Amino acid dipepetide frequency for Sphingomonas changbaiensis NBRC 104936

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.685AlaAla: 19.685 ± 0.232	1.035AlaCys: 1.035 ± 0.033	7.559AlaAsp: 7.559 ± 0.093	8.399AlaGlu: 8.399 ± 0.112	4.452AlaPhe: 4.452 ± 0.073	11.508AlaGly: 11.508 ± 0.127	2.411AlaHis: 2.411 ± 0.056	6.672AlaIle: 6.672 ± 0.1	4.174AlaLys: 4.174 ± 0.081	14.271AlaLeu: 14.271 ± 0.141	3.578AlaMet: 3.578 ± 0.064	3.198AlaAsn: 3.198 ± 0.072	6.625AlaPro: 6.625 ± 0.108	4.426AlaGln: 4.426 ± 0.082	10.2AlaArg: 10.2 ± 0.117	6.412AlaSer: 6.412 ± 0.093	6.332AlaThr: 6.332 ± 0.081	8.895AlaVal: 8.895 ± 0.095	1.692AlaTrp: 1.692 ± 0.04	2.506AlaTyr: 2.506 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.033	0.074CysCys: 0.074 ± 0.009	0.483CysAsp: 0.483 ± 0.027	0.401CysGlu: 0.401 ± 0.021	0.299CysPhe: 0.299 ± 0.019	0.846CysGly: 0.846 ± 0.031	0.23CysHis: 0.23 ± 0.021	0.319CysIle: 0.319 ± 0.018	0.144CysLys: 0.144 ± 0.013	0.67CysLeu: 0.67 ± 0.023	0.126CysMet: 0.126 ± 0.011	0.169CysAsn: 0.169 ± 0.014	0.453CysPro: 0.453 ± 0.026	0.191CysGln: 0.191 ± 0.017	0.533CysArg: 0.533 ± 0.019	0.415CysSer: 0.415 ± 0.019	0.363CysThr: 0.363 ± 0.023	0.502CysVal: 0.502 ± 0.025	0.104CysTrp: 0.104 ± 0.01	0.172CysTyr: 0.172 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.788AspAla: 7.788 ± 0.094	0.451AspCys: 0.451 ± 0.024	3.165AspAsp: 3.165 ± 0.063	3.581AspGlu: 3.581 ± 0.066	2.108AspPhe: 2.108 ± 0.048	5.452AspGly: 5.452 ± 0.088	1.227AspHis: 1.227 ± 0.042	2.672AspIle: 2.672 ± 0.063	1.716AspLys: 1.716 ± 0.045	5.755AspLeu: 5.755 ± 0.083	1.27AspMet: 1.27 ± 0.037	1.372AspAsn: 1.372 ± 0.047	4.04AspPro: 4.04 ± 0.065	1.919AspGln: 1.919 ± 0.046	5.021AspArg: 5.021 ± 0.081	2.302AspSer: 2.302 ± 0.045	2.532AspThr: 2.532 ± 0.052	4.177AspVal: 4.177 ± 0.065	1.145AspTrp: 1.145 ± 0.035	1.625AspTyr: 1.625 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.095GluAla: 8.095 ± 0.12	0.308GluCys: 0.308 ± 0.017	2.657GluAsp: 2.657 ± 0.067	2.88GluGlu: 2.88 ± 0.067	1.428GluPhe: 1.428 ± 0.044	4.374GluGly: 4.374 ± 0.085	1.232GluHis: 1.232 ± 0.04	2.739GluIle: 2.739 ± 0.054	1.83GluLys: 1.83 ± 0.047	5.601GluLeu: 5.601 ± 0.085	1.334GluMet: 1.334 ± 0.038	1.291GluAsn: 1.291 ± 0.035	2.887GluPro: 2.887 ± 0.062	2.226GluGln: 2.226 ± 0.048	5.62GluArg: 5.62 ± 0.093	2.292GluSer: 2.292 ± 0.05	3.038GluThr: 3.038 ± 0.055	3.659GluVal: 3.659 ± 0.06	0.751GluTrp: 0.751 ± 0.029	0.86GluTyr: 0.86 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.807PheAla: 4.807 ± 0.073	0.321PheCys: 0.321 ± 0.019	2.796PheAsp: 2.796 ± 0.057	2.069PheGlu: 2.069 ± 0.044	1.295PhePhe: 1.295 ± 0.042	3.828PheGly: 3.828 ± 0.062	0.713PheHis: 0.713 ± 0.026	1.298PheIle: 1.298 ± 0.038	0.872PheLys: 0.872 ± 0.032	2.994PheLeu: 2.994 ± 0.065	0.685PheMet: 0.685 ± 0.027	1.0PheAsn: 1.0 ± 0.041	1.495PhePro: 1.495 ± 0.038	0.914PheGln: 0.914 ± 0.032	2.337PheArg: 2.337 ± 0.053	1.923PheSer: 1.923 ± 0.047	1.956PheThr: 1.956 ± 0.044	2.799PheVal: 2.799 ± 0.058	0.552PheTrp: 0.552 ± 0.029	0.896PheTyr: 0.896 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.33GlyAla: 10.33 ± 0.125	0.847GlyCys: 0.847 ± 0.025	4.888GlyAsp: 4.888 ± 0.082	4.843GlyGlu: 4.843 ± 0.082	3.63GlyPhe: 3.63 ± 0.063	8.421GlyGly: 8.421 ± 0.16	1.835GlyHis: 1.835 ± 0.041	4.214GlyIle: 4.214 ± 0.065	3.181GlyLys: 3.181 ± 0.062	8.859GlyLeu: 8.859 ± 0.102	2.14GlyMet: 2.14 ± 0.042	2.289GlyAsn: 2.289 ± 0.065	4.023GlyPro: 4.023 ± 0.063	2.984GlyGln: 2.984 ± 0.06	6.921GlyArg: 6.921 ± 0.098	4.875GlySer: 4.875 ± 0.095	4.951GlyThr: 4.951 ± 0.08	6.266GlyVal: 6.266 ± 0.088	1.663GlyTrp: 1.663 ± 0.044	2.341GlyTyr: 2.341 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.435HisAla: 2.435 ± 0.055	0.19HisCys: 0.19 ± 0.015	1.21HisAsp: 1.21 ± 0.033	0.999HisGlu: 0.999 ± 0.034	0.796HisPhe: 0.796 ± 0.031	1.95HisGly: 1.95 ± 0.045	0.476HisHis: 0.476 ± 0.026	0.928HisIle: 0.928 ± 0.036	0.478HisLys: 0.478 ± 0.021	1.841HisLeu: 1.841 ± 0.049	0.462HisMet: 0.462 ± 0.024	0.46HisAsn: 0.46 ± 0.02	1.331HisPro: 1.331 ± 0.039	0.611HisGln: 0.611 ± 0.026	1.485HisArg: 1.485 ± 0.044	0.94HisSer: 0.94 ± 0.031	0.711HisThr: 0.711 ± 0.027	1.505HisVal: 1.505 ± 0.041	0.369HisTrp: 0.369 ± 0.02	0.54HisTyr: 0.54 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	7.73IleAla: 7.73 ± 0.078	0.393IleCys: 0.393 ± 0.021	3.862IleAsp: 3.862 ± 0.068	3.488IleGlu: 3.488 ± 0.073	1.529IlePhe: 1.529 ± 0.042	5.155IleGly: 5.155 ± 0.073	0.799IleHis: 0.799 ± 0.033	1.71IleIle: 1.71 ± 0.045	1.201IleLys: 1.201 ± 0.035	3.774IleLeu: 3.774 ± 0.067	0.795IleMet: 0.795 ± 0.031	1.194IleAsn: 1.194 ± 0.039	2.115IlePro: 2.115 ± 0.051	1.156IleGln: 1.156 ± 0.032	3.315IleArg: 3.315 ± 0.062	2.275IleSer: 2.275 ± 0.051	2.325IleThr: 2.325 ± 0.055	4.212IleVal: 4.212 ± 0.072	0.557IleTrp: 0.557 ± 0.024	0.998IleTyr: 0.998 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.128LysAla: 4.128 ± 0.076	0.156LysCys: 0.156 ± 0.015	1.558LysAsp: 1.558 ± 0.045	1.322LysGlu: 1.322 ± 0.041	0.764LysPhe: 0.764 ± 0.027	2.543LysGly: 2.543 ± 0.059	0.548LysHis: 0.548 ± 0.024	1.357LysIle: 1.357 ± 0.037	1.059LysLys: 1.059 ± 0.045	3.409LysLeu: 3.409 ± 0.061	0.744LysMet: 0.744 ± 0.032	0.749LysAsn: 0.749 ± 0.028	2.077LysPro: 2.077 ± 0.051	0.994LysGln: 0.994 ± 0.037	2.441LysArg: 2.441 ± 0.057	1.521LysSer: 1.521 ± 0.038	1.644LysThr: 1.644 ± 0.049	2.132LysVal: 2.132 ± 0.05	0.369LysTrp: 0.369 ± 0.02	0.591LysTyr: 0.591 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	14.096LeuAla: 14.096 ± 0.139	0.739LeuCys: 0.739 ± 0.029	6.382LeuAsp: 6.382 ± 0.098	4.877LeuGlu: 4.877 ± 0.084	3.604LeuPhe: 3.604 ± 0.073	8.621LeuGly: 8.621 ± 0.105	1.821LeuHis: 1.821 ± 0.046	5.181LeuIle: 5.181 ± 0.072	3.359LeuLys: 3.359 ± 0.065	9.711LeuLeu: 9.711 ± 0.141	2.108LeuMet: 2.108 ± 0.052	2.504LeuAsn: 2.504 ± 0.055	5.639LeuPro: 5.639 ± 0.07	2.619LeuGln: 2.619 ± 0.051	6.815LeuArg: 6.815 ± 0.094	5.785LeuSer: 5.785 ± 0.088	5.664LeuThr: 5.664 ± 0.078	7.239LeuVal: 7.239 ± 0.093	1.23LeuTrp: 1.23 ± 0.041	2.002LeuTyr: 2.002 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.917MetAla: 2.917 ± 0.051	0.14MetCys: 0.14 ± 0.012	1.04MetAsp: 1.04 ± 0.033	0.864MetGlu: 0.864 ± 0.028	0.651MetPhe: 0.651 ± 0.028	1.785MetGly: 1.785 ± 0.044	0.482MetHis: 0.482 ± 0.023	1.31MetIle: 1.31 ± 0.04	0.898MetLys: 0.898 ± 0.036	2.589MetLeu: 2.589 ± 0.06	0.589MetMet: 0.589 ± 0.027	0.614MetAsn: 0.614 ± 0.023	1.378MetPro: 1.378 ± 0.04	0.669MetGln: 0.669 ± 0.028	1.882MetArg: 1.882 ± 0.04	1.314MetSer: 1.314 ± 0.031	1.577MetThr: 1.577 ± 0.043	1.413MetVal: 1.413 ± 0.041	0.206MetTrp: 0.206 ± 0.013	0.301MetTyr: 0.301 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.196AsnAla: 3.196 ± 0.058	0.213AsnCys: 0.213 ± 0.014	1.37AsnAsp: 1.37 ± 0.045	1.154AsnGlu: 1.154 ± 0.034	0.882AsnPhe: 0.882 ± 0.036	2.504AsnGly: 2.504 ± 0.07	0.477AsnHis: 0.477 ± 0.022	1.164AsnIle: 1.164 ± 0.04	0.632AsnLys: 0.632 ± 0.027	2.554AsnLeu: 2.554 ± 0.047	0.497AsnMet: 0.497 ± 0.024	0.691AsnAsn: 0.691 ± 0.032	1.774AsnPro: 1.774 ± 0.05	0.772AsnGln: 0.772 ± 0.029	1.896AsnArg: 1.896 ± 0.05	1.192AsnSer: 1.192 ± 0.044	1.19AsnThr: 1.19 ± 0.036	1.879AsnVal: 1.879 ± 0.05	0.358AsnTrp: 0.358 ± 0.021	0.644AsnTyr: 0.644 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	7.311ProAla: 7.311 ± 0.109	0.315ProCys: 0.315 ± 0.02	4.035ProAsp: 4.035 ± 0.065	3.934ProGlu: 3.934 ± 0.076	1.992ProPhe: 1.992 ± 0.048	5.107ProGly: 5.107 ± 0.077	1.115ProHis: 1.115 ± 0.034	2.526ProIle: 2.526 ± 0.049	1.748ProLys: 1.748 ± 0.048	5.079ProLeu: 5.079 ± 0.078	1.125ProMet: 1.125 ± 0.037	1.452ProAsn: 1.452 ± 0.041	3.146ProPro: 3.146 ± 0.074	1.717ProGln: 1.717 ± 0.052	3.157ProArg: 3.157 ± 0.06	2.806ProSer: 2.806 ± 0.058	2.64ProThr: 2.64 ± 0.051	4.442ProVal: 4.442 ± 0.073	0.684ProTrp: 0.684 ± 0.028	1.077ProTyr: 1.077 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.377GlnAla: 4.377 ± 0.069	0.18GlnCys: 0.18 ± 0.014	1.358GlnAsp: 1.358 ± 0.037	1.229GlnGlu: 1.229 ± 0.035	1.085GlnPhe: 1.085 ± 0.034	2.537GlnGly: 2.537 ± 0.045	0.616GlnHis: 0.616 ± 0.025	1.612GlnIle: 1.612 ± 0.039	0.93GlnLys: 0.93 ± 0.037	3.323GlnLeu: 3.323 ± 0.056	0.766GlnMet: 0.766 ± 0.024	0.753GlnAsn: 0.753 ± 0.031	1.944GlnPro: 1.944 ± 0.046	1.186GlnGln: 1.186 ± 0.042	2.506GlnArg: 2.506 ± 0.059	1.681GlnSer: 1.681 ± 0.038	1.603GlnThr: 1.603 ± 0.04	2.403GlnVal: 2.403 ± 0.051	0.378GlnTrp: 0.378 ± 0.022	0.555GlnTyr: 0.555 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.601ArgAla: 9.601 ± 0.112	0.529ArgCys: 0.529 ± 0.021	4.461ArgAsp: 4.461 ± 0.076	4.168ArgGlu: 4.168 ± 0.082	3.227ArgPhe: 3.227 ± 0.06	5.327ArgGly: 5.327 ± 0.094	1.65ArgHis: 1.65 ± 0.044	4.235ArgIle: 4.235 ± 0.069	1.963ArgLys: 1.963 ± 0.043	8.518ArgLeu: 8.518 ± 0.102	1.909ArgMet: 1.909 ± 0.049	1.785ArgAsn: 1.785 ± 0.043	4.134ArgPro: 4.134 ± 0.067	2.5ArgGln: 2.5 ± 0.054	6.134ArgArg: 6.134 ± 0.1	3.719ArgSer: 3.719 ± 0.069	3.753ArgThr: 3.753 ± 0.066	5.177ArgVal: 5.177 ± 0.077	1.297ArgTrp: 1.297 ± 0.035	1.882ArgTyr: 1.882 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.427SerAla: 6.427 ± 0.093	0.393SerCys: 0.393 ± 0.02	2.871SerAsp: 2.871 ± 0.059	2.443SerGlu: 2.443 ± 0.049	2.215SerPhe: 2.215 ± 0.049	5.408SerGly: 5.408 ± 0.102	0.947SerHis: 0.947 ± 0.034	2.603SerIle: 2.603 ± 0.054	1.399SerLys: 1.399 ± 0.042	4.921SerLeu: 4.921 ± 0.072	1.154SerMet: 1.154 ± 0.034	1.356SerAsn: 1.356 ± 0.042	2.912SerPro: 2.912 ± 0.065	1.372SerGln: 1.372 ± 0.034	3.441SerArg: 3.441 ± 0.062	2.68SerSer: 2.68 ± 0.051	2.482SerThr: 2.482 ± 0.056	3.687SerVal: 3.687 ± 0.068	0.771SerTrp: 0.771 ± 0.027	1.356SerTyr: 1.356 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.193ThrAla: 6.193 ± 0.089	0.344ThrCys: 0.344 ± 0.02	2.968ThrAsp: 2.968 ± 0.057	2.334ThrGlu: 2.334 ± 0.049	1.798ThrPhe: 1.798 ± 0.048	5.331ThrGly: 5.331 ± 0.092	0.969ThrHis: 0.969 ± 0.032	3.0ThrIle: 3.0 ± 0.056	1.319ThrLys: 1.319 ± 0.046	5.581ThrLeu: 5.581 ± 0.089	1.141ThrMet: 1.141 ± 0.039	1.249ThrAsn: 1.249 ± 0.041	3.499ThrPro: 3.499 ± 0.072	1.328ThrGln: 1.328 ± 0.036	3.461ThrArg: 3.461 ± 0.059	2.584ThrSer: 2.584 ± 0.058	2.612ThrThr: 2.612 ± 0.06	4.087ThrVal: 4.087 ± 0.072	0.676ThrTrp: 0.676 ± 0.029	1.152ThrTyr: 1.152 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.704ValAla: 9.704 ± 0.113	0.547ValCys: 0.547 ± 0.026	4.421ValAsp: 4.421 ± 0.07	4.472ValGlu: 4.472 ± 0.07	2.352ValPhe: 2.352 ± 0.059	5.691ValGly: 5.691 ± 0.078	1.358ValHis: 1.358 ± 0.037	3.531ValIle: 3.531 ± 0.049	2.124ValLys: 2.124 ± 0.057	6.711ValLeu: 6.711 ± 0.098	1.494ValMet: 1.494 ± 0.04	1.956ValAsn: 1.956 ± 0.048	4.124ValPro: 4.124 ± 0.059	2.151ValGln: 2.151 ± 0.046	5.503ValArg: 5.503 ± 0.073	4.047ValSer: 4.047 ± 0.086	4.391ValThr: 4.391 ± 0.072	5.054ValVal: 5.054 ± 0.078	0.929ValTrp: 0.929 ± 0.032	1.408ValTyr: 1.408 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.544TrpAla: 1.544 ± 0.042	0.117TrpCys: 0.117 ± 0.012	0.727TrpAsp: 0.727 ± 0.031	0.568TrpGlu: 0.568 ± 0.023	0.562TrpPhe: 0.562 ± 0.027	0.939TrpGly: 0.939 ± 0.034	0.352TrpHis: 0.352 ± 0.021	0.706TrpIle: 0.706 ± 0.029	0.474TrpLys: 0.474 ± 0.023	1.721TrpLeu: 1.721 ± 0.045	0.354TrpMet: 0.354 ± 0.019	0.418TrpAsn: 0.418 ± 0.021	0.736TrpPro: 0.736 ± 0.023	0.542TrpGln: 0.542 ± 0.028	1.4TrpArg: 1.4 ± 0.043	0.886TrpSer: 0.886 ± 0.03	0.886TrpThr: 0.886 ± 0.034	0.853TrpVal: 0.853 ± 0.031	0.259TrpTrp: 0.259 ± 0.016	0.271TrpTyr: 0.271 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.663TyrAla: 2.663 ± 0.058	0.207TyrCys: 0.207 ± 0.013	1.504TyrAsp: 1.504 ± 0.05	1.076TyrGlu: 1.076 ± 0.035	0.883TyrPhe: 0.883 ± 0.034	2.171TyrGly: 2.171 ± 0.053	0.458TyrHis: 0.458 ± 0.02	0.808TyrIle: 0.808 ± 0.031	0.606TyrLys: 0.606 ± 0.027	2.116TyrLeu: 2.116 ± 0.046	0.348TyrMet: 0.348 ± 0.019	0.539TyrAsn: 0.539 ± 0.026	1.076TyrPro: 1.076 ± 0.036	0.744TyrGln: 0.744 ± 0.03	1.9TyrArg: 1.9 ± 0.051	1.188TyrSer: 1.188 ± 0.04	0.977TyrThr: 0.977 ± 0.032	1.586TyrVal: 1.586 ± 0.043	0.327TyrTrp: 0.327 ± 0.02	0.619TyrTyr: 0.619 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3151 proteins (976675 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---