2.26 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.469HisAla: 2.469 ± 0.064
0.098HisCys: 0.098 ± 0.011
1.413HisAsp: 1.413 ± 0.041
1.164HisGlu: 1.164 ± 0.038
0.52HisPhe: 0.52 ± 0.027
1.864HisGly: 1.864 ± 0.051
0.56HisHis: 0.56 ± 0.032
0.954HisIle: 0.954 ± 0.039
0.38HisLys: 0.38 ± 0.024
1.856HisLeu: 1.856 ± 0.049
0.334HisMet: 0.334 ± 0.02
0.434HisAsn: 0.434 ± 0.026
1.303HisPro: 1.303 ± 0.043
0.53HisGln: 0.53 ± 0.026
1.401HisArg: 1.401 ± 0.042
1.038HisSer: 1.038 ± 0.034
1.078HisThr: 1.078 ± 0.037
1.701HisVal: 1.701 ± 0.05
0.241HisTrp: 0.241 ± 0.018
0.423HisTyr: 0.423 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
8.252IleAla: 8.252 ± 0.128
0.256IleCys: 0.256 ± 0.019
3.874IleAsp: 3.874 ± 0.073
3.176IleGlu: 3.176 ± 0.068
1.488IlePhe: 1.488 ± 0.058
4.71IleGly: 4.71 ± 0.085
0.778IleHis: 0.778 ± 0.033
2.406IleIle: 2.406 ± 0.07
0.997IleLys: 0.997 ± 0.034
4.027IleLeu: 4.027 ± 0.083
0.9IleMet: 0.9 ± 0.039
1.195IleAsn: 1.195 ± 0.037
2.421IlePro: 2.421 ± 0.058
1.093IleGln: 1.093 ± 0.034
2.663IleArg: 2.663 ± 0.062
2.955IleSer: 2.955 ± 0.056
3.369IleThr: 3.369 ± 0.066
5.381IleVal: 5.381 ± 0.081
0.55IleTrp: 0.55 ± 0.028
0.897IleTyr: 0.897 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
2.652LysAla: 2.652 ± 0.071
0.075LysCys: 0.075 ± 0.01
1.272LysAsp: 1.272 ± 0.045
1.154LysGlu: 1.154 ± 0.041
0.658LysPhe: 0.658 ± 0.024
1.578LysGly: 1.578 ± 0.054
0.548LysHis: 0.548 ± 0.03
1.203LysIle: 1.203 ± 0.043
1.052LysLys: 1.052 ± 0.054
2.245LysLeu: 2.245 ± 0.056
0.521LysMet: 0.521 ± 0.023
0.7LysAsn: 0.7 ± 0.035
1.429LysPro: 1.429 ± 0.042
0.895LysGln: 0.895 ± 0.035
1.802LysArg: 1.802 ± 0.053
1.355LysSer: 1.355 ± 0.046
1.619LysThr: 1.619 ± 0.043
1.773LysVal: 1.773 ± 0.058
0.298LysTrp: 0.298 ± 0.02
0.533LysTyr: 0.533 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.589LeuAla: 13.589 ± 0.169
0.465LeuCys: 0.465 ± 0.025
5.956LeuAsp: 5.956 ± 0.089
4.9LeuGlu: 4.9 ± 0.077
2.924LeuPhe: 2.924 ± 0.08
8.195LeuGly: 8.195 ± 0.123
1.792LeuHis: 1.792 ± 0.052
5.193LeuIle: 5.193 ± 0.093
2.011LeuLys: 2.011 ± 0.051
9.129LeuLeu: 9.129 ± 0.14
1.899LeuMet: 1.899 ± 0.052
2.159LeuAsn: 2.159 ± 0.042
4.978LeuPro: 4.978 ± 0.083
2.61LeuGln: 2.61 ± 0.054
6.718LeuArg: 6.718 ± 0.107
5.831LeuSer: 5.831 ± 0.096
6.704LeuThr: 6.704 ± 0.11
8.455LeuVal: 8.455 ± 0.13
1.244LeuTrp: 1.244 ± 0.043
1.679LeuTyr: 1.679 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.469MetAla: 2.469 ± 0.057
0.124MetCys: 0.124 ± 0.014
0.808MetAsp: 0.808 ± 0.036
0.749MetGlu: 0.749 ± 0.031
0.613MetPhe: 0.613 ± 0.026
1.477MetGly: 1.477 ± 0.04
0.377MetHis: 0.377 ± 0.022
1.059MetIle: 1.059 ± 0.04
0.585MetLys: 0.585 ± 0.029
2.065MetLeu: 2.065 ± 0.055
0.445MetMet: 0.445 ± 0.025
0.649MetAsn: 0.649 ± 0.028
1.191MetPro: 1.191 ± 0.041
0.722MetGln: 0.722 ± 0.026
1.515MetArg: 1.515 ± 0.044
1.658MetSer: 1.658 ± 0.051
1.971MetThr: 1.971 ± 0.046
1.579MetVal: 1.579 ± 0.044
0.274MetTrp: 0.274 ± 0.019
0.372MetTyr: 0.372 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.014AsnAla: 3.014 ± 0.067
0.114AsnCys: 0.114 ± 0.012
1.505AsnAsp: 1.505 ± 0.041
1.362AsnGlu: 1.362 ± 0.042
0.731AsnPhe: 0.731 ± 0.029
2.083AsnGly: 2.083 ± 0.057
0.47AsnHis: 0.47 ± 0.025
1.132AsnIle: 1.132 ± 0.043
0.551AsnLys: 0.551 ± 0.024
2.175AsnLeu: 2.175 ± 0.06
0.418AsnMet: 0.418 ± 0.024
0.634AsnAsn: 0.634 ± 0.028
1.901AsnPro: 1.901 ± 0.051
0.721AsnGln: 0.721 ± 0.031
1.455AsnArg: 1.455 ± 0.045
1.129AsnSer: 1.129 ± 0.05
1.381AsnThr: 1.381 ± 0.057
1.951AsnVal: 1.951 ± 0.048
0.321AsnTrp: 0.321 ± 0.019
0.565AsnTyr: 0.565 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.686ProAla: 6.686 ± 0.125
0.195ProCys: 0.195 ± 0.015
3.199ProAsp: 3.199 ± 0.072
3.565ProGlu: 3.565 ± 0.069
1.702ProPhe: 1.702 ± 0.047
4.332ProGly: 4.332 ± 0.09
1.088ProHis: 1.088 ± 0.033
2.343ProIle: 2.343 ± 0.062
1.181ProLys: 1.181 ± 0.042
4.642ProLeu: 4.642 ± 0.079
0.994ProMet: 0.994 ± 0.034
1.194ProAsn: 1.194 ± 0.043
2.044ProPro: 2.044 ± 0.069
1.772ProGln: 1.772 ± 0.046
3.046ProArg: 3.046 ± 0.071
3.035ProSer: 3.035 ± 0.06
3.577ProThr: 3.577 ± 0.081
4.323ProVal: 4.323 ± 0.078
0.79ProTrp: 0.79 ± 0.032
1.064ProTyr: 1.064 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.758GlnAla: 3.758 ± 0.073
0.136GlnCys: 0.136 ± 0.013
1.271GlnAsp: 1.271 ± 0.041
1.353GlnGlu: 1.353 ± 0.041
0.994GlnPhe: 0.994 ± 0.037
2.01GlnGly: 2.01 ± 0.052
0.763GlnHis: 0.763 ± 0.03
1.59GlnIle: 1.59 ± 0.045
0.749GlnLys: 0.749 ± 0.03
3.16GlnLeu: 3.16 ± 0.061
0.602GlnMet: 0.602 ± 0.028
0.78GlnAsn: 0.78 ± 0.03
1.729GlnPro: 1.729 ± 0.052
1.345GlnGln: 1.345 ± 0.043
2.685GlnArg: 2.685 ± 0.065
1.677GlnSer: 1.677 ± 0.053
1.836GlnThr: 1.836 ± 0.052
2.422GlnVal: 2.422 ± 0.055
0.533GlnTrp: 0.533 ± 0.028
0.698GlnTyr: 0.698 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
8.3ArgAla: 8.3 ± 0.123
0.308ArgCys: 0.308 ± 0.02
4.216ArgAsp: 4.216 ± 0.087
4.463ArgGlu: 4.463 ± 0.085
2.199ArgPhe: 2.199 ± 0.059
5.113ArgGly: 5.113 ± 0.085
1.377ArgHis: 1.377 ± 0.043
3.364ArgIle: 3.364 ± 0.068
1.629ArgLys: 1.629 ± 0.055
6.44ArgLeu: 6.44 ± 0.11
1.576ArgMet: 1.576 ± 0.048
1.54ArgAsn: 1.54 ± 0.046
2.923ArgPro: 2.923 ± 0.071
2.021ArgGln: 2.021 ± 0.057
5.422ArgArg: 5.422 ± 0.128
3.675ArgSer: 3.675 ± 0.068
3.858ArgThr: 3.858 ± 0.073
5.691ArgVal: 5.691 ± 0.089
1.083ArgTrp: 1.083 ± 0.034
1.425ArgTyr: 1.425 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
7.305SerAla: 7.305 ± 0.105
0.303SerCys: 0.303 ± 0.027
3.382SerAsp: 3.382 ± 0.066
3.028SerGlu: 3.028 ± 0.068
2.009SerPhe: 2.009 ± 0.057
5.539SerGly: 5.539 ± 0.091
1.141SerHis: 1.141 ± 0.039
2.799SerIle: 2.799 ± 0.068
1.238SerLys: 1.238 ± 0.048
5.464SerLeu: 5.464 ± 0.084
1.363SerMet: 1.363 ± 0.041
1.3SerAsn: 1.3 ± 0.044
2.971SerPro: 2.971 ± 0.057
1.593SerGln: 1.593 ± 0.043
3.854SerArg: 3.854 ± 0.065
3.412SerSer: 3.412 ± 0.069
3.617SerThr: 3.617 ± 0.076
4.707SerVal: 4.707 ± 0.092
0.877SerTrp: 0.877 ± 0.035
1.215SerTyr: 1.215 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
8.071ThrAla: 8.071 ± 0.121
0.334ThrCys: 0.334 ± 0.026
3.725ThrAsp: 3.725 ± 0.078
3.341ThrGlu: 3.341 ± 0.061
2.15ThrPhe: 2.15 ± 0.058
5.644ThrGly: 5.644 ± 0.105
1.267ThrHis: 1.267 ± 0.04
3.598ThrIle: 3.598 ± 0.071
1.503ThrLys: 1.503 ± 0.043
6.353ThrLeu: 6.353 ± 0.132
1.299ThrMet: 1.299 ± 0.038
1.568ThrAsn: 1.568 ± 0.065
4.134ThrPro: 4.134 ± 0.088
1.787ThrGln: 1.787 ± 0.048
3.679ThrArg: 3.679 ± 0.075
3.505ThrSer: 3.505 ± 0.068
4.429ThrThr: 4.429 ± 0.092
5.923ThrVal: 5.923 ± 0.109
0.931ThrTrp: 0.931 ± 0.039
1.327ThrTyr: 1.327 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
11.732ValAla: 11.732 ± 0.154
0.494ValCys: 0.494 ± 0.025
5.226ValAsp: 5.226 ± 0.09
4.602ValGlu: 4.602 ± 0.073
2.793ValPhe: 2.793 ± 0.065
6.723ValGly: 6.723 ± 0.108
1.578ValHis: 1.578 ± 0.049
5.015ValIle: 5.015 ± 0.079
1.781ValLys: 1.781 ± 0.049
8.506ValLeu: 8.506 ± 0.114
1.803ValMet: 1.803 ± 0.047
2.011ValAsn: 2.011 ± 0.05
4.631ValPro: 4.631 ± 0.07
2.313ValGln: 2.313 ± 0.055
5.654ValArg: 5.654 ± 0.098
5.164ValSer: 5.164 ± 0.068
6.266ValThr: 6.266 ± 0.133
8.549ValVal: 8.549 ± 0.133
1.093ValTrp: 1.093 ± 0.037
1.512ValTyr: 1.512 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.626TrpAla: 1.626 ± 0.043
0.091TrpCys: 0.091 ± 0.01
0.732TrpAsp: 0.732 ± 0.032
0.639TrpGlu: 0.639 ± 0.027
0.576TrpPhe: 0.576 ± 0.03
1.116TrpGly: 1.116 ± 0.039
0.342TrpHis: 0.342 ± 0.02
0.742TrpIle: 0.742 ± 0.033
0.27TrpLys: 0.27 ± 0.019
1.692TrpLeu: 1.692 ± 0.056
0.342TrpMet: 0.342 ± 0.023
0.53TrpAsn: 0.53 ± 0.028
0.677TrpPro: 0.677 ± 0.03
0.593TrpGln: 0.593 ± 0.024
1.087TrpArg: 1.087 ± 0.038
0.835TrpSer: 0.835 ± 0.037
0.828TrpThr: 0.828 ± 0.037
1.198TrpVal: 1.198 ± 0.038
0.327TrpTrp: 0.327 ± 0.021
0.276TrpTyr: 0.276 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.518TyrAla: 2.518 ± 0.064
0.107TyrCys: 0.107 ± 0.01
1.347TyrAsp: 1.347 ± 0.037
1.202TyrGlu: 1.202 ± 0.044
0.775TyrPhe: 0.775 ± 0.034
1.976TyrGly: 1.976 ± 0.053
0.309TyrHis: 0.309 ± 0.018
0.819TyrIle: 0.819 ± 0.037
0.395TyrLys: 0.395 ± 0.022
2.116TyrLeu: 2.116 ± 0.053
0.328TyrMet: 0.328 ± 0.017
0.515TyrAsn: 0.515 ± 0.024
1.08TyrPro: 1.08 ± 0.04
0.646TyrGln: 0.646 ± 0.038
1.522TyrArg: 1.522 ± 0.045
1.137TyrSer: 1.137 ± 0.04
1.215TyrThr: 1.215 ± 0.048
1.735TyrVal: 1.735 ± 0.044
0.314TyrTrp: 0.314 ± 0.019
0.451TyrTyr: 0.451 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2481 proteins (825282 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski