Amino acid dipepetide frequency for Aliiglaciecola sp. M165

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.003AlaAla: 7.003 ± 0.094
0.904AlaCys: 0.904 ± 0.025
4.634AlaAsp: 4.634 ± 0.06
4.968AlaGlu: 4.968 ± 0.068
3.677AlaPhe: 3.677 ± 0.054
5.506AlaGly: 5.506 ± 0.08
1.568AlaHis: 1.568 ± 0.04
5.735AlaIle: 5.735 ± 0.076
4.907AlaLys: 4.907 ± 0.066
9.2AlaLeu: 9.2 ± 0.099
2.323AlaMet: 2.323 ± 0.045
3.862AlaAsn: 3.862 ± 0.054
2.737AlaPro: 2.737 ± 0.049
4.172AlaGln: 4.172 ± 0.066
3.448AlaArg: 3.448 ± 0.057
5.445AlaSer: 5.445 ± 0.074
4.345AlaThr: 4.345 ± 0.057
5.507AlaVal: 5.507 ± 0.074
0.884AlaTrp: 0.884 ± 0.029
2.359AlaTyr: 2.359 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.818CysAla: 0.818 ± 0.026
0.172CysCys: 0.172 ± 0.011
0.564CysAsp: 0.564 ± 0.02
0.597CysGlu: 0.597 ± 0.019
0.448CysPhe: 0.448 ± 0.02
0.771CysGly: 0.771 ± 0.027
0.332CysHis: 0.332 ± 0.017
0.614CysIle: 0.614 ± 0.02
0.451CysLys: 0.451 ± 0.02
0.949CysLeu: 0.949 ± 0.028
0.209CysMet: 0.209 ± 0.012
0.347CysAsn: 0.347 ± 0.015
0.395CysPro: 0.395 ± 0.019
0.471CysGln: 0.471 ± 0.018
0.415CysArg: 0.415 ± 0.018
0.678CysSer: 0.678 ± 0.023
0.429CysThr: 0.429 ± 0.018
0.619CysVal: 0.619 ± 0.024
0.124CysTrp: 0.124 ± 0.01
0.312CysTyr: 0.312 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.69AspAla: 4.69 ± 0.079
0.493AspCys: 0.493 ± 0.021
3.404AspAsp: 3.404 ± 0.056
3.997AspGlu: 3.997 ± 0.067
2.861AspPhe: 2.861 ± 0.048
4.023AspGly: 4.023 ± 0.095
1.127AspHis: 1.127 ± 0.027
4.159AspIle: 4.159 ± 0.066
3.323AspLys: 3.323 ± 0.05
5.46AspLeu: 5.46 ± 0.062
1.53AspMet: 1.53 ± 0.032
2.687AspAsn: 2.687 ± 0.064
2.425AspPro: 2.425 ± 0.052
2.118AspGln: 2.118 ± 0.035
2.245AspArg: 2.245 ± 0.043
3.579AspSer: 3.579 ± 0.062
2.898AspThr: 2.898 ± 0.044
4.208AspVal: 4.208 ± 0.057
0.915AspTrp: 0.915 ± 0.03
2.064AspTyr: 2.064 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
4.79GluAla: 4.79 ± 0.065
0.445GluCys: 0.445 ± 0.015
3.146GluAsp: 3.146 ± 0.056
3.654GluGlu: 3.654 ± 0.06
2.651GluPhe: 2.651 ± 0.045
3.454GluGly: 3.454 ± 0.054
1.64GluHis: 1.64 ± 0.04
3.941GluIle: 3.941 ± 0.057
3.865GluLys: 3.865 ± 0.064
6.719GluLeu: 6.719 ± 0.075
1.555GluMet: 1.555 ± 0.037
3.057GluAsn: 3.057 ± 0.054
1.982GluPro: 1.982 ± 0.044
4.244GluGln: 4.244 ± 0.071
2.964GluArg: 2.964 ± 0.043
3.948GluSer: 3.948 ± 0.059
3.004GluThr: 3.004 ± 0.052
3.998GluVal: 3.998 ± 0.065
0.656GluTrp: 0.656 ± 0.019
1.84GluTyr: 1.84 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.896PheAla: 3.896 ± 0.051
0.498PheCys: 0.498 ± 0.02
3.309PheAsp: 3.309 ± 0.053
3.021PheGlu: 3.021 ± 0.046
1.919PhePhe: 1.919 ± 0.039
3.271PheGly: 3.271 ± 0.055
0.89PheHis: 0.89 ± 0.025
2.828PheIle: 2.828 ± 0.047
2.123PheLys: 2.123 ± 0.04
3.673PheLeu: 3.673 ± 0.063
1.048PheMet: 1.048 ± 0.029
2.23PheAsn: 2.23 ± 0.042
1.522PhePro: 1.522 ± 0.035
1.346PheGln: 1.346 ± 0.033
1.66PheArg: 1.66 ± 0.04
3.709PheSer: 3.709 ± 0.052
2.399PheThr: 2.399 ± 0.043
3.364PheVal: 3.364 ± 0.05
0.618PheTrp: 0.618 ± 0.023
1.481PheTyr: 1.481 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.091GlyAla: 5.091 ± 0.069
0.783GlyCys: 0.783 ± 0.027
3.764GlyAsp: 3.764 ± 0.066
4.095GlyGlu: 4.095 ± 0.057
3.576GlyPhe: 3.576 ± 0.064
4.708GlyGly: 4.708 ± 0.086
1.498GlyHis: 1.498 ± 0.034
4.589GlyIle: 4.589 ± 0.058
3.846GlyLys: 3.846 ± 0.063
6.87GlyLeu: 6.87 ± 0.079
1.83GlyMet: 1.83 ± 0.042
2.915GlyAsn: 2.915 ± 0.064
1.722GlyPro: 1.722 ± 0.035
2.921GlyGln: 2.921 ± 0.052
2.878GlyArg: 2.878 ± 0.047
4.062GlySer: 4.062 ± 0.066
3.365GlyThr: 3.365 ± 0.059
4.84GlyVal: 4.84 ± 0.078
0.934GlyTrp: 0.934 ± 0.027
2.321GlyTyr: 2.321 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.626HisAla: 1.626 ± 0.033
0.315HisCys: 0.315 ± 0.013
1.112HisAsp: 1.112 ± 0.03
1.115HisGlu: 1.115 ± 0.028
1.215HisPhe: 1.215 ± 0.035
1.437HisGly: 1.437 ± 0.038
0.649HisHis: 0.649 ± 0.024
1.449HisIle: 1.449 ± 0.032
1.085HisLys: 1.085 ± 0.027
2.214HisLeu: 2.214 ± 0.041
0.535HisMet: 0.535 ± 0.02
0.938HisAsn: 0.938 ± 0.028
1.125HisPro: 1.125 ± 0.03
1.199HisGln: 1.199 ± 0.03
1.05HisArg: 1.05 ± 0.029
1.472HisSer: 1.472 ± 0.036
1.039HisThr: 1.039 ± 0.03
1.338HisVal: 1.338 ± 0.033
0.382HisTrp: 0.382 ± 0.018
0.89HisTyr: 0.89 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.109IleAla: 6.109 ± 0.074
0.682IleCys: 0.682 ± 0.021
4.51IleAsp: 4.51 ± 0.064
4.897IleGlu: 4.897 ± 0.067
2.348IlePhe: 2.348 ± 0.052
4.546IleGly: 4.546 ± 0.061
1.241IleHis: 1.241 ± 0.028
3.395IleIle: 3.395 ± 0.058
3.403IleLys: 3.403 ± 0.048
5.376IleLeu: 5.376 ± 0.075
1.253IleMet: 1.253 ± 0.033
3.257IleAsn: 3.257 ± 0.05
2.687IlePro: 2.687 ± 0.047
2.447IleGln: 2.447 ± 0.041
2.782IleArg: 2.782 ± 0.048
4.723IleSer: 4.723 ± 0.07
3.475IleThr: 3.475 ± 0.054
4.411IleVal: 4.411 ± 0.056
0.684IleTrp: 0.684 ± 0.021
1.777IleTyr: 1.777 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.379LysAla: 4.379 ± 0.065
0.328LysCys: 0.328 ± 0.019
2.766LysAsp: 2.766 ± 0.047
3.009LysGlu: 3.009 ± 0.052
1.732LysPhe: 1.732 ± 0.036
3.226LysGly: 3.226 ± 0.058
1.426LysHis: 1.426 ± 0.034
3.312LysIle: 3.312 ± 0.057
2.941LysLys: 2.941 ± 0.059
5.362LysLeu: 5.362 ± 0.073
1.477LysMet: 1.477 ± 0.034
2.501LysAsn: 2.501 ± 0.043
2.162LysPro: 2.162 ± 0.042
3.123LysGln: 3.123 ± 0.054
2.862LysArg: 2.862 ± 0.054
3.437LysSer: 3.437 ± 0.053
2.993LysThr: 2.993 ± 0.048
3.79LysVal: 3.79 ± 0.062
0.682LysTrp: 0.682 ± 0.023
1.423LysTyr: 1.423 ± 0.033
0.001LysXaa: 0.001 ± 0.001
Leu
9.319LeuAla: 9.319 ± 0.091
1.062LeuCys: 1.062 ± 0.027
5.929LeuAsp: 5.929 ± 0.076
5.895LeuGlu: 5.895 ± 0.081
4.509LeuPhe: 4.509 ± 0.064
6.582LeuGly: 6.582 ± 0.083
2.065LeuHis: 2.065 ± 0.04
6.272LeuIle: 6.272 ± 0.082
5.288LeuLys: 5.288 ± 0.074
10.175LeuLeu: 10.175 ± 0.122
2.486LeuMet: 2.486 ± 0.048
4.945LeuAsn: 4.945 ± 0.064
4.487LeuPro: 4.487 ± 0.064
4.108LeuGln: 4.108 ± 0.068
4.33LeuArg: 4.33 ± 0.058
8.006LeuSer: 8.006 ± 0.086
5.791LeuThr: 5.791 ± 0.071
6.979LeuVal: 6.979 ± 0.073
1.035LeuTrp: 1.035 ± 0.028
2.671LeuTyr: 2.671 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.26MetAla: 2.26 ± 0.045
0.191MetCys: 0.191 ± 0.011
1.212MetAsp: 1.212 ± 0.032
1.243MetGlu: 1.243 ± 0.03
0.963MetPhe: 0.963 ± 0.028
1.668MetGly: 1.668 ± 0.03
0.565MetHis: 0.565 ± 0.019
1.39MetIle: 1.39 ± 0.034
1.353MetLys: 1.353 ± 0.031
2.777MetLeu: 2.777 ± 0.051
0.668MetMet: 0.668 ± 0.026
1.046MetAsn: 1.046 ± 0.027
1.264MetPro: 1.264 ± 0.03
1.306MetGln: 1.306 ± 0.03
1.176MetArg: 1.176 ± 0.031
1.902MetSer: 1.902 ± 0.036
1.495MetThr: 1.495 ± 0.034
1.626MetVal: 1.626 ± 0.037
0.241MetTrp: 0.241 ± 0.014
0.506MetTyr: 0.506 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.726AsnAla: 3.726 ± 0.056
0.472AsnCys: 0.472 ± 0.016
2.626AsnAsp: 2.626 ± 0.056
2.661AsnGlu: 2.661 ± 0.043
1.782AsnPhe: 1.782 ± 0.037
3.218AsnGly: 3.218 ± 0.061
0.94AsnHis: 0.94 ± 0.027
3.112AsnIle: 3.112 ± 0.05
2.389AsnLys: 2.389 ± 0.044
4.448AsnLeu: 4.448 ± 0.059
1.111AsnMet: 1.111 ± 0.024
2.243AsnAsn: 2.243 ± 0.05
2.077AsnPro: 2.077 ± 0.042
2.51AsnGln: 2.51 ± 0.045
2.246AsnArg: 2.246 ± 0.045
2.824AsnSer: 2.824 ± 0.054
2.421AsnThr: 2.421 ± 0.039
3.146AsnVal: 3.146 ± 0.056
0.718AsnTrp: 0.718 ± 0.022
1.424AsnTyr: 1.424 ± 0.035
0.001AsnXaa: 0.001 ± 0.001
Pro
2.911ProAla: 2.911 ± 0.057
0.272ProCys: 0.272 ± 0.014
2.557ProAsp: 2.557 ± 0.048
3.02ProGlu: 3.02 ± 0.056
1.832ProPhe: 1.832 ± 0.037
2.534ProGly: 2.534 ± 0.046
0.79ProHis: 0.79 ± 0.027
2.518ProIle: 2.518 ± 0.042
2.015ProLys: 2.015 ± 0.043
3.848ProLeu: 3.848 ± 0.049
0.949ProMet: 0.949 ± 0.027
1.983ProAsn: 1.983 ± 0.043
1.253ProPro: 1.253 ± 0.042
1.662ProGln: 1.662 ± 0.036
1.277ProArg: 1.277 ± 0.032
2.563ProSer: 2.563 ± 0.043
2.029ProThr: 2.029 ± 0.047
2.898ProVal: 2.898 ± 0.048
0.51ProTrp: 0.51 ± 0.019
1.146ProTyr: 1.146 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.184GlnAla: 4.184 ± 0.053
0.424GlnCys: 0.424 ± 0.019
2.295GlnAsp: 2.295 ± 0.043
2.415GlnGlu: 2.415 ± 0.057
1.986GlnPhe: 1.986 ± 0.038
2.924GlnGly: 2.924 ± 0.049
1.289GlnHis: 1.289 ± 0.033
3.148GlnIle: 3.148 ± 0.049
2.49GlnLys: 2.49 ± 0.05
5.08GlnLeu: 5.08 ± 0.073
1.12GlnMet: 1.12 ± 0.03
2.223GlnAsn: 2.223 ± 0.043
1.762GlnPro: 1.762 ± 0.036
3.359GlnGln: 3.359 ± 0.086
2.477GlnArg: 2.477 ± 0.047
3.323GlnSer: 3.323 ± 0.051
2.514GlnThr: 2.514 ± 0.047
3.053GlnVal: 3.053 ± 0.056
0.69GlnTrp: 0.69 ± 0.029
1.387GlnTyr: 1.387 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.329ArgAla: 3.329 ± 0.046
0.392ArgCys: 0.392 ± 0.016
2.398ArgAsp: 2.398 ± 0.045
2.709ArgGlu: 2.709 ± 0.042
2.364ArgPhe: 2.364 ± 0.037
2.579ArgGly: 2.579 ± 0.046
1.055ArgHis: 1.055 ± 0.029
3.007ArgIle: 3.007 ± 0.048
2.323ArgLys: 2.323 ± 0.048
4.828ArgLeu: 4.828 ± 0.064
1.187ArgMet: 1.187 ± 0.029
1.915ArgAsn: 1.915 ± 0.038
1.551ArgPro: 1.551 ± 0.033
2.242ArgGln: 2.242 ± 0.043
2.173ArgArg: 2.173 ± 0.047
2.663ArgSer: 2.663 ± 0.048
2.101ArgThr: 2.101 ± 0.045
3.084ArgVal: 3.084 ± 0.047
0.604ArgTrp: 0.604 ± 0.022
1.693ArgTyr: 1.693 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
5.656SerAla: 5.656 ± 0.066
0.587SerCys: 0.587 ± 0.02
4.007SerAsp: 4.007 ± 0.07
4.284SerGlu: 4.284 ± 0.069
3.168SerPhe: 3.168 ± 0.053
5.015SerGly: 5.015 ± 0.072
1.555SerHis: 1.555 ± 0.038
4.591SerIle: 4.591 ± 0.065
3.339SerLys: 3.339 ± 0.049
7.143SerLeu: 7.143 ± 0.087
1.755SerMet: 1.755 ± 0.033
2.954SerAsn: 2.954 ± 0.053
2.573SerPro: 2.573 ± 0.043
3.246SerGln: 3.246 ± 0.057
2.943SerArg: 2.943 ± 0.044
4.621SerSer: 4.621 ± 0.068
3.429SerThr: 3.429 ± 0.054
4.854SerVal: 4.854 ± 0.06
0.885SerTrp: 0.885 ± 0.026
1.912SerTyr: 1.912 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
4.29ThrAla: 4.29 ± 0.067
0.457ThrCys: 0.457 ± 0.02
3.193ThrAsp: 3.193 ± 0.058
3.046ThrGlu: 3.046 ± 0.051
2.374ThrPhe: 2.374 ± 0.045
3.816ThrGly: 3.816 ± 0.058
1.15ThrHis: 1.15 ± 0.032
3.243ThrIle: 3.243 ± 0.047
2.285ThrLys: 2.285 ± 0.042
6.063ThrLeu: 6.063 ± 0.071
1.079ThrMet: 1.079 ± 0.026
2.124ThrAsn: 2.124 ± 0.05
2.518ThrPro: 2.518 ± 0.046
2.578ThrGln: 2.578 ± 0.047
2.142ThrArg: 2.142 ± 0.042
3.496ThrSer: 3.496 ± 0.051
2.766ThrThr: 2.766 ± 0.057
3.601ThrVal: 3.601 ± 0.052
0.609ThrTrp: 0.609 ± 0.024
1.579ThrTyr: 1.579 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.956ValAla: 5.956 ± 0.077
0.754ValCys: 0.754 ± 0.023
4.413ValAsp: 4.413 ± 0.058
4.651ValGlu: 4.651 ± 0.065
3.175ValPhe: 3.175 ± 0.042
4.554ValGly: 4.554 ± 0.061
1.289ValHis: 1.289 ± 0.036
4.427ValIle: 4.427 ± 0.052
3.649ValLys: 3.649 ± 0.056
6.906ValLeu: 6.906 ± 0.076
1.781ValMet: 1.781 ± 0.037
3.29ValAsn: 3.29 ± 0.056
2.56ValPro: 2.56 ± 0.047
2.261ValGln: 2.261 ± 0.037
2.765ValArg: 2.765 ± 0.044
5.143ValSer: 5.143 ± 0.071
3.988ValThr: 3.988 ± 0.049
5.282ValVal: 5.282 ± 0.071
0.747ValTrp: 0.747 ± 0.028
1.857ValTyr: 1.857 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.79TrpAla: 0.79 ± 0.028
0.129TrpCys: 0.129 ± 0.009
0.627TrpAsp: 0.627 ± 0.022
0.533TrpGlu: 0.533 ± 0.019
0.621TrpPhe: 0.621 ± 0.026
0.743TrpGly: 0.743 ± 0.024
0.379TrpHis: 0.379 ± 0.017
0.711TrpIle: 0.711 ± 0.023
0.504TrpLys: 0.504 ± 0.022
1.672TrpLeu: 1.672 ± 0.037
0.348TrpMet: 0.348 ± 0.017
0.487TrpAsn: 0.487 ± 0.02
0.475TrpPro: 0.475 ± 0.019
1.037TrpGln: 1.037 ± 0.034
0.715TrpArg: 0.715 ± 0.026
0.804TrpSer: 0.804 ± 0.029
0.542TrpThr: 0.542 ± 0.022
0.886TrpVal: 0.886 ± 0.03
0.189TrpTrp: 0.189 ± 0.013
0.373TrpTyr: 0.373 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.362TyrAla: 2.362 ± 0.041
0.354TyrCys: 0.354 ± 0.016
1.741TyrAsp: 1.741 ± 0.045
1.738TyrGlu: 1.738 ± 0.039
1.604TyrPhe: 1.604 ± 0.036
2.033TyrGly: 2.033 ± 0.043
0.74TyrHis: 0.74 ± 0.023
1.561TyrIle: 1.561 ± 0.035
1.354TyrLys: 1.354 ± 0.038
3.168TyrLeu: 3.168 ± 0.051
0.607TyrMet: 0.607 ± 0.022
1.087TyrAsn: 1.087 ± 0.029
1.29TyrPro: 1.29 ± 0.033
1.793TyrGln: 1.793 ± 0.038
1.651TyrArg: 1.651 ± 0.035
2.117TyrSer: 2.117 ± 0.037
1.39TyrThr: 1.39 ± 0.033
1.964TyrVal: 1.964 ± 0.042
0.462TyrTrp: 0.462 ± 0.019
1.059TyrTyr: 1.059 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4070 proteins (1360031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski