Amino acid dipepetide frequency for Gloeothece verrucosa (strain PCC 7822) (Cyanothece sp. (strain PCC 7822))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.572AlaAla: 6.572 ± 0.085
0.732AlaCys: 0.732 ± 0.019
3.432AlaAsp: 3.432 ± 0.055
4.342AlaGlu: 4.342 ± 0.053
2.718AlaPhe: 2.718 ± 0.041
4.667AlaGly: 4.667 ± 0.069
1.192AlaHis: 1.192 ± 0.032
5.963AlaIle: 5.963 ± 0.062
4.13AlaLys: 4.13 ± 0.06
8.175AlaLeu: 8.175 ± 0.088
1.397AlaMet: 1.397 ± 0.031
3.325AlaAsn: 3.325 ± 0.053
2.567AlaPro: 2.567 ± 0.057
4.214AlaGln: 4.214 ± 0.057
3.031AlaArg: 3.031 ± 0.046
4.359AlaSer: 4.359 ± 0.057
4.25AlaThr: 4.25 ± 0.067
4.556AlaVal: 4.556 ± 0.058
0.963AlaTrp: 0.963 ± 0.024
2.367AlaTyr: 2.367 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.019
0.17CysCys: 0.17 ± 0.009
0.48CysAsp: 0.48 ± 0.016
0.549CysGlu: 0.549 ± 0.016
0.42CysPhe: 0.42 ± 0.015
0.739CysGly: 0.739 ± 0.019
0.304CysHis: 0.304 ± 0.014
0.522CysIle: 0.522 ± 0.018
0.373CysLys: 0.373 ± 0.014
1.233CysLeu: 1.233 ± 0.03
0.13CysMet: 0.13 ± 0.007
0.366CysAsn: 0.366 ± 0.014
0.582CysPro: 0.582 ± 0.02
0.679CysGln: 0.679 ± 0.018
0.544CysArg: 0.544 ± 0.017
0.654CysSer: 0.654 ± 0.021
0.407CysThr: 0.407 ± 0.016
0.49CysVal: 0.49 ± 0.017
0.182CysTrp: 0.182 ± 0.01
0.416CysTyr: 0.416 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.004AspAla: 3.004 ± 0.049
0.519AspCys: 0.519 ± 0.016
2.264AspAsp: 2.264 ± 0.047
3.301AspGlu: 3.301 ± 0.042
2.317AspPhe: 2.317 ± 0.04
3.229AspGly: 3.229 ± 0.065
0.886AspHis: 0.886 ± 0.026
3.285AspIle: 3.285 ± 0.046
2.47AspLys: 2.47 ± 0.044
5.911AspLeu: 5.911 ± 0.06
0.646AspMet: 0.646 ± 0.018
2.383AspAsn: 2.383 ± 0.048
2.535AspPro: 2.535 ± 0.039
2.13AspGln: 2.13 ± 0.03
2.396AspArg: 2.396 ± 0.034
2.955AspSer: 2.955 ± 0.05
2.342AspThr: 2.342 ± 0.06
2.663AspVal: 2.663 ± 0.038
0.911AspTrp: 0.911 ± 0.021
2.11AspTyr: 2.11 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
5.213GluAla: 5.213 ± 0.067
0.474GluCys: 0.474 ± 0.017
2.898GluAsp: 2.898 ± 0.041
4.638GluGlu: 4.638 ± 0.075
2.403GluPhe: 2.403 ± 0.034
3.49GluGly: 3.49 ± 0.048
0.974GluHis: 0.974 ± 0.023
5.449GluIle: 5.449 ± 0.062
4.468GluLys: 4.468 ± 0.059
6.852GluLeu: 6.852 ± 0.076
1.301GluMet: 1.301 ± 0.029
3.158GluAsn: 3.158 ± 0.041
2.548GluPro: 2.548 ± 0.043
4.123GluGln: 4.123 ± 0.058
3.37GluArg: 3.37 ± 0.049
3.504GluSer: 3.504 ± 0.045
3.645GluThr: 3.645 ± 0.046
3.97GluVal: 3.97 ± 0.052
0.828GluTrp: 0.828 ± 0.019
1.917GluTyr: 1.917 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
2.703PheAla: 2.703 ± 0.042
0.563PheCys: 0.563 ± 0.018
2.23PheAsp: 2.23 ± 0.036
2.47PheGlu: 2.47 ± 0.039
1.913PhePhe: 1.913 ± 0.034
2.726PheGly: 2.726 ± 0.041
0.671PheHis: 0.671 ± 0.018
2.635PheIle: 2.635 ± 0.039
2.056PheLys: 2.056 ± 0.036
4.423PheLeu: 4.423 ± 0.064
0.673PheMet: 0.673 ± 0.017
2.173PheAsn: 2.173 ± 0.039
1.978PhePro: 1.978 ± 0.037
1.717PheGln: 1.717 ± 0.027
1.758PheArg: 1.758 ± 0.028
3.159PheSer: 3.159 ± 0.046
2.268PheThr: 2.268 ± 0.042
2.24PheVal: 2.24 ± 0.029
0.712PheTrp: 0.712 ± 0.02
1.554PheTyr: 1.554 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
4.209GlyAla: 4.209 ± 0.074
0.722GlyCys: 0.722 ± 0.019
3.178GlyAsp: 3.178 ± 0.066
4.04GlyGlu: 4.04 ± 0.051
2.847GlyPhe: 2.847 ± 0.041
4.725GlyGly: 4.725 ± 0.09
1.197GlyHis: 1.197 ± 0.029
5.114GlyIle: 5.114 ± 0.054
4.163GlyLys: 4.163 ± 0.054
6.817GlyLeu: 6.817 ± 0.067
1.305GlyMet: 1.305 ± 0.026
3.365GlyAsn: 3.365 ± 0.098
1.314GlyPro: 1.314 ± 0.033
3.142GlyGln: 3.142 ± 0.05
2.848GlyArg: 2.848 ± 0.041
3.899GlySer: 3.899 ± 0.056
3.845GlyThr: 3.845 ± 0.079
4.345GlyVal: 4.345 ± 0.052
1.071GlyTrp: 1.071 ± 0.025
2.434GlyTyr: 2.434 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
0.864HisAla: 0.864 ± 0.022
0.276HisCys: 0.276 ± 0.012
0.689HisAsp: 0.689 ± 0.021
0.86HisGlu: 0.86 ± 0.021
0.842HisPhe: 0.842 ± 0.021
0.954HisGly: 0.954 ± 0.021
0.628HisHis: 0.628 ± 0.022
1.05HisIle: 1.05 ± 0.027
0.808HisLys: 0.808 ± 0.022
2.404HisLeu: 2.404 ± 0.034
0.184HisMet: 0.184 ± 0.01
0.716HisAsn: 0.716 ± 0.02
1.291HisPro: 1.291 ± 0.031
1.296HisGln: 1.296 ± 0.029
0.97HisArg: 0.97 ± 0.022
1.181HisSer: 1.181 ± 0.027
0.834HisThr: 0.834 ± 0.022
0.634HisVal: 0.634 ± 0.018
0.379HisTrp: 0.379 ± 0.014
0.725HisTyr: 0.725 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
6.134IleAla: 6.134 ± 0.059
0.766IleCys: 0.766 ± 0.02
3.872IleAsp: 3.872 ± 0.042
4.982IleGlu: 4.982 ± 0.053
3.002IlePhe: 3.002 ± 0.04
4.501IleGly: 4.501 ± 0.064
1.192IleHis: 1.192 ± 0.028
4.891IleIle: 4.891 ± 0.069
3.907IleLys: 3.907 ± 0.052
7.366IleLeu: 7.366 ± 0.074
0.946IleMet: 0.946 ± 0.024
3.77IleAsn: 3.77 ± 0.053
3.791IlePro: 3.791 ± 0.045
2.967IleGln: 2.967 ± 0.041
3.046IleArg: 3.046 ± 0.048
4.79IleSer: 4.79 ± 0.051
4.244IleThr: 4.244 ± 0.06
4.085IleVal: 4.085 ± 0.045
0.932IleTrp: 0.932 ± 0.022
2.395IleTyr: 2.395 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.291LysAla: 4.291 ± 0.052
0.358LysCys: 0.358 ± 0.015
2.553LysAsp: 2.553 ± 0.037
3.515LysGlu: 3.515 ± 0.048
1.94LysPhe: 1.94 ± 0.033
3.125LysGly: 3.125 ± 0.041
0.816LysHis: 0.816 ± 0.023
4.541LysIle: 4.541 ± 0.059
3.449LysLys: 3.449 ± 0.058
5.789LysLeu: 5.789 ± 0.065
1.033LysMet: 1.033 ± 0.026
2.949LysAsn: 2.949 ± 0.049
2.678LysPro: 2.678 ± 0.042
3.01LysGln: 3.01 ± 0.042
2.658LysArg: 2.658 ± 0.047
3.205LysSer: 3.205 ± 0.041
3.615LysThr: 3.615 ± 0.043
3.249LysVal: 3.249 ± 0.046
0.591LysTrp: 0.591 ± 0.017
1.679LysTyr: 1.679 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
9.034LeuAla: 9.034 ± 0.074
1.065LeuCys: 1.065 ± 0.027
5.378LeuAsp: 5.378 ± 0.06
8.159LeuGlu: 8.159 ± 0.087
4.017LeuPhe: 4.017 ± 0.05
7.416LeuGly: 7.416 ± 0.072
1.658LeuHis: 1.658 ± 0.03
7.937LeuIle: 7.937 ± 0.074
7.096LeuLys: 7.096 ± 0.067
11.263LeuLeu: 11.263 ± 0.102
2.102LeuMet: 2.102 ± 0.036
5.275LeuAsn: 5.275 ± 0.058
5.426LeuPro: 5.426 ± 0.056
5.021LeuGln: 5.021 ± 0.053
4.815LeuArg: 4.815 ± 0.054
8.225LeuSer: 8.225 ± 0.073
6.695LeuThr: 6.695 ± 0.075
6.597LeuVal: 6.597 ± 0.065
1.412LeuTrp: 1.412 ± 0.031
2.986LeuTyr: 2.986 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
1.551MetAla: 1.551 ± 0.033
0.116MetCys: 0.116 ± 0.008
0.692MetAsp: 0.692 ± 0.019
0.887MetGlu: 0.887 ± 0.022
0.53MetPhe: 0.53 ± 0.018
1.295MetGly: 1.295 ± 0.03
0.175MetHis: 0.175 ± 0.009
1.272MetIle: 1.272 ± 0.026
1.001MetLys: 1.001 ± 0.024
1.745MetLeu: 1.745 ± 0.038
0.412MetMet: 0.412 ± 0.014
0.823MetAsn: 0.823 ± 0.02
0.82MetPro: 0.82 ± 0.022
0.649MetGln: 0.649 ± 0.02
0.813MetArg: 0.813 ± 0.02
1.306MetSer: 1.306 ± 0.025
1.306MetThr: 1.306 ± 0.025
1.123MetVal: 1.123 ± 0.027
0.142MetTrp: 0.142 ± 0.008
0.374MetTyr: 0.374 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.898AsnAla: 2.898 ± 0.053
0.5AsnCys: 0.5 ± 0.02
2.102AsnAsp: 2.102 ± 0.069
2.152AsnGlu: 2.152 ± 0.034
2.261AsnPhe: 2.261 ± 0.038
2.917AsnGly: 2.917 ± 0.071
0.958AsnHis: 0.958 ± 0.024
3.195AsnIle: 3.195 ± 0.054
2.267AsnLys: 2.267 ± 0.034
6.21AsnLeu: 6.21 ± 0.085
0.614AsnMet: 0.614 ± 0.017
2.827AsnAsn: 2.827 ± 0.091
3.309AsnPro: 3.309 ± 0.049
2.952AsnGln: 2.952 ± 0.047
2.347AsnArg: 2.347 ± 0.039
3.409AsnSer: 3.409 ± 0.059
2.433AsnThr: 2.433 ± 0.057
2.143AsnVal: 2.143 ± 0.045
0.848AsnTrp: 0.848 ± 0.019
1.946AsnTyr: 1.946 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
2.631ProAla: 2.631 ± 0.04
0.362ProCys: 0.362 ± 0.014
2.887ProAsp: 2.887 ± 0.045
3.811ProGlu: 3.811 ± 0.051
1.894ProPhe: 1.894 ± 0.035
2.645ProGly: 2.645 ± 0.049
0.926ProHis: 0.926 ± 0.026
3.275ProIle: 3.275 ± 0.042
2.399ProLys: 2.399 ± 0.042
5.048ProLeu: 5.048 ± 0.058
0.717ProMet: 0.717 ± 0.019
2.377ProAsn: 2.377 ± 0.046
2.403ProPro: 2.403 ± 0.049
2.624ProGln: 2.624 ± 0.037
1.645ProArg: 1.645 ± 0.032
3.427ProSer: 3.427 ± 0.043
2.834ProThr: 2.834 ± 0.057
3.169ProVal: 3.169 ± 0.049
0.603ProTrp: 0.603 ± 0.018
1.481ProTyr: 1.481 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.421GlnAla: 4.421 ± 0.051
0.382GlnCys: 0.382 ± 0.015
2.144GlnAsp: 2.144 ± 0.037
3.915GlnGlu: 3.915 ± 0.058
1.943GlnPhe: 1.943 ± 0.031
3.357GlnGly: 3.357 ± 0.053
0.755GlnHis: 0.755 ± 0.021
3.906GlnIle: 3.906 ± 0.05
3.311GlnLys: 3.311 ± 0.048
6.082GlnLeu: 6.082 ± 0.065
1.029GlnMet: 1.029 ± 0.022
2.228GlnAsn: 2.228 ± 0.038
2.451GlnPro: 2.451 ± 0.041
3.917GlnGln: 3.917 ± 0.066
2.428GlnArg: 2.428 ± 0.038
2.99GlnSer: 2.99 ± 0.043
3.001GlnThr: 3.001 ± 0.051
3.456GlnVal: 3.456 ± 0.046
0.861GlnTrp: 0.861 ± 0.021
1.463GlnTyr: 1.463 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.878ArgAla: 2.878 ± 0.046
0.457ArgCys: 0.457 ± 0.015
2.162ArgAsp: 2.162 ± 0.035
3.26ArgGlu: 3.26 ± 0.049
2.024ArgPhe: 2.024 ± 0.034
2.707ArgGly: 2.707 ± 0.043
0.935ArgHis: 0.935 ± 0.026
3.02ArgIle: 3.02 ± 0.045
2.28ArgLys: 2.28 ± 0.036
5.609ArgLeu: 5.609 ± 0.067
0.832ArgMet: 0.832 ± 0.021
1.88ArgAsn: 1.88 ± 0.03
1.829ArgPro: 1.829 ± 0.03
2.931ArgGln: 2.931 ± 0.047
2.627ArgArg: 2.627 ± 0.045
2.806ArgSer: 2.806 ± 0.041
2.175ArgThr: 2.175 ± 0.033
3.055ArgVal: 3.055 ± 0.041
0.796ArgTrp: 0.796 ± 0.02
1.82ArgTyr: 1.82 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
4.074SerAla: 4.074 ± 0.053
0.666SerCys: 0.666 ± 0.02
3.223SerAsp: 3.223 ± 0.049
3.962SerGlu: 3.962 ± 0.049
2.738SerPhe: 2.738 ± 0.039
4.666SerGly: 4.666 ± 0.068
1.257SerHis: 1.257 ± 0.027
4.066SerIle: 4.066 ± 0.044
2.886SerLys: 2.886 ± 0.04
7.991SerLeu: 7.991 ± 0.068
1.097SerMet: 1.097 ± 0.024
3.057SerAsn: 3.057 ± 0.061
3.599SerPro: 3.599 ± 0.047
3.864SerGln: 3.864 ± 0.055
2.954SerArg: 2.954 ± 0.044
5.011SerSer: 5.011 ± 0.069
3.316SerThr: 3.316 ± 0.051
3.981SerVal: 3.981 ± 0.044
0.981SerTrp: 0.981 ± 0.027
2.104SerTyr: 2.104 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
4.175ThrAla: 4.175 ± 0.054
0.466ThrCys: 0.466 ± 0.016
2.768ThrAsp: 2.768 ± 0.055
3.47ThrGlu: 3.47 ± 0.041
2.221ThrPhe: 2.221 ± 0.038
4.232ThrGly: 4.232 ± 0.075
1.076ThrHis: 1.076 ± 0.022
3.989ThrIle: 3.989 ± 0.053
2.3ThrLys: 2.3 ± 0.039
6.678ThrLeu: 6.678 ± 0.088
0.725ThrMet: 0.725 ± 0.021
2.438ThrAsn: 2.438 ± 0.058
3.4ThrPro: 3.4 ± 0.055
2.912ThrGln: 2.912 ± 0.046
2.34ThrArg: 2.34 ± 0.035
3.393ThrSer: 3.393 ± 0.056
3.29ThrThr: 3.29 ± 0.064
4.066ThrVal: 4.066 ± 0.082
0.702ThrTrp: 0.702 ± 0.022
1.766ThrTyr: 1.766 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
4.929ValAla: 4.929 ± 0.053
0.627ValCys: 0.627 ± 0.02
2.964ValAsp: 2.964 ± 0.037
4.083ValGlu: 4.083 ± 0.051
2.435ValPhe: 2.435 ± 0.034
4.066ValGly: 4.066 ± 0.057
0.901ValHis: 0.901 ± 0.025
4.594ValIle: 4.594 ± 0.051
3.442ValLys: 3.442 ± 0.045
5.967ValLeu: 5.967 ± 0.066
1.18ValMet: 1.18 ± 0.029
3.0ValAsn: 3.0 ± 0.05
2.575ValPro: 2.575 ± 0.051
2.415ValGln: 2.415 ± 0.036
2.744ValArg: 2.744 ± 0.039
4.136ValSer: 4.136 ± 0.067
3.588ValThr: 3.588 ± 0.073
3.994ValVal: 3.994 ± 0.047
0.802ValTrp: 0.802 ± 0.022
1.919ValTyr: 1.919 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
0.857TrpAla: 0.857 ± 0.025
0.149TrpCys: 0.149 ± 0.009
0.702TrpAsp: 0.702 ± 0.024
0.979TrpGlu: 0.979 ± 0.025
0.65TrpPhe: 0.65 ± 0.019
1.001TrpGly: 1.001 ± 0.022
0.314TrpHis: 0.314 ± 0.014
0.937TrpIle: 0.937 ± 0.024
0.762TrpLys: 0.762 ± 0.02
1.984TrpLeu: 1.984 ± 0.04
0.308TrpMet: 0.308 ± 0.012
0.644TrpAsn: 0.644 ± 0.019
0.312TrpPro: 0.312 ± 0.013
1.092TrpGln: 1.092 ± 0.023
0.745TrpArg: 0.745 ± 0.021
0.844TrpSer: 0.844 ± 0.02
0.697TrpThr: 0.697 ± 0.027
0.897TrpVal: 0.897 ± 0.023
0.245TrpTrp: 0.245 ± 0.011
0.476TrpTyr: 0.476 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.955TyrAla: 1.955 ± 0.034
0.426TyrCys: 0.426 ± 0.016
1.641TyrAsp: 1.641 ± 0.039
1.848TyrGlu: 1.848 ± 0.033
1.507TyrPhe: 1.507 ± 0.031
2.124TyrGly: 2.124 ± 0.036
0.769TyrHis: 0.769 ± 0.021
1.938TyrIle: 1.938 ± 0.028
1.476TyrLys: 1.476 ± 0.027
4.033TyrLeu: 4.033 ± 0.047
0.4TyrMet: 0.4 ± 0.013
1.533TyrAsn: 1.533 ± 0.035
1.752TyrPro: 1.752 ± 0.033
2.384TyrGln: 2.384 ± 0.033
2.006TyrArg: 2.006 ± 0.03
2.237TyrSer: 2.237 ± 0.035
1.624TyrThr: 1.624 ± 0.042
1.647TyrVal: 1.647 ± 0.03
0.632TyrTrp: 0.632 ± 0.019
1.396TyrTyr: 1.396 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6559 proteins (2140918 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski