Amino acid dipepetide frequency for Klebsiella phage ST405-OXA48phi1.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.22AlaAla: 12.22 ± 1.756
0.886AlaCys: 0.886 ± 0.247
6.021AlaAsp: 6.021 ± 0.632
5.667AlaGlu: 5.667 ± 0.699
2.834AlaPhe: 2.834 ± 0.631
8.501AlaGly: 8.501 ± 1.212
1.594AlaHis: 1.594 ± 0.355
5.402AlaIle: 5.402 ± 0.379
3.985AlaLys: 3.985 ± 0.604
9.475AlaLeu: 9.475 ± 0.944
4.073AlaMet: 4.073 ± 0.656
3.099AlaAsn: 3.099 ± 0.728
2.922AlaPro: 2.922 ± 0.459
3.896AlaGln: 3.896 ± 0.555
6.553AlaArg: 6.553 ± 0.646
7.261AlaSer: 7.261 ± 1.049
6.464AlaThr: 6.464 ± 0.672
7.261AlaVal: 7.261 ± 0.673
1.86AlaTrp: 1.86 ± 0.392
2.391AlaTyr: 2.391 ± 0.506
0.0AlaXaa: 0.0 ± 0.0
Cys
0.266CysAla: 0.266 ± 0.192
0.089CysCys: 0.089 ± 0.084
0.354CysAsp: 0.354 ± 0.17
0.266CysGlu: 0.266 ± 0.153
0.177CysPhe: 0.177 ± 0.122
0.974CysGly: 0.974 ± 0.286
0.089CysHis: 0.089 ± 0.085
0.886CysIle: 0.886 ± 0.313
0.0CysLys: 0.0 ± 0.0
0.62CysLeu: 0.62 ± 0.24
0.0CysMet: 0.0 ± 0.0
0.62CysAsn: 0.62 ± 0.252
0.531CysPro: 0.531 ± 0.214
0.354CysGln: 0.354 ± 0.152
0.531CysArg: 0.531 ± 0.24
0.266CysSer: 0.266 ± 0.179
0.443CysThr: 0.443 ± 0.186
0.177CysVal: 0.177 ± 0.143
0.266CysTrp: 0.266 ± 0.186
0.354CysTyr: 0.354 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
8.147AspAla: 8.147 ± 0.794
0.443AspCys: 0.443 ± 0.161
4.605AspAsp: 4.605 ± 0.671
3.896AspGlu: 3.896 ± 0.466
1.771AspPhe: 1.771 ± 0.363
6.021AspGly: 6.021 ± 0.763
0.886AspHis: 0.886 ± 0.301
4.428AspIle: 4.428 ± 0.767
2.391AspLys: 2.391 ± 0.486
5.136AspLeu: 5.136 ± 0.635
1.151AspMet: 1.151 ± 0.307
3.011AspAsn: 3.011 ± 0.478
2.302AspPro: 2.302 ± 0.474
1.948AspGln: 1.948 ± 0.427
3.011AspArg: 3.011 ± 0.512
4.25AspSer: 4.25 ± 0.569
2.922AspThr: 2.922 ± 0.496
5.047AspVal: 5.047 ± 0.685
1.063AspTrp: 1.063 ± 0.249
2.037AspTyr: 2.037 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
4.959GluAla: 4.959 ± 1.037
0.443GluCys: 0.443 ± 0.181
2.302GluAsp: 2.302 ± 0.326
2.568GluGlu: 2.568 ± 0.493
1.86GluPhe: 1.86 ± 0.367
2.568GluGly: 2.568 ± 0.528
1.063GluHis: 1.063 ± 0.367
3.188GluIle: 3.188 ± 0.605
3.453GluLys: 3.453 ± 0.784
7.615GluLeu: 7.615 ± 0.715
1.417GluMet: 1.417 ± 0.352
1.86GluAsn: 1.86 ± 0.359
2.834GluPro: 2.834 ± 0.566
2.922GluGln: 2.922 ± 0.481
3.188GluArg: 3.188 ± 0.563
3.542GluSer: 3.542 ± 0.564
2.922GluThr: 2.922 ± 0.527
3.453GluVal: 3.453 ± 0.544
1.86GluTrp: 1.86 ± 0.344
2.391GluTyr: 2.391 ± 0.436
0.0GluXaa: 0.0 ± 0.0
Phe
2.745PheAla: 2.745 ± 0.597
0.708PheCys: 0.708 ± 0.247
3.099PheAsp: 3.099 ± 0.443
1.594PheGlu: 1.594 ± 0.411
1.24PhePhe: 1.24 ± 0.283
2.214PheGly: 2.214 ± 0.373
0.354PheHis: 0.354 ± 0.239
2.391PheIle: 2.391 ± 0.512
1.151PheLys: 1.151 ± 0.277
2.302PheLeu: 2.302 ± 0.48
0.443PheMet: 0.443 ± 0.205
1.594PheAsn: 1.594 ± 0.299
1.151PhePro: 1.151 ± 0.368
1.24PheGln: 1.24 ± 0.259
2.214PheArg: 2.214 ± 0.429
2.037PheSer: 2.037 ± 0.464
1.948PheThr: 1.948 ± 0.372
2.745PheVal: 2.745 ± 0.398
0.354PheTrp: 0.354 ± 0.167
0.708PheTyr: 0.708 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
5.402GlyAla: 5.402 ± 0.711
0.62GlyCys: 0.62 ± 0.231
3.719GlyAsp: 3.719 ± 0.567
3.896GlyGlu: 3.896 ± 0.483
2.391GlyPhe: 2.391 ± 0.457
5.49GlyGly: 5.49 ± 0.791
1.771GlyHis: 1.771 ± 0.345
4.605GlyIle: 4.605 ± 0.837
4.25GlyLys: 4.25 ± 0.667
6.818GlyLeu: 6.818 ± 0.785
2.037GlyMet: 2.037 ± 0.41
3.276GlyAsn: 3.276 ± 0.515
2.657GlyPro: 2.657 ± 0.501
3.276GlyGln: 3.276 ± 0.548
5.579GlyArg: 5.579 ± 0.688
5.402GlySer: 5.402 ± 0.793
3.631GlyThr: 3.631 ± 0.619
4.605GlyVal: 4.605 ± 0.681
1.86GlyTrp: 1.86 ± 0.437
2.922GlyTyr: 2.922 ± 0.614
0.0GlyXaa: 0.0 ± 0.0
His
0.797HisAla: 0.797 ± 0.372
0.0HisCys: 0.0 ± 0.0
1.417HisAsp: 1.417 ± 0.304
0.797HisGlu: 0.797 ± 0.255
0.797HisPhe: 0.797 ± 0.27
1.86HisGly: 1.86 ± 0.423
0.177HisHis: 0.177 ± 0.117
0.443HisIle: 0.443 ± 0.186
0.62HisLys: 0.62 ± 0.254
2.125HisLeu: 2.125 ± 0.374
0.886HisMet: 0.886 ± 0.269
0.708HisAsn: 0.708 ± 0.371
0.886HisPro: 0.886 ± 0.205
0.531HisGln: 0.531 ± 0.211
0.886HisArg: 0.886 ± 0.244
1.328HisSer: 1.328 ± 0.347
0.531HisThr: 0.531 ± 0.336
0.886HisVal: 0.886 ± 0.23
0.089HisTrp: 0.089 ± 0.089
0.708HisTyr: 0.708 ± 0.333
0.0HisXaa: 0.0 ± 0.0
Ile
5.667IleAla: 5.667 ± 0.758
0.177IleCys: 0.177 ± 0.124
3.365IleAsp: 3.365 ± 0.527
3.276IleGlu: 3.276 ± 0.522
1.328IlePhe: 1.328 ± 0.292
3.276IleGly: 3.276 ± 0.566
1.151IleHis: 1.151 ± 0.377
3.365IleIle: 3.365 ± 0.525
2.391IleLys: 2.391 ± 0.412
3.808IleLeu: 3.808 ± 0.664
1.063IleMet: 1.063 ± 0.29
2.745IleAsn: 2.745 ± 0.652
2.568IlePro: 2.568 ± 0.554
2.391IleGln: 2.391 ± 0.415
4.428IleArg: 4.428 ± 0.592
3.099IleSer: 3.099 ± 0.529
4.339IleThr: 4.339 ± 0.719
3.719IleVal: 3.719 ± 0.503
0.797IleTrp: 0.797 ± 0.309
1.682IleTyr: 1.682 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
4.428LysAla: 4.428 ± 0.569
0.266LysCys: 0.266 ± 0.128
1.86LysAsp: 1.86 ± 0.387
2.302LysGlu: 2.302 ± 0.561
0.974LysPhe: 0.974 ± 0.261
3.011LysGly: 3.011 ± 0.543
0.531LysHis: 0.531 ± 0.242
2.302LysIle: 2.302 ± 0.452
3.365LysLys: 3.365 ± 0.732
4.693LysLeu: 4.693 ± 0.633
1.151LysMet: 1.151 ± 0.376
2.214LysAsn: 2.214 ± 0.529
1.948LysPro: 1.948 ± 0.456
1.594LysGln: 1.594 ± 0.424
2.834LysArg: 2.834 ± 0.716
2.745LysSer: 2.745 ± 0.457
2.479LysThr: 2.479 ± 0.452
2.125LysVal: 2.125 ± 0.354
0.62LysTrp: 0.62 ± 0.215
1.328LysTyr: 1.328 ± 0.377
0.0LysXaa: 0.0 ± 0.0
Leu
8.147LeuAla: 8.147 ± 1.038
1.151LeuCys: 1.151 ± 0.375
5.49LeuAsp: 5.49 ± 0.75
5.224LeuGlu: 5.224 ± 0.579
2.657LeuPhe: 2.657 ± 0.422
5.844LeuGly: 5.844 ± 0.596
1.063LeuHis: 1.063 ± 0.391
4.959LeuIle: 4.959 ± 0.551
3.808LeuLys: 3.808 ± 0.67
7.97LeuLeu: 7.97 ± 0.89
2.391LeuMet: 2.391 ± 0.381
4.782LeuAsn: 4.782 ± 0.496
5.579LeuPro: 5.579 ± 0.685
4.693LeuGln: 4.693 ± 0.715
5.844LeuArg: 5.844 ± 0.639
6.021LeuSer: 6.021 ± 0.841
6.376LeuThr: 6.376 ± 0.876
5.136LeuVal: 5.136 ± 0.572
1.24LeuTrp: 1.24 ± 0.444
2.657LeuTyr: 2.657 ± 0.587
0.0LeuXaa: 0.0 ± 0.0
Met
3.453MetAla: 3.453 ± 0.554
0.266MetCys: 0.266 ± 0.147
1.948MetAsp: 1.948 ± 0.412
1.594MetGlu: 1.594 ± 0.396
0.708MetPhe: 0.708 ± 0.225
1.328MetGly: 1.328 ± 0.289
0.443MetHis: 0.443 ± 0.213
0.886MetIle: 0.886 ± 0.262
1.682MetLys: 1.682 ± 0.478
2.125MetLeu: 2.125 ± 0.378
0.62MetMet: 0.62 ± 0.248
0.62MetAsn: 0.62 ± 0.241
1.682MetPro: 1.682 ± 0.381
0.797MetGln: 0.797 ± 0.268
1.505MetArg: 1.505 ± 0.392
1.682MetSer: 1.682 ± 0.339
1.948MetThr: 1.948 ± 0.447
1.24MetVal: 1.24 ± 0.374
0.177MetTrp: 0.177 ± 0.124
0.531MetTyr: 0.531 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
3.719AsnAla: 3.719 ± 0.728
0.177AsnCys: 0.177 ± 0.129
2.834AsnAsp: 2.834 ± 0.499
2.037AsnGlu: 2.037 ± 0.397
0.974AsnPhe: 0.974 ± 0.223
4.25AsnGly: 4.25 ± 0.571
0.797AsnHis: 0.797 ± 0.401
1.86AsnIle: 1.86 ± 0.434
2.302AsnLys: 2.302 ± 0.421
3.099AsnLeu: 3.099 ± 0.519
1.24AsnMet: 1.24 ± 0.295
2.214AsnAsn: 2.214 ± 0.403
2.125AsnPro: 2.125 ± 0.606
1.771AsnGln: 1.771 ± 0.457
1.771AsnArg: 1.771 ± 0.394
2.479AsnSer: 2.479 ± 0.457
2.657AsnThr: 2.657 ± 0.549
2.391AsnVal: 2.391 ± 0.413
0.177AsnTrp: 0.177 ± 0.121
0.886AsnTyr: 0.886 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
6.199ProAla: 6.199 ± 0.897
0.0ProCys: 0.0 ± 0.0
4.428ProAsp: 4.428 ± 0.629
2.568ProGlu: 2.568 ± 0.481
1.948ProPhe: 1.948 ± 0.432
3.542ProGly: 3.542 ± 0.549
0.797ProHis: 0.797 ± 0.264
1.151ProIle: 1.151 ± 0.418
1.063ProLys: 1.063 ± 0.273
3.631ProLeu: 3.631 ± 0.523
0.708ProMet: 0.708 ± 0.251
1.151ProAsn: 1.151 ± 0.411
1.771ProPro: 1.771 ± 0.42
1.682ProGln: 1.682 ± 0.478
2.568ProArg: 2.568 ± 0.449
3.631ProSer: 3.631 ± 0.618
1.417ProThr: 1.417 ± 0.454
3.985ProVal: 3.985 ± 0.581
0.886ProTrp: 0.886 ± 0.295
1.063ProTyr: 1.063 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
5.313GlnAla: 5.313 ± 0.804
0.443GlnCys: 0.443 ± 0.185
1.948GlnAsp: 1.948 ± 0.449
2.391GlnGlu: 2.391 ± 0.369
1.328GlnPhe: 1.328 ± 0.309
2.391GlnGly: 2.391 ± 0.381
1.151GlnHis: 1.151 ± 0.309
2.214GlnIle: 2.214 ± 0.522
1.948GlnLys: 1.948 ± 0.391
4.782GlnLeu: 4.782 ± 0.851
1.505GlnMet: 1.505 ± 0.446
1.594GlnAsn: 1.594 ± 0.334
1.594GlnPro: 1.594 ± 0.415
2.391GlnGln: 2.391 ± 0.608
3.365GlnArg: 3.365 ± 0.671
3.631GlnSer: 3.631 ± 0.743
2.568GlnThr: 2.568 ± 0.598
3.188GlnVal: 3.188 ± 0.596
0.177GlnTrp: 0.177 ± 0.129
1.151GlnTyr: 1.151 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
5.933ArgAla: 5.933 ± 0.611
0.266ArgCys: 0.266 ± 0.155
4.605ArgAsp: 4.605 ± 0.789
4.339ArgGlu: 4.339 ± 0.712
2.391ArgPhe: 2.391 ± 0.431
4.428ArgGly: 4.428 ± 0.593
1.24ArgHis: 1.24 ± 0.479
3.453ArgIle: 3.453 ± 0.615
2.922ArgLys: 2.922 ± 0.477
5.756ArgLeu: 5.756 ± 0.604
1.594ArgMet: 1.594 ± 0.457
2.214ArgAsn: 2.214 ± 0.388
3.188ArgPro: 3.188 ± 0.532
3.011ArgGln: 3.011 ± 0.644
5.313ArgArg: 5.313 ± 0.869
3.985ArgSer: 3.985 ± 0.593
2.922ArgThr: 2.922 ± 0.527
4.87ArgVal: 4.87 ± 0.716
0.886ArgTrp: 0.886 ± 0.251
2.214ArgTyr: 2.214 ± 0.579
0.0ArgXaa: 0.0 ± 0.0
Ser
6.818SerAla: 6.818 ± 0.711
0.266SerCys: 0.266 ± 0.168
5.667SerAsp: 5.667 ± 0.672
3.896SerGlu: 3.896 ± 0.47
2.568SerPhe: 2.568 ± 0.295
7.261SerGly: 7.261 ± 0.84
0.974SerHis: 0.974 ± 0.341
2.834SerIle: 2.834 ± 0.377
1.948SerLys: 1.948 ± 0.369
6.553SerLeu: 6.553 ± 0.825
1.417SerMet: 1.417 ± 0.323
1.948SerAsn: 1.948 ± 0.492
2.214SerPro: 2.214 ± 0.378
4.162SerGln: 4.162 ± 0.623
4.339SerArg: 4.339 ± 0.701
4.693SerSer: 4.693 ± 0.79
4.516SerThr: 4.516 ± 0.538
4.782SerVal: 4.782 ± 0.658
0.708SerTrp: 0.708 ± 0.228
1.417SerTyr: 1.417 ± 0.321
0.0SerXaa: 0.0 ± 0.0
Thr
7.97ThrAla: 7.97 ± 0.948
0.266ThrCys: 0.266 ± 0.157
4.693ThrAsp: 4.693 ± 0.549
3.188ThrGlu: 3.188 ± 0.448
1.505ThrPhe: 1.505 ± 0.342
4.605ThrGly: 4.605 ± 0.777
0.797ThrHis: 0.797 ± 0.266
3.808ThrIle: 3.808 ± 0.631
1.328ThrLys: 1.328 ± 0.356
5.313ThrLeu: 5.313 ± 0.869
0.886ThrMet: 0.886 ± 0.339
1.682ThrAsn: 1.682 ± 0.343
3.011ThrPro: 3.011 ± 0.546
2.568ThrGln: 2.568 ± 0.362
3.276ThrArg: 3.276 ± 0.55
4.162ThrSer: 4.162 ± 0.543
4.428ThrThr: 4.428 ± 0.895
4.516ThrVal: 4.516 ± 0.825
0.531ThrTrp: 0.531 ± 0.2
1.063ThrTyr: 1.063 ± 0.278
0.0ThrXaa: 0.0 ± 0.0
Val
6.287ValAla: 6.287 ± 0.733
0.177ValCys: 0.177 ± 0.123
3.719ValAsp: 3.719 ± 0.588
4.605ValGlu: 4.605 ± 0.553
2.302ValPhe: 2.302 ± 0.444
3.365ValGly: 3.365 ± 0.466
0.797ValHis: 0.797 ± 0.327
4.428ValIle: 4.428 ± 0.699
2.657ValLys: 2.657 ± 0.508
5.402ValLeu: 5.402 ± 0.563
1.594ValMet: 1.594 ± 0.489
3.011ValAsn: 3.011 ± 0.517
2.922ValPro: 2.922 ± 0.551
3.365ValGln: 3.365 ± 0.597
4.87ValArg: 4.87 ± 0.587
5.224ValSer: 5.224 ± 0.854
4.959ValThr: 4.959 ± 0.804
3.808ValVal: 3.808 ± 0.663
0.974ValTrp: 0.974 ± 0.283
1.594ValTyr: 1.594 ± 0.385
0.0ValXaa: 0.0 ± 0.0
Trp
0.974TrpAla: 0.974 ± 0.242
0.354TrpCys: 0.354 ± 0.165
0.797TrpAsp: 0.797 ± 0.297
1.063TrpGlu: 1.063 ± 0.252
0.62TrpPhe: 0.62 ± 0.321
0.62TrpGly: 0.62 ± 0.308
0.62TrpHis: 0.62 ± 0.199
0.797TrpIle: 0.797 ± 0.319
0.354TrpLys: 0.354 ± 0.179
1.682TrpLeu: 1.682 ± 0.341
0.531TrpMet: 0.531 ± 0.215
0.62TrpAsn: 0.62 ± 0.198
0.797TrpPro: 0.797 ± 0.225
0.531TrpGln: 0.531 ± 0.203
0.974TrpArg: 0.974 ± 0.38
1.505TrpSer: 1.505 ± 0.372
0.62TrpThr: 0.62 ± 0.233
0.974TrpVal: 0.974 ± 0.197
0.177TrpTrp: 0.177 ± 0.11
0.708TrpTyr: 0.708 ± 0.286
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.922TyrAla: 2.922 ± 0.654
0.266TyrCys: 0.266 ± 0.17
1.594TyrAsp: 1.594 ± 0.393
1.24TyrGlu: 1.24 ± 0.414
1.86TyrPhe: 1.86 ± 0.429
2.657TyrGly: 2.657 ± 0.503
0.177TyrHis: 0.177 ± 0.12
1.24TyrIle: 1.24 ± 0.395
1.151TyrLys: 1.151 ± 0.326
2.125TyrLeu: 2.125 ± 0.424
0.443TyrMet: 0.443 ± 0.156
0.797TyrAsn: 0.797 ± 0.366
1.505TyrPro: 1.505 ± 0.343
1.948TyrGln: 1.948 ± 0.412
2.479TyrArg: 2.479 ± 0.554
2.037TyrSer: 2.037 ± 0.647
1.505TyrThr: 1.505 ± 0.297
1.24TyrVal: 1.24 ± 0.297
0.62TyrTrp: 0.62 ± 0.227
0.62TyrTyr: 0.62 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski