Amino acid dipepetide frequency for Mycobacterium phage Larenn

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.419AlaAla: 11.419 ± 0.988
0.427AlaCys: 0.427 ± 0.144
5.496AlaAsp: 5.496 ± 0.647
8.427AlaGlu: 8.427 ± 0.965
3.786AlaPhe: 3.786 ± 0.464
7.572AlaGly: 7.572 ± 0.815
1.588AlaHis: 1.588 ± 0.284
3.664AlaIle: 3.664 ± 0.437
5.313AlaLys: 5.313 ± 0.616
9.099AlaLeu: 9.099 ± 0.94
2.687AlaMet: 2.687 ± 0.351
2.565AlaAsn: 2.565 ± 0.436
4.702AlaPro: 4.702 ± 0.615
4.641AlaGln: 4.641 ± 0.673
6.717AlaArg: 6.717 ± 0.567
4.824AlaSer: 4.824 ± 0.525
5.129AlaThr: 5.129 ± 0.585
8.244AlaVal: 8.244 ± 0.644
1.893AlaTrp: 1.893 ± 0.322
2.565AlaTyr: 2.565 ± 0.477
0.0AlaXaa: 0.0 ± 0.0
Cys
0.733CysAla: 0.733 ± 0.176
0.0CysCys: 0.0 ± 0.0
0.855CysAsp: 0.855 ± 0.262
0.244CysGlu: 0.244 ± 0.105
0.427CysPhe: 0.427 ± 0.178
0.794CysGly: 0.794 ± 0.265
0.244CysHis: 0.244 ± 0.153
0.305CysIle: 0.305 ± 0.149
0.916CysLys: 0.916 ± 0.25
0.733CysLeu: 0.733 ± 0.262
0.183CysMet: 0.183 ± 0.106
0.366CysAsn: 0.366 ± 0.141
0.489CysPro: 0.489 ± 0.192
0.183CysGln: 0.183 ± 0.126
0.611CysArg: 0.611 ± 0.192
0.183CysSer: 0.183 ± 0.114
0.55CysThr: 0.55 ± 0.164
0.55CysVal: 0.55 ± 0.16
0.305CysTrp: 0.305 ± 0.144
0.244CysTyr: 0.244 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
6.839AspAla: 6.839 ± 0.708
0.672AspCys: 0.672 ± 0.238
3.603AspAsp: 3.603 ± 0.474
5.191AspGlu: 5.191 ± 0.731
2.809AspPhe: 2.809 ± 0.518
4.946AspGly: 4.946 ± 0.624
1.221AspHis: 1.221 ± 0.344
3.786AspIle: 3.786 ± 0.522
2.565AspLys: 2.565 ± 0.35
5.496AspLeu: 5.496 ± 0.744
1.71AspMet: 1.71 ± 0.344
1.404AspAsn: 1.404 ± 0.346
5.129AspPro: 5.129 ± 0.562
2.015AspGln: 2.015 ± 0.316
2.443AspArg: 2.443 ± 0.358
3.175AspSer: 3.175 ± 0.554
2.687AspThr: 2.687 ± 0.362
4.58AspVal: 4.58 ± 0.609
1.282AspTrp: 1.282 ± 0.268
2.076AspTyr: 2.076 ± 0.334
0.0AspXaa: 0.0 ± 0.0
Glu
6.9GluAla: 6.9 ± 0.824
0.611GluCys: 0.611 ± 0.227
5.374GluAsp: 5.374 ± 0.767
5.068GluGlu: 5.068 ± 0.787
2.626GluPhe: 2.626 ± 0.452
4.519GluGly: 4.519 ± 0.538
2.076GluHis: 2.076 ± 0.377
3.969GluIle: 3.969 ± 0.46
2.504GluLys: 2.504 ± 0.322
7.511GluLeu: 7.511 ± 0.831
2.015GluMet: 2.015 ± 0.372
2.015GluAsn: 2.015 ± 0.308
2.748GluPro: 2.748 ± 0.382
2.198GluGln: 2.198 ± 0.318
4.763GluArg: 4.763 ± 0.605
3.359GluSer: 3.359 ± 0.376
4.152GluThr: 4.152 ± 0.475
4.091GluVal: 4.091 ± 0.599
1.343GluTrp: 1.343 ± 0.297
2.565GluTyr: 2.565 ± 0.36
0.0GluXaa: 0.0 ± 0.0
Phe
2.992PheAla: 2.992 ± 0.418
0.244PheCys: 0.244 ± 0.137
2.076PheAsp: 2.076 ± 0.361
2.443PheGlu: 2.443 ± 0.304
0.916PhePhe: 0.916 ± 0.268
3.42PheGly: 3.42 ± 0.449
0.855PheHis: 0.855 ± 0.261
1.771PheIle: 1.771 ± 0.255
1.099PheLys: 1.099 ± 0.274
2.565PheLeu: 2.565 ± 0.546
0.611PheMet: 0.611 ± 0.161
1.832PheAsn: 1.832 ± 0.327
1.954PhePro: 1.954 ± 0.349
1.221PheGln: 1.221 ± 0.259
2.076PheArg: 2.076 ± 0.331
1.893PheSer: 1.893 ± 0.301
2.259PheThr: 2.259 ± 0.295
2.382PheVal: 2.382 ± 0.388
0.305PheTrp: 0.305 ± 0.105
0.611PheTyr: 0.611 ± 0.17
0.0PheXaa: 0.0 ± 0.0
Gly
6.106GlyAla: 6.106 ± 0.682
0.733GlyCys: 0.733 ± 0.213
6.045GlyAsp: 6.045 ± 0.589
4.336GlyGlu: 4.336 ± 0.535
3.053GlyPhe: 3.053 ± 0.416
6.168GlyGly: 6.168 ± 0.522
1.527GlyHis: 1.527 ± 0.337
4.152GlyIle: 4.152 ± 0.616
4.03GlyLys: 4.03 ± 0.675
6.351GlyLeu: 6.351 ± 0.663
2.32GlyMet: 2.32 ± 0.417
3.42GlyAsn: 3.42 ± 0.461
3.359GlyPro: 3.359 ± 0.435
3.664GlyGln: 3.664 ± 0.427
3.603GlyArg: 3.603 ± 0.381
3.298GlySer: 3.298 ± 0.466
5.068GlyThr: 5.068 ± 0.762
6.473GlyVal: 6.473 ± 0.608
1.466GlyTrp: 1.466 ± 0.291
2.626GlyTyr: 2.626 ± 0.347
0.0GlyXaa: 0.0 ± 0.0
His
1.527HisAla: 1.527 ± 0.344
0.305HisCys: 0.305 ± 0.114
1.404HisAsp: 1.404 ± 0.266
1.038HisGlu: 1.038 ± 0.266
0.672HisPhe: 0.672 ± 0.207
1.649HisGly: 1.649 ± 0.403
0.672HisHis: 0.672 ± 0.199
1.221HisIle: 1.221 ± 0.238
0.794HisLys: 0.794 ± 0.267
1.282HisLeu: 1.282 ± 0.297
0.427HisMet: 0.427 ± 0.151
0.366HisAsn: 0.366 ± 0.147
1.221HisPro: 1.221 ± 0.259
0.672HisGln: 0.672 ± 0.215
1.771HisArg: 1.771 ± 0.365
0.977HisSer: 0.977 ± 0.233
1.038HisThr: 1.038 ± 0.237
1.282HisVal: 1.282 ± 0.294
0.305HisTrp: 0.305 ± 0.145
0.733HisTyr: 0.733 ± 0.23
0.0HisXaa: 0.0 ± 0.0
Ile
5.984IleAla: 5.984 ± 0.62
0.55IleCys: 0.55 ± 0.165
3.603IleAsp: 3.603 ± 0.5
4.519IleGlu: 4.519 ± 0.436
1.282IlePhe: 1.282 ± 0.217
4.885IleGly: 4.885 ± 0.551
1.282IleHis: 1.282 ± 0.262
1.466IleIle: 1.466 ± 0.294
2.32IleLys: 2.32 ± 0.352
3.725IleLeu: 3.725 ± 0.407
0.489IleMet: 0.489 ± 0.208
1.893IleAsn: 1.893 ± 0.406
3.481IlePro: 3.481 ± 0.521
1.649IleGln: 1.649 ± 0.3
2.931IleArg: 2.931 ± 0.455
2.259IleSer: 2.259 ± 0.413
2.809IleThr: 2.809 ± 0.381
2.992IleVal: 2.992 ± 0.456
0.427IleTrp: 0.427 ± 0.131
1.038IleTyr: 1.038 ± 0.215
0.0IleXaa: 0.0 ± 0.0
Lys
5.435LysAla: 5.435 ± 0.735
0.305LysCys: 0.305 ± 0.166
2.443LysAsp: 2.443 ± 0.302
2.565LysGlu: 2.565 ± 0.502
0.916LysPhe: 0.916 ± 0.198
3.114LysGly: 3.114 ± 0.397
0.733LysHis: 0.733 ± 0.231
2.626LysIle: 2.626 ± 0.375
3.114LysLys: 3.114 ± 0.546
4.458LysLeu: 4.458 ± 0.517
0.977LysMet: 0.977 ± 0.248
1.649LysAsn: 1.649 ± 0.232
2.382LysPro: 2.382 ± 0.467
1.649LysGln: 1.649 ± 0.297
3.298LysArg: 3.298 ± 0.413
2.015LysSer: 2.015 ± 0.289
3.298LysThr: 3.298 ± 0.522
4.152LysVal: 4.152 ± 0.433
0.733LysTrp: 0.733 ± 0.224
1.649LysTyr: 1.649 ± 0.293
0.0LysXaa: 0.0 ± 0.0
Leu
9.16LeuAla: 9.16 ± 0.857
0.611LeuCys: 0.611 ± 0.203
4.824LeuAsp: 4.824 ± 0.574
5.435LeuGlu: 5.435 ± 0.73
2.198LeuPhe: 2.198 ± 0.317
5.984LeuGly: 5.984 ± 0.656
1.649LeuHis: 1.649 ± 0.369
4.641LeuIle: 4.641 ± 0.436
3.298LeuLys: 3.298 ± 0.442
6.106LeuLeu: 6.106 ± 0.632
2.87LeuMet: 2.87 ± 0.445
2.809LeuAsn: 2.809 ± 0.428
4.458LeuPro: 4.458 ± 0.484
2.748LeuGln: 2.748 ± 0.532
6.9LeuArg: 6.9 ± 0.939
5.313LeuSer: 5.313 ± 0.673
6.168LeuThr: 6.168 ± 0.808
4.641LeuVal: 4.641 ± 0.652
1.282LeuTrp: 1.282 ± 0.272
2.259LeuTyr: 2.259 ± 0.418
0.0LeuXaa: 0.0 ± 0.0
Met
3.114MetAla: 3.114 ± 0.428
0.061MetCys: 0.061 ± 0.067
0.855MetAsp: 0.855 ± 0.244
1.893MetGlu: 1.893 ± 0.257
0.489MetPhe: 0.489 ± 0.181
1.588MetGly: 1.588 ± 0.352
0.55MetHis: 0.55 ± 0.186
1.588MetIle: 1.588 ± 0.319
1.954MetLys: 1.954 ± 0.365
1.527MetLeu: 1.527 ± 0.257
0.672MetMet: 0.672 ± 0.192
0.672MetAsn: 0.672 ± 0.211
1.466MetPro: 1.466 ± 0.318
0.977MetGln: 0.977 ± 0.236
1.404MetArg: 1.404 ± 0.309
2.076MetSer: 2.076 ± 0.313
2.198MetThr: 2.198 ± 0.271
1.343MetVal: 1.343 ± 0.286
0.244MetTrp: 0.244 ± 0.115
0.672MetTyr: 0.672 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
3.236AsnAla: 3.236 ± 0.475
0.611AsnCys: 0.611 ± 0.194
1.954AsnAsp: 1.954 ± 0.292
2.443AsnGlu: 2.443 ± 0.352
0.794AsnPhe: 0.794 ± 0.25
3.236AsnGly: 3.236 ± 0.51
0.855AsnHis: 0.855 ± 0.19
1.466AsnIle: 1.466 ± 0.304
1.16AsnLys: 1.16 ± 0.303
2.87AsnLeu: 2.87 ± 0.509
1.038AsnMet: 1.038 ± 0.23
0.855AsnAsn: 0.855 ± 0.34
2.504AsnPro: 2.504 ± 0.42
0.855AsnGln: 0.855 ± 0.224
1.832AsnArg: 1.832 ± 0.417
1.404AsnSer: 1.404 ± 0.226
1.404AsnThr: 1.404 ± 0.284
2.32AsnVal: 2.32 ± 0.31
0.794AsnTrp: 0.794 ± 0.2
0.977AsnTyr: 0.977 ± 0.218
0.0AsnXaa: 0.0 ± 0.0
Pro
5.618ProAla: 5.618 ± 0.586
0.427ProCys: 0.427 ± 0.186
3.847ProAsp: 3.847 ± 0.549
4.946ProGlu: 4.946 ± 0.599
2.076ProPhe: 2.076 ± 0.379
3.908ProGly: 3.908 ± 0.563
0.794ProHis: 0.794 ± 0.23
2.626ProIle: 2.626 ± 0.369
2.198ProLys: 2.198 ± 0.482
3.481ProLeu: 3.481 ± 0.516
1.16ProMet: 1.16 ± 0.241
2.198ProAsn: 2.198 ± 0.397
2.259ProPro: 2.259 ± 0.362
1.71ProGln: 1.71 ± 0.301
3.908ProArg: 3.908 ± 0.58
2.382ProSer: 2.382 ± 0.427
3.908ProThr: 3.908 ± 0.539
3.908ProVal: 3.908 ± 0.484
1.282ProTrp: 1.282 ± 0.329
1.282ProTyr: 1.282 ± 0.263
0.0ProXaa: 0.0 ± 0.0
Gln
4.824GlnAla: 4.824 ± 0.621
0.183GlnCys: 0.183 ± 0.104
1.282GlnAsp: 1.282 ± 0.256
1.771GlnGlu: 1.771 ± 0.339
1.404GlnPhe: 1.404 ± 0.27
2.748GlnGly: 2.748 ± 0.406
0.489GlnHis: 0.489 ± 0.161
2.015GlnIle: 2.015 ± 0.314
1.71GlnLys: 1.71 ± 0.322
3.725GlnLeu: 3.725 ± 0.737
1.221GlnMet: 1.221 ± 0.264
1.038GlnAsn: 1.038 ± 0.305
1.649GlnPro: 1.649 ± 0.344
2.565GlnGln: 2.565 ± 0.554
2.748GlnArg: 2.748 ± 0.422
2.076GlnSer: 2.076 ± 0.367
1.832GlnThr: 1.832 ± 0.307
2.565GlnVal: 2.565 ± 0.374
0.794GlnTrp: 0.794 ± 0.216
0.855GlnTyr: 0.855 ± 0.19
0.0GlnXaa: 0.0 ± 0.0
Arg
5.801ArgAla: 5.801 ± 0.588
0.733ArgCys: 0.733 ± 0.254
4.519ArgAsp: 4.519 ± 0.551
5.557ArgGlu: 5.557 ± 0.888
2.626ArgPhe: 2.626 ± 0.445
4.702ArgGly: 4.702 ± 0.537
1.466ArgHis: 1.466 ± 0.274
3.725ArgIle: 3.725 ± 0.446
3.236ArgLys: 3.236 ± 0.559
5.557ArgLeu: 5.557 ± 0.619
2.198ArgMet: 2.198 ± 0.381
1.832ArgAsn: 1.832 ± 0.384
2.565ArgPro: 2.565 ± 0.417
2.137ArgGln: 2.137 ± 0.328
5.252ArgArg: 5.252 ± 0.674
2.748ArgSer: 2.748 ± 0.412
3.359ArgThr: 3.359 ± 0.481
4.152ArgVal: 4.152 ± 0.469
1.527ArgTrp: 1.527 ± 0.334
2.137ArgTyr: 2.137 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
5.007SerAla: 5.007 ± 0.576
0.611SerCys: 0.611 ± 0.197
3.42SerAsp: 3.42 ± 0.455
3.236SerGlu: 3.236 ± 0.426
1.954SerPhe: 1.954 ± 0.301
4.336SerGly: 4.336 ± 0.678
0.55SerHis: 0.55 ± 0.219
1.649SerIle: 1.649 ± 0.307
2.809SerLys: 2.809 ± 0.516
4.458SerLeu: 4.458 ± 0.559
1.588SerMet: 1.588 ± 0.253
1.343SerAsn: 1.343 ± 0.295
2.931SerPro: 2.931 ± 0.407
1.832SerGln: 1.832 ± 0.377
3.359SerArg: 3.359 ± 0.453
2.687SerSer: 2.687 ± 0.336
3.175SerThr: 3.175 ± 0.525
3.236SerVal: 3.236 ± 0.488
1.282SerTrp: 1.282 ± 0.272
1.466SerTyr: 1.466 ± 0.258
0.0SerXaa: 0.0 ± 0.0
Thr
5.923ThrAla: 5.923 ± 0.615
0.611ThrCys: 0.611 ± 0.216
3.481ThrAsp: 3.481 ± 0.469
3.542ThrGlu: 3.542 ± 0.454
1.71ThrPhe: 1.71 ± 0.263
5.313ThrGly: 5.313 ± 0.669
0.794ThrHis: 0.794 ± 0.248
2.626ThrIle: 2.626 ± 0.445
3.298ThrLys: 3.298 ± 0.417
5.191ThrLeu: 5.191 ± 0.681
1.16ThrMet: 1.16 ± 0.223
1.954ThrAsn: 1.954 ± 0.362
4.824ThrPro: 4.824 ± 0.554
2.198ThrGln: 2.198 ± 0.297
3.481ThrArg: 3.481 ± 0.516
2.992ThrSer: 2.992 ± 0.532
3.664ThrThr: 3.664 ± 0.597
4.946ThrVal: 4.946 ± 0.555
1.16ThrTrp: 1.16 ± 0.26
2.137ThrTyr: 2.137 ± 0.442
0.0ThrXaa: 0.0 ± 0.0
Val
5.435ValAla: 5.435 ± 0.737
0.611ValCys: 0.611 ± 0.222
5.435ValAsp: 5.435 ± 0.681
4.397ValGlu: 4.397 ± 0.554
2.198ValPhe: 2.198 ± 0.477
5.252ValGly: 5.252 ± 0.476
0.977ValHis: 0.977 ± 0.226
4.336ValIle: 4.336 ± 0.585
3.42ValLys: 3.42 ± 0.408
5.435ValLeu: 5.435 ± 0.594
0.977ValMet: 0.977 ± 0.305
2.504ValAsn: 2.504 ± 0.405
3.42ValPro: 3.42 ± 0.548
2.076ValGln: 2.076 ± 0.343
5.007ValArg: 5.007 ± 0.656
4.58ValSer: 4.58 ± 0.584
5.007ValThr: 5.007 ± 0.49
5.435ValVal: 5.435 ± 0.42
1.649ValTrp: 1.649 ± 0.347
1.771ValTyr: 1.771 ± 0.352
0.0ValXaa: 0.0 ± 0.0
Trp
1.771TrpAla: 1.771 ± 0.333
0.366TrpCys: 0.366 ± 0.158
1.099TrpAsp: 1.099 ± 0.271
1.282TrpGlu: 1.282 ± 0.269
0.672TrpPhe: 0.672 ± 0.187
1.16TrpGly: 1.16 ± 0.232
0.489TrpHis: 0.489 ± 0.16
0.733TrpIle: 0.733 ± 0.175
0.855TrpLys: 0.855 ± 0.227
1.343TrpLeu: 1.343 ± 0.268
0.611TrpMet: 0.611 ± 0.208
0.977TrpAsn: 0.977 ± 0.219
1.038TrpPro: 1.038 ± 0.255
1.16TrpGln: 1.16 ± 0.221
1.16TrpArg: 1.16 ± 0.237
1.099TrpSer: 1.099 ± 0.291
1.16TrpThr: 1.16 ± 0.252
1.038TrpVal: 1.038 ± 0.198
0.489TrpTrp: 0.489 ± 0.168
0.55TrpTyr: 0.55 ± 0.181
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.992TyrAla: 2.992 ± 0.388
0.244TyrCys: 0.244 ± 0.114
2.015TyrAsp: 2.015 ± 0.359
2.076TyrGlu: 2.076 ± 0.393
0.916TyrPhe: 0.916 ± 0.233
2.504TyrGly: 2.504 ± 0.37
0.55TyrHis: 0.55 ± 0.195
1.221TyrIle: 1.221 ± 0.285
0.916TyrLys: 0.916 ± 0.203
2.443TyrLeu: 2.443 ± 0.404
0.366TyrMet: 0.366 ± 0.172
0.916TyrAsn: 0.916 ± 0.228
1.343TyrPro: 1.343 ± 0.264
1.343TyrGln: 1.343 ± 0.262
2.565TyrArg: 2.565 ± 0.435
1.588TyrSer: 1.588 ± 0.307
2.137TyrThr: 2.137 ± 0.363
1.588TyrVal: 1.588 ± 0.387
0.489TyrTrp: 0.489 ± 0.177
0.855TyrTyr: 0.855 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (16377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski