Amino acid dipepetide frequency for Winogradskyella endarachnes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.843AlaAla: 3.843 ± 0.081	0.528AlaCys: 0.528 ± 0.023	3.379AlaAsp: 3.379 ± 0.065	4.147AlaGlu: 4.147 ± 0.078	3.247AlaPhe: 3.247 ± 0.058	3.856AlaGly: 3.856 ± 0.079	1.043AlaHis: 1.043 ± 0.034	5.704AlaIle: 5.704 ± 0.089	4.788AlaLys: 4.788 ± 0.082	6.221AlaLeu: 6.221 ± 0.096	1.51AlaMet: 1.51 ± 0.045	3.592AlaAsn: 3.592 ± 0.07	1.704AlaPro: 1.704 ± 0.045	2.28AlaGln: 2.28 ± 0.054	1.776AlaArg: 1.776 ± 0.045	4.194AlaSer: 4.194 ± 0.071	3.78AlaThr: 3.78 ± 0.073	3.909AlaVal: 3.909 ± 0.07	0.562AlaTrp: 0.562 ± 0.025	2.437AlaTyr: 2.437 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.461CysAla: 0.461 ± 0.024	0.105CysCys: 0.105 ± 0.011	0.477CysAsp: 0.477 ± 0.029	0.483CysGlu: 0.483 ± 0.023	0.423CysPhe: 0.423 ± 0.021	0.616CysGly: 0.616 ± 0.026	0.18CysHis: 0.18 ± 0.013	0.617CysIle: 0.617 ± 0.024	0.469CysLys: 0.469 ± 0.022	0.615CysLeu: 0.615 ± 0.022	0.124CysMet: 0.124 ± 0.011	0.469CysAsn: 0.469 ± 0.024	0.327CysPro: 0.327 ± 0.021	0.193CysGln: 0.193 ± 0.013	0.166CysArg: 0.166 ± 0.013	0.566CysSer: 0.566 ± 0.03	0.417CysThr: 0.417 ± 0.027	0.444CysVal: 0.444 ± 0.023	0.059CysTrp: 0.059 ± 0.009	0.318CysTyr: 0.318 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.06AspAla: 4.06 ± 0.07	0.471AspCys: 0.471 ± 0.025	3.424AspAsp: 3.424 ± 0.081	3.734AspGlu: 3.734 ± 0.06	3.786AspPhe: 3.786 ± 0.069	3.962AspGly: 3.962 ± 0.099	0.787AspHis: 0.787 ± 0.025	4.894AspIle: 4.894 ± 0.082	4.085AspLys: 4.085 ± 0.072	5.406AspLeu: 5.406 ± 0.067	1.128AspMet: 1.128 ± 0.033	3.651AspAsn: 3.651 ± 0.069	1.477AspPro: 1.477 ± 0.052	1.463AspGln: 1.463 ± 0.038	1.624AspArg: 1.624 ± 0.043	3.487AspSer: 3.487 ± 0.064	3.125AspThr: 3.125 ± 0.065	3.895AspVal: 3.895 ± 0.071	0.705AspTrp: 0.705 ± 0.03	3.164AspTyr: 3.164 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.725GluAla: 4.725 ± 0.086	0.317GluCys: 0.317 ± 0.019	4.195GluAsp: 4.195 ± 0.066	4.706GluGlu: 4.706 ± 0.087	3.136GluPhe: 3.136 ± 0.058	3.651GluGly: 3.651 ± 0.066	1.178GluHis: 1.178 ± 0.035	5.525GluIle: 5.525 ± 0.083	5.268GluLys: 5.268 ± 0.094	6.246GluLeu: 6.246 ± 0.093	1.4GluMet: 1.4 ± 0.041	4.657GluAsn: 4.657 ± 0.069	1.595GluPro: 1.595 ± 0.043	2.278GluGln: 2.278 ± 0.045	2.375GluArg: 2.375 ± 0.059	3.595GluSer: 3.595 ± 0.052	4.118GluThr: 4.118 ± 0.062	4.206GluVal: 4.206 ± 0.076	0.547GluTrp: 0.547 ± 0.019	2.228GluTyr: 2.228 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.826PheAla: 2.826 ± 0.057	0.401PheCys: 0.401 ± 0.02	3.154PheAsp: 3.154 ± 0.059	3.485PheGlu: 3.485 ± 0.056	2.522PhePhe: 2.522 ± 0.066	3.743PheGly: 3.743 ± 0.065	0.779PheHis: 0.779 ± 0.025	4.055PheIle: 4.055 ± 0.077	4.25PheLys: 4.25 ± 0.079	4.379PheLeu: 4.379 ± 0.09	1.06PheMet: 1.06 ± 0.031	3.841PheAsn: 3.841 ± 0.065	1.573PhePro: 1.573 ± 0.039	1.493PheGln: 1.493 ± 0.04	1.465PheArg: 1.465 ± 0.041	4.011PheSer: 4.011 ± 0.063	3.24PheThr: 3.24 ± 0.064	2.987PheVal: 2.987 ± 0.05	0.53PheTrp: 0.53 ± 0.023	2.171PheTyr: 2.171 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	3.866GlyAla: 3.866 ± 0.086	0.602GlyCys: 0.602 ± 0.031	3.534GlyAsp: 3.534 ± 0.078	3.569GlyGlu: 3.569 ± 0.07	3.617GlyPhe: 3.617 ± 0.057	4.254GlyGly: 4.254 ± 0.088	1.088GlyHis: 1.088 ± 0.035	5.179GlyIle: 5.179 ± 0.076	4.609GlyLys: 4.609 ± 0.07	5.69GlyLeu: 5.69 ± 0.087	1.447GlyMet: 1.447 ± 0.046	3.645GlyAsn: 3.645 ± 0.072	1.278GlyPro: 1.278 ± 0.033	1.781GlyGln: 1.781 ± 0.042	1.901GlyArg: 1.901 ± 0.045	3.995GlySer: 3.995 ± 0.076	4.143GlyThr: 4.143 ± 0.116	4.173GlyVal: 4.173 ± 0.069	0.684GlyTrp: 0.684 ± 0.026	2.794GlyTyr: 2.794 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.92HisAla: 0.92 ± 0.027	0.173HisCys: 0.173 ± 0.014	0.732HisAsp: 0.732 ± 0.026	0.795HisGlu: 0.795 ± 0.03	1.088HisPhe: 1.088 ± 0.032	0.987HisGly: 0.987 ± 0.03	0.424HisHis: 0.424 ± 0.025	1.467HisIle: 1.467 ± 0.039	1.305HisLys: 1.305 ± 0.036	1.719HisLeu: 1.719 ± 0.038	0.305HisMet: 0.305 ± 0.017	1.157HisAsn: 1.157 ± 0.031	0.815HisPro: 0.815 ± 0.032	0.672HisGln: 0.672 ± 0.026	0.56HisArg: 0.56 ± 0.022	0.991HisSer: 0.991 ± 0.032	0.902HisThr: 0.902 ± 0.027	0.918HisVal: 0.918 ± 0.028	0.201HisTrp: 0.201 ± 0.013	0.811HisTyr: 0.811 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.72IleAla: 5.72 ± 0.078	0.668IleCys: 0.668 ± 0.026	5.403IleAsp: 5.403 ± 0.084	6.045IleGlu: 6.045 ± 0.081	3.622IlePhe: 3.622 ± 0.072	5.082IleGly: 5.082 ± 0.092	1.227IleHis: 1.227 ± 0.039	6.575IleIle: 6.575 ± 0.109	6.16IleLys: 6.16 ± 0.099	7.093IleLeu: 7.093 ± 0.103	1.412IleMet: 1.412 ± 0.041	5.358IleAsn: 5.358 ± 0.079	3.12IlePro: 3.12 ± 0.06	2.345IleGln: 2.345 ± 0.045	2.227IleArg: 2.227 ± 0.044	6.08IleSer: 6.08 ± 0.081	5.406IleThr: 5.406 ± 0.085	5.006IleVal: 5.006 ± 0.081	0.642IleTrp: 0.642 ± 0.026	3.025IleTyr: 3.025 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.163LysAla: 5.163 ± 0.089	0.342LysCys: 0.342 ± 0.018	4.716LysAsp: 4.716 ± 0.077	5.611LysGlu: 5.611 ± 0.089	3.082LysPhe: 3.082 ± 0.058	4.235LysGly: 4.235 ± 0.071	1.589LysHis: 1.589 ± 0.039	5.994LysIle: 5.994 ± 0.086	6.296LysLys: 6.296 ± 0.108	6.778LysLeu: 6.778 ± 0.1	1.815LysMet: 1.815 ± 0.05	5.026LysAsn: 5.026 ± 0.095	2.525LysPro: 2.525 ± 0.058	2.883LysGln: 2.883 ± 0.063	2.951LysArg: 2.951 ± 0.062	4.944LysSer: 4.944 ± 0.081	5.156LysThr: 5.156 ± 0.083	4.677LysVal: 4.677 ± 0.07	0.718LysTrp: 0.718 ± 0.029	2.899LysTyr: 2.899 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.467LeuAla: 5.467 ± 0.093	0.718LeuCys: 0.718 ± 0.03	5.242LeuAsp: 5.242 ± 0.077	6.265LeuGlu: 6.265 ± 0.08	4.745LeuPhe: 4.745 ± 0.087	5.65LeuGly: 5.65 ± 0.082	1.511LeuHis: 1.511 ± 0.041	7.338LeuIle: 7.338 ± 0.11	8.229LeuLys: 8.229 ± 0.121	8.379LeuLeu: 8.379 ± 0.126	1.979LeuMet: 1.979 ± 0.051	6.369LeuAsn: 6.369 ± 0.098	3.311LeuPro: 3.311 ± 0.055	3.04LeuGln: 3.04 ± 0.056	2.926LeuArg: 2.926 ± 0.055	6.622LeuSer: 6.622 ± 0.088	5.208LeuThr: 5.208 ± 0.072	5.463LeuVal: 5.463 ± 0.078	0.741LeuTrp: 0.741 ± 0.03	3.229LeuTyr: 3.229 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.558MetAla: 1.558 ± 0.042	0.143MetCys: 0.143 ± 0.011	1.052MetAsp: 1.052 ± 0.033	1.191MetGlu: 1.191 ± 0.038	0.863MetPhe: 0.863 ± 0.027	1.141MetGly: 1.141 ± 0.032	0.398MetHis: 0.398 ± 0.018	1.444MetIle: 1.444 ± 0.038	1.991MetLys: 1.991 ± 0.037	1.905MetLeu: 1.905 ± 0.042	0.542MetMet: 0.542 ± 0.026	1.215MetAsn: 1.215 ± 0.032	0.861MetPro: 0.861 ± 0.03	0.75MetGln: 0.75 ± 0.025	0.758MetArg: 0.758 ± 0.026	1.51MetSer: 1.51 ± 0.036	1.071MetThr: 1.071 ± 0.029	1.311MetVal: 1.311 ± 0.039	0.159MetTrp: 0.159 ± 0.012	0.673MetTyr: 0.673 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.064AsnAla: 4.064 ± 0.068	0.508AsnCys: 0.508 ± 0.028	3.676AsnAsp: 3.676 ± 0.083	4.082AsnGlu: 4.082 ± 0.065	3.288AsnPhe: 3.288 ± 0.071	4.133AsnGly: 4.133 ± 0.08	1.091AsnHis: 1.091 ± 0.036	5.203AsnIle: 5.203 ± 0.079	4.691AsnLys: 4.691 ± 0.077	5.93AsnLeu: 5.93 ± 0.083	1.253AsnMet: 1.253 ± 0.028	4.473AsnAsn: 4.473 ± 0.104	2.636AsnPro: 2.636 ± 0.051	2.239AsnGln: 2.239 ± 0.046	2.054AsnArg: 2.054 ± 0.045	4.469AsnSer: 4.469 ± 0.081	4.144AsnThr: 4.144 ± 0.073	3.931AsnVal: 3.931 ± 0.067	0.776AsnTrp: 0.776 ± 0.028	3.21AsnTyr: 3.21 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.609ProAla: 1.609 ± 0.042	0.207ProCys: 0.207 ± 0.014	1.85ProAsp: 1.85 ± 0.041	2.731ProGlu: 2.731 ± 0.057	1.757ProPhe: 1.757 ± 0.04	1.652ProGly: 1.652 ± 0.045	0.555ProHis: 0.555 ± 0.021	2.777ProIle: 2.777 ± 0.048	2.489ProLys: 2.489 ± 0.059	2.792ProLeu: 2.792 ± 0.049	0.66ProMet: 0.66 ± 0.025	2.351ProAsn: 2.351 ± 0.052	0.729ProPro: 0.729 ± 0.035	1.003ProGln: 1.003 ± 0.034	0.811ProArg: 0.811 ± 0.029	2.096ProSer: 2.096 ± 0.048	2.003ProThr: 2.003 ± 0.053	1.971ProVal: 1.971 ± 0.042	0.295ProTrp: 0.295 ± 0.019	1.368ProTyr: 1.368 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.843GlnAla: 1.843 ± 0.047	0.173GlnCys: 0.173 ± 0.012	1.677GlnAsp: 1.677 ± 0.042	1.95GlnGlu: 1.95 ± 0.051	1.763GlnPhe: 1.763 ± 0.039	1.621GlnGly: 1.621 ± 0.041	0.575GlnHis: 0.575 ± 0.021	2.705GlnIle: 2.705 ± 0.049	2.486GlnLys: 2.486 ± 0.05	3.667GlnLeu: 3.667 ± 0.063	0.748GlnMet: 0.748 ± 0.027	2.166GlnAsn: 2.166 ± 0.05	1.121GlnPro: 1.121 ± 0.032	1.392GlnGln: 1.392 ± 0.039	1.147GlnArg: 1.147 ± 0.033	1.961GlnSer: 1.961 ± 0.042	1.938GlnThr: 1.938 ± 0.041	1.782GlnVal: 1.782 ± 0.045	0.321GlnTrp: 0.321 ± 0.017	1.276GlnTyr: 1.276 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.971ArgAla: 1.971 ± 0.049	0.185ArgCys: 0.185 ± 0.012	1.633ArgAsp: 1.633 ± 0.04	1.879ArgGlu: 1.879 ± 0.048	1.739ArgPhe: 1.739 ± 0.043	1.717ArgGly: 1.717 ± 0.046	0.555ArgHis: 0.555 ± 0.023	2.711ArgIle: 2.711 ± 0.049	2.481ArgLys: 2.481 ± 0.053	3.122ArgLeu: 3.122 ± 0.056	0.743ArgMet: 0.743 ± 0.028	1.909ArgAsn: 1.909 ± 0.047	0.959ArgPro: 0.959 ± 0.033	1.082ArgGln: 1.082 ± 0.033	1.246ArgArg: 1.246 ± 0.04	1.714ArgSer: 1.714 ± 0.045	1.747ArgThr: 1.747 ± 0.043	1.912ArgVal: 1.912 ± 0.044	0.328ArgTrp: 0.328 ± 0.02	1.412ArgTyr: 1.412 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.827SerAla: 3.827 ± 0.065	0.642SerCys: 0.642 ± 0.026	3.803SerAsp: 3.803 ± 0.07	4.247SerGlu: 4.247 ± 0.069	3.791SerPhe: 3.791 ± 0.075	4.543SerGly: 4.543 ± 0.081	1.081SerHis: 1.081 ± 0.034	5.66SerIle: 5.66 ± 0.074	5.25SerLys: 5.25 ± 0.09	6.052SerLeu: 6.052 ± 0.081	1.201SerMet: 1.201 ± 0.034	4.514SerAsn: 4.514 ± 0.084	1.986SerPro: 1.986 ± 0.049	2.1SerGln: 2.1 ± 0.046	1.919SerArg: 1.919 ± 0.049	4.502SerSer: 4.502 ± 0.08	4.019SerThr: 4.019 ± 0.082	4.149SerVal: 4.149 ± 0.067	0.632SerTrp: 0.632 ± 0.025	2.949SerTyr: 2.949 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	3.747ThrAla: 3.747 ± 0.085	0.411ThrCys: 0.411 ± 0.023	3.65ThrAsp: 3.65 ± 0.075	4.096ThrGlu: 4.096 ± 0.063	3.173ThrPhe: 3.173 ± 0.058	4.061ThrGly: 4.061 ± 0.092	0.999ThrHis: 0.999 ± 0.028	5.61ThrIle: 5.61 ± 0.086	4.158ThrLys: 4.158 ± 0.056	5.675ThrLeu: 5.675 ± 0.071	0.968ThrMet: 0.968 ± 0.029	3.797ThrAsn: 3.797 ± 0.079	2.225ThrPro: 2.225 ± 0.057	1.861ThrGln: 1.861 ± 0.04	1.543ThrArg: 1.543 ± 0.042	4.13ThrSer: 4.13 ± 0.08	4.013ThrThr: 4.013 ± 0.097	4.054ThrVal: 4.054 ± 0.083	0.599ThrTrp: 0.599 ± 0.031	2.787ThrTyr: 2.787 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	3.885ValAla: 3.885 ± 0.069	0.527ValCys: 0.527 ± 0.025	3.765ValAsp: 3.765 ± 0.067	4.089ValGlu: 4.089 ± 0.065	3.323ValPhe: 3.323 ± 0.067	3.816ValGly: 3.816 ± 0.066	0.89ValHis: 0.89 ± 0.03	5.096ValIle: 5.096 ± 0.074	4.447ValLys: 4.447 ± 0.069	5.911ValLeu: 5.911 ± 0.082	1.231ValMet: 1.231 ± 0.038	3.764ValAsn: 3.764 ± 0.06	1.928ValPro: 1.928 ± 0.042	1.578ValGln: 1.578 ± 0.039	1.836ValArg: 1.836 ± 0.042	4.563ValSer: 4.563 ± 0.066	3.957ValThr: 3.957 ± 0.096	4.255ValVal: 4.255 ± 0.077	0.546ValTrp: 0.546 ± 0.026	2.418ValTyr: 2.418 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.517TrpAla: 0.517 ± 0.024	0.084TrpCys: 0.084 ± 0.009	0.542TrpAsp: 0.542 ± 0.023	0.598TrpGlu: 0.598 ± 0.027	0.542TrpPhe: 0.542 ± 0.024	0.51TrpGly: 0.51 ± 0.022	0.218TrpHis: 0.218 ± 0.014	0.678TrpIle: 0.678 ± 0.026	0.69TrpLys: 0.69 ± 0.026	0.966TrpLeu: 0.966 ± 0.031	0.28TrpMet: 0.28 ± 0.017	0.661TrpAsn: 0.661 ± 0.026	0.202TrpPro: 0.202 ± 0.015	0.419TrpGln: 0.419 ± 0.019	0.34TrpArg: 0.34 ± 0.018	0.664TrpSer: 0.664 ± 0.028	0.586TrpThr: 0.586 ± 0.027	0.561TrpVal: 0.561 ± 0.022	0.131TrpTrp: 0.131 ± 0.013	0.437TrpTyr: 0.437 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.426TyrAla: 2.426 ± 0.046	0.323TyrCys: 0.323 ± 0.017	2.426TyrAsp: 2.426 ± 0.05	2.239TyrGlu: 2.239 ± 0.048	2.456TyrPhe: 2.456 ± 0.053	2.616TyrGly: 2.616 ± 0.05	0.777TyrHis: 0.777 ± 0.033	2.984TyrIle: 2.984 ± 0.053	3.259TyrLys: 3.259 ± 0.061	3.888TyrLeu: 3.888 ± 0.065	0.729TyrMet: 0.729 ± 0.025	3.235TyrAsn: 3.235 ± 0.069	1.335TyrPro: 1.335 ± 0.033	1.459TyrGln: 1.459 ± 0.041	1.421TyrArg: 1.421 ± 0.042	2.774TyrSer: 2.774 ± 0.065	2.587TyrThr: 2.587 ± 0.066	2.222TyrVal: 2.222 ± 0.04	0.449TyrTrp: 0.449 ± 0.022	1.958TyrTyr: 1.958 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3122 proteins (1080222 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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