Amino acid dipepetide frequency for Aspergillus bertholletiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.157AlaAla: 8.157 ± 0.047	1.156AlaCys: 1.156 ± 0.013	4.028AlaAsp: 4.028 ± 0.029	4.732AlaGlu: 4.732 ± 0.038	3.201AlaPhe: 3.201 ± 0.027	5.502AlaGly: 5.502 ± 0.036	1.793AlaHis: 1.793 ± 0.015	4.423AlaIle: 4.423 ± 0.025	3.651AlaLys: 3.651 ± 0.025	7.844AlaLeu: 7.844 ± 0.042	1.947AlaMet: 1.947 ± 0.02	2.833AlaAsn: 2.833 ± 0.025	4.353AlaPro: 4.353 ± 0.036	3.266AlaGln: 3.266 ± 0.028	4.617AlaArg: 4.617 ± 0.029	6.922AlaSer: 6.922 ± 0.039	5.124AlaThr: 5.124 ± 0.03	5.397AlaVal: 5.397 ± 0.033	1.183AlaTrp: 1.183 ± 0.016	2.266AlaTyr: 2.266 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	1.024CysAla: 1.024 ± 0.012	0.282CysCys: 0.282 ± 0.008	0.755CysAsp: 0.755 ± 0.012	0.644CysGlu: 0.644 ± 0.011	0.598CysPhe: 0.598 ± 0.01	1.011CysGly: 1.011 ± 0.015	0.387CysHis: 0.387 ± 0.008	0.822CysIle: 0.822 ± 0.012	0.514CysLys: 0.514 ± 0.01	1.449CysLeu: 1.449 ± 0.017	0.306CysMet: 0.306 ± 0.007	0.48CysAsn: 0.48 ± 0.009	0.727CysPro: 0.727 ± 0.014	0.531CysGln: 0.531 ± 0.011	0.867CysArg: 0.867 ± 0.012	1.061CysSer: 1.061 ± 0.015	0.763CysThr: 0.763 ± 0.013	0.898CysVal: 0.898 ± 0.012	0.233CysTrp: 0.233 ± 0.007	0.413CysTyr: 0.413 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.372AspAla: 4.372 ± 0.032	0.658AspCys: 0.658 ± 0.01	3.732AspAsp: 3.732 ± 0.033	4.003AspGlu: 4.003 ± 0.035	2.13AspPhe: 2.13 ± 0.023	3.885AspGly: 3.885 ± 0.028	1.306AspHis: 1.306 ± 0.014	3.296AspIle: 3.296 ± 0.023	2.219AspLys: 2.219 ± 0.019	5.075AspLeu: 5.075 ± 0.028	1.263AspMet: 1.263 ± 0.013	1.912AspAsn: 1.912 ± 0.02	3.296AspPro: 3.296 ± 0.027	1.938AspGln: 1.938 ± 0.017	3.058AspArg: 3.058 ± 0.027	4.114AspSer: 4.114 ± 0.029	2.98AspThr: 2.98 ± 0.025	3.559AspVal: 3.559 ± 0.027	0.883AspTrp: 0.883 ± 0.012	1.662AspTyr: 1.662 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.983GluAla: 4.983 ± 0.037	0.688GluCys: 0.688 ± 0.013	3.814GluAsp: 3.814 ± 0.031	5.008GluGlu: 5.008 ± 0.045	1.97GluPhe: 1.97 ± 0.018	3.561GluGly: 3.561 ± 0.029	1.381GluHis: 1.381 ± 0.017	3.075GluIle: 3.075 ± 0.022	3.514GluLys: 3.514 ± 0.03	5.137GluLeu: 5.137 ± 0.035	1.401GluMet: 1.401 ± 0.016	2.298GluAsn: 2.298 ± 0.02	2.727GluPro: 2.727 ± 0.032	2.449GluGln: 2.449 ± 0.023	3.754GluArg: 3.754 ± 0.035	4.326GluSer: 4.326 ± 0.027	3.422GluThr: 3.422 ± 0.028	3.441GluVal: 3.441 ± 0.028	0.888GluTrp: 0.888 ± 0.013	1.76GluTyr: 1.76 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.029PheAla: 3.029 ± 0.026	0.637PheCys: 0.637 ± 0.01	2.252PheAsp: 2.252 ± 0.019	2.043PheGlu: 2.043 ± 0.019	1.809PhePhe: 1.809 ± 0.023	2.839PheGly: 2.839 ± 0.027	1.005PheHis: 1.005 ± 0.013	2.007PheIle: 2.007 ± 0.021	1.43PheLys: 1.43 ± 0.015	3.847PheLeu: 3.847 ± 0.03	0.84PheMet: 0.84 ± 0.014	1.471PheAsn: 1.471 ± 0.019	2.077PhePro: 2.077 ± 0.019	1.485PheGln: 1.485 ± 0.016	2.022PheArg: 2.022 ± 0.019	3.163PheSer: 3.163 ± 0.026	2.251PheThr: 2.251 ± 0.021	2.426PheVal: 2.426 ± 0.023	0.694PheTrp: 0.694 ± 0.011	1.244PheTyr: 1.244 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.123GlyAla: 5.123 ± 0.039	0.981GlyCys: 0.981 ± 0.013	3.538GlyAsp: 3.538 ± 0.027	3.496GlyGlu: 3.496 ± 0.026	2.865GlyPhe: 2.865 ± 0.025	5.316GlyGly: 5.316 ± 0.051	1.731GlyHis: 1.731 ± 0.02	3.758GlyIle: 3.758 ± 0.024	3.229GlyLys: 3.229 ± 0.024	6.309GlyLeu: 6.309 ± 0.034	1.55GlyMet: 1.55 ± 0.017	2.52GlyAsn: 2.52 ± 0.018	3.3GlyPro: 3.3 ± 0.026	2.607GlyGln: 2.607 ± 0.024	3.977GlyArg: 3.977 ± 0.026	5.67GlySer: 5.67 ± 0.036	3.929GlyThr: 3.929 ± 0.028	4.474GlyVal: 4.474 ± 0.031	1.217GlyTrp: 1.217 ± 0.016	2.266GlyTyr: 2.266 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.858HisAla: 1.858 ± 0.02	0.392HisCys: 0.392 ± 0.009	1.345HisAsp: 1.345 ± 0.016	1.351HisGlu: 1.351 ± 0.018	0.952HisPhe: 0.952 ± 0.012	1.781HisGly: 1.781 ± 0.018	0.871HisHis: 0.871 ± 0.015	1.346HisIle: 1.346 ± 0.017	0.872HisLys: 0.872 ± 0.01	2.416HisLeu: 2.416 ± 0.023	0.528HisMet: 0.528 ± 0.008	0.863HisAsn: 0.863 ± 0.013	1.71HisPro: 1.71 ± 0.019	0.982HisGln: 0.982 ± 0.013	1.622HisArg: 1.622 ± 0.015	1.987HisSer: 1.987 ± 0.023	1.326HisThr: 1.326 ± 0.013	1.437HisVal: 1.437 ± 0.014	0.389HisTrp: 0.389 ± 0.008	0.76HisTyr: 0.76 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.341IleAla: 4.341 ± 0.031	0.873IleCys: 0.873 ± 0.013	2.905IleAsp: 2.905 ± 0.025	2.86IleGlu: 2.86 ± 0.023	2.223IlePhe: 2.223 ± 0.023	3.4IleGly: 3.4 ± 0.025	1.322IleHis: 1.322 ± 0.017	2.782IleIle: 2.782 ± 0.026	2.047IleLys: 2.047 ± 0.022	4.994IleLeu: 4.994 ± 0.031	1.096IleMet: 1.096 ± 0.015	1.898IleAsn: 1.898 ± 0.017	3.268IlePro: 3.268 ± 0.023	2.083IleGln: 2.083 ± 0.021	2.897IleArg: 2.897 ± 0.024	4.214IleSer: 4.214 ± 0.028	2.957IleThr: 2.957 ± 0.023	3.368IleVal: 3.368 ± 0.028	0.781IleTrp: 0.781 ± 0.012	1.627IleTyr: 1.627 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.87LysAla: 3.87 ± 0.03	0.555LysCys: 0.555 ± 0.01	2.623LysAsp: 2.623 ± 0.025	3.153LysGlu: 3.153 ± 0.03	1.393LysPhe: 1.393 ± 0.017	2.841LysGly: 2.841 ± 0.023	1.072LysHis: 1.072 ± 0.013	2.211LysIle: 2.211 ± 0.021	2.897LysLys: 2.897 ± 0.038	3.882LysLeu: 3.882 ± 0.028	0.924LysMet: 0.924 ± 0.015	1.704LysAsn: 1.704 ± 0.018	2.517LysPro: 2.517 ± 0.025	1.786LysGln: 1.786 ± 0.02	3.167LysArg: 3.167 ± 0.026	3.323LysSer: 3.323 ± 0.031	2.596LysThr: 2.596 ± 0.021	2.724LysVal: 2.724 ± 0.025	0.662LysTrp: 0.662 ± 0.011	1.38LysTyr: 1.38 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.846LeuAla: 7.846 ± 0.038	1.379LeuCys: 1.379 ± 0.017	5.232LeuAsp: 5.232 ± 0.033	5.554LeuGlu: 5.554 ± 0.035	3.622LeuPhe: 3.622 ± 0.031	6.16LeuGly: 6.16 ± 0.036	2.386LeuHis: 2.386 ± 0.022	4.233LeuIle: 4.233 ± 0.036	4.027LeuLys: 4.027 ± 0.026	8.955LeuLeu: 8.955 ± 0.051	1.885LeuMet: 1.885 ± 0.02	3.316LeuAsn: 3.316 ± 0.025	5.584LeuPro: 5.584 ± 0.033	4.065LeuGln: 4.065 ± 0.031	5.874LeuArg: 5.874 ± 0.033	7.825LeuSer: 7.825 ± 0.041	4.997LeuThr: 4.997 ± 0.032	5.709LeuVal: 5.709 ± 0.036	1.297LeuTrp: 1.297 ± 0.017	2.632LeuTyr: 2.632 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.178MetAla: 2.178 ± 0.018	0.284MetCys: 0.284 ± 0.007	1.233MetAsp: 1.233 ± 0.015	1.288MetGlu: 1.288 ± 0.016	0.773MetPhe: 0.773 ± 0.011	1.492MetGly: 1.492 ± 0.018	0.498MetHis: 0.498 ± 0.009	1.086MetIle: 1.086 ± 0.013	1.021MetLys: 1.021 ± 0.011	1.915MetLeu: 1.915 ± 0.019	0.565MetMet: 0.565 ± 0.011	0.819MetAsn: 0.819 ± 0.012	1.203MetPro: 1.203 ± 0.017	0.872MetGln: 0.872 ± 0.012	1.248MetArg: 1.248 ± 0.013	1.853MetSer: 1.853 ± 0.017	1.304MetThr: 1.304 ± 0.018	1.4MetVal: 1.4 ± 0.016	0.275MetTrp: 0.275 ± 0.007	0.561MetTyr: 0.561 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.049AsnAla: 3.049 ± 0.024	0.496AsnCys: 0.496 ± 0.01	1.955AsnAsp: 1.955 ± 0.019	2.006AsnGlu: 2.006 ± 0.02	1.373AsnPhe: 1.373 ± 0.016	2.933AsnGly: 2.933 ± 0.024	0.894AsnHis: 0.894 ± 0.012	2.207AsnIle: 2.207 ± 0.021	1.463AsnLys: 1.463 ± 0.014	3.294AsnLeu: 3.294 ± 0.026	0.86AsnMet: 0.86 ± 0.012	1.472AsnAsn: 1.472 ± 0.02	2.5AsnPro: 2.5 ± 0.026	1.382AsnGln: 1.382 ± 0.016	2.001AsnArg: 2.001 ± 0.021	2.77AsnSer: 2.77 ± 0.022	2.204AsnThr: 2.204 ± 0.018	2.35AsnVal: 2.35 ± 0.02	0.591AsnTrp: 0.591 ± 0.01	1.111AsnTyr: 1.111 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.693ProAla: 4.693 ± 0.035	0.629ProCys: 0.629 ± 0.012	3.166ProAsp: 3.166 ± 0.025	3.787ProGlu: 3.787 ± 0.029	2.154ProPhe: 2.154 ± 0.02	3.885ProGly: 3.885 ± 0.032	1.337ProHis: 1.337 ± 0.017	2.611ProIle: 2.611 ± 0.02	2.487ProLys: 2.487 ± 0.023	4.863ProLeu: 4.863 ± 0.027	1.095ProMet: 1.095 ± 0.016	2.196ProAsn: 2.196 ± 0.019	4.552ProPro: 4.552 ± 0.056	2.428ProGln: 2.428 ± 0.025	3.325ProArg: 3.325 ± 0.029	5.909ProSer: 5.909 ± 0.041	3.883ProThr: 3.883 ± 0.03	3.625ProVal: 3.625 ± 0.03	0.812ProTrp: 0.812 ± 0.013	1.583ProTyr: 1.583 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.308GlnAla: 3.308 ± 0.027	0.523GlnCys: 0.523 ± 0.01	2.065GlnAsp: 2.065 ± 0.02	2.456GlnGlu: 2.456 ± 0.021	1.329GlnPhe: 1.329 ± 0.016	2.526GlnGly: 2.526 ± 0.021	1.072GlnHis: 1.072 ± 0.014	2.01GlnIle: 2.01 ± 0.021	1.978GlnLys: 1.978 ± 0.019	3.625GlnLeu: 3.625 ± 0.026	0.887GlnMet: 0.887 ± 0.013	1.586GlnAsn: 1.586 ± 0.017	2.508GlnPro: 2.508 ± 0.025	2.257GlnGln: 2.257 ± 0.04	2.663GlnArg: 2.663 ± 0.024	3.238GlnSer: 3.238 ± 0.024	2.332GlnThr: 2.332 ± 0.021	2.245GlnVal: 2.245 ± 0.023	0.616GlnTrp: 0.616 ± 0.009	1.237GlnTyr: 1.237 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.466ArgAla: 4.466 ± 0.03	0.807ArgCys: 0.807 ± 0.014	3.251ArgAsp: 3.251 ± 0.028	3.661ArgGlu: 3.661 ± 0.029	2.234ArgPhe: 2.234 ± 0.021	3.603ArgGly: 3.603 ± 0.027	1.6ArgHis: 1.6 ± 0.017	2.991ArgIle: 2.991 ± 0.026	3.234ArgLys: 3.234 ± 0.026	5.676ArgLeu: 5.676 ± 0.034	1.305ArgMet: 1.305 ± 0.016	2.235ArgAsn: 2.235 ± 0.019	3.415ArgPro: 3.415 ± 0.025	2.608ArgGln: 2.608 ± 0.021	4.897ArgArg: 4.897 ± 0.036	4.772ArgSer: 4.772 ± 0.039	3.199ArgThr: 3.199 ± 0.024	3.472ArgVal: 3.472 ± 0.024	0.989ArgTrp: 0.989 ± 0.014	1.797ArgTyr: 1.797 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.436SerAla: 6.436 ± 0.04	1.027SerCys: 1.027 ± 0.015	4.239SerAsp: 4.239 ± 0.029	4.179SerGlu: 4.179 ± 0.029	3.231SerPhe: 3.231 ± 0.025	5.554SerGly: 5.554 ± 0.037	2.093SerHis: 2.093 ± 0.021	4.223SerIle: 4.223 ± 0.028	3.569SerLys: 3.569 ± 0.03	7.762SerLeu: 7.762 ± 0.043	1.755SerMet: 1.755 ± 0.019	3.059SerAsn: 3.059 ± 0.023	5.338SerPro: 5.338 ± 0.043	3.387SerGln: 3.387 ± 0.029	4.967SerArg: 4.967 ± 0.039	8.618SerSer: 8.618 ± 0.063	5.509SerThr: 5.509 ± 0.038	4.748SerVal: 4.748 ± 0.032	1.22SerTrp: 1.22 ± 0.012	2.213SerTyr: 2.213 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.095ThrAla: 5.095 ± 0.03	0.805ThrCys: 0.805 ± 0.013	2.874ThrAsp: 2.874 ± 0.022	3.172ThrGlu: 3.172 ± 0.029	2.28ThrPhe: 2.28 ± 0.023	4.236ThrGly: 4.236 ± 0.028	1.331ThrHis: 1.331 ± 0.014	3.187ThrIle: 3.187 ± 0.026	2.468ThrLys: 2.468 ± 0.023	5.399ThrLeu: 5.399 ± 0.028	1.247ThrMet: 1.247 ± 0.013	2.083ThrAsn: 2.083 ± 0.018	4.105ThrPro: 4.105 ± 0.035	2.083ThrGln: 2.083 ± 0.022	3.051ThrArg: 3.051 ± 0.022	5.156ThrSer: 5.156 ± 0.036	4.117ThrThr: 4.117 ± 0.034	3.911ThrVal: 3.911 ± 0.028	0.902ThrTrp: 0.902 ± 0.014	1.688ThrTyr: 1.688 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.184ValAla: 5.184 ± 0.031	0.916ValCys: 0.916 ± 0.013	3.731ValAsp: 3.731 ± 0.027	3.736ValGlu: 3.736 ± 0.029	2.558ValPhe: 2.558 ± 0.023	4.107ValGly: 4.107 ± 0.032	1.496ValHis: 1.496 ± 0.016	3.212ValIle: 3.212 ± 0.027	2.733ValLys: 2.733 ± 0.026	5.762ValLeu: 5.762 ± 0.036	1.356ValMet: 1.356 ± 0.017	2.308ValAsn: 2.308 ± 0.021	3.586ValPro: 3.586 ± 0.027	2.459ValGln: 2.459 ± 0.022	3.456ValArg: 3.456 ± 0.028	4.882ValSer: 4.882 ± 0.03	3.616ValThr: 3.616 ± 0.026	4.304ValVal: 4.304 ± 0.031	0.9ValTrp: 0.9 ± 0.013	1.888ValTyr: 1.888 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.162TrpAla: 1.162 ± 0.014	0.211TrpCys: 0.211 ± 0.007	0.924TrpAsp: 0.924 ± 0.013	0.886TrpGlu: 0.886 ± 0.013	0.584TrpPhe: 0.584 ± 0.011	0.996TrpGly: 0.996 ± 0.013	0.38TrpHis: 0.38 ± 0.008	0.84TrpIle: 0.84 ± 0.014	0.828TrpLys: 0.828 ± 0.012	1.46TrpLeu: 1.46 ± 0.017	0.392TrpMet: 0.392 ± 0.009	0.66TrpAsn: 0.66 ± 0.011	0.632TrpPro: 0.632 ± 0.01	0.6TrpGln: 0.6 ± 0.01	0.995TrpArg: 0.995 ± 0.015	1.116TrpSer: 1.116 ± 0.014	0.936TrpThr: 0.936 ± 0.012	0.952TrpVal: 0.952 ± 0.014	0.303TrpTrp: 0.303 ± 0.008	0.462TrpTyr: 0.462 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.224TyrAla: 2.224 ± 0.02	0.466TyrCys: 0.466 ± 0.01	1.678TyrAsp: 1.678 ± 0.018	1.582TyrGlu: 1.582 ± 0.019	1.291TyrPhe: 1.291 ± 0.016	2.229TyrGly: 2.229 ± 0.021	0.838TyrHis: 0.838 ± 0.012	1.614TyrIle: 1.614 ± 0.018	1.096TyrLys: 1.096 ± 0.015	2.916TyrLeu: 2.916 ± 0.028	0.663TyrMet: 0.663 ± 0.011	1.199TyrAsn: 1.199 ± 0.013	1.623TyrPro: 1.623 ± 0.02	1.193TyrGln: 1.193 ± 0.014	1.755TyrArg: 1.755 ± 0.018	2.207TyrSer: 2.207 ± 0.021	1.746TyrThr: 1.746 ± 0.019	1.748TyrVal: 1.748 ± 0.015	0.483TyrTrp: 0.483 ± 0.011	1.039TyrTyr: 1.039 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12944 proteins (5951370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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