Amino acid dipepetide frequency for Mycobacterium xenopi 3993

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.29AlaAla: 20.29 ± 0.178
1.489AlaCys: 1.489 ± 0.034
7.487AlaAsp: 7.487 ± 0.069
6.825AlaGlu: 6.825 ± 0.066
2.96AlaPhe: 2.96 ± 0.038
11.677AlaGly: 11.677 ± 0.088
2.733AlaHis: 2.733 ± 0.041
4.793AlaIle: 4.793 ± 0.056
2.927AlaLys: 2.927 ± 0.054
11.157AlaLeu: 11.157 ± 0.088
3.004AlaMet: 3.004 ± 0.051
2.658AlaAsn: 2.658 ± 0.048
6.205AlaPro: 6.205 ± 0.065
3.904AlaGln: 3.904 ± 0.048
10.635AlaArg: 10.635 ± 0.094
6.935AlaSer: 6.935 ± 0.073
7.449AlaThr: 7.449 ± 0.09
10.536AlaVal: 10.536 ± 0.097
1.891AlaTrp: 1.891 ± 0.039
2.024AlaTyr: 2.024 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.953CysAla: 1.953 ± 0.039
0.716CysCys: 0.716 ± 0.028
0.628CysAsp: 0.628 ± 0.019
0.459CysGlu: 0.459 ± 0.018
0.341CysPhe: 0.341 ± 0.014
1.764CysGly: 1.764 ± 0.035
0.311CysHis: 0.311 ± 0.014
0.359CysIle: 0.359 ± 0.015
0.182CysLys: 0.182 ± 0.011
0.84CysLeu: 0.84 ± 0.024
0.471CysMet: 0.471 ± 0.018
0.234CysAsn: 0.234 ± 0.012
1.125CysPro: 1.125 ± 0.029
0.324CysGln: 0.324 ± 0.017
2.131CysArg: 2.131 ± 0.036
1.473CysSer: 1.473 ± 0.031
0.883CysThr: 0.883 ± 0.023
0.748CysVal: 0.748 ± 0.023
0.679CysTrp: 0.679 ± 0.023
0.23CysTyr: 0.23 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.5AspAla: 6.5 ± 0.066
0.531AspCys: 0.531 ± 0.018
3.543AspAsp: 3.543 ± 0.056
3.52AspGlu: 3.52 ± 0.042
1.48AspPhe: 1.48 ± 0.027
4.989AspGly: 4.989 ± 0.057
1.491AspHis: 1.491 ± 0.032
2.245AspIle: 2.245 ± 0.042
1.17AspLys: 1.17 ± 0.026
4.955AspLeu: 4.955 ± 0.055
0.854AspMet: 0.854 ± 0.025
1.09AspAsn: 1.09 ± 0.026
3.861AspPro: 3.861 ± 0.057
1.756AspGln: 1.756 ± 0.039
4.777AspArg: 4.777 ± 0.067
2.394AspSer: 2.394 ± 0.04
2.797AspThr: 2.797 ± 0.042
4.584AspVal: 4.584 ± 0.062
0.841AspTrp: 0.841 ± 0.025
1.249AspTyr: 1.249 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
5.09GluAla: 5.09 ± 0.056
0.412GluCys: 0.412 ± 0.017
1.909GluAsp: 1.909 ± 0.035
2.027GluGlu: 2.027 ± 0.043
1.522GluPhe: 1.522 ± 0.03
2.639GluGly: 2.639 ± 0.039
1.458GluHis: 1.458 ± 0.031
2.264GluIle: 2.264 ± 0.043
1.147GluLys: 1.147 ± 0.03
5.688GluLeu: 5.688 ± 0.064
0.929GluMet: 0.929 ± 0.027
0.96GluAsn: 0.96 ± 0.026
2.75GluPro: 2.75 ± 0.048
2.042GluGln: 2.042 ± 0.039
4.149GluArg: 4.149 ± 0.056
2.268GluSer: 2.268 ± 0.046
2.271GluThr: 2.271 ± 0.037
3.538GluVal: 3.538 ± 0.053
0.633GluTrp: 0.633 ± 0.02
0.972GluTyr: 0.972 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.535PheAla: 3.535 ± 0.048
0.383PheCys: 0.383 ± 0.019
2.083PheAsp: 2.083 ± 0.035
1.3PheGlu: 1.3 ± 0.03
0.836PhePhe: 0.836 ± 0.022
2.958PheGly: 2.958 ± 0.042
0.63PheHis: 0.63 ± 0.021
0.906PheIle: 0.906 ± 0.029
0.454PheLys: 0.454 ± 0.015
2.104PheLeu: 2.104 ± 0.04
0.463PheMet: 0.463 ± 0.015
0.61PheAsn: 0.61 ± 0.02
1.444PhePro: 1.444 ± 0.032
0.601PheGln: 0.601 ± 0.022
1.898PheArg: 1.898 ± 0.037
1.603PheSer: 1.603 ± 0.033
1.827PheThr: 1.827 ± 0.035
2.146PheVal: 2.146 ± 0.042
0.45PheTrp: 0.45 ± 0.018
0.625PheTyr: 0.625 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
8.906GlyAla: 8.906 ± 0.08
1.732GlyCys: 1.732 ± 0.034
4.298GlyAsp: 4.298 ± 0.055
3.583GlyGlu: 3.583 ± 0.047
2.688GlyPhe: 2.688 ± 0.043
7.203GlyGly: 7.203 ± 0.088
2.266GlyHis: 2.266 ± 0.041
3.556GlyIle: 3.556 ± 0.049
2.136GlyLys: 2.136 ± 0.038
7.453GlyLeu: 7.453 ± 0.078
2.356GlyMet: 2.356 ± 0.039
1.797GlyAsn: 1.797 ± 0.036
4.486GlyPro: 4.486 ± 0.047
2.895GlyGln: 2.895 ± 0.049
8.188GlyArg: 8.188 ± 0.075
5.567GlySer: 5.567 ± 0.062
4.561GlyThr: 4.561 ± 0.051
6.486GlyVal: 6.486 ± 0.067
2.072GlyTrp: 2.072 ± 0.038
2.167GlyTyr: 2.167 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.568HisAla: 2.568 ± 0.045
0.394HisCys: 0.394 ± 0.016
1.344HisAsp: 1.344 ± 0.026
0.956HisGlu: 0.956 ± 0.025
0.593HisPhe: 0.593 ± 0.021
2.225HisGly: 2.225 ± 0.039
0.958HisHis: 0.958 ± 0.026
0.798HisIle: 0.798 ± 0.024
0.382HisLys: 0.382 ± 0.015
2.139HisLeu: 2.139 ± 0.037
0.394HisMet: 0.394 ± 0.017
0.53HisAsn: 0.53 ± 0.018
2.032HisPro: 2.032 ± 0.037
0.856HisGln: 0.856 ± 0.02
3.113HisArg: 3.113 ± 0.048
1.169HisSer: 1.169 ± 0.026
1.3HisThr: 1.3 ± 0.029
1.637HisVal: 1.637 ± 0.034
0.452HisTrp: 0.452 ± 0.018
0.532HisTyr: 0.532 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.644IleAla: 5.644 ± 0.065
0.549IleCys: 0.549 ± 0.016
3.021IleAsp: 3.021 ± 0.046
2.265IleGlu: 2.265 ± 0.036
0.885IlePhe: 0.885 ± 0.03
3.872IleGly: 3.872 ± 0.05
0.757IleHis: 0.757 ± 0.025
1.235IleIle: 1.235 ± 0.032
0.81IleLys: 0.81 ± 0.023
2.519IleLeu: 2.519 ± 0.045
0.61IleMet: 0.61 ± 0.02
1.014IleAsn: 1.014 ± 0.03
2.368IlePro: 2.368 ± 0.04
0.892IleGln: 0.892 ± 0.027
2.923IleArg: 2.923 ± 0.042
2.368IleSer: 2.368 ± 0.038
2.587IleThr: 2.587 ± 0.041
3.052IleVal: 3.052 ± 0.045
0.582IleTrp: 0.582 ± 0.022
0.752IleTyr: 0.752 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.512LysAla: 2.512 ± 0.047
0.195LysCys: 0.195 ± 0.012
0.952LysAsp: 0.952 ± 0.028
0.864LysGlu: 0.864 ± 0.026
0.584LysPhe: 0.584 ± 0.022
1.283LysGly: 1.283 ± 0.027
0.5LysHis: 0.5 ± 0.017
0.981LysIle: 0.981 ± 0.029
0.576LysLys: 0.576 ± 0.022
2.15LysLeu: 2.15 ± 0.043
0.461LysMet: 0.461 ± 0.017
0.471LysAsn: 0.471 ± 0.018
1.719LysPro: 1.719 ± 0.033
0.778LysGln: 0.778 ± 0.022
1.797LysArg: 1.797 ± 0.034
1.353LysSer: 1.353 ± 0.028
1.47LysThr: 1.47 ± 0.033
1.761LysVal: 1.761 ± 0.033
0.321LysTrp: 0.321 ± 0.013
0.428LysTyr: 0.428 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
12.761LeuAla: 12.761 ± 0.11
0.991LeuCys: 0.991 ± 0.025
5.508LeuAsp: 5.508 ± 0.069
3.651LeuGlu: 3.651 ± 0.053
2.338LeuPhe: 2.338 ± 0.045
7.453LeuGly: 7.453 ± 0.076
2.081LeuHis: 2.081 ± 0.036
3.551LeuIle: 3.551 ± 0.052
1.631LeuLys: 1.631 ± 0.035
8.316LeuLeu: 8.316 ± 0.087
1.562LeuMet: 1.562 ± 0.029
1.83LeuAsn: 1.83 ± 0.039
5.683LeuPro: 5.683 ± 0.06
2.38LeuGln: 2.38 ± 0.043
7.997LeuArg: 7.997 ± 0.068
5.189LeuSer: 5.189 ± 0.065
5.694LeuThr: 5.694 ± 0.059
7.294LeuVal: 7.294 ± 0.069
1.198LeuTrp: 1.198 ± 0.029
1.424LeuTyr: 1.424 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
2.781MetAla: 2.781 ± 0.042
0.324MetCys: 0.324 ± 0.017
0.849MetAsp: 0.849 ± 0.025
0.708MetGlu: 0.708 ± 0.025
0.687MetPhe: 0.687 ± 0.022
1.535MetGly: 1.535 ± 0.03
0.506MetHis: 0.506 ± 0.015
1.01MetIle: 1.01 ± 0.024
0.456MetLys: 0.456 ± 0.018
2.38MetLeu: 2.38 ± 0.043
0.5MetMet: 0.5 ± 0.019
0.513MetAsn: 0.513 ± 0.02
1.588MetPro: 1.588 ± 0.032
0.655MetGln: 0.655 ± 0.02
2.027MetArg: 2.027 ± 0.038
1.55MetSer: 1.55 ± 0.031
1.789MetThr: 1.789 ± 0.03
1.737MetVal: 1.737 ± 0.031
0.373MetTrp: 0.373 ± 0.016
0.364MetTyr: 0.364 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.488AsnAla: 2.488 ± 0.045
0.337AsnCys: 0.337 ± 0.014
1.07AsnAsp: 1.07 ± 0.03
0.917AsnGlu: 0.917 ± 0.026
0.585AsnPhe: 0.585 ± 0.021
1.929AsnGly: 1.929 ± 0.043
0.526AsnHis: 0.526 ± 0.018
0.823AsnIle: 0.823 ± 0.023
0.406AsnLys: 0.406 ± 0.018
1.821AsnLeu: 1.821 ± 0.04
0.423AsnMet: 0.423 ± 0.018
0.544AsnAsn: 0.544 ± 0.021
1.741AsnPro: 1.741 ± 0.034
0.649AsnGln: 0.649 ± 0.022
1.862AsnArg: 1.862 ± 0.031
1.268AsnSer: 1.268 ± 0.027
1.298AsnThr: 1.298 ± 0.032
1.527AsnVal: 1.527 ± 0.036
0.423AsnTrp: 0.423 ± 0.016
0.527AsnTyr: 0.527 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
8.524ProAla: 8.524 ± 0.085
0.78ProCys: 0.78 ± 0.023
3.927ProAsp: 3.927 ± 0.052
3.013ProGlu: 3.013 ± 0.048
1.456ProPhe: 1.456 ± 0.032
6.036ProGly: 6.036 ± 0.068
1.51ProHis: 1.51 ± 0.032
2.289ProIle: 2.289 ± 0.037
1.529ProLys: 1.529 ± 0.033
4.635ProLeu: 4.635 ± 0.051
1.459ProMet: 1.459 ± 0.033
1.46ProAsn: 1.46 ± 0.032
5.029ProPro: 5.029 ± 0.076
1.842ProGln: 1.842 ± 0.039
6.095ProArg: 6.095 ± 0.078
4.36ProSer: 4.36 ± 0.065
4.795ProThr: 4.795 ± 0.058
4.846ProVal: 4.846 ± 0.055
1.065ProTrp: 1.065 ± 0.025
1.072ProTyr: 1.072 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.649GlnAla: 3.649 ± 0.051
0.363GlnCys: 0.363 ± 0.015
1.042GlnAsp: 1.042 ± 0.031
0.92GlnGlu: 0.92 ± 0.027
0.901GlnPhe: 0.901 ± 0.026
1.882GlnGly: 1.882 ± 0.034
0.912GlnHis: 0.912 ± 0.025
1.396GlnIle: 1.396 ± 0.03
0.569GlnLys: 0.569 ± 0.022
3.571GlnLeu: 3.571 ± 0.05
0.63GlnMet: 0.63 ± 0.021
0.559GlnAsn: 0.559 ± 0.018
2.352GlnPro: 2.352 ± 0.046
1.346GlnGln: 1.346 ± 0.03
3.512GlnArg: 3.512 ± 0.051
1.47GlnSer: 1.47 ± 0.03
1.506GlnThr: 1.506 ± 0.03
2.441GlnVal: 2.441 ± 0.04
0.537GlnTrp: 0.537 ± 0.019
0.559GlnTyr: 0.559 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.917ArgAla: 9.917 ± 0.087
2.691ArgCys: 2.691 ± 0.047
4.265ArgAsp: 4.265 ± 0.057
3.513ArgGlu: 3.513 ± 0.049
2.488ArgPhe: 2.488 ± 0.04
6.442ArgGly: 6.442 ± 0.07
2.732ArgHis: 2.732 ± 0.043
3.545ArgIle: 3.545 ± 0.047
1.837ArgLys: 1.837 ± 0.033
8.194ArgLeu: 8.194 ± 0.085
2.864ArgMet: 2.864 ± 0.043
1.791ArgAsn: 1.791 ± 0.037
6.972ArgPro: 6.972 ± 0.081
2.924ArgGln: 2.924 ± 0.049
13.055ArgArg: 13.055 ± 0.14
7.003ArgSer: 7.003 ± 0.078
4.832ArgThr: 4.832 ± 0.057
5.724ArgVal: 5.724 ± 0.063
2.637ArgTrp: 2.637 ± 0.045
2.003ArgTyr: 2.003 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
8.1SerAla: 8.1 ± 0.069
1.193SerCys: 1.193 ± 0.027
2.725SerAsp: 2.725 ± 0.042
2.126SerGlu: 2.126 ± 0.037
1.493SerPhe: 1.493 ± 0.028
5.812SerGly: 5.812 ± 0.069
1.163SerHis: 1.163 ± 0.026
2.095SerIle: 2.095 ± 0.04
1.334SerLys: 1.334 ± 0.034
4.381SerLeu: 4.381 ± 0.044
1.628SerMet: 1.628 ± 0.034
1.194SerAsn: 1.194 ± 0.027
4.778SerPro: 4.778 ± 0.058
1.552SerGln: 1.552 ± 0.036
6.073SerArg: 6.073 ± 0.059
4.922SerSer: 4.922 ± 0.072
4.92SerThr: 4.92 ± 0.061
4.09SerVal: 4.09 ± 0.047
1.365SerTrp: 1.365 ± 0.034
1.127SerTyr: 1.127 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
8.032ThrAla: 8.032 ± 0.077
0.986ThrCys: 0.986 ± 0.028
3.09ThrAsp: 3.09 ± 0.051
2.54ThrGlu: 2.54 ± 0.041
1.561ThrPhe: 1.561 ± 0.032
5.734ThrGly: 5.734 ± 0.064
1.149ThrHis: 1.149 ± 0.027
2.216ThrIle: 2.216 ± 0.039
1.336ThrLys: 1.336 ± 0.029
4.87ThrLeu: 4.87 ± 0.062
1.455ThrMet: 1.455 ± 0.034
1.271ThrAsn: 1.271 ± 0.029
4.44ThrPro: 4.44 ± 0.058
1.426ThrGln: 1.426 ± 0.031
5.142ThrArg: 5.142 ± 0.061
4.282ThrSer: 4.282 ± 0.057
4.629ThrThr: 4.629 ± 0.069
4.998ThrVal: 4.998 ± 0.052
1.051ThrTrp: 1.051 ± 0.026
1.128ThrTyr: 1.128 ± 0.026
0.0ThrXaa: 0.0 ± 0.0
Val
10.141ValAla: 10.141 ± 0.079
0.99ValCys: 0.99 ± 0.028
5.012ValAsp: 5.012 ± 0.058
3.953ValGlu: 3.953 ± 0.049
2.286ValPhe: 2.286 ± 0.045
6.282ValGly: 6.282 ± 0.068
1.804ValHis: 1.804 ± 0.033
3.438ValIle: 3.438 ± 0.047
1.56ValLys: 1.56 ± 0.037
7.468ValLeu: 7.468 ± 0.08
1.476ValMet: 1.476 ± 0.03
1.819ValAsn: 1.819 ± 0.036
4.175ValPro: 4.175 ± 0.048
1.946ValGln: 1.946 ± 0.031
5.917ValArg: 5.917 ± 0.064
4.372ValSer: 4.372 ± 0.054
4.63ValThr: 4.63 ± 0.051
7.475ValVal: 7.475 ± 0.09
1.081ValTrp: 1.081 ± 0.026
1.359ValTyr: 1.359 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.969TrpAla: 1.969 ± 0.041
0.547TrpCys: 0.547 ± 0.022
0.692TrpAsp: 0.692 ± 0.019
0.61TrpGlu: 0.61 ± 0.023
0.475TrpPhe: 0.475 ± 0.017
0.866TrpGly: 0.866 ± 0.022
0.425TrpHis: 0.425 ± 0.016
0.642TrpIle: 0.642 ± 0.021
0.372TrpLys: 0.372 ± 0.015
1.835TrpLeu: 1.835 ± 0.032
0.501TrpMet: 0.501 ± 0.016
0.423TrpAsn: 0.423 ± 0.017
1.755TrpPro: 1.755 ± 0.035
0.657TrpGln: 0.657 ± 0.02
2.192TrpArg: 2.192 ± 0.04
1.535TrpSer: 1.535 ± 0.035
1.021TrpThr: 1.021 ± 0.025
1.16TrpVal: 1.16 ± 0.027
0.579TrpTrp: 0.579 ± 0.02
0.334TrpTyr: 0.334 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.222TyrAla: 2.222 ± 0.039
0.251TyrCys: 0.251 ± 0.012
1.18TyrAsp: 1.18 ± 0.028
0.913TyrGlu: 0.913 ± 0.026
0.699TyrPhe: 0.699 ± 0.024
1.814TyrGly: 1.814 ± 0.038
0.461TyrHis: 0.461 ± 0.017
0.563TyrIle: 0.563 ± 0.021
0.342TyrLys: 0.342 ± 0.014
2.058TyrLeu: 2.058 ± 0.037
0.291TyrMet: 0.291 ± 0.014
0.397TyrAsn: 0.397 ± 0.015
1.218TyrPro: 1.218 ± 0.029
0.692TyrGln: 0.692 ± 0.02
1.947TyrArg: 1.947 ± 0.038
0.989TyrSer: 0.989 ± 0.023
1.076TyrThr: 1.076 ± 0.03
1.403TyrVal: 1.403 ± 0.031
0.36TyrTrp: 0.36 ± 0.016
0.431TyrTyr: 0.431 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10123 proteins (1523496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski