Amino acid dipepetide frequency for Acidipila rosea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.459AlaAla: 14.459 ± 0.157	0.956AlaCys: 0.956 ± 0.027	5.155AlaAsp: 5.155 ± 0.067	6.391AlaGlu: 6.391 ± 0.079	3.769AlaPhe: 3.769 ± 0.057	8.892AlaGly: 8.892 ± 0.098	2.416AlaHis: 2.416 ± 0.048	5.749AlaIle: 5.749 ± 0.066	4.048AlaLys: 4.048 ± 0.068	11.233AlaLeu: 11.233 ± 0.125	2.86AlaMet: 2.86 ± 0.055	3.265AlaAsn: 3.265 ± 0.065	5.134AlaPro: 5.134 ± 0.082	4.721AlaGln: 4.721 ± 0.076	6.431AlaArg: 6.431 ± 0.086	6.636AlaSer: 6.636 ± 0.077	5.992AlaThr: 5.992 ± 0.071	7.922AlaVal: 7.922 ± 0.086	1.333AlaTrp: 1.333 ± 0.039	2.679AlaTyr: 2.679 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.929CysAla: 0.929 ± 0.027	0.169CysCys: 0.169 ± 0.014	0.421CysAsp: 0.421 ± 0.017	0.444CysGlu: 0.444 ± 0.021	0.353CysPhe: 0.353 ± 0.017	0.938CysGly: 0.938 ± 0.027	0.241CysHis: 0.241 ± 0.02	0.44CysIle: 0.44 ± 0.02	0.228CysLys: 0.228 ± 0.014	0.811CysLeu: 0.811 ± 0.026	0.197CysMet: 0.197 ± 0.013	0.23CysAsn: 0.23 ± 0.013	0.459CysPro: 0.459 ± 0.022	0.223CysGln: 0.223 ± 0.014	0.497CysArg: 0.497 ± 0.022	0.614CysSer: 0.614 ± 0.025	0.428CysThr: 0.428 ± 0.018	0.611CysVal: 0.611 ± 0.02	0.11CysTrp: 0.11 ± 0.01	0.255CysTyr: 0.255 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.54AspAla: 5.54 ± 0.072	0.407AspCys: 0.407 ± 0.019	2.218AspAsp: 2.218 ± 0.049	2.974AspGlu: 2.974 ± 0.058	2.141AspPhe: 2.141 ± 0.044	4.206AspGly: 4.206 ± 0.076	1.244AspHis: 1.244 ± 0.032	2.381AspIle: 2.381 ± 0.043	1.702AspLys: 1.702 ± 0.035	5.084AspLeu: 5.084 ± 0.058	0.99AspMet: 0.99 ± 0.03	1.419AspAsn: 1.419 ± 0.039	3.185AspPro: 3.185 ± 0.057	1.845AspGln: 1.845 ± 0.035	3.192AspArg: 3.192 ± 0.048	2.802AspSer: 2.802 ± 0.048	2.492AspThr: 2.492 ± 0.041	3.553AspVal: 3.553 ± 0.066	0.842AspTrp: 0.842 ± 0.027	1.715AspTyr: 1.715 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.028GluAla: 6.028 ± 0.089	0.422GluCys: 0.422 ± 0.019	2.577GluAsp: 2.577 ± 0.053	3.407GluGlu: 3.407 ± 0.076	1.944GluPhe: 1.944 ± 0.042	3.645GluGly: 3.645 ± 0.064	1.452GluHis: 1.452 ± 0.032	3.238GluIle: 3.238 ± 0.064	2.451GluLys: 2.451 ± 0.053	5.76GluLeu: 5.76 ± 0.073	1.57GluMet: 1.57 ± 0.037	1.719GluAsn: 1.719 ± 0.039	2.414GluPro: 2.414 ± 0.044	2.83GluGln: 2.83 ± 0.051	4.239GluArg: 4.239 ± 0.078	3.123GluSer: 3.123 ± 0.051	2.994GluThr: 2.994 ± 0.054	3.696GluVal: 3.696 ± 0.057	0.73GluTrp: 0.73 ± 0.023	1.501GluTyr: 1.501 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.301PheAla: 4.301 ± 0.069	0.371PheCys: 0.371 ± 0.016	2.345PheAsp: 2.345 ± 0.04	2.035PheGlu: 2.035 ± 0.042	1.639PhePhe: 1.639 ± 0.043	3.326PheGly: 3.326 ± 0.063	1.023PheHis: 1.023 ± 0.029	1.61PheIle: 1.61 ± 0.04	1.037PheLys: 1.037 ± 0.033	3.902PheLeu: 3.902 ± 0.067	0.733PheMet: 0.733 ± 0.025	1.375PheAsn: 1.375 ± 0.046	1.823PhePro: 1.823 ± 0.043	1.269PheGln: 1.269 ± 0.03	2.324PheArg: 2.324 ± 0.045	2.682PheSer: 2.682 ± 0.051	2.362PheThr: 2.362 ± 0.045	2.474PheVal: 2.474 ± 0.05	0.541PheTrp: 0.541 ± 0.023	1.211PheTyr: 1.211 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.718GlyAla: 7.718 ± 0.088	0.826GlyCys: 0.826 ± 0.027	3.761GlyAsp: 3.761 ± 0.06	4.029GlyGlu: 4.029 ± 0.067	3.329GlyPhe: 3.329 ± 0.052	6.274GlyGly: 6.274 ± 0.102	1.912GlyHis: 1.912 ± 0.038	4.669GlyIle: 4.669 ± 0.069	3.471GlyLys: 3.471 ± 0.056	7.473GlyLeu: 7.473 ± 0.095	2.06GlyMet: 2.06 ± 0.039	2.599GlyAsn: 2.599 ± 0.056	3.13GlyPro: 3.13 ± 0.051	2.955GlyGln: 2.955 ± 0.05	4.738GlyArg: 4.738 ± 0.063	5.323GlySer: 5.323 ± 0.079	4.705GlyThr: 4.705 ± 0.087	5.635GlyVal: 5.635 ± 0.075	1.351GlyTrp: 1.351 ± 0.04	2.544GlyTyr: 2.544 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.518HisAla: 2.518 ± 0.044	0.255HisCys: 0.255 ± 0.015	1.211HisAsp: 1.211 ± 0.026	1.275HisGlu: 1.275 ± 0.031	1.046HisPhe: 1.046 ± 0.031	2.13HisGly: 2.13 ± 0.044	0.675HisHis: 0.675 ± 0.027	1.132HisIle: 1.132 ± 0.029	0.683HisLys: 0.683 ± 0.025	2.464HisLeu: 2.464 ± 0.052	0.536HisMet: 0.536 ± 0.02	0.739HisAsn: 0.739 ± 0.025	1.549HisPro: 1.549 ± 0.039	0.884HisGln: 0.884 ± 0.024	1.461HisArg: 1.461 ± 0.037	1.443HisSer: 1.443 ± 0.039	1.255HisThr: 1.255 ± 0.038	1.529HisVal: 1.529 ± 0.038	0.425HisTrp: 0.425 ± 0.022	0.748HisTyr: 0.748 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.38IleAla: 6.38 ± 0.086	0.48IleCys: 0.48 ± 0.019	3.102IleAsp: 3.102 ± 0.053	3.326IleGlu: 3.326 ± 0.063	1.972IlePhe: 1.972 ± 0.038	4.241IleGly: 4.241 ± 0.073	1.191IleHis: 1.191 ± 0.037	1.975IleIle: 1.975 ± 0.047	1.501IleLys: 1.501 ± 0.04	4.623IleLeu: 4.623 ± 0.071	0.762IleMet: 0.762 ± 0.024	1.657IleAsn: 1.657 ± 0.04	2.778IlePro: 2.778 ± 0.051	1.657IleGln: 1.657 ± 0.038	3.093IleArg: 3.093 ± 0.046	3.326IleSer: 3.326 ± 0.06	3.091IleThr: 3.091 ± 0.053	3.785IleVal: 3.785 ± 0.056	0.53IleTrp: 0.53 ± 0.022	1.551IleTyr: 1.551 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.76LysAla: 3.76 ± 0.062	0.217LysCys: 0.217 ± 0.015	1.791LysAsp: 1.791 ± 0.042	1.861LysGlu: 1.861 ± 0.044	1.128LysPhe: 1.128 ± 0.03	2.358LysGly: 2.358 ± 0.047	0.841LysHis: 0.841 ± 0.025	1.856LysIle: 1.856 ± 0.039	1.637LysLys: 1.637 ± 0.051	3.928LysLeu: 3.928 ± 0.067	0.957LysMet: 0.957 ± 0.029	1.192LysAsn: 1.192 ± 0.031	2.178LysPro: 2.178 ± 0.045	1.758LysGln: 1.758 ± 0.044	2.243LysArg: 2.243 ± 0.046	2.165LysSer: 2.165 ± 0.051	2.261LysThr: 2.261 ± 0.04	2.539LysVal: 2.539 ± 0.058	0.413LysTrp: 0.413 ± 0.02	1.058LysTyr: 1.058 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.93LeuAla: 11.93 ± 0.121	0.936LeuCys: 0.936 ± 0.028	5.325LeuAsp: 5.325 ± 0.068	5.498LeuGlu: 5.498 ± 0.075	3.704LeuPhe: 3.704 ± 0.062	7.589LeuGly: 7.589 ± 0.091	2.539LeuHis: 2.539 ± 0.05	4.738LeuIle: 4.738 ± 0.079	3.851LeuLys: 3.851 ± 0.064	11.19LeuLeu: 11.19 ± 0.137	2.117LeuMet: 2.117 ± 0.047	3.341LeuAsn: 3.341 ± 0.068	5.796LeuPro: 5.796 ± 0.068	3.665LeuGln: 3.665 ± 0.056	7.288LeuArg: 7.288 ± 0.083	6.515LeuSer: 6.515 ± 0.077	6.047LeuThr: 6.047 ± 0.072	6.526LeuVal: 6.526 ± 0.084	1.273LeuTrp: 1.273 ± 0.038	2.674LeuTyr: 2.674 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.452MetAla: 2.452 ± 0.047	0.14MetCys: 0.14 ± 0.012	1.052MetAsp: 1.052 ± 0.032	1.157MetGlu: 1.157 ± 0.032	0.621MetPhe: 0.621 ± 0.019	1.664MetGly: 1.664 ± 0.04	0.567MetHis: 0.567 ± 0.021	1.074MetIle: 1.074 ± 0.031	1.168MetLys: 1.168 ± 0.037	2.522MetLeu: 2.522 ± 0.046	0.609MetMet: 0.609 ± 0.025	0.871MetAsn: 0.871 ± 0.031	1.475MetPro: 1.475 ± 0.038	1.087MetGln: 1.087 ± 0.03	1.761MetArg: 1.761 ± 0.036	1.416MetSer: 1.416 ± 0.034	1.404MetThr: 1.404 ± 0.033	1.547MetVal: 1.547 ± 0.035	0.233MetTrp: 0.233 ± 0.017	0.434MetTyr: 0.434 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.268AsnAla: 3.268 ± 0.053	0.314AsnCys: 0.314 ± 0.016	1.57AsnAsp: 1.57 ± 0.039	1.524AsnGlu: 1.524 ± 0.037	1.395AsnPhe: 1.395 ± 0.042	2.967AsnGly: 2.967 ± 0.067	0.711AsnHis: 0.711 ± 0.024	1.687AsnIle: 1.687 ± 0.035	0.904AsnLys: 0.904 ± 0.029	3.294AsnLeu: 3.294 ± 0.054	0.662AsnMet: 0.662 ± 0.024	1.175AsnAsn: 1.175 ± 0.044	2.312AsnPro: 2.312 ± 0.052	1.331AsnGln: 1.331 ± 0.037	1.917AsnArg: 1.917 ± 0.043	2.007AsnSer: 2.007 ± 0.044	1.809AsnThr: 1.809 ± 0.046	2.162AsnVal: 2.162 ± 0.049	0.526AsnTrp: 0.526 ± 0.019	1.244AsnTyr: 1.244 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	6.247ProAla: 6.247 ± 0.082	0.357ProCys: 0.357 ± 0.018	3.022ProAsp: 3.022 ± 0.059	3.679ProGlu: 3.679 ± 0.063	1.921ProPhe: 1.921 ± 0.041	4.543ProGly: 4.543 ± 0.076	1.245ProHis: 1.245 ± 0.037	2.258ProIle: 2.258 ± 0.045	1.676ProLys: 1.676 ± 0.041	5.007ProLeu: 5.007 ± 0.066	1.173ProMet: 1.173 ± 0.032	1.716ProAsn: 1.716 ± 0.04	2.578ProPro: 2.578 ± 0.063	2.345ProGln: 2.345 ± 0.049	2.701ProArg: 2.701 ± 0.05	3.315ProSer: 3.315 ± 0.049	2.705ProThr: 2.705 ± 0.043	4.162ProVal: 4.162 ± 0.06	0.674ProTrp: 0.674 ± 0.024	1.415ProTyr: 1.415 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.199GlnAla: 4.199 ± 0.072	0.216GlnCys: 0.216 ± 0.014	1.671GlnAsp: 1.671 ± 0.037	1.941GlnGlu: 1.941 ± 0.045	1.481GlnPhe: 1.481 ± 0.041	2.709GlnGly: 2.709 ± 0.045	0.968GlnHis: 0.968 ± 0.027	2.222GlnIle: 2.222 ± 0.047	1.581GlnLys: 1.581 ± 0.041	4.058GlnLeu: 4.058 ± 0.056	1.189GlnMet: 1.189 ± 0.031	1.397GlnAsn: 1.397 ± 0.038	2.347GlnPro: 2.347 ± 0.046	2.79GlnGln: 2.79 ± 0.06	2.728GlnArg: 2.728 ± 0.052	2.535GlnSer: 2.535 ± 0.05	2.335GlnThr: 2.335 ± 0.046	2.746GlnVal: 2.746 ± 0.046	0.539GlnTrp: 0.539 ± 0.025	1.116GlnTyr: 1.116 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	5.986ArgAla: 5.986 ± 0.074	0.496ArgCys: 0.496 ± 0.021	3.156ArgAsp: 3.156 ± 0.052	4.119ArgGlu: 4.119 ± 0.069	2.623ArgPhe: 2.623 ± 0.051	4.029ArgGly: 4.029 ± 0.06	1.535ArgHis: 1.535 ± 0.035	3.776ArgIle: 3.776 ± 0.052	2.584ArgLys: 2.584 ± 0.049	6.603ArgLeu: 6.603 ± 0.084	1.775ArgMet: 1.775 ± 0.036	2.178ArgAsn: 2.178 ± 0.043	2.836ArgPro: 2.836 ± 0.058	2.689ArgGln: 2.689 ± 0.05	4.543ArgArg: 4.543 ± 0.072	3.855ArgSer: 3.855 ± 0.055	3.379ArgThr: 3.379 ± 0.055	4.437ArgVal: 4.437 ± 0.058	0.981ArgTrp: 0.981 ± 0.03	1.983ArgTyr: 1.983 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.679SerAla: 6.679 ± 0.092	0.54SerCys: 0.54 ± 0.021	2.897SerAsp: 2.897 ± 0.047	3.069SerGlu: 3.069 ± 0.056	2.681SerPhe: 2.681 ± 0.052	5.83SerGly: 5.83 ± 0.082	1.436SerHis: 1.436 ± 0.034	3.428SerIle: 3.428 ± 0.057	2.004SerLys: 2.004 ± 0.044	6.523SerLeu: 6.523 ± 0.074	1.416SerMet: 1.416 ± 0.032	2.026SerAsn: 2.026 ± 0.047	3.423SerPro: 3.423 ± 0.056	2.328SerGln: 2.328 ± 0.053	3.77SerArg: 3.77 ± 0.058	4.328SerSer: 4.328 ± 0.074	3.614SerThr: 3.614 ± 0.062	4.291SerVal: 4.291 ± 0.066	0.865SerTrp: 0.865 ± 0.028	1.851SerTyr: 1.851 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.462ThrAla: 6.462 ± 0.083	0.452ThrCys: 0.452 ± 0.021	2.693ThrAsp: 2.693 ± 0.046	2.672ThrGlu: 2.672 ± 0.049	2.118ThrPhe: 2.118 ± 0.049	5.126ThrGly: 5.126 ± 0.079	1.301ThrHis: 1.301 ± 0.038	3.141ThrIle: 3.141 ± 0.061	1.659ThrLys: 1.659 ± 0.037	6.137ThrLeu: 6.137 ± 0.075	1.165ThrMet: 1.165 ± 0.035	1.814ThrAsn: 1.814 ± 0.047	3.666ThrPro: 3.666 ± 0.06	2.057ThrGln: 2.057 ± 0.047	3.103ThrArg: 3.103 ± 0.046	3.446ThrSer: 3.446 ± 0.06	3.269ThrThr: 3.269 ± 0.063	4.356ThrVal: 4.356 ± 0.076	0.739ThrTrp: 0.739 ± 0.027	1.512ThrTyr: 1.512 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	7.371ValAla: 7.371 ± 0.089	0.651ValCys: 0.651 ± 0.019	3.719ValAsp: 3.719 ± 0.056	4.228ValGlu: 4.228 ± 0.072	2.674ValPhe: 2.674 ± 0.049	4.625ValGly: 4.625 ± 0.073	1.562ValHis: 1.562 ± 0.04	3.75ValIle: 3.75 ± 0.061	2.44ValLys: 2.44 ± 0.042	7.431ValLeu: 7.431 ± 0.097	1.562ValMet: 1.562 ± 0.041	2.482ValAsn: 2.482 ± 0.052	3.625ValPro: 3.625 ± 0.055	2.454ValGln: 2.454 ± 0.047	4.551ValArg: 4.551 ± 0.061	4.605ValSer: 4.605 ± 0.067	4.363ValThr: 4.363 ± 0.067	5.232ValVal: 5.232 ± 0.073	0.842ValTrp: 0.842 ± 0.031	1.754ValTyr: 1.754 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.041TrpAla: 1.041 ± 0.029	0.13TrpCys: 0.13 ± 0.01	0.599TrpAsp: 0.599 ± 0.024	0.58TrpGlu: 0.58 ± 0.026	0.558TrpPhe: 0.558 ± 0.022	0.884TrpGly: 0.884 ± 0.032	0.37TrpHis: 0.37 ± 0.018	0.776TrpIle: 0.776 ± 0.027	0.639TrpLys: 0.639 ± 0.024	1.573TrpLeu: 1.573 ± 0.045	0.425TrpMet: 0.425 ± 0.02	0.56TrpAsn: 0.56 ± 0.024	0.631TrpPro: 0.631 ± 0.027	0.744TrpGln: 0.744 ± 0.028	0.979TrpArg: 0.979 ± 0.031	0.914TrpSer: 0.914 ± 0.031	0.787TrpThr: 0.787 ± 0.024	0.823TrpVal: 0.823 ± 0.026	0.237TrpTrp: 0.237 ± 0.015	0.383TrpTyr: 0.383 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.054	0.261TyrCys: 0.261 ± 0.014	1.645TyrAsp: 1.645 ± 0.039	1.533TyrGlu: 1.533 ± 0.042	1.288TyrPhe: 1.288 ± 0.025	2.522TyrGly: 2.522 ± 0.048	0.731TyrHis: 0.731 ± 0.022	1.122TyrIle: 1.122 ± 0.029	0.879TyrLys: 0.879 ± 0.03	2.923TyrLeu: 2.923 ± 0.052	0.498TyrMet: 0.498 ± 0.019	1.021TyrAsn: 1.021 ± 0.037	1.4TyrPro: 1.4 ± 0.035	1.135TyrGln: 1.135 ± 0.033	2.004TyrArg: 2.004 ± 0.04	1.949TyrSer: 1.949 ± 0.046	1.597TyrThr: 1.597 ± 0.039	1.898TyrVal: 1.898 ± 0.039	0.447TyrTrp: 0.447 ± 0.019	0.972TyrTyr: 0.972 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3487 proteins (1276136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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