Amino acid dipepetide frequency for Clostridium carboxidivorans P7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.092AlaAla: 5.092 ± 0.089	0.83AlaCys: 0.83 ± 0.026	2.787AlaAsp: 2.787 ± 0.048	3.604AlaGlu: 3.604 ± 0.053	2.67AlaPhe: 2.67 ± 0.056	4.011AlaGly: 4.011 ± 0.063	0.84AlaHis: 0.84 ± 0.022	5.471AlaIle: 5.471 ± 0.059	4.769AlaLys: 4.769 ± 0.057	6.107AlaLeu: 6.107 ± 0.081	1.653AlaMet: 1.653 ± 0.036	2.684AlaAsn: 2.684 ± 0.048	1.539AlaPro: 1.539 ± 0.038	1.586AlaGln: 1.586 ± 0.039	1.815AlaArg: 1.815 ± 0.033	3.935AlaSer: 3.935 ± 0.056	2.495AlaThr: 2.495 ± 0.046	4.8AlaVal: 4.8 ± 0.076	0.386AlaTrp: 0.386 ± 0.017	2.197AlaTyr: 2.197 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.712CysAla: 0.712 ± 0.023	0.247CysCys: 0.247 ± 0.012	0.694CysAsp: 0.694 ± 0.023	0.87CysGlu: 0.87 ± 0.025	0.587CysPhe: 0.587 ± 0.022	1.229CysGly: 1.229 ± 0.035	0.269CysHis: 0.269 ± 0.013	1.363CysIle: 1.363 ± 0.033	1.118CysLys: 1.118 ± 0.027	0.954CysLeu: 0.954 ± 0.027	0.392CysMet: 0.392 ± 0.015	0.789CysAsn: 0.789 ± 0.022	0.528CysPro: 0.528 ± 0.022	0.247CysGln: 0.247 ± 0.012	0.409CysArg: 0.409 ± 0.017	0.975CysSer: 0.975 ± 0.024	0.679CysThr: 0.679 ± 0.022	0.809CysVal: 0.809 ± 0.028	0.085CysTrp: 0.085 ± 0.007	0.511CysTyr: 0.511 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.877AspAla: 2.877 ± 0.044	0.656AspCys: 0.656 ± 0.02	2.601AspAsp: 2.601 ± 0.048	4.326AspGlu: 4.326 ± 0.056	2.642AspPhe: 2.642 ± 0.04	3.183AspGly: 3.183 ± 0.052	0.538AspHis: 0.538 ± 0.021	5.837AspIle: 5.837 ± 0.064	5.59AspLys: 5.59 ± 0.073	4.537AspLeu: 4.537 ± 0.056	1.523AspMet: 1.523 ± 0.033	3.269AspAsn: 3.269 ± 0.045	1.312AspPro: 1.312 ± 0.032	0.815AspGln: 0.815 ± 0.02	1.666AspArg: 1.666 ± 0.034	3.147AspSer: 3.147 ± 0.051	2.566AspThr: 2.566 ± 0.048	3.536AspVal: 3.536 ± 0.057	0.382AspTrp: 0.382 ± 0.015	2.397AspTyr: 2.397 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.204GluAla: 4.204 ± 0.061	0.742GluCys: 0.742 ± 0.023	4.161GluAsp: 4.161 ± 0.058	6.236GluGlu: 6.236 ± 0.083	2.78GluPhe: 2.78 ± 0.044	3.873GluGly: 3.873 ± 0.055	0.936GluHis: 0.936 ± 0.026	6.566GluIle: 6.566 ± 0.068	7.752GluLys: 7.752 ± 0.091	6.425GluLeu: 6.425 ± 0.068	1.863GluMet: 1.863 ± 0.034	5.284GluAsn: 5.284 ± 0.061	1.353GluPro: 1.353 ± 0.031	2.003GluGln: 2.003 ± 0.038	2.35GluArg: 2.35 ± 0.044	3.521GluSer: 3.521 ± 0.049	2.992GluThr: 2.992 ± 0.05	4.505GluVal: 4.505 ± 0.053	0.425GluTrp: 0.425 ± 0.018	2.793GluTyr: 2.793 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	2.358PheAla: 2.358 ± 0.046	0.629PheCys: 0.629 ± 0.019	2.336PheAsp: 2.336 ± 0.046	2.632PheGlu: 2.632 ± 0.048	1.937PhePhe: 1.937 ± 0.044	2.799PheGly: 2.799 ± 0.049	0.61PheHis: 0.61 ± 0.019	4.539PheIle: 4.539 ± 0.07	3.777PheLys: 3.777 ± 0.05	3.88PheLeu: 3.88 ± 0.059	1.281PheMet: 1.281 ± 0.032	2.881PheAsn: 2.881 ± 0.049	1.276PhePro: 1.276 ± 0.031	1.078PheGln: 1.078 ± 0.03	1.215PheArg: 1.215 ± 0.027	3.341PheSer: 3.341 ± 0.052	2.4PheThr: 2.4 ± 0.045	2.721PheVal: 2.721 ± 0.049	0.314PheTrp: 0.314 ± 0.013	1.766PheTyr: 1.766 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.161GlyAla: 4.161 ± 0.064	1.063GlyCys: 1.063 ± 0.032	3.045GlyAsp: 3.045 ± 0.048	4.086GlyGlu: 4.086 ± 0.056	3.078GlyPhe: 3.078 ± 0.048	4.263GlyGly: 4.263 ± 0.061	0.959GlyHis: 0.959 ± 0.023	6.815GlyIle: 6.815 ± 0.079	5.767GlyLys: 5.767 ± 0.065	5.133GlyLeu: 5.133 ± 0.064	1.943GlyMet: 1.943 ± 0.042	3.385GlyAsn: 3.385 ± 0.045	1.184GlyPro: 1.184 ± 0.032	1.567GlyGln: 1.567 ± 0.033	2.068GlyArg: 2.068 ± 0.044	3.697GlySer: 3.697 ± 0.055	3.623GlyThr: 3.623 ± 0.054	4.472GlyVal: 4.472 ± 0.057	0.511GlyTrp: 0.511 ± 0.021	2.932GlyTyr: 2.932 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.687HisAla: 0.687 ± 0.022	0.217HisCys: 0.217 ± 0.012	0.709HisAsp: 0.709 ± 0.02	0.882HisGlu: 0.882 ± 0.027	0.61HisPhe: 0.61 ± 0.02	1.023HisGly: 1.023 ± 0.027	0.308HisHis: 0.308 ± 0.016	1.368HisIle: 1.368 ± 0.026	1.055HisLys: 1.055 ± 0.027	1.178HisLeu: 1.178 ± 0.029	0.39HisMet: 0.39 ± 0.016	0.853HisAsn: 0.853 ± 0.024	0.606HisPro: 0.606 ± 0.021	0.333HisGln: 0.333 ± 0.013	0.491HisArg: 0.491 ± 0.02	0.911HisSer: 0.911 ± 0.023	0.682HisThr: 0.682 ± 0.02	0.799HisVal: 0.799 ± 0.025	0.103HisTrp: 0.103 ± 0.009	0.55HisTyr: 0.55 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.834IleAla: 5.834 ± 0.078	1.372IleCys: 1.372 ± 0.029	5.456IleAsp: 5.456 ± 0.067	6.623IleGlu: 6.623 ± 0.075	4.302IlePhe: 4.302 ± 0.06	6.219IleGly: 6.219 ± 0.079	1.266IleHis: 1.266 ± 0.029	9.035IleIle: 9.035 ± 0.108	8.719IleLys: 8.719 ± 0.081	8.905IleLeu: 8.905 ± 0.098	2.554IleMet: 2.554 ± 0.045	6.096IleAsn: 6.096 ± 0.061	3.285IlePro: 3.285 ± 0.047	2.227IleGln: 2.227 ± 0.034	2.878IleArg: 2.878 ± 0.048	7.11IleSer: 7.11 ± 0.074	4.964IleThr: 4.964 ± 0.061	6.245IleVal: 6.245 ± 0.074	0.555IleTrp: 0.555 ± 0.017	3.463IleTyr: 3.463 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.169LysAla: 5.169 ± 0.063	1.056LysCys: 1.056 ± 0.032	5.81LysAsp: 5.81 ± 0.071	8.149LysGlu: 8.149 ± 0.082	3.528LysPhe: 3.528 ± 0.044	5.162LysGly: 5.162 ± 0.068	1.18LysHis: 1.18 ± 0.028	8.255LysIle: 8.255 ± 0.085	8.372LysLys: 8.372 ± 0.084	7.876LysLeu: 7.876 ± 0.069	2.591LysMet: 2.591 ± 0.037	6.788LysAsn: 6.788 ± 0.078	2.213LysPro: 2.213 ± 0.036	2.473LysGln: 2.473 ± 0.043	2.88LysArg: 2.88 ± 0.047	5.636LysSer: 5.636 ± 0.055	4.128LysThr: 4.128 ± 0.046	6.357LysVal: 6.357 ± 0.07	0.668LysTrp: 0.668 ± 0.022	4.083LysTyr: 4.083 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.115LeuAla: 5.115 ± 0.069	1.243LeuCys: 1.243 ± 0.03	4.757LeuAsp: 4.757 ± 0.052	5.758LeuGlu: 5.758 ± 0.077	3.672LeuPhe: 3.672 ± 0.057	5.781LeuGly: 5.781 ± 0.075	1.155LeuHis: 1.155 ± 0.025	8.023LeuIle: 8.023 ± 0.097	9.158LeuLys: 9.158 ± 0.076	7.55LeuLeu: 7.55 ± 0.085	2.396LeuMet: 2.396 ± 0.043	6.036LeuAsn: 6.036 ± 0.062	2.824LeuPro: 2.824 ± 0.048	2.369LeuGln: 2.369 ± 0.043	2.845LeuArg: 2.845 ± 0.045	6.605LeuSer: 6.605 ± 0.066	4.453LeuThr: 4.453 ± 0.067	5.254LeuVal: 5.254 ± 0.067	0.627LeuTrp: 0.627 ± 0.022	3.164LeuTyr: 3.164 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.793MetAla: 1.793 ± 0.039	0.336MetCys: 0.336 ± 0.015	1.702MetAsp: 1.702 ± 0.032	2.066MetGlu: 2.066 ± 0.036	1.107MetPhe: 1.107 ± 0.026	1.804MetGly: 1.804 ± 0.037	0.403MetHis: 0.403 ± 0.014	2.307MetIle: 2.307 ± 0.043	2.683MetLys: 2.683 ± 0.04	2.483MetLeu: 2.483 ± 0.042	0.76MetMet: 0.76 ± 0.021	1.797MetAsn: 1.797 ± 0.034	0.983MetPro: 0.983 ± 0.026	0.708MetGln: 0.708 ± 0.023	0.808MetArg: 0.808 ± 0.026	1.855MetSer: 1.855 ± 0.04	1.219MetThr: 1.219 ± 0.026	1.683MetVal: 1.683 ± 0.034	0.157MetTrp: 0.157 ± 0.011	0.918MetTyr: 0.918 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.12AsnAla: 3.12 ± 0.047	0.85AsnCys: 0.85 ± 0.025	2.875AsnAsp: 2.875 ± 0.043	4.189AsnGlu: 4.189 ± 0.049	2.736AsnPhe: 2.736 ± 0.049	3.662AsnGly: 3.662 ± 0.059	0.784AsnHis: 0.784 ± 0.024	6.855AsnIle: 6.855 ± 0.077	6.0AsnLys: 6.0 ± 0.071	5.844AsnLeu: 5.844 ± 0.072	1.766AsnMet: 1.766 ± 0.033	4.264AsnAsn: 4.264 ± 0.065	2.074AsnPro: 2.074 ± 0.034	1.362AsnGln: 1.362 ± 0.033	1.888AsnArg: 1.888 ± 0.039	4.316AsnSer: 4.316 ± 0.064	3.094AsnThr: 3.094 ± 0.047	4.145AsnVal: 4.145 ± 0.048	0.483AsnTrp: 0.483 ± 0.017	2.674AsnTyr: 2.674 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	1.544ProAla: 1.544 ± 0.038	0.38ProCys: 0.38 ± 0.016	1.544ProAsp: 1.544 ± 0.034	2.303ProGlu: 2.303 ± 0.047	1.352ProPhe: 1.352 ± 0.032	1.764ProGly: 1.764 ± 0.035	0.472ProHis: 0.472 ± 0.018	2.727ProIle: 2.727 ± 0.042	2.318ProLys: 2.318 ± 0.039	2.529ProLeu: 2.529 ± 0.045	0.789ProMet: 0.789 ± 0.024	1.513ProAsn: 1.513 ± 0.032	0.631ProPro: 0.631 ± 0.023	0.806ProGln: 0.806 ± 0.023	0.785ProArg: 0.785 ± 0.026	1.8ProSer: 1.8 ± 0.034	1.431ProThr: 1.431 ± 0.032	2.181ProVal: 2.181 ± 0.039	0.253ProTrp: 0.253 ± 0.012	1.257ProTyr: 1.257 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.589GlnAla: 1.589 ± 0.033	0.38GlnCys: 0.38 ± 0.016	1.227GlnAsp: 1.227 ± 0.031	1.656GlnGlu: 1.656 ± 0.035	0.985GlnPhe: 0.985 ± 0.027	1.635GlnGly: 1.635 ± 0.034	0.36GlnHis: 0.36 ± 0.015	2.284GlnIle: 2.284 ± 0.043	2.219GlnLys: 2.219 ± 0.041	2.223GlnLeu: 2.223 ± 0.04	0.704GlnMet: 0.704 ± 0.02	1.618GlnAsn: 1.618 ± 0.033	0.633GlnPro: 0.633 ± 0.022	0.878GlnGln: 0.878 ± 0.031	0.888GlnArg: 0.888 ± 0.025	1.556GlnSer: 1.556 ± 0.034	1.143GlnThr: 1.143 ± 0.032	1.623GlnVal: 1.623 ± 0.035	0.226GlnTrp: 0.226 ± 0.011	1.062GlnTyr: 1.062 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	1.769ArgAla: 1.769 ± 0.035	0.392ArgCys: 0.392 ± 0.015	1.613ArgAsp: 1.613 ± 0.034	2.588ArgGlu: 2.588 ± 0.047	1.346ArgPhe: 1.346 ± 0.028	1.84ArgGly: 1.84 ± 0.031	0.467ArgHis: 0.467 ± 0.016	3.01ArgIle: 3.01 ± 0.044	3.04ArgLys: 3.04 ± 0.044	2.633ArgLeu: 2.633 ± 0.037	0.883ArgMet: 0.883 ± 0.024	1.95ArgAsn: 1.95 ± 0.036	0.788ArgPro: 0.788 ± 0.022	0.866ArgGln: 0.866 ± 0.021	1.297ArgArg: 1.297 ± 0.031	1.595ArgSer: 1.595 ± 0.033	1.533ArgThr: 1.533 ± 0.034	1.984ArgVal: 1.984 ± 0.039	0.235ArgTrp: 0.235 ± 0.014	1.324ArgTyr: 1.324 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.649SerAla: 3.649 ± 0.047	0.779SerCys: 0.779 ± 0.022	3.276SerAsp: 3.276 ± 0.05	4.267SerGlu: 4.267 ± 0.057	3.011SerPhe: 3.011 ± 0.048	4.587SerGly: 4.587 ± 0.06	0.951SerHis: 0.951 ± 0.024	6.943SerIle: 6.943 ± 0.076	6.129SerLys: 6.129 ± 0.067	5.907SerLeu: 5.907 ± 0.073	1.868SerMet: 1.868 ± 0.036	4.028SerAsn: 4.028 ± 0.067	1.75SerPro: 1.75 ± 0.037	1.74SerGln: 1.74 ± 0.037	1.941SerArg: 1.941 ± 0.032	4.867SerSer: 4.867 ± 0.075	3.407SerThr: 3.407 ± 0.048	4.05SerVal: 4.05 ± 0.055	0.459SerTrp: 0.459 ± 0.018	2.535SerTyr: 2.535 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	3.361ThrAla: 3.361 ± 0.063	0.608ThrCys: 0.608 ± 0.019	2.397ThrAsp: 2.397 ± 0.044	2.941ThrGlu: 2.941 ± 0.046	2.185ThrPhe: 2.185 ± 0.041	3.712ThrGly: 3.712 ± 0.05	0.715ThrHis: 0.715 ± 0.021	4.77ThrIle: 4.77 ± 0.057	3.789ThrLys: 3.789 ± 0.048	4.65ThrLeu: 4.65 ± 0.06	1.198ThrMet: 1.198 ± 0.032	2.745ThrAsn: 2.745 ± 0.051	1.843ThrPro: 1.843 ± 0.039	1.164ThrGln: 1.164 ± 0.027	1.429ThrArg: 1.429 ± 0.029	3.288ThrSer: 3.288 ± 0.049	2.634ThrThr: 2.634 ± 0.047	3.528ThrVal: 3.528 ± 0.059	0.348ThrTrp: 0.348 ± 0.016	1.855ThrTyr: 1.855 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	3.83ValAla: 3.83 ± 0.058	0.965ValCys: 0.965 ± 0.026	3.759ValAsp: 3.759 ± 0.058	4.446ValGlu: 4.446 ± 0.056	2.91ValPhe: 2.91 ± 0.047	4.155ValGly: 4.155 ± 0.057	0.884ValHis: 0.884 ± 0.027	6.29ValIle: 6.29 ± 0.066	5.904ValLys: 5.904 ± 0.064	5.942ValLeu: 5.942 ± 0.054	1.685ValMet: 1.685 ± 0.035	3.923ValAsn: 3.923 ± 0.051	2.143ValPro: 2.143 ± 0.041	1.68ValGln: 1.68 ± 0.032	1.896ValArg: 1.896 ± 0.035	4.701ValSer: 4.701 ± 0.058	3.436ValThr: 3.436 ± 0.061	4.708ValVal: 4.708 ± 0.068	0.449ValTrp: 0.449 ± 0.017	2.47ValTyr: 2.47 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.348TrpAla: 0.348 ± 0.015	0.114TrpCys: 0.114 ± 0.009	0.364TrpAsp: 0.364 ± 0.016	0.378TrpGlu: 0.378 ± 0.016	0.349TrpPhe: 0.349 ± 0.014	0.496TrpGly: 0.496 ± 0.017	0.125TrpHis: 0.125 ± 0.01	0.731TrpIle: 0.731 ± 0.024	0.564TrpLys: 0.564 ± 0.018	0.588TrpLeu: 0.588 ± 0.018	0.221TrpMet: 0.221 ± 0.011	0.505TrpAsn: 0.505 ± 0.02	0.181TrpPro: 0.181 ± 0.012	0.223TrpGln: 0.223 ± 0.012	0.251TrpArg: 0.251 ± 0.015	0.458TrpSer: 0.458 ± 0.017	0.327TrpThr: 0.327 ± 0.014	0.44TrpVal: 0.44 ± 0.017	0.079TrpTrp: 0.079 ± 0.007	0.306TrpTyr: 0.306 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.058TyrAla: 2.058 ± 0.042	0.606TyrCys: 0.606 ± 0.022	2.285TyrAsp: 2.285 ± 0.04	2.766TyrGlu: 2.766 ± 0.05	1.983TyrPhe: 1.983 ± 0.039	2.556TyrGly: 2.556 ± 0.041	0.532TyrHis: 0.532 ± 0.017	3.918TyrIle: 3.918 ± 0.05	3.651TyrLys: 3.651 ± 0.056	3.443TyrLeu: 3.443 ± 0.05	1.112TyrMet: 1.112 ± 0.029	2.574TyrAsn: 2.574 ± 0.052	1.234TyrPro: 1.234 ± 0.032	0.763TyrGln: 0.763 ± 0.023	1.353TyrArg: 1.353 ± 0.027	2.831TyrSer: 2.831 ± 0.045	1.952TyrThr: 1.952 ± 0.033	2.337TyrVal: 2.337 ± 0.038	0.301TyrTrp: 0.301 ± 0.013	1.797TyrTyr: 1.797 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5458 proteins (1581288 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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