Amino acid dipepetide frequency for Sulfolobus spindle-shaped virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.263AlaAla: 1.263 ± 0.883
0.21AlaCys: 0.21 ± 0.261
0.631AlaAsp: 0.631 ± 0.365
2.946AlaGlu: 2.946 ± 0.9
1.684AlaPhe: 1.684 ± 0.604
2.525AlaGly: 2.525 ± 1.007
0.421AlaHis: 0.421 ± 0.319
4.84AlaIle: 4.84 ± 1.151
5.682AlaLys: 5.682 ± 1.51
5.051AlaLeu: 5.051 ± 0.936
0.842AlaMet: 0.842 ± 0.35
3.367AlaAsn: 3.367 ± 0.841
1.263AlaPro: 1.263 ± 0.515
1.894AlaGln: 1.894 ± 0.589
1.052AlaArg: 1.052 ± 0.51
3.577AlaSer: 3.577 ± 0.953
3.577AlaThr: 3.577 ± 0.947
3.157AlaVal: 3.157 ± 0.671
0.631AlaTrp: 0.631 ± 0.312
3.367AlaTyr: 3.367 ± 0.696
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.21CysCys: 0.21 ± 0.261
0.21CysAsp: 0.21 ± 0.214
0.0CysGlu: 0.0 ± 0.0
0.631CysPhe: 0.631 ± 0.51
0.421CysGly: 0.421 ± 0.27
0.0CysHis: 0.0 ± 0.0
0.842CysIle: 0.842 ± 0.375
0.21CysLys: 0.21 ± 0.192
1.052CysLeu: 1.052 ± 0.539
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.631CysPro: 0.631 ± 0.441
0.0CysGln: 0.0 ± 0.0
0.21CysArg: 0.21 ± 0.214
0.842CysSer: 0.842 ± 0.733
0.0CysThr: 0.0 ± 0.0
0.842CysVal: 0.842 ± 0.414
0.21CysTrp: 0.21 ± 0.19
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.684AspAla: 1.684 ± 0.718
0.21AspCys: 0.21 ± 0.19
1.894AspAsp: 1.894 ± 0.795
3.157AspGlu: 3.157 ± 1.118
0.842AspPhe: 0.842 ± 0.394
2.946AspGly: 2.946 ± 0.687
0.631AspHis: 0.631 ± 0.331
3.367AspIle: 3.367 ± 1.163
2.736AspLys: 2.736 ± 0.991
3.367AspLeu: 3.367 ± 1.295
1.263AspMet: 1.263 ± 0.537
0.631AspAsn: 0.631 ± 0.45
0.631AspPro: 0.631 ± 0.332
1.052AspGln: 1.052 ± 0.579
1.052AspArg: 1.052 ± 0.482
2.736AspSer: 2.736 ± 0.725
1.052AspThr: 1.052 ± 0.411
1.684AspVal: 1.684 ± 0.744
0.421AspTrp: 0.421 ± 0.293
1.684AspTyr: 1.684 ± 0.613
0.0AspXaa: 0.0 ± 0.0
Glu
3.998GluAla: 3.998 ± 1.297
0.421GluCys: 0.421 ± 0.301
3.788GluAsp: 3.788 ± 1.45
7.155GluGlu: 7.155 ± 2.683
1.684GluPhe: 1.684 ± 0.527
2.104GluGly: 2.104 ± 0.869
0.842GluHis: 0.842 ± 0.567
4.84GluIle: 4.84 ± 1.518
5.051GluLys: 5.051 ± 1.767
7.365GluLeu: 7.365 ± 2.371
2.104GluMet: 2.104 ± 0.584
2.104GluAsn: 2.104 ± 0.911
2.315GluPro: 2.315 ± 0.847
1.263GluGln: 1.263 ± 0.383
2.946GluArg: 2.946 ± 1.262
2.946GluSer: 2.946 ± 0.828
1.263GluThr: 1.263 ± 0.541
4.84GluVal: 4.84 ± 1.461
0.631GluTrp: 0.631 ± 0.33
2.946GluTyr: 2.946 ± 1.011
0.0GluXaa: 0.0 ± 0.0
Phe
1.894PheAla: 1.894 ± 0.464
0.21PheCys: 0.21 ± 0.2
2.736PheAsp: 2.736 ± 0.707
1.473PheGlu: 1.473 ± 0.524
2.736PhePhe: 2.736 ± 0.84
2.315PheGly: 2.315 ± 0.632
0.842PheHis: 0.842 ± 0.448
2.525PheIle: 2.525 ± 0.787
2.104PheLys: 2.104 ± 0.583
4.419PheLeu: 4.419 ± 1.267
1.263PheMet: 1.263 ± 0.602
1.473PheAsn: 1.473 ± 0.504
1.684PhePro: 1.684 ± 0.482
1.052PheGln: 1.052 ± 0.558
1.684PheArg: 1.684 ± 0.553
4.63PheSer: 4.63 ± 1.043
3.577PheThr: 3.577 ± 0.806
3.788PheVal: 3.788 ± 1.13
0.631PheTrp: 0.631 ± 0.289
5.051PheTyr: 5.051 ± 0.959
0.0PheXaa: 0.0 ± 0.0
Gly
2.104GlyAla: 2.104 ± 0.751
0.0GlyCys: 0.0 ± 0.0
2.104GlyAsp: 2.104 ± 0.598
1.473GlyGlu: 1.473 ± 0.597
4.84GlyPhe: 4.84 ± 1.306
3.998GlyGly: 3.998 ± 1.012
0.631GlyHis: 0.631 ± 0.345
5.682GlyIle: 5.682 ± 1.039
4.419GlyLys: 4.419 ± 1.035
8.838GlyLeu: 8.838 ± 1.516
1.473GlyMet: 1.473 ± 0.523
2.525GlyAsn: 2.525 ± 0.547
2.104GlyPro: 2.104 ± 0.977
2.525GlyGln: 2.525 ± 1.092
2.946GlyArg: 2.946 ± 1.049
4.209GlySer: 4.209 ± 1.518
5.051GlyThr: 5.051 ± 1.198
4.209GlyVal: 4.209 ± 0.859
1.052GlyTrp: 1.052 ± 0.371
3.157GlyTyr: 3.157 ± 1.127
0.0GlyXaa: 0.0 ± 0.0
His
0.631HisAla: 0.631 ± 0.382
0.0HisCys: 0.0 ± 0.0
0.21HisAsp: 0.21 ± 0.19
1.052HisGlu: 1.052 ± 0.463
0.631HisPhe: 0.631 ± 0.364
1.052HisGly: 1.052 ± 0.484
0.21HisHis: 0.21 ± 0.213
0.421HisIle: 0.421 ± 0.28
0.842HisLys: 0.842 ± 0.439
1.052HisLeu: 1.052 ± 0.62
0.21HisMet: 0.21 ± 0.19
0.842HisAsn: 0.842 ± 0.541
0.421HisPro: 0.421 ± 0.278
0.21HisGln: 0.21 ± 0.25
0.631HisArg: 0.631 ± 0.39
0.421HisSer: 0.421 ± 0.35
0.631HisThr: 0.631 ± 0.309
0.631HisVal: 0.631 ± 0.372
0.0HisTrp: 0.0 ± 0.0
0.842HisTyr: 0.842 ± 0.364
0.0HisXaa: 0.0 ± 0.0
Ile
3.998IleAla: 3.998 ± 1.037
0.631IleCys: 0.631 ± 0.434
1.894IleAsp: 1.894 ± 0.546
4.419IleGlu: 4.419 ± 1.284
5.682IlePhe: 5.682 ± 1.055
4.63IleGly: 4.63 ± 1.292
1.052IleHis: 1.052 ± 0.573
8.418IleIle: 8.418 ± 1.601
4.63IleLys: 4.63 ± 1.478
9.47IleLeu: 9.47 ± 1.56
1.684IleMet: 1.684 ± 0.587
3.788IleAsn: 3.788 ± 1.183
4.209IlePro: 4.209 ± 0.9
2.104IleGln: 2.104 ± 0.636
5.051IleArg: 5.051 ± 1.379
5.682IleSer: 5.682 ± 1.125
5.892IleThr: 5.892 ± 1.652
5.682IleVal: 5.682 ± 1.307
0.842IleTrp: 0.842 ± 0.414
4.419IleTyr: 4.419 ± 0.83
0.0IleXaa: 0.0 ± 0.0
Lys
3.157LysAla: 3.157 ± 0.768
0.631LysCys: 0.631 ± 0.355
1.894LysAsp: 1.894 ± 0.767
8.207LysGlu: 8.207 ± 2.047
2.946LysPhe: 2.946 ± 0.838
3.998LysGly: 3.998 ± 0.894
0.842LysHis: 0.842 ± 0.391
7.576LysIle: 7.576 ± 2.079
6.944LysLys: 6.944 ± 2.065
9.47LysLeu: 9.47 ± 1.905
2.315LysMet: 2.315 ± 0.619
3.157LysAsn: 3.157 ± 0.785
2.104LysPro: 2.104 ± 0.768
2.315LysGln: 2.315 ± 0.875
1.894LysArg: 1.894 ± 0.789
4.209LysSer: 4.209 ± 1.496
3.998LysThr: 3.998 ± 0.911
3.157LysVal: 3.157 ± 0.836
1.052LysTrp: 1.052 ± 0.419
3.788LysTyr: 3.788 ± 1.176
0.0LysXaa: 0.0 ± 0.0
Leu
4.209LeuAla: 4.209 ± 0.772
0.842LeuCys: 0.842 ± 0.547
3.577LeuAsp: 3.577 ± 1.154
4.419LeuGlu: 4.419 ± 1.315
5.682LeuPhe: 5.682 ± 1.428
7.576LeuGly: 7.576 ± 1.271
0.842LeuHis: 0.842 ± 0.397
10.311LeuIle: 10.311 ± 1.838
6.103LeuLys: 6.103 ± 1.475
12.837LeuLeu: 12.837 ± 2.208
2.315LeuMet: 2.315 ± 0.645
7.576LeuAsn: 7.576 ± 1.598
5.261LeuPro: 5.261 ± 0.9
3.998LeuGln: 3.998 ± 0.94
4.63LeuArg: 4.63 ± 1.525
5.892LeuSer: 5.892 ± 1.337
8.628LeuThr: 8.628 ± 1.168
9.049LeuVal: 9.049 ± 1.998
1.894LeuTrp: 1.894 ± 0.697
5.261LeuTyr: 5.261 ± 1.043
0.0LeuXaa: 0.0 ± 0.0
Met
0.842MetAla: 0.842 ± 0.387
0.0MetCys: 0.0 ± 0.0
0.842MetAsp: 0.842 ± 0.583
1.684MetGlu: 1.684 ± 0.556
0.421MetPhe: 0.421 ± 0.301
2.736MetGly: 2.736 ± 0.79
0.21MetHis: 0.21 ± 0.19
1.052MetIle: 1.052 ± 0.472
2.315MetLys: 2.315 ± 0.771
2.525MetLeu: 2.525 ± 0.813
1.263MetMet: 1.263 ± 0.615
0.631MetAsn: 0.631 ± 0.324
0.842MetPro: 0.842 ± 0.289
0.842MetGln: 0.842 ± 0.371
1.473MetArg: 1.473 ± 0.553
1.263MetSer: 1.263 ± 0.5
2.104MetThr: 2.104 ± 0.676
1.473MetVal: 1.473 ± 0.587
0.421MetTrp: 0.421 ± 0.314
0.631MetTyr: 0.631 ± 0.393
0.0MetXaa: 0.0 ± 0.0
Asn
2.946AsnAla: 2.946 ± 0.563
0.631AsnCys: 0.631 ± 0.395
2.525AsnAsp: 2.525 ± 0.816
2.104AsnGlu: 2.104 ± 0.865
2.525AsnPhe: 2.525 ± 0.685
4.84AsnGly: 4.84 ± 1.224
0.21AsnHis: 0.21 ± 0.19
5.051AsnIle: 5.051 ± 1.114
3.577AsnLys: 3.577 ± 0.83
3.788AsnLeu: 3.788 ± 1.093
0.631AsnMet: 0.631 ± 0.328
5.051AsnAsn: 5.051 ± 0.913
2.946AsnPro: 2.946 ± 0.768
1.473AsnGln: 1.473 ± 0.889
1.473AsnArg: 1.473 ± 0.627
2.736AsnSer: 2.736 ± 1.097
3.577AsnThr: 3.577 ± 1.003
3.998AsnVal: 3.998 ± 1.804
0.631AsnTrp: 0.631 ± 0.28
4.419AsnTyr: 4.419 ± 0.843
0.0AsnXaa: 0.0 ± 0.0
Pro
2.946ProAla: 2.946 ± 0.574
0.0ProCys: 0.0 ± 0.0
2.104ProAsp: 2.104 ± 0.758
0.842ProGlu: 0.842 ± 0.426
2.525ProPhe: 2.525 ± 0.676
2.104ProGly: 2.104 ± 0.69
1.052ProHis: 1.052 ± 0.432
1.684ProIle: 1.684 ± 0.52
3.577ProLys: 3.577 ± 1.091
2.736ProLeu: 2.736 ± 0.891
0.421ProMet: 0.421 ± 0.282
2.525ProAsn: 2.525 ± 0.73
4.419ProPro: 4.419 ± 1.523
1.473ProGln: 1.473 ± 0.513
1.052ProArg: 1.052 ± 0.565
2.525ProSer: 2.525 ± 1.092
2.736ProThr: 2.736 ± 1.003
2.946ProVal: 2.946 ± 0.878
0.842ProTrp: 0.842 ± 0.556
2.736ProTyr: 2.736 ± 0.879
0.0ProXaa: 0.0 ± 0.0
Gln
1.052GlnAla: 1.052 ± 0.417
0.21GlnCys: 0.21 ± 0.2
0.631GlnAsp: 0.631 ± 0.397
1.473GlnGlu: 1.473 ± 0.652
1.473GlnPhe: 1.473 ± 0.855
1.263GlnGly: 1.263 ± 0.402
0.421GlnHis: 0.421 ± 0.27
2.946GlnIle: 2.946 ± 0.717
1.894GlnLys: 1.894 ± 0.814
3.998GlnLeu: 3.998 ± 0.894
0.421GlnMet: 0.421 ± 0.361
2.525GlnAsn: 2.525 ± 0.808
1.894GlnPro: 1.894 ± 0.815
0.631GlnGln: 0.631 ± 0.385
0.631GlnArg: 0.631 ± 0.331
2.525GlnSer: 2.525 ± 0.74
2.525GlnThr: 2.525 ± 0.694
2.525GlnVal: 2.525 ± 1.143
0.421GlnTrp: 0.421 ± 0.257
1.263GlnTyr: 1.263 ± 0.653
0.0GlnXaa: 0.0 ± 0.0
Arg
0.842ArgAla: 0.842 ± 0.463
0.631ArgCys: 0.631 ± 0.375
0.842ArgAsp: 0.842 ± 0.38
3.367ArgGlu: 3.367 ± 1.116
0.631ArgPhe: 0.631 ± 0.53
2.946ArgGly: 2.946 ± 0.87
0.842ArgHis: 0.842 ± 0.471
2.946ArgIle: 2.946 ± 0.947
4.419ArgLys: 4.419 ± 1.123
2.525ArgLeu: 2.525 ± 0.804
1.052ArgMet: 1.052 ± 0.517
2.525ArgAsn: 2.525 ± 0.652
0.842ArgPro: 0.842 ± 0.434
1.684ArgGln: 1.684 ± 0.559
2.525ArgArg: 2.525 ± 1.026
1.473ArgSer: 1.473 ± 0.557
1.052ArgThr: 1.052 ± 0.496
3.788ArgVal: 3.788 ± 1.307
0.21ArgTrp: 0.21 ± 0.231
1.894ArgTyr: 1.894 ± 1.12
0.0ArgXaa: 0.0 ± 0.0
Ser
3.998SerAla: 3.998 ± 0.835
0.21SerCys: 0.21 ± 0.214
1.473SerAsp: 1.473 ± 0.426
4.419SerGlu: 4.419 ± 1.293
2.736SerPhe: 2.736 ± 0.626
5.892SerGly: 5.892 ± 1.189
0.842SerHis: 0.842 ± 0.421
5.892SerIle: 5.892 ± 1.739
5.892SerLys: 5.892 ± 1.428
6.103SerLeu: 6.103 ± 1.101
0.842SerMet: 0.842 ± 0.47
4.419SerAsn: 4.419 ± 0.829
2.315SerPro: 2.315 ± 0.737
2.315SerGln: 2.315 ± 0.68
1.473SerArg: 1.473 ± 0.722
5.471SerSer: 5.471 ± 1.576
3.157SerThr: 3.157 ± 1.607
5.051SerVal: 5.051 ± 1.407
1.052SerTrp: 1.052 ± 0.429
3.788SerTyr: 3.788 ± 1.097
0.0SerXaa: 0.0 ± 0.0
Thr
3.998ThrAla: 3.998 ± 1.395
0.21ThrCys: 0.21 ± 0.192
1.052ThrAsp: 1.052 ± 0.429
4.209ThrGlu: 4.209 ± 1.177
2.736ThrPhe: 2.736 ± 0.803
3.367ThrGly: 3.367 ± 1.115
0.631ThrHis: 0.631 ± 0.404
5.682ThrIle: 5.682 ± 1.649
3.788ThrLys: 3.788 ± 0.998
8.207ThrLeu: 8.207 ± 1.51
1.263ThrMet: 1.263 ± 0.513
3.367ThrAsn: 3.367 ± 0.91
2.525ThrPro: 2.525 ± 0.921
2.525ThrGln: 2.525 ± 0.835
2.104ThrArg: 2.104 ± 0.638
4.209ThrSer: 4.209 ± 1.153
3.998ThrThr: 3.998 ± 1.398
4.84ThrVal: 4.84 ± 1.095
0.842ThrTrp: 0.842 ± 0.39
3.157ThrTyr: 3.157 ± 0.743
0.0ThrXaa: 0.0 ± 0.0
Val
3.157ValAla: 3.157 ± 0.886
0.631ValCys: 0.631 ± 0.577
1.894ValAsp: 1.894 ± 0.67
5.051ValGlu: 5.051 ± 1.777
1.684ValPhe: 1.684 ± 0.516
4.209ValGly: 4.209 ± 1.052
0.21ValHis: 0.21 ± 0.19
5.051ValIle: 5.051 ± 1.184
4.84ValLys: 4.84 ± 1.133
8.207ValLeu: 8.207 ± 1.186
2.104ValMet: 2.104 ± 0.61
4.84ValAsn: 4.84 ± 1.114
2.315ValPro: 2.315 ± 0.824
1.473ValGln: 1.473 ± 1.032
1.894ValArg: 1.894 ± 0.776
8.418ValSer: 8.418 ± 1.583
5.261ValThr: 5.261 ± 1.3
4.84ValVal: 4.84 ± 1.264
1.684ValTrp: 1.684 ± 0.91
4.63ValTyr: 4.63 ± 1.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.842TrpAla: 0.842 ± 0.52
0.21TrpCys: 0.21 ± 0.214
0.631TrpAsp: 0.631 ± 0.362
0.421TrpGlu: 0.421 ± 0.279
1.263TrpPhe: 1.263 ± 0.44
1.263TrpGly: 1.263 ± 0.535
0.0TrpHis: 0.0 ± 0.0
0.631TrpIle: 0.631 ± 0.372
0.631TrpLys: 0.631 ± 0.314
2.946TrpLeu: 2.946 ± 0.749
0.21TrpMet: 0.21 ± 0.231
0.0TrpAsn: 0.0 ± 0.0
0.21TrpPro: 0.21 ± 0.226
0.21TrpGln: 0.21 ± 0.193
0.631TrpArg: 0.631 ± 0.335
0.421TrpSer: 0.421 ± 0.261
1.473TrpThr: 1.473 ± 0.635
1.052TrpVal: 1.052 ± 0.477
0.0TrpTrp: 0.0 ± 0.0
1.684TrpTyr: 1.684 ± 0.674
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.419TyrAla: 4.419 ± 1.082
0.21TyrCys: 0.21 ± 0.231
2.104TyrAsp: 2.104 ± 0.775
2.736TyrGlu: 2.736 ± 0.887
2.736TyrPhe: 2.736 ± 0.75
3.157TyrGly: 3.157 ± 0.896
0.21TyrHis: 0.21 ± 0.251
4.63TyrIle: 4.63 ± 0.893
3.998TyrLys: 3.998 ± 1.197
6.944TyrLeu: 6.944 ± 0.94
1.684TyrMet: 1.684 ± 0.623
3.788TyrAsn: 3.788 ± 1.351
2.315TyrPro: 2.315 ± 0.996
1.684TyrGln: 1.684 ± 0.501
1.684TyrArg: 1.684 ± 0.59
3.157TyrSer: 3.157 ± 0.92
3.157TyrThr: 3.157 ± 1.052
4.84TyrVal: 4.84 ± 0.97
1.263TyrTrp: 1.263 ± 0.51
3.367TyrTyr: 3.367 ± 1.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 31 proteins (4753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski