Amino acid dipepetide frequency for Streptococcus satellite phage Javan357

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.0AlaCys: 0.0 ± 0.0
2.009AlaAsp: 2.009 ± 0.705
3.616AlaGlu: 3.616 ± 1.105
1.607AlaPhe: 1.607 ± 0.727
2.009AlaGly: 2.009 ± 0.714
0.0AlaHis: 0.0 ± 0.0
2.009AlaIle: 2.009 ± 0.826
7.232AlaLys: 7.232 ± 1.578
3.616AlaLeu: 3.616 ± 1.091
2.009AlaMet: 2.009 ± 0.825
2.812AlaAsn: 2.812 ± 1.01
0.402AlaPro: 0.402 ± 0.385
0.402AlaGln: 0.402 ± 0.385
2.812AlaArg: 2.812 ± 0.946
1.205AlaSer: 1.205 ± 0.841
4.018AlaThr: 4.018 ± 0.887
1.607AlaVal: 1.607 ± 0.634
0.402AlaTrp: 0.402 ± 0.385
3.214AlaTyr: 3.214 ± 0.957
0.0AlaXaa: 0.0 ± 0.0
Cys
0.402CysAla: 0.402 ± 0.385
0.0CysCys: 0.0 ± 0.0
0.402CysAsp: 0.402 ± 0.338
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.205CysGly: 1.205 ± 0.545
0.0CysHis: 0.0 ± 0.0
0.804CysIle: 0.804 ± 0.527
0.402CysLys: 0.402 ± 0.432
0.804CysLeu: 0.804 ± 0.629
0.402CysMet: 0.402 ± 0.393
0.0CysAsn: 0.0 ± 0.0
0.804CysPro: 0.804 ± 0.464
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.402CysThr: 0.402 ± 0.315
0.402CysVal: 0.402 ± 0.338
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.804AspAla: 0.804 ± 0.59
0.804AspCys: 0.804 ± 0.444
6.027AspAsp: 6.027 ± 1.702
2.411AspGlu: 2.411 ± 0.597
6.027AspPhe: 6.027 ± 1.352
4.018AspGly: 4.018 ± 0.917
0.804AspHis: 0.804 ± 0.463
5.223AspIle: 5.223 ± 1.46
6.428AspLys: 6.428 ± 1.082
7.634AspLeu: 7.634 ± 1.596
1.205AspMet: 1.205 ± 0.562
6.027AspAsn: 6.027 ± 1.427
0.402AspPro: 0.402 ± 0.432
0.804AspGln: 0.804 ± 0.381
2.009AspArg: 2.009 ± 0.754
4.018AspSer: 4.018 ± 0.814
4.821AspThr: 4.821 ± 1.468
3.616AspVal: 3.616 ± 1.115
0.804AspTrp: 0.804 ± 0.456
1.205AspTyr: 1.205 ± 0.684
0.0AspXaa: 0.0 ± 0.0
Glu
3.616GluAla: 3.616 ± 1.212
1.205GluCys: 1.205 ± 0.501
6.027GluAsp: 6.027 ± 1.719
4.419GluGlu: 4.419 ± 1.282
3.214GluPhe: 3.214 ± 0.979
2.812GluGly: 2.812 ± 1.073
0.804GluHis: 0.804 ± 0.407
7.634GluIle: 7.634 ± 1.47
12.455GluLys: 12.455 ± 2.467
8.437GluLeu: 8.437 ± 1.607
0.804GluMet: 0.804 ± 0.603
5.223GluAsn: 5.223 ± 1.292
1.607GluPro: 1.607 ± 1.158
3.214GluGln: 3.214 ± 1.073
3.214GluArg: 3.214 ± 1.128
3.616GluSer: 3.616 ± 0.936
5.625GluThr: 5.625 ± 1.375
3.214GluVal: 3.214 ± 0.989
0.804GluTrp: 0.804 ± 0.381
4.018GluTyr: 4.018 ± 1.449
0.0GluXaa: 0.0 ± 0.0
Phe
1.205PheAla: 1.205 ± 0.819
0.402PheCys: 0.402 ± 0.338
5.223PheAsp: 5.223 ± 1.298
5.223PheGlu: 5.223 ± 1.227
3.214PhePhe: 3.214 ± 0.821
2.411PheGly: 2.411 ± 0.67
0.804PheHis: 0.804 ± 0.463
2.009PheIle: 2.009 ± 0.831
4.821PheLys: 4.821 ± 1.571
6.027PheLeu: 6.027 ± 1.409
0.804PheMet: 0.804 ± 0.578
0.804PheAsn: 0.804 ± 0.675
1.205PhePro: 1.205 ± 0.86
0.804PheGln: 0.804 ± 0.59
0.804PheArg: 0.804 ± 0.428
4.018PheSer: 4.018 ± 1.116
2.411PheThr: 2.411 ± 1.101
3.214PheVal: 3.214 ± 1.1
0.804PheTrp: 0.804 ± 0.381
1.205PheTyr: 1.205 ± 0.665
0.0PheXaa: 0.0 ± 0.0
Gly
1.607GlyAla: 1.607 ± 0.837
0.402GlyCys: 0.402 ± 0.315
2.009GlyAsp: 2.009 ± 0.914
0.804GlyGlu: 0.804 ± 0.562
2.009GlyPhe: 2.009 ± 0.743
2.812GlyGly: 2.812 ± 1.394
0.804GlyHis: 0.804 ± 0.381
3.616GlyIle: 3.616 ± 0.996
5.223GlyLys: 5.223 ± 1.753
4.018GlyLeu: 4.018 ± 1.003
0.804GlyMet: 0.804 ± 0.407
3.616GlyAsn: 3.616 ± 0.842
0.0GlyPro: 0.0 ± 0.0
1.205GlyGln: 1.205 ± 0.538
2.009GlyArg: 2.009 ± 0.783
4.018GlySer: 4.018 ± 1.39
3.214GlyThr: 3.214 ± 0.925
3.214GlyVal: 3.214 ± 0.738
1.205GlyTrp: 1.205 ± 0.577
4.419GlyTyr: 4.419 ± 1.533
0.0GlyXaa: 0.0 ± 0.0
His
3.214HisAla: 3.214 ± 1.174
0.0HisCys: 0.0 ± 0.0
0.402HisAsp: 0.402 ± 0.344
0.804HisGlu: 0.804 ± 0.521
0.0HisPhe: 0.0 ± 0.0
0.402HisGly: 0.402 ± 0.344
0.402HisHis: 0.402 ± 0.385
0.804HisIle: 0.804 ± 0.463
3.214HisLys: 3.214 ± 1.104
2.009HisLeu: 2.009 ± 1.072
0.0HisMet: 0.0 ± 0.0
0.402HisAsn: 0.402 ± 0.344
0.0HisPro: 0.0 ± 0.0
1.205HisGln: 1.205 ± 0.674
0.0HisArg: 0.0 ± 0.0
0.402HisSer: 0.402 ± 0.408
3.214HisThr: 3.214 ± 1.055
0.402HisVal: 0.402 ± 0.324
0.0HisTrp: 0.0 ± 0.0
0.402HisTyr: 0.402 ± 0.418
0.0HisXaa: 0.0 ± 0.0
Ile
1.607IleAla: 1.607 ± 0.92
0.0IleCys: 0.0 ± 0.0
5.223IleAsp: 5.223 ± 0.932
3.616IleGlu: 3.616 ± 1.308
3.214IlePhe: 3.214 ± 1.021
2.009IleGly: 2.009 ± 0.68
1.205IleHis: 1.205 ± 0.631
4.018IleIle: 4.018 ± 1.016
7.232IleLys: 7.232 ± 1.54
8.035IleLeu: 8.035 ± 1.736
0.804IleMet: 0.804 ± 0.449
5.625IleAsn: 5.625 ± 1.352
2.812IlePro: 2.812 ± 0.889
3.214IleGln: 3.214 ± 0.835
1.607IleArg: 1.607 ± 0.504
6.027IleSer: 6.027 ± 1.229
3.616IleThr: 3.616 ± 1.142
2.009IleVal: 2.009 ± 0.892
0.0IleTrp: 0.0 ± 0.0
2.411IleTyr: 2.411 ± 0.903
0.0IleXaa: 0.0 ± 0.0
Lys
5.625LysAla: 5.625 ± 1.426
0.804LysCys: 0.804 ± 0.543
5.223LysAsp: 5.223 ± 1.36
12.053LysGlu: 12.053 ± 1.567
4.018LysPhe: 4.018 ± 1.696
5.625LysGly: 5.625 ± 1.317
2.411LysHis: 2.411 ± 0.728
7.232LysIle: 7.232 ± 1.276
10.044LysLys: 10.044 ± 1.867
6.428LysLeu: 6.428 ± 0.812
4.419LysMet: 4.419 ± 1.403
8.035LysAsn: 8.035 ± 1.697
1.607LysPro: 1.607 ± 0.671
5.625LysGln: 5.625 ± 1.373
8.035LysArg: 8.035 ± 1.369
7.634LysSer: 7.634 ± 1.542
7.634LysThr: 7.634 ± 2.042
6.83LysVal: 6.83 ± 1.333
0.804LysTrp: 0.804 ± 0.473
3.214LysTyr: 3.214 ± 0.778
0.0LysXaa: 0.0 ± 0.0
Leu
4.419LeuAla: 4.419 ± 1.279
0.804LeuCys: 0.804 ± 0.484
9.642LeuAsp: 9.642 ± 1.864
11.651LeuGlu: 11.651 ± 1.84
4.018LeuPhe: 4.018 ± 1.037
7.232LeuGly: 7.232 ± 1.245
2.411LeuHis: 2.411 ± 0.956
6.027LeuIle: 6.027 ± 1.479
10.044LeuLys: 10.044 ± 1.55
8.437LeuLeu: 8.437 ± 1.56
2.009LeuMet: 2.009 ± 0.489
6.428LeuAsn: 6.428 ± 1.9
2.411LeuPro: 2.411 ± 0.737
4.419LeuGln: 4.419 ± 0.908
2.411LeuArg: 2.411 ± 0.646
3.616LeuSer: 3.616 ± 0.758
5.223LeuThr: 5.223 ± 1.534
5.223LeuVal: 5.223 ± 1.65
0.402LeuTrp: 0.402 ± 0.389
3.214LeuTyr: 3.214 ± 0.911
0.0LeuXaa: 0.0 ± 0.0
Met
0.804MetAla: 0.804 ± 0.506
0.0MetCys: 0.0 ± 0.0
2.009MetAsp: 2.009 ± 0.563
2.411MetGlu: 2.411 ± 1.433
0.402MetPhe: 0.402 ± 0.398
0.804MetGly: 0.804 ± 0.505
0.0MetHis: 0.0 ± 0.0
1.607MetIle: 1.607 ± 0.824
2.411MetLys: 2.411 ± 0.699
1.205MetLeu: 1.205 ± 0.423
0.0MetMet: 0.0 ± 0.0
2.411MetAsn: 2.411 ± 0.803
0.402MetPro: 0.402 ± 0.389
0.402MetGln: 0.402 ± 0.344
2.009MetArg: 2.009 ± 0.901
0.402MetSer: 0.402 ± 0.432
2.411MetThr: 2.411 ± 1.228
1.607MetVal: 1.607 ± 0.624
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.411AsnAla: 2.411 ± 0.842
0.402AsnCys: 0.402 ± 0.315
2.812AsnAsp: 2.812 ± 1.088
2.411AsnGlu: 2.411 ± 1.128
3.214AsnPhe: 3.214 ± 0.593
4.018AsnGly: 4.018 ± 1.273
2.009AsnHis: 2.009 ± 0.832
2.411AsnIle: 2.411 ± 0.841
6.027AsnLys: 6.027 ± 1.282
7.634AsnLeu: 7.634 ± 1.221
2.411AsnMet: 2.411 ± 1.401
5.223AsnAsn: 5.223 ± 1.681
2.411AsnPro: 2.411 ± 0.766
2.812AsnGln: 2.812 ± 1.027
2.812AsnArg: 2.812 ± 0.689
3.616AsnSer: 3.616 ± 1.48
5.625AsnThr: 5.625 ± 1.712
2.009AsnVal: 2.009 ± 0.969
0.402AsnTrp: 0.402 ± 0.389
3.214AsnTyr: 3.214 ± 1.164
0.0AsnXaa: 0.0 ± 0.0
Pro
0.402ProAla: 0.402 ± 0.315
0.0ProCys: 0.0 ± 0.0
1.607ProAsp: 1.607 ± 0.96
2.009ProGlu: 2.009 ± 0.88
1.205ProPhe: 1.205 ± 0.582
0.402ProGly: 0.402 ± 0.389
0.402ProHis: 0.402 ± 0.344
1.205ProIle: 1.205 ± 0.604
4.419ProLys: 4.419 ± 1.539
0.402ProLeu: 0.402 ± 0.344
0.402ProMet: 0.402 ± 0.385
0.804ProAsn: 0.804 ± 0.543
0.402ProPro: 0.402 ± 0.398
0.804ProGln: 0.804 ± 0.795
0.804ProArg: 0.804 ± 0.462
1.205ProSer: 1.205 ± 0.665
1.205ProThr: 1.205 ± 0.86
1.205ProVal: 1.205 ± 0.501
0.0ProTrp: 0.0 ± 0.0
0.804ProTyr: 0.804 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
4.018GlnAla: 4.018 ± 1.213
0.402GlnCys: 0.402 ± 0.432
2.009GlnAsp: 2.009 ± 0.733
4.018GlnGlu: 4.018 ± 1.03
2.009GlnPhe: 2.009 ± 0.72
0.402GlnGly: 0.402 ± 0.393
1.205GlnHis: 1.205 ± 0.673
1.205GlnIle: 1.205 ± 0.423
3.214GlnLys: 3.214 ± 0.819
1.607GlnLeu: 1.607 ± 0.746
0.402GlnMet: 0.402 ± 0.662
1.205GlnAsn: 1.205 ± 0.518
0.402GlnPro: 0.402 ± 0.385
1.205GlnGln: 1.205 ± 0.798
3.616GlnArg: 3.616 ± 0.771
0.804GlnSer: 0.804 ± 0.615
2.812GlnThr: 2.812 ± 1.027
4.018GlnVal: 4.018 ± 0.926
0.402GlnTrp: 0.402 ± 0.324
1.607GlnTyr: 1.607 ± 0.566
0.0GlnXaa: 0.0 ± 0.0
Arg
2.009ArgAla: 2.009 ± 0.881
0.0ArgCys: 0.0 ± 0.0
2.812ArgAsp: 2.812 ± 0.775
4.018ArgGlu: 4.018 ± 1.25
2.009ArgPhe: 2.009 ± 0.668
2.009ArgGly: 2.009 ± 0.995
0.402ArgHis: 0.402 ± 0.315
2.812ArgIle: 2.812 ± 0.858
8.035ArgLys: 8.035 ± 1.244
5.223ArgLeu: 5.223 ± 1.175
0.402ArgMet: 0.402 ± 0.408
2.411ArgAsn: 2.411 ± 0.884
0.402ArgPro: 0.402 ± 0.389
2.009ArgGln: 2.009 ± 0.703
1.205ArgArg: 1.205 ± 0.643
2.411ArgSer: 2.411 ± 0.741
4.018ArgThr: 4.018 ± 1.232
1.205ArgVal: 1.205 ± 0.518
0.0ArgTrp: 0.0 ± 0.0
2.411ArgTyr: 2.411 ± 1.023
0.0ArgXaa: 0.0 ± 0.0
Ser
0.804SerAla: 0.804 ± 0.462
0.402SerCys: 0.402 ± 0.389
3.616SerAsp: 3.616 ± 1.002
6.428SerGlu: 6.428 ± 1.375
3.616SerPhe: 3.616 ± 1.265
4.018SerGly: 4.018 ± 1.042
2.812SerHis: 2.812 ± 1.014
2.009SerIle: 2.009 ± 0.992
6.027SerLys: 6.027 ± 1.945
6.027SerLeu: 6.027 ± 1.629
1.607SerMet: 1.607 ± 0.718
2.411SerAsn: 2.411 ± 1.045
0.804SerPro: 0.804 ± 0.526
2.411SerGln: 2.411 ± 0.946
1.607SerArg: 1.607 ± 0.671
2.812SerSer: 2.812 ± 1.147
3.616SerThr: 3.616 ± 0.913
3.214SerVal: 3.214 ± 1.106
0.804SerTrp: 0.804 ± 0.523
2.009SerTyr: 2.009 ± 0.897
0.0SerXaa: 0.0 ± 0.0
Thr
3.616ThrAla: 3.616 ± 1.561
0.0ThrCys: 0.0 ± 0.0
1.607ThrAsp: 1.607 ± 0.716
4.821ThrGlu: 4.821 ± 1.153
2.009ThrPhe: 2.009 ± 0.596
4.018ThrGly: 4.018 ± 1.175
0.804ThrHis: 0.804 ± 0.54
6.428ThrIle: 6.428 ± 1.736
6.027ThrLys: 6.027 ± 1.722
8.839ThrLeu: 8.839 ± 1.679
1.205ThrMet: 1.205 ± 0.516
3.214ThrAsn: 3.214 ± 0.722
2.009ThrPro: 2.009 ± 0.807
2.009ThrGln: 2.009 ± 1.345
5.625ThrArg: 5.625 ± 1.921
4.018ThrSer: 4.018 ± 1.501
4.018ThrThr: 4.018 ± 1.031
6.83ThrVal: 6.83 ± 1.28
0.804ThrTrp: 0.804 ± 0.514
2.812ThrTyr: 2.812 ± 1.525
0.0ThrXaa: 0.0 ± 0.0
Val
2.411ValAla: 2.411 ± 1.147
0.402ValCys: 0.402 ± 0.338
4.821ValAsp: 4.821 ± 1.377
6.027ValGlu: 6.027 ± 1.457
2.009ValPhe: 2.009 ± 0.661
0.0ValGly: 0.0 ± 0.0
0.0ValHis: 0.0 ± 0.0
3.616ValIle: 3.616 ± 1.035
5.223ValLys: 5.223 ± 1.443
5.223ValLeu: 5.223 ± 1.082
0.402ValMet: 0.402 ± 0.385
4.419ValAsn: 4.419 ± 1.003
1.205ValPro: 1.205 ± 0.665
2.411ValGln: 2.411 ± 0.774
1.607ValArg: 1.607 ± 0.888
4.821ValSer: 4.821 ± 1.128
4.821ValThr: 4.821 ± 1.022
2.009ValVal: 2.009 ± 0.883
0.0ValTrp: 0.0 ± 0.0
2.411ValTyr: 2.411 ± 0.713
0.0ValXaa: 0.0 ± 0.0
Trp
1.205TrpAla: 1.205 ± 0.423
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.009TrpGlu: 2.009 ± 0.885
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.804TrpIle: 0.804 ± 0.522
0.402TrpLys: 0.402 ± 0.389
1.205TrpLeu: 1.205 ± 0.86
0.402TrpMet: 0.402 ± 0.408
0.402TrpAsn: 0.402 ± 0.324
0.0TrpPro: 0.0 ± 0.0
0.402TrpGln: 0.402 ± 0.315
0.0TrpArg: 0.0 ± 0.0
0.402TrpSer: 0.402 ± 0.315
0.402TrpThr: 0.402 ± 0.344
0.402TrpVal: 0.402 ± 0.324
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.804TyrAla: 0.804 ± 0.487
0.0TyrCys: 0.0 ± 0.0
1.607TyrAsp: 1.607 ± 0.726
3.214TyrGlu: 3.214 ± 0.905
3.616TyrPhe: 3.616 ± 0.961
0.804TyrGly: 0.804 ± 0.428
0.0TyrHis: 0.0 ± 0.0
2.812TyrIle: 2.812 ± 0.982
4.419TyrLys: 4.419 ± 1.442
7.232TyrLeu: 7.232 ± 1.359
0.402TyrMet: 0.402 ± 0.414
2.411TyrAsn: 2.411 ± 0.812
0.402TyrPro: 0.402 ± 0.393
1.607TyrGln: 1.607 ± 0.59
3.616TyrArg: 3.616 ± 1.554
2.009TyrSer: 2.009 ± 0.971
1.607TyrThr: 1.607 ± 0.803
1.607TyrVal: 1.607 ± 0.651
0.402TyrTrp: 0.402 ± 0.338
1.205TyrTyr: 1.205 ± 0.795
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski