Amino acid dipepetide frequency for Alphaproteobacteria bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.201AlaAla: 17.201 ± 0.155
1.267AlaCys: 1.267 ± 0.033
7.093AlaAsp: 7.093 ± 0.067
7.161AlaGlu: 7.161 ± 0.088
4.718AlaPhe: 4.718 ± 0.058
10.689AlaGly: 10.689 ± 0.093
2.158AlaHis: 2.158 ± 0.039
6.273AlaIle: 6.273 ± 0.067
5.335AlaLys: 5.335 ± 0.08
12.096AlaLeu: 12.096 ± 0.103
3.624AlaMet: 3.624 ± 0.055
3.545AlaAsn: 3.545 ± 0.052
6.598AlaPro: 6.598 ± 0.092
4.262AlaGln: 4.262 ± 0.06
8.146AlaArg: 8.146 ± 0.094
7.263AlaSer: 7.263 ± 0.077
6.449AlaThr: 6.449 ± 0.072
8.171AlaVal: 8.171 ± 0.074
1.649AlaTrp: 1.649 ± 0.034
2.677AlaTyr: 2.677 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
1.037CysAla: 1.037 ± 0.028
0.087CysCys: 0.087 ± 0.009
0.468CysAsp: 0.468 ± 0.017
0.413CysGlu: 0.413 ± 0.019
0.292CysPhe: 0.292 ± 0.015
0.779CysGly: 0.779 ± 0.025
0.212CysHis: 0.212 ± 0.012
0.388CysIle: 0.388 ± 0.017
0.228CysLys: 0.228 ± 0.013
0.65CysLeu: 0.65 ± 0.02
0.147CysMet: 0.147 ± 0.009
0.222CysAsn: 0.222 ± 0.012
0.395CysPro: 0.395 ± 0.017
0.2CysGln: 0.2 ± 0.011
0.493CysArg: 0.493 ± 0.02
0.474CysSer: 0.474 ± 0.017
0.426CysThr: 0.426 ± 0.016
0.647CysVal: 0.647 ± 0.02
0.113CysTrp: 0.113 ± 0.008
0.176CysTyr: 0.176 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.286AspAla: 7.286 ± 0.062
0.416AspCys: 0.416 ± 0.017
3.175AspAsp: 3.175 ± 0.06
3.305AspGlu: 3.305 ± 0.049
2.209AspPhe: 2.209 ± 0.044
5.327AspGly: 5.327 ± 0.065
1.147AspHis: 1.147 ± 0.027
2.998AspIle: 2.998 ± 0.043
2.284AspLys: 2.284 ± 0.043
5.517AspLeu: 5.517 ± 0.066
1.396AspMet: 1.396 ± 0.035
1.425AspAsn: 1.425 ± 0.034
3.582AspPro: 3.582 ± 0.053
1.857AspGln: 1.857 ± 0.039
3.936AspArg: 3.936 ± 0.055
2.092AspSer: 2.092 ± 0.032
2.942AspThr: 2.942 ± 0.054
4.319AspVal: 4.319 ± 0.055
1.028AspTrp: 1.028 ± 0.029
1.518AspTyr: 1.518 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
7.845GluAla: 7.845 ± 0.092
0.308GluCys: 0.308 ± 0.011
2.752GluAsp: 2.752 ± 0.047
2.964GluGlu: 2.964 ± 0.054
1.827GluPhe: 1.827 ± 0.037
4.337GluGly: 4.337 ± 0.049
1.121GluHis: 1.121 ± 0.028
3.27GluIle: 3.27 ± 0.047
2.539GluLys: 2.539 ± 0.045
5.278GluLeu: 5.278 ± 0.062
1.53GluMet: 1.53 ± 0.032
1.513GluAsn: 1.513 ± 0.028
2.652GluPro: 2.652 ± 0.047
2.183GluGln: 2.183 ± 0.04
4.438GluArg: 4.438 ± 0.061
2.29GluSer: 2.29 ± 0.04
3.73GluThr: 3.73 ± 0.052
3.598GluVal: 3.598 ± 0.058
0.809GluTrp: 0.809 ± 0.024
1.108GluTyr: 1.108 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.789PheAla: 4.789 ± 0.059
0.36PheCys: 0.36 ± 0.016
2.703PheAsp: 2.703 ± 0.047
2.232PheGlu: 2.232 ± 0.04
1.45PhePhe: 1.45 ± 0.036
3.765PheGly: 3.765 ± 0.054
0.709PheHis: 0.709 ± 0.02
1.763PheIle: 1.763 ± 0.041
1.197PheLys: 1.197 ± 0.032
2.996PheLeu: 2.996 ± 0.051
0.903PheMet: 0.903 ± 0.025
1.278PheAsn: 1.278 ± 0.033
1.531PhePro: 1.531 ± 0.031
0.972PheGln: 0.972 ± 0.029
2.056PheArg: 2.056 ± 0.042
2.181PheSer: 2.181 ± 0.041
2.166PheThr: 2.166 ± 0.037
2.741PheVal: 2.741 ± 0.049
0.603PheTrp: 0.603 ± 0.024
0.917PheTyr: 0.917 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.099GlyAla: 10.099 ± 0.092
0.734GlyCys: 0.734 ± 0.024
4.87GlyAsp: 4.87 ± 0.063
4.905GlyGlu: 4.905 ± 0.054
3.728GlyPhe: 3.728 ± 0.061
7.862GlyGly: 7.862 ± 0.096
1.618GlyHis: 1.618 ± 0.036
3.867GlyIle: 3.867 ± 0.057
4.052GlyLys: 4.052 ± 0.06
8.137GlyLeu: 8.137 ± 0.077
2.405GlyMet: 2.405 ± 0.045
2.166GlyAsn: 2.166 ± 0.053
3.872GlyPro: 3.872 ± 0.054
2.964GlyGln: 2.964 ± 0.05
5.495GlyArg: 5.495 ± 0.062
4.563GlySer: 4.563 ± 0.067
3.821GlyThr: 3.821 ± 0.057
6.917GlyVal: 6.917 ± 0.079
1.587GlyTrp: 1.587 ± 0.037
2.328GlyTyr: 2.328 ± 0.046
0.001GlyXaa: 0.001 ± 0.001
His
2.274HisAla: 2.274 ± 0.037
0.186HisCys: 0.186 ± 0.011
1.091HisAsp: 1.091 ± 0.025
1.011HisGlu: 1.011 ± 0.027
0.698HisPhe: 0.698 ± 0.022
1.655HisGly: 1.655 ± 0.031
0.448HisHis: 0.448 ± 0.018
0.922HisIle: 0.922 ± 0.025
0.588HisLys: 0.588 ± 0.02
1.648HisLeu: 1.648 ± 0.035
0.512HisMet: 0.512 ± 0.02
0.487HisAsn: 0.487 ± 0.018
1.216HisPro: 1.216 ± 0.031
0.539HisGln: 0.539 ± 0.019
1.248HisArg: 1.248 ± 0.029
0.867HisSer: 0.867 ± 0.027
0.908HisThr: 0.908 ± 0.023
1.39HisVal: 1.39 ± 0.032
0.345HisTrp: 0.345 ± 0.015
0.503HisTyr: 0.503 ± 0.019
0.001HisXaa: 0.001 ± 0.001
Ile
7.261IleAla: 7.261 ± 0.071
0.417IleCys: 0.417 ± 0.018
3.554IleAsp: 3.554 ± 0.049
3.39IleGlu: 3.39 ± 0.046
1.672IlePhe: 1.672 ± 0.036
4.754IleGly: 4.754 ± 0.064
0.923IleHis: 0.923 ± 0.028
2.306IleIle: 2.306 ± 0.047
1.605IleLys: 1.605 ± 0.035
3.899IleLeu: 3.899 ± 0.053
1.045IleMet: 1.045 ± 0.026
1.589IleAsn: 1.589 ± 0.035
2.302IlePro: 2.302 ± 0.043
1.304IleGln: 1.304 ± 0.032
2.992IleArg: 2.992 ± 0.042
2.935IleSer: 2.935 ± 0.049
2.841IleThr: 2.841 ± 0.046
4.053IleVal: 4.053 ± 0.068
0.659IleTrp: 0.659 ± 0.021
1.169IleTyr: 1.169 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
5.183LysAla: 5.183 ± 0.067
0.194LysCys: 0.194 ± 0.011
2.245LysAsp: 2.245 ± 0.04
1.987LysGlu: 1.987 ± 0.043
1.285LysPhe: 1.285 ± 0.029
3.141LysGly: 3.141 ± 0.056
0.719LysHis: 0.719 ± 0.022
1.823LysIle: 1.823 ± 0.04
1.75LysLys: 1.75 ± 0.046
4.253LysLeu: 4.253 ± 0.061
0.952LysMet: 0.952 ± 0.027
1.003LysAsn: 1.003 ± 0.028
2.844LysPro: 2.844 ± 0.056
1.307LysGln: 1.307 ± 0.034
2.902LysArg: 2.902 ± 0.046
2.332LysSer: 2.332 ± 0.038
2.38LysThr: 2.38 ± 0.044
2.842LysVal: 2.842 ± 0.049
0.537LysTrp: 0.537 ± 0.02
0.788LysTyr: 0.788 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
12.44LeuAla: 12.44 ± 0.116
0.727LeuCys: 0.727 ± 0.023
5.544LeuAsp: 5.544 ± 0.06
5.024LeuGlu: 5.024 ± 0.07
3.133LeuPhe: 3.133 ± 0.05
7.744LeuGly: 7.744 ± 0.082
1.581LeuHis: 1.581 ± 0.032
4.765LeuIle: 4.765 ± 0.072
4.124LeuLys: 4.124 ± 0.056
7.79LeuLeu: 7.79 ± 0.095
2.281LeuMet: 2.281 ± 0.044
2.837LeuAsn: 2.837 ± 0.051
4.889LeuPro: 4.889 ± 0.065
2.741LeuGln: 2.741 ± 0.047
5.816LeuArg: 5.816 ± 0.068
5.897LeuSer: 5.897 ± 0.075
5.318LeuThr: 5.318 ± 0.061
6.689LeuVal: 6.689 ± 0.072
1.097LeuTrp: 1.097 ± 0.03
1.89LeuTyr: 1.89 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.287MetAla: 3.287 ± 0.049
0.184MetCys: 0.184 ± 0.013
1.269MetAsp: 1.269 ± 0.026
1.162MetGlu: 1.162 ± 0.029
0.855MetPhe: 0.855 ± 0.025
1.909MetGly: 1.909 ± 0.037
0.438MetHis: 0.438 ± 0.016
1.429MetIle: 1.429 ± 0.036
1.297MetLys: 1.297 ± 0.033
2.552MetLeu: 2.552 ± 0.042
0.777MetMet: 0.777 ± 0.026
0.786MetAsn: 0.786 ± 0.023
1.446MetPro: 1.446 ± 0.029
0.808MetGln: 0.808 ± 0.021
1.896MetArg: 1.896 ± 0.035
1.802MetSer: 1.802 ± 0.036
1.906MetThr: 1.906 ± 0.039
1.556MetVal: 1.556 ± 0.034
0.264MetTrp: 0.264 ± 0.016
0.343MetTyr: 0.343 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.697AsnAla: 3.697 ± 0.059
0.253AsnCys: 0.253 ± 0.013
1.567AsnAsp: 1.567 ± 0.036
1.359AsnGlu: 1.359 ± 0.033
1.066AsnPhe: 1.066 ± 0.025
2.776AsnGly: 2.776 ± 0.056
0.514AsnHis: 0.514 ± 0.02
1.493AsnIle: 1.493 ± 0.034
0.913AsnLys: 0.913 ± 0.025
2.627AsnLeu: 2.627 ± 0.043
0.649AsnMet: 0.649 ± 0.023
0.88AsnAsn: 0.88 ± 0.03
1.976AsnPro: 1.976 ± 0.035
0.849AsnGln: 0.849 ± 0.028
1.685AsnArg: 1.685 ± 0.034
1.401AsnSer: 1.401 ± 0.038
1.546AsnThr: 1.546 ± 0.039
2.166AsnVal: 2.166 ± 0.049
0.474AsnTrp: 0.474 ± 0.018
0.807AsnTyr: 0.807 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.812ProAla: 6.812 ± 0.089
0.281ProCys: 0.281 ± 0.013
3.592ProAsp: 3.592 ± 0.049
3.75ProGlu: 3.75 ± 0.056
1.948ProPhe: 1.948 ± 0.037
4.621ProGly: 4.621 ± 0.065
1.013ProHis: 1.013 ± 0.031
2.433ProIle: 2.433 ± 0.042
2.32ProLys: 2.32 ± 0.041
4.307ProLeu: 4.307 ± 0.057
1.33ProMet: 1.33 ± 0.029
1.715ProAsn: 1.715 ± 0.037
3.012ProPro: 3.012 ± 0.067
1.639ProGln: 1.639 ± 0.036
2.733ProArg: 2.733 ± 0.048
2.894ProSer: 2.894 ± 0.042
2.895ProThr: 2.895 ± 0.045
4.209ProVal: 4.209 ± 0.055
0.724ProTrp: 0.724 ± 0.023
1.186ProTyr: 1.186 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.859GlnAla: 3.859 ± 0.049
0.209GlnCys: 0.209 ± 0.014
1.463GlnAsp: 1.463 ± 0.031
1.443GlnGlu: 1.443 ± 0.035
1.161GlnPhe: 1.161 ± 0.029
2.443GlnGly: 2.443 ± 0.044
0.608GlnHis: 0.608 ± 0.022
1.835GlnIle: 1.835 ± 0.051
1.275GlnLys: 1.275 ± 0.029
3.134GlnLeu: 3.134 ± 0.054
0.954GlnMet: 0.954 ± 0.028
0.838GlnAsn: 0.838 ± 0.026
1.888GlnPro: 1.888 ± 0.04
1.29GlnGln: 1.29 ± 0.04
2.386GlnArg: 2.386 ± 0.042
1.757GlnSer: 1.757 ± 0.041
1.979GlnThr: 1.979 ± 0.039
2.334GlnVal: 2.334 ± 0.047
0.428GlnTrp: 0.428 ± 0.017
0.672GlnTyr: 0.672 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
7.458ArgAla: 7.458 ± 0.096
0.464ArgCys: 0.464 ± 0.015
3.773ArgAsp: 3.773 ± 0.065
4.007ArgGlu: 4.007 ± 0.056
2.625ArgPhe: 2.625 ± 0.042
4.631ArgGly: 4.631 ± 0.053
1.328ArgHis: 1.328 ± 0.032
3.773ArgIle: 3.773 ± 0.053
2.679ArgLys: 2.679 ± 0.043
6.707ArgLeu: 6.707 ± 0.064
1.902ArgMet: 1.902 ± 0.035
1.904ArgAsn: 1.904 ± 0.039
3.302ArgPro: 3.302 ± 0.047
2.175ArgGln: 2.175 ± 0.035
4.656ArgArg: 4.656 ± 0.073
3.505ArgSer: 3.505 ± 0.053
3.542ArgThr: 3.542 ± 0.049
4.75ArgVal: 4.75 ± 0.054
1.021ArgTrp: 1.021 ± 0.026
1.606ArgTyr: 1.606 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
6.576SerAla: 6.576 ± 0.076
0.431SerCys: 0.431 ± 0.017
3.098SerAsp: 3.098 ± 0.044
2.88SerGlu: 2.88 ± 0.041
2.207SerPhe: 2.207 ± 0.043
5.458SerGly: 5.458 ± 0.065
0.993SerHis: 0.993 ± 0.029
2.763SerIle: 2.763 ± 0.05
1.947SerLys: 1.947 ± 0.037
5.261SerLeu: 5.261 ± 0.061
1.412SerMet: 1.412 ± 0.033
1.566SerAsn: 1.566 ± 0.036
3.155SerPro: 3.155 ± 0.046
1.755SerGln: 1.755 ± 0.034
3.605SerArg: 3.605 ± 0.057
3.086SerSer: 3.086 ± 0.051
3.034SerThr: 3.034 ± 0.052
3.824SerVal: 3.824 ± 0.053
0.835SerTrp: 0.835 ± 0.025
1.328SerTyr: 1.328 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.291ThrAla: 6.291 ± 0.068
0.402ThrCys: 0.402 ± 0.017
3.062ThrAsp: 3.062 ± 0.046
2.724ThrGlu: 2.724 ± 0.039
2.185ThrPhe: 2.185 ± 0.04
5.357ThrGly: 5.357 ± 0.074
1.032ThrHis: 1.032 ± 0.025
2.725ThrIle: 2.725 ± 0.045
1.911ThrLys: 1.911 ± 0.038
5.394ThrLeu: 5.394 ± 0.062
1.283ThrMet: 1.283 ± 0.032
1.555ThrAsn: 1.555 ± 0.039
3.953ThrPro: 3.953 ± 0.054
1.813ThrGln: 1.813 ± 0.069
3.532ThrArg: 3.532 ± 0.053
3.24ThrSer: 3.24 ± 0.049
3.085ThrThr: 3.085 ± 0.066
3.965ThrVal: 3.965 ± 0.051
0.757ThrTrp: 0.757 ± 0.022
1.356ThrTyr: 1.356 ± 0.03
0.001ThrXaa: 0.001 ± 0.001
Val
8.907ValAla: 8.907 ± 0.084
0.614ValCys: 0.614 ± 0.021
4.238ValAsp: 4.238 ± 0.055
4.436ValGlu: 4.436 ± 0.061
2.749ValPhe: 2.749 ± 0.043
5.623ValGly: 5.623 ± 0.067
1.231ValHis: 1.231 ± 0.032
4.061ValIle: 4.061 ± 0.057
3.042ValLys: 3.042 ± 0.053
6.508ValLeu: 6.508 ± 0.064
1.966ValMet: 1.966 ± 0.037
2.109ValAsn: 2.109 ± 0.047
3.059ValPro: 3.059 ± 0.046
2.096ValGln: 2.096 ± 0.034
4.799ValArg: 4.799 ± 0.061
4.347ValSer: 4.347 ± 0.05
4.468ValThr: 4.468 ± 0.06
5.772ValVal: 5.772 ± 0.079
1.032ValTrp: 1.032 ± 0.027
1.56ValTyr: 1.56 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.406TrpAla: 1.406 ± 0.035
0.121TrpCys: 0.121 ± 0.009
0.709TrpAsp: 0.709 ± 0.021
0.61TrpGlu: 0.61 ± 0.02
0.58TrpPhe: 0.58 ± 0.02
1.021TrpGly: 1.021 ± 0.032
0.282TrpHis: 0.282 ± 0.015
0.789TrpIle: 0.789 ± 0.024
0.643TrpLys: 0.643 ± 0.021
1.567TrpLeu: 1.567 ± 0.033
0.45TrpMet: 0.45 ± 0.022
0.509TrpAsn: 0.509 ± 0.019
0.678TrpPro: 0.678 ± 0.026
0.477TrpGln: 0.477 ± 0.017
1.321TrpArg: 1.321 ± 0.034
0.945TrpSer: 0.945 ± 0.026
0.936TrpThr: 0.936 ± 0.025
0.969TrpVal: 0.969 ± 0.031
0.258TrpTrp: 0.258 ± 0.014
0.286TrpTyr: 0.286 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.667TyrAla: 2.667 ± 0.043
0.192TyrCys: 0.192 ± 0.013
1.493TyrAsp: 1.493 ± 0.034
1.328TyrGlu: 1.328 ± 0.028
0.923TyrPhe: 0.923 ± 0.027
2.102TyrGly: 2.102 ± 0.039
0.458TyrHis: 0.458 ± 0.016
0.996TyrIle: 0.996 ± 0.028
0.739TyrLys: 0.739 ± 0.022
2.006TyrLeu: 2.006 ± 0.039
0.448TyrMet: 0.448 ± 0.017
0.774TyrAsn: 0.774 ± 0.03
1.065TyrPro: 1.065 ± 0.027
0.724TyrGln: 0.724 ± 0.024
1.672TyrArg: 1.672 ± 0.032
1.344TyrSer: 1.344 ± 0.036
1.249TyrThr: 1.249 ± 0.037
1.703TyrVal: 1.703 ± 0.038
0.336TyrTrp: 0.336 ± 0.018
0.553TyrTyr: 0.553 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 5432 proteins (1485962 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski