Amino acid dipepetide frequency for Halomonas sp. TQ8S

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.679AlaAla: 10.679 ± 0.113	1.205AlaCys: 1.205 ± 0.028	5.376AlaAsp: 5.376 ± 0.068	6.862AlaGlu: 6.862 ± 0.087	3.894AlaPhe: 3.894 ± 0.055	8.041AlaGly: 8.041 ± 0.087	2.338AlaHis: 2.338 ± 0.036	5.35AlaIle: 5.35 ± 0.076	3.365AlaLys: 3.365 ± 0.059	13.151AlaLeu: 13.151 ± 0.14	3.294AlaMet: 3.294 ± 0.053	2.779AlaAsn: 2.779 ± 0.049	4.341AlaPro: 4.341 ± 0.077	4.487AlaGln: 4.487 ± 0.069	6.912AlaArg: 6.912 ± 0.081	6.091AlaSer: 6.091 ± 0.078	5.304AlaThr: 5.304 ± 0.077	7.103AlaVal: 7.103 ± 0.084	1.746AlaTrp: 1.746 ± 0.04	2.527AlaTyr: 2.527 ± 0.052	0.001AlaXaa: 0.001 ± 0.001
Cys	0.909CysAla: 0.909 ± 0.027	0.118CysCys: 0.118 ± 0.01	0.544CysAsp: 0.544 ± 0.019	0.578CysGlu: 0.578 ± 0.022	0.339CysPhe: 0.339 ± 0.017	0.897CysGly: 0.897 ± 0.031	0.383CysHis: 0.383 ± 0.02	0.408CysIle: 0.408 ± 0.018	0.274CysLys: 0.274 ± 0.016	1.076CysLeu: 1.076 ± 0.029	0.214CysMet: 0.214 ± 0.014	0.246CysAsn: 0.246 ± 0.014	0.506CysPro: 0.506 ± 0.021	0.429CysGln: 0.429 ± 0.017	0.739CysArg: 0.739 ± 0.026	0.489CysSer: 0.489 ± 0.02	0.422CysThr: 0.422 ± 0.016	0.696CysVal: 0.696 ± 0.024	0.131CysTrp: 0.131 ± 0.011	0.27CysTyr: 0.27 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.251AspAla: 6.251 ± 0.077	0.507AspCys: 0.507 ± 0.021	3.425AspAsp: 3.425 ± 0.055	3.768AspGlu: 3.768 ± 0.054	2.134AspPhe: 2.134 ± 0.043	4.112AspGly: 4.112 ± 0.06	1.353AspHis: 1.353 ± 0.035	3.274AspIle: 3.274 ± 0.055	1.889AspLys: 1.889 ± 0.043	5.24AspLeu: 5.24 ± 0.067	1.449AspMet: 1.449 ± 0.034	1.789AspAsn: 1.789 ± 0.038	2.817AspPro: 2.817 ± 0.051	2.159AspGln: 2.159 ± 0.041	3.203AspArg: 3.203 ± 0.051	2.887AspSer: 2.887 ± 0.056	3.135AspThr: 3.135 ± 0.055	3.808AspVal: 3.808 ± 0.053	0.966AspTrp: 0.966 ± 0.029	1.745AspTyr: 1.745 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.406GluAla: 7.406 ± 0.101	0.51GluCys: 0.51 ± 0.022	3.189GluAsp: 3.189 ± 0.058	4.146GluGlu: 4.146 ± 0.068	1.772GluPhe: 1.772 ± 0.043	4.737GluGly: 4.737 ± 0.063	1.756GluHis: 1.756 ± 0.04	3.313GluIle: 3.313 ± 0.063	2.526GluLys: 2.526 ± 0.05	6.691GluLeu: 6.691 ± 0.073	1.63GluMet: 1.63 ± 0.037	1.985GluAsn: 1.985 ± 0.039	2.703GluPro: 2.703 ± 0.046	3.579GluGln: 3.579 ± 0.066	5.483GluArg: 5.483 ± 0.063	3.508GluSer: 3.508 ± 0.05	3.599GluThr: 3.599 ± 0.052	4.6GluVal: 4.6 ± 0.065	0.883GluTrp: 0.883 ± 0.031	1.323GluTyr: 1.323 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.363PheAla: 3.363 ± 0.054	0.436PheCys: 0.436 ± 0.017	2.433PheAsp: 2.433 ± 0.049	2.179PheGlu: 2.179 ± 0.041	1.377PhePhe: 1.377 ± 0.034	2.85PheGly: 2.85 ± 0.043	0.914PheHis: 0.914 ± 0.028	1.821PheIle: 1.821 ± 0.039	1.098PheLys: 1.098 ± 0.032	3.241PheLeu: 3.241 ± 0.054	0.904PheMet: 0.904 ± 0.027	1.215PheAsn: 1.215 ± 0.032	1.514PhePro: 1.514 ± 0.03	1.321PheGln: 1.321 ± 0.032	1.95PheArg: 1.95 ± 0.035	2.479PheSer: 2.479 ± 0.049	1.955PheThr: 1.955 ± 0.046	2.346PheVal: 2.346 ± 0.047	0.525PheTrp: 0.525 ± 0.021	0.992PheTyr: 0.992 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.547GlyAla: 6.547 ± 0.081	0.906GlyCys: 0.906 ± 0.032	4.141GlyAsp: 4.141 ± 0.065	5.252GlyGlu: 5.252 ± 0.07	3.17GlyPhe: 3.17 ± 0.057	5.797GlyGly: 5.797 ± 0.091	1.912GlyHis: 1.912 ± 0.038	4.453GlyIle: 4.453 ± 0.066	3.146GlyLys: 3.146 ± 0.06	8.355GlyLeu: 8.355 ± 0.089	2.4GlyMet: 2.4 ± 0.05	2.285GlyAsn: 2.285 ± 0.051	2.44GlyPro: 2.44 ± 0.052	2.941GlyGln: 2.941 ± 0.046	4.996GlyArg: 4.996 ± 0.068	4.229GlySer: 4.229 ± 0.066	3.692GlyThr: 3.692 ± 0.054	5.782GlyVal: 5.782 ± 0.079	1.372GlyTrp: 1.372 ± 0.036	2.407GlyTyr: 2.407 ± 0.05	0.001GlyXaa: 0.001 ± 0.001
His	2.597HisAla: 2.597 ± 0.043	0.341HisCys: 0.341 ± 0.016	1.523HisAsp: 1.523 ± 0.033	1.524HisGlu: 1.524 ± 0.035	1.083HisPhe: 1.083 ± 0.029	2.07HisGly: 2.07 ± 0.043	0.81HisHis: 0.81 ± 0.026	1.04HisIle: 1.04 ± 0.027	0.7HisLys: 0.7 ± 0.024	2.791HisLeu: 2.791 ± 0.049	0.531HisMet: 0.531 ± 0.019	0.619HisAsn: 0.619 ± 0.024	1.571HisPro: 1.571 ± 0.038	1.293HisGln: 1.293 ± 0.032	1.717HisArg: 1.717 ± 0.034	1.293HisSer: 1.293 ± 0.034	1.081HisThr: 1.081 ± 0.028	1.448HisVal: 1.448 ± 0.035	0.494HisTrp: 0.494 ± 0.02	0.882HisTyr: 0.882 ± 0.027	0.001HisXaa: 0.001 ± 0.001
Ile	5.53IleAla: 5.53 ± 0.067	0.469IleCys: 0.469 ± 0.017	3.484IleAsp: 3.484 ± 0.053	3.806IleGlu: 3.806 ± 0.061	1.545IlePhe: 1.545 ± 0.035	4.008IleGly: 4.008 ± 0.061	1.151IleHis: 1.151 ± 0.032	2.244IleIle: 2.244 ± 0.046	1.728IleLys: 1.728 ± 0.04	4.209IleLeu: 4.209 ± 0.065	1.009IleMet: 1.009 ± 0.034	1.814IleAsn: 1.814 ± 0.038	2.337IlePro: 2.337 ± 0.046	1.743IleGln: 1.743 ± 0.037	3.091IleArg: 3.091 ± 0.047	3.114IleSer: 3.114 ± 0.051	2.921IleThr: 2.921 ± 0.036	3.221IleVal: 3.221 ± 0.067	0.527IleTrp: 0.527 ± 0.022	1.133IleTyr: 1.133 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.941LysAla: 3.941 ± 0.069	0.216LysCys: 0.216 ± 0.013	1.638LysAsp: 1.638 ± 0.047	1.917LysGlu: 1.917 ± 0.048	0.738LysPhe: 0.738 ± 0.025	2.595LysGly: 2.595 ± 0.051	0.818LysHis: 0.818 ± 0.026	1.444LysIle: 1.444 ± 0.039	1.487LysLys: 1.487 ± 0.043	3.332LysLeu: 3.332 ± 0.058	0.791LysMet: 0.791 ± 0.026	0.986LysAsn: 0.986 ± 0.033	1.822LysPro: 1.822 ± 0.041	1.598LysGln: 1.598 ± 0.039	2.904LysArg: 2.904 ± 0.051	1.863LysSer: 1.863 ± 0.041	1.876LysThr: 1.876 ± 0.044	2.388LysVal: 2.388 ± 0.044	0.361LysTrp: 0.361 ± 0.018	0.628LysTyr: 0.628 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	13.228LeuAla: 13.228 ± 0.137	1.108LeuCys: 1.108 ± 0.027	6.658LeuAsp: 6.658 ± 0.084	7.783LeuGlu: 7.783 ± 0.093	3.682LeuPhe: 3.682 ± 0.073	8.654LeuGly: 8.654 ± 0.097	2.554LeuHis: 2.554 ± 0.042	5.318LeuIle: 5.318 ± 0.076	4.075LeuLys: 4.075 ± 0.065	11.952LeuLeu: 11.952 ± 0.161	2.909LeuMet: 2.909 ± 0.055	3.338LeuAsn: 3.338 ± 0.055	6.064LeuPro: 6.064 ± 0.082	3.599LeuGln: 3.599 ± 0.057	6.716LeuArg: 6.716 ± 0.083	7.213LeuSer: 7.213 ± 0.082	5.795LeuThr: 5.795 ± 0.068	7.763LeuVal: 7.763 ± 0.096	1.405LeuTrp: 1.405 ± 0.046	2.43LeuTyr: 2.43 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.157MetAla: 3.157 ± 0.053	0.169MetCys: 0.169 ± 0.011	1.187MetAsp: 1.187 ± 0.034	1.336MetGlu: 1.336 ± 0.034	0.662MetPhe: 0.662 ± 0.021	1.928MetGly: 1.928 ± 0.051	0.6MetHis: 0.6 ± 0.022	1.273MetIle: 1.273 ± 0.038	0.872MetLys: 0.872 ± 0.026	3.034MetLeu: 3.034 ± 0.053	0.677MetMet: 0.677 ± 0.027	0.848MetAsn: 0.848 ± 0.026	1.53MetPro: 1.53 ± 0.04	1.187MetGln: 1.187 ± 0.035	1.684MetArg: 1.684 ± 0.033	1.756MetSer: 1.756 ± 0.036	1.626MetThr: 1.626 ± 0.039	1.784MetVal: 1.784 ± 0.042	0.21MetTrp: 0.21 ± 0.015	0.357MetTyr: 0.357 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.303AsnAla: 3.303 ± 0.045	0.235AsnCys: 0.235 ± 0.014	1.746AsnAsp: 1.746 ± 0.037	1.745AsnGlu: 1.745 ± 0.037	0.898AsnPhe: 0.898 ± 0.029	2.22AsnGly: 2.22 ± 0.044	0.744AsnHis: 0.744 ± 0.028	1.486AsnIle: 1.486 ± 0.034	0.847AsnLys: 0.847 ± 0.028	2.994AsnLeu: 2.994 ± 0.05	0.667AsnMet: 0.667 ± 0.022	0.916AsnAsn: 0.916 ± 0.032	1.842AsnPro: 1.842 ± 0.036	1.34AsnGln: 1.34 ± 0.037	2.022AsnArg: 2.022 ± 0.046	1.381AsnSer: 1.381 ± 0.036	1.498AsnThr: 1.498 ± 0.035	2.053AsnVal: 2.053 ± 0.045	0.422AsnTrp: 0.422 ± 0.017	0.725AsnTyr: 0.725 ± 0.026	0.001AsnXaa: 0.001 ± 0.001
Pro	4.844ProAla: 4.844 ± 0.075	0.376ProCys: 0.376 ± 0.017	3.229ProAsp: 3.229 ± 0.05	4.108ProGlu: 4.108 ± 0.062	1.719ProPhe: 1.719 ± 0.039	3.912ProGly: 3.912 ± 0.064	1.101ProHis: 1.101 ± 0.033	2.085ProIle: 2.085 ± 0.043	1.445ProLys: 1.445 ± 0.036	5.492ProLeu: 5.492 ± 0.07	1.226ProMet: 1.226 ± 0.029	1.301ProAsn: 1.301 ± 0.037	2.211ProPro: 2.211 ± 0.043	1.823ProGln: 1.823 ± 0.043	2.681ProArg: 2.681 ± 0.046	2.944ProSer: 2.944 ± 0.052	2.339ProThr: 2.339 ± 0.047	3.685ProVal: 3.685 ± 0.06	0.799ProTrp: 0.799 ± 0.027	1.071ProTyr: 1.071 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.842GlnAla: 5.842 ± 0.081	0.367GlnCys: 0.367 ± 0.016	1.946GlnAsp: 1.946 ± 0.046	2.543GlnGlu: 2.543 ± 0.051	1.14GlnPhe: 1.14 ± 0.029	3.539GlnGly: 3.539 ± 0.055	1.165GlnHis: 1.165 ± 0.033	1.678GlnIle: 1.678 ± 0.04	1.287GlnLys: 1.287 ± 0.031	4.803GlnLeu: 4.803 ± 0.077	0.97GlnMet: 0.97 ± 0.029	0.918GlnAsn: 0.918 ± 0.03	2.097GlnPro: 2.097 ± 0.045	2.672GlnGln: 2.672 ± 0.068	3.814GlnArg: 3.814 ± 0.061	2.174GlnSer: 2.174 ± 0.044	1.926GlnThr: 1.926 ± 0.041	3.124GlnVal: 3.124 ± 0.051	0.722GlnTrp: 0.722 ± 0.024	0.813GlnTyr: 0.813 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.64ArgAla: 5.64 ± 0.067	0.596ArgCys: 0.596 ± 0.021	3.98ArgAsp: 3.98 ± 0.062	4.883ArgGlu: 4.883 ± 0.059	2.941ArgPhe: 2.941 ± 0.046	4.023ArgGly: 4.023 ± 0.061	2.334ArgHis: 2.334 ± 0.048	3.353ArgIle: 3.353 ± 0.054	2.283ArgLys: 2.283 ± 0.053	9.08ArgLeu: 9.08 ± 0.124	1.663ArgMet: 1.663 ± 0.037	1.921ArgAsn: 1.921 ± 0.043	2.719ArgPro: 2.719 ± 0.043	3.66ArgGln: 3.66 ± 0.066	5.068ArgArg: 5.068 ± 0.085	3.253ArgSer: 3.253 ± 0.05	2.839ArgThr: 2.839 ± 0.046	4.43ArgVal: 4.43 ± 0.059	1.172ArgTrp: 1.172 ± 0.03	2.254ArgTyr: 2.254 ± 0.045	0.001ArgXaa: 0.001 ± 0.001
Ser	5.548SerAla: 5.548 ± 0.069	0.489SerCys: 0.489 ± 0.02	3.1SerAsp: 3.1 ± 0.049	3.399SerGlu: 3.399 ± 0.052	2.007SerPhe: 2.007 ± 0.041	4.893SerGly: 4.893 ± 0.072	1.494SerHis: 1.494 ± 0.034	2.741SerIle: 2.741 ± 0.051	1.658SerLys: 1.658 ± 0.038	6.833SerLeu: 6.833 ± 0.081	1.561SerMet: 1.561 ± 0.037	1.574SerAsn: 1.574 ± 0.035	2.976SerPro: 2.976 ± 0.056	2.63SerGln: 2.63 ± 0.049	4.245SerArg: 4.245 ± 0.062	3.408SerSer: 3.408 ± 0.062	2.81SerThr: 2.81 ± 0.051	3.854SerVal: 3.854 ± 0.059	0.849SerTrp: 0.849 ± 0.026	1.314SerTyr: 1.314 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.054ThrAla: 5.054 ± 0.063	0.449ThrCys: 0.449 ± 0.017	2.54ThrAsp: 2.54 ± 0.047	2.66ThrGlu: 2.66 ± 0.05	1.896ThrPhe: 1.896 ± 0.043	4.173ThrGly: 4.173 ± 0.059	1.392ThrHis: 1.392 ± 0.031	2.202ThrIle: 2.202 ± 0.04	1.176ThrLys: 1.176 ± 0.034	7.361ThrLeu: 7.361 ± 0.094	1.069ThrMet: 1.069 ± 0.032	1.278ThrAsn: 1.278 ± 0.034	3.525ThrPro: 3.525 ± 0.055	2.497ThrGln: 2.497 ± 0.046	3.359ThrArg: 3.359 ± 0.056	2.863ThrSer: 2.863 ± 0.048	2.763ThrThr: 2.763 ± 0.055	3.371ThrVal: 3.371 ± 0.063	0.716ThrTrp: 0.716 ± 0.024	1.13ThrTyr: 1.13 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	7.492ValAla: 7.492 ± 0.085	0.692ValCys: 0.692 ± 0.023	3.897ValAsp: 3.897 ± 0.051	4.792ValGlu: 4.792 ± 0.064	2.459ValPhe: 2.459 ± 0.052	4.936ValGly: 4.936 ± 0.064	1.439ValHis: 1.439 ± 0.039	3.986ValIle: 3.986 ± 0.056	2.348ValLys: 2.348 ± 0.044	7.347ValLeu: 7.347 ± 0.087	2.025ValMet: 2.025 ± 0.032	2.184ValAsn: 2.184 ± 0.046	3.253ValPro: 3.253 ± 0.046	2.284ValGln: 2.284 ± 0.038	4.087ValArg: 4.087 ± 0.052	4.3ValSer: 4.3 ± 0.061	4.148ValThr: 4.148 ± 0.053	5.644ValVal: 5.644 ± 0.083	0.841ValTrp: 0.841 ± 0.03	1.562ValTyr: 1.562 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.133TrpAla: 1.133 ± 0.029	0.159TrpCys: 0.159 ± 0.011	0.602TrpAsp: 0.602 ± 0.021	0.776TrpGlu: 0.776 ± 0.025	0.528TrpPhe: 0.528 ± 0.025	0.898TrpGly: 0.898 ± 0.027	0.467TrpHis: 0.467 ± 0.017	0.649TrpIle: 0.649 ± 0.024	0.466TrpLys: 0.466 ± 0.019	2.37TrpLeu: 2.37 ± 0.061	0.39TrpMet: 0.39 ± 0.02	0.435TrpAsn: 0.435 ± 0.018	0.739TrpPro: 0.739 ± 0.027	1.011TrpGln: 1.011 ± 0.034	1.194TrpArg: 1.194 ± 0.036	0.744TrpSer: 0.744 ± 0.024	0.574TrpThr: 0.574 ± 0.021	1.081TrpVal: 1.081 ± 0.032	0.296TrpTrp: 0.296 ± 0.015	0.338TrpTyr: 0.338 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.382TyrAla: 2.382 ± 0.045	0.319TyrCys: 0.319 ± 0.014	1.273TyrAsp: 1.273 ± 0.035	1.283TyrGlu: 1.283 ± 0.034	0.927TyrPhe: 0.927 ± 0.028	1.939TyrGly: 1.939 ± 0.04	0.686TyrHis: 0.686 ± 0.024	0.968TyrIle: 0.968 ± 0.028	0.674TyrLys: 0.674 ± 0.023	2.892TyrLeu: 2.892 ± 0.047	0.498TyrMet: 0.498 ± 0.019	0.654TyrAsn: 0.654 ± 0.023	1.38TyrPro: 1.38 ± 0.032	1.287TyrGln: 1.287 ± 0.03	2.225TyrArg: 2.225 ± 0.041	1.392TyrSer: 1.392 ± 0.031	1.173TyrThr: 1.173 ± 0.035	1.536TyrVal: 1.536 ± 0.035	0.414TyrTrp: 0.414 ± 0.018	0.705TyrTyr: 0.705 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4010 proteins (1279303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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