Amino acid dipepetide frequency for Kingella kingae ATCC 23330

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.499AlaAla: 12.499 ± 0.214
1.468AlaCys: 1.468 ± 0.063
5.563AlaAsp: 5.563 ± 0.095
6.317AlaGlu: 6.317 ± 0.12
3.927AlaPhe: 3.927 ± 0.091
6.951AlaGly: 6.951 ± 0.12
2.261AlaHis: 2.261 ± 0.072
5.654AlaIle: 5.654 ± 0.103
5.532AlaLys: 5.532 ± 0.106
10.545AlaLeu: 10.545 ± 0.181
2.834AlaMet: 2.834 ± 0.076
4.222AlaAsn: 4.222 ± 0.098
3.803AlaPro: 3.803 ± 0.104
6.464AlaGln: 6.464 ± 0.14
4.508AlaArg: 4.508 ± 0.094
5.072AlaSer: 5.072 ± 0.118
5.085AlaThr: 5.085 ± 0.112
6.723AlaVal: 6.723 ± 0.105
1.318AlaTrp: 1.318 ± 0.048
2.789AlaTyr: 2.789 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
1.041CysAla: 1.041 ± 0.04
0.161CysCys: 0.161 ± 0.017
0.574CysAsp: 0.574 ± 0.03
0.538CysGlu: 0.538 ± 0.032
0.468CysPhe: 0.468 ± 0.031
1.018CysGly: 1.018 ± 0.04
0.304CysHis: 0.304 ± 0.024
0.536CysIle: 0.536 ± 0.036
0.358CysLys: 0.358 ± 0.023
1.123CysLeu: 1.123 ± 0.049
0.182CysMet: 0.182 ± 0.018
0.374CysAsn: 0.374 ± 0.026
0.515CysPro: 0.515 ± 0.034
0.526CysGln: 0.526 ± 0.032
0.613CysArg: 0.613 ± 0.032
0.606CysSer: 0.606 ± 0.034
0.698CysThr: 0.698 ± 0.038
0.777CysVal: 0.777 ± 0.039
0.105CysTrp: 0.105 ± 0.016
0.307CysTyr: 0.307 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.793AspAla: 4.793 ± 0.098
0.557AspCys: 0.557 ± 0.034
2.841AspAsp: 2.841 ± 0.074
3.548AspGlu: 3.548 ± 0.088
2.518AspPhe: 2.518 ± 0.064
3.553AspGly: 3.553 ± 0.094
0.737AspHis: 0.737 ± 0.036
3.286AspIle: 3.286 ± 0.082
3.169AspLys: 3.169 ± 0.073
5.607AspLeu: 5.607 ± 0.09
1.332AspMet: 1.332 ± 0.051
2.434AspAsn: 2.434 ± 0.075
1.544AspPro: 1.544 ± 0.06
1.24AspGln: 1.24 ± 0.048
1.798AspArg: 1.798 ± 0.059
2.623AspSer: 2.623 ± 0.06
2.694AspThr: 2.694 ± 0.074
3.93AspVal: 3.93 ± 0.082
0.997AspTrp: 0.997 ± 0.041
1.905AspTyr: 1.905 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.734GluAla: 4.734 ± 0.107
0.545GluCys: 0.545 ± 0.034
2.087GluAsp: 2.087 ± 0.067
2.569GluGlu: 2.569 ± 0.08
2.298GluPhe: 2.298 ± 0.071
2.425GluGly: 2.425 ± 0.08
1.617GluHis: 1.617 ± 0.053
3.841GluIle: 3.841 ± 0.083
3.452GluLys: 3.452 ± 0.097
5.86GluLeu: 5.86 ± 0.103
1.716GluMet: 1.716 ± 0.053
2.993GluAsn: 2.993 ± 0.089
1.968GluPro: 1.968 ± 0.067
4.287GluGln: 4.287 ± 0.101
3.279GluArg: 3.279 ± 0.079
2.783GluSer: 2.783 ± 0.073
2.913GluThr: 2.913 ± 0.092
3.335GluVal: 3.335 ± 0.098
0.819GluTrp: 0.819 ± 0.039
1.58GluTyr: 1.58 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
4.617PheAla: 4.617 ± 0.104
0.562PheCys: 0.562 ± 0.034
2.558PheAsp: 2.558 ± 0.073
2.16PheGlu: 2.16 ± 0.067
1.772PhePhe: 1.772 ± 0.074
3.354PheGly: 3.354 ± 0.091
0.843PheHis: 0.843 ± 0.038
2.34PheIle: 2.34 ± 0.081
1.839PheLys: 1.839 ± 0.062
3.595PheLeu: 3.595 ± 0.099
1.093PheMet: 1.093 ± 0.05
1.987PheAsn: 1.987 ± 0.051
1.421PhePro: 1.421 ± 0.053
1.414PheGln: 1.414 ± 0.056
1.636PheArg: 1.636 ± 0.054
2.514PheSer: 2.514 ± 0.079
2.24PheThr: 2.24 ± 0.058
3.103PheVal: 3.103 ± 0.074
0.627PheTrp: 0.627 ± 0.04
1.372PheTyr: 1.372 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
6.178GlyAla: 6.178 ± 0.119
0.966GlyCys: 0.966 ± 0.043
3.506GlyAsp: 3.506 ± 0.084
4.035GlyGlu: 4.035 ± 0.089
2.989GlyPhe: 2.989 ± 0.071
4.868GlyGly: 4.868 ± 0.113
1.317GlyHis: 1.317 ± 0.059
4.4GlyIle: 4.4 ± 0.103
4.786GlyLys: 4.786 ± 0.1
6.702GlyLeu: 6.702 ± 0.132
2.099GlyMet: 2.099 ± 0.06
2.935GlyAsn: 2.935 ± 0.1
0.814GlyPro: 0.814 ± 0.039
2.586GlyGln: 2.586 ± 0.07
2.97GlyArg: 2.97 ± 0.082
4.226GlySer: 4.226 ± 0.099
3.318GlyThr: 3.318 ± 0.087
5.175GlyVal: 5.175 ± 0.106
0.969GlyTrp: 0.969 ± 0.038
2.314GlyTyr: 2.314 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.359HisAla: 2.359 ± 0.066
0.286HisCys: 0.286 ± 0.019
1.358HisAsp: 1.358 ± 0.054
1.42HisGlu: 1.42 ± 0.053
1.072HisPhe: 1.072 ± 0.043
1.778HisGly: 1.778 ± 0.061
0.739HisHis: 0.739 ± 0.04
1.863HisIle: 1.863 ± 0.062
1.098HisLys: 1.098 ± 0.044
2.158HisLeu: 2.158 ± 0.072
0.477HisMet: 0.477 ± 0.032
1.112HisAsn: 1.112 ± 0.042
1.02HisPro: 1.02 ± 0.044
1.069HisGln: 1.069 ± 0.05
1.144HisArg: 1.144 ± 0.045
1.371HisSer: 1.371 ± 0.052
1.404HisThr: 1.404 ± 0.047
1.299HisVal: 1.299 ± 0.049
0.339HisTrp: 0.339 ± 0.027
0.894HisTyr: 0.894 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.14IleAla: 7.14 ± 0.123
0.664IleCys: 0.664 ± 0.037
3.298IleAsp: 3.298 ± 0.075
3.428IleGlu: 3.428 ± 0.09
2.198IlePhe: 2.198 ± 0.07
4.524IleGly: 4.524 ± 0.11
1.269IleHis: 1.269 ± 0.046
3.429IleIle: 3.429 ± 0.087
2.911IleLys: 2.911 ± 0.073
5.275IleLeu: 5.275 ± 0.112
1.498IleMet: 1.498 ± 0.057
2.733IleAsn: 2.733 ± 0.068
2.263IlePro: 2.263 ± 0.07
2.537IleGln: 2.537 ± 0.074
2.947IleArg: 2.947 ± 0.07
3.583IleSer: 3.583 ± 0.088
3.456IleThr: 3.456 ± 0.076
4.407IleVal: 4.407 ± 0.092
0.681IleTrp: 0.681 ± 0.035
1.594IleTyr: 1.594 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.582LysAla: 4.582 ± 0.104
0.318LysCys: 0.318 ± 0.021
2.38LysAsp: 2.38 ± 0.071
2.532LysGlu: 2.532 ± 0.07
1.61LysPhe: 1.61 ± 0.064
3.054LysGly: 3.054 ± 0.081
1.261LysHis: 1.261 ± 0.048
3.597LysIle: 3.597 ± 0.079
2.909LysLys: 2.909 ± 0.087
5.298LysLeu: 5.298 ± 0.094
1.757LysMet: 1.757 ± 0.052
2.609LysAsn: 2.609 ± 0.071
2.413LysPro: 2.413 ± 0.07
3.283LysGln: 3.283 ± 0.086
2.75LysArg: 2.75 ± 0.083
2.837LysSer: 2.837 ± 0.078
3.237LysThr: 3.237 ± 0.079
3.084LysVal: 3.084 ± 0.075
0.597LysTrp: 0.597 ± 0.036
1.329LysTyr: 1.329 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
10.871LeuAla: 10.871 ± 0.194
1.111LeuCys: 1.111 ± 0.047
5.39LeuAsp: 5.39 ± 0.108
4.458LeuGlu: 4.458 ± 0.097
4.262LeuPhe: 4.262 ± 0.093
7.0LeuGly: 7.0 ± 0.135
3.028LeuHis: 3.028 ± 0.09
5.565LeuIle: 5.565 ± 0.11
4.673LeuLys: 4.673 ± 0.104
10.409LeuLeu: 10.409 ± 0.21
2.488LeuMet: 2.488 ± 0.069
4.905LeuAsn: 4.905 ± 0.113
5.914LeuPro: 5.914 ± 0.108
4.999LeuGln: 4.999 ± 0.111
5.312LeuArg: 5.312 ± 0.105
6.703LeuSer: 6.703 ± 0.114
5.308LeuThr: 5.308 ± 0.099
6.122LeuVal: 6.122 ± 0.125
1.14LeuTrp: 1.14 ± 0.054
2.495LeuTyr: 2.495 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.549MetAla: 2.549 ± 0.068
0.251MetCys: 0.251 ± 0.023
1.133MetAsp: 1.133 ± 0.048
1.093MetGlu: 1.093 ± 0.045
0.887MetPhe: 0.887 ± 0.042
1.767MetGly: 1.767 ± 0.057
0.489MetHis: 0.489 ± 0.03
1.503MetIle: 1.503 ± 0.056
1.53MetLys: 1.53 ± 0.051
2.719MetLeu: 2.719 ± 0.076
0.87MetMet: 0.87 ± 0.044
1.299MetAsn: 1.299 ± 0.046
1.259MetPro: 1.259 ± 0.044
1.599MetGln: 1.599 ± 0.057
1.35MetArg: 1.35 ± 0.051
1.659MetSer: 1.659 ± 0.06
1.58MetThr: 1.58 ± 0.048
1.65MetVal: 1.65 ± 0.058
0.288MetTrp: 0.288 ± 0.023
0.547MetTyr: 0.547 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
4.494AsnAla: 4.494 ± 0.122
0.361AsnCys: 0.361 ± 0.026
2.102AsnAsp: 2.102 ± 0.062
2.352AsnGlu: 2.352 ± 0.067
1.502AsnPhe: 1.502 ± 0.055
3.59AsnGly: 3.59 ± 0.096
1.058AsnHis: 1.058 ± 0.041
2.736AsnIle: 2.736 ± 0.079
2.399AsnLys: 2.399 ± 0.077
3.988AsnLeu: 3.988 ± 0.075
1.083AsnMet: 1.083 ± 0.041
2.025AsnAsn: 2.025 ± 0.092
2.612AsnPro: 2.612 ± 0.072
2.637AsnGln: 2.637 ± 0.078
2.369AsnArg: 2.369 ± 0.071
2.219AsnSer: 2.219 ± 0.068
2.446AsnThr: 2.446 ± 0.087
3.106AsnVal: 3.106 ± 0.074
0.662AsnTrp: 0.662 ± 0.031
1.294AsnTyr: 1.294 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
4.278ProAla: 4.278 ± 0.091
0.398ProCys: 0.398 ± 0.026
2.476ProAsp: 2.476 ± 0.063
3.4ProGlu: 3.4 ± 0.075
1.856ProPhe: 1.856 ± 0.063
1.02ProGly: 1.02 ± 0.053
1.156ProHis: 1.156 ± 0.049
2.478ProIle: 2.478 ± 0.074
2.202ProLys: 2.202 ± 0.059
3.721ProLeu: 3.721 ± 0.076
1.062ProMet: 1.062 ± 0.04
2.42ProAsn: 2.42 ± 0.064
1.245ProPro: 1.245 ± 0.049
1.95ProGln: 1.95 ± 0.067
1.565ProArg: 1.565 ± 0.05
2.122ProSer: 2.122 ± 0.065
2.507ProThr: 2.507 ± 0.073
2.961ProVal: 2.961 ± 0.084
0.381ProTrp: 0.381 ± 0.028
1.294ProTyr: 1.294 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
6.593GlnAla: 6.593 ± 0.135
0.379GlnCys: 0.379 ± 0.025
2.095GlnAsp: 2.095 ± 0.06
2.371GlnGlu: 2.371 ± 0.067
2.085GlnPhe: 2.085 ± 0.061
2.97GlnGly: 2.97 ± 0.074
1.647GlnHis: 1.647 ± 0.061
3.557GlnIle: 3.557 ± 0.087
2.682GlnLys: 2.682 ± 0.077
4.708GlnLeu: 4.708 ± 0.108
1.28GlnMet: 1.28 ± 0.045
2.696GlnAsn: 2.696 ± 0.07
2.527GlnPro: 2.527 ± 0.072
3.66GlnGln: 3.66 ± 0.124
2.701GlnArg: 2.701 ± 0.08
3.082GlnSer: 3.082 ± 0.072
3.384GlnThr: 3.384 ± 0.082
2.893GlnVal: 2.893 ± 0.066
0.677GlnTrp: 0.677 ± 0.04
1.558GlnTyr: 1.558 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
4.362ArgAla: 4.362 ± 0.082
0.388ArgCys: 0.388 ± 0.026
2.836ArgAsp: 2.836 ± 0.082
3.394ArgGlu: 3.394 ± 0.092
2.34ArgPhe: 2.34 ± 0.067
2.932ArgGly: 2.932 ± 0.078
1.264ArgHis: 1.264 ± 0.045
2.921ArgIle: 2.921 ± 0.07
2.352ArgLys: 2.352 ± 0.065
5.289ArgLeu: 5.289 ± 0.101
1.25ArgMet: 1.25 ± 0.049
1.915ArgAsn: 1.915 ± 0.059
1.805ArgPro: 1.805 ± 0.062
2.75ArgGln: 2.75 ± 0.079
2.478ArgArg: 2.478 ± 0.064
2.333ArgSer: 2.333 ± 0.059
2.261ArgThr: 2.261 ± 0.067
3.555ArgVal: 3.555 ± 0.082
0.595ArgTrp: 0.595 ± 0.032
1.797ArgTyr: 1.797 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.418SerAla: 5.418 ± 0.101
0.54SerCys: 0.54 ± 0.032
2.981SerAsp: 2.981 ± 0.067
3.019SerGlu: 3.019 ± 0.084
2.205SerPhe: 2.205 ± 0.072
4.887SerGly: 4.887 ± 0.111
1.434SerHis: 1.434 ± 0.05
3.064SerIle: 3.064 ± 0.078
2.628SerLys: 2.628 ± 0.07
6.307SerLeu: 6.307 ± 0.124
1.315SerMet: 1.315 ± 0.049
2.275SerAsn: 2.275 ± 0.072
2.406SerPro: 2.406 ± 0.057
2.733SerGln: 2.733 ± 0.075
2.768SerArg: 2.768 ± 0.072
3.698SerSer: 3.698 ± 0.087
2.668SerThr: 2.668 ± 0.077
3.93SerVal: 3.93 ± 0.085
0.73SerTrp: 0.73 ± 0.039
1.461SerTyr: 1.461 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.549ThrAla: 5.549 ± 0.105
0.435ThrCys: 0.435 ± 0.031
2.555ThrAsp: 2.555 ± 0.071
2.872ThrGlu: 2.872 ± 0.079
2.003ThrPhe: 2.003 ± 0.063
3.918ThrGly: 3.918 ± 0.09
1.358ThrHis: 1.358 ± 0.053
3.036ThrIle: 3.036 ± 0.08
2.031ThrLys: 2.031 ± 0.07
6.164ThrLeu: 6.164 ± 0.107
1.173ThrMet: 1.173 ± 0.049
1.853ThrAsn: 1.853 ± 0.061
2.993ThrPro: 2.993 ± 0.078
2.906ThrGln: 2.906 ± 0.075
2.556ThrArg: 2.556 ± 0.07
2.754ThrSer: 2.754 ± 0.091
2.787ThrThr: 2.787 ± 0.091
4.168ThrVal: 4.168 ± 0.097
0.693ThrTrp: 0.693 ± 0.033
1.324ThrTyr: 1.324 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
7.43ValAla: 7.43 ± 0.141
0.868ValCys: 0.868 ± 0.046
3.279ValAsp: 3.279 ± 0.088
3.669ValGlu: 3.669 ± 0.096
2.836ValPhe: 2.836 ± 0.081
4.73ValGly: 4.73 ± 0.1
1.372ValHis: 1.372 ± 0.047
3.745ValIle: 3.745 ± 0.086
3.234ValLys: 3.234 ± 0.077
7.554ValLeu: 7.554 ± 0.12
1.708ValMet: 1.708 ± 0.06
2.706ValAsn: 2.706 ± 0.097
2.558ValPro: 2.558 ± 0.071
3.903ValGln: 3.903 ± 0.085
3.407ValArg: 3.407 ± 0.076
4.175ValSer: 4.175 ± 0.09
2.775ValThr: 2.775 ± 0.087
5.065ValVal: 5.065 ± 0.108
0.922ValTrp: 0.922 ± 0.044
1.907ValTyr: 1.907 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
1.135TrpAla: 1.135 ± 0.053
0.199TrpCys: 0.199 ± 0.02
0.583TrpAsp: 0.583 ± 0.031
0.51TrpGlu: 0.51 ± 0.029
0.707TrpPhe: 0.707 ± 0.041
0.77TrpGly: 0.77 ± 0.041
0.389TrpHis: 0.389 ± 0.024
0.779TrpIle: 0.779 ± 0.032
0.512TrpLys: 0.512 ± 0.029
2.031TrpLeu: 2.031 ± 0.072
0.224TrpMet: 0.224 ± 0.021
0.468TrpAsn: 0.468 ± 0.03
0.101TrpPro: 0.101 ± 0.013
1.441TrpGln: 1.441 ± 0.062
0.817TrpArg: 0.817 ± 0.047
0.526TrpSer: 0.526 ± 0.031
0.609TrpThr: 0.609 ± 0.033
0.803TrpVal: 0.803 ± 0.039
0.203TrpTrp: 0.203 ± 0.021
0.365TrpTyr: 0.365 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.914TyrAla: 2.914 ± 0.082
0.367TyrCys: 0.367 ± 0.026
1.51TyrAsp: 1.51 ± 0.054
1.416TyrGlu: 1.416 ± 0.048
1.514TyrPhe: 1.514 ± 0.05
2.041TyrGly: 2.041 ± 0.06
0.716TyrHis: 0.716 ± 0.034
1.503TyrIle: 1.503 ± 0.05
1.142TyrLys: 1.142 ± 0.046
3.103TyrLeu: 3.103 ± 0.065
0.581TyrMet: 0.581 ± 0.031
1.076TyrAsn: 1.076 ± 0.053
1.31TyrPro: 1.31 ± 0.049
1.563TyrGln: 1.563 ± 0.057
1.849TyrArg: 1.849 ± 0.052
1.582TyrSer: 1.582 ± 0.048
1.757TyrThr: 1.757 ± 0.053
1.753TyrVal: 1.753 ± 0.058
0.428TyrTrp: 0.428 ± 0.027
0.91TyrTyr: 0.91 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2102 proteins (572704 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski