Amino acid dipepetide frequency for Infectious hematopoietic necrosis virus (strain WRAC) (IHNV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.556AlaAla: 5.556 ± 1.754
1.462AlaCys: 1.462 ± 0.824
1.754AlaAsp: 1.754 ± 0.746
3.509AlaGlu: 3.509 ± 2.564
1.17AlaPhe: 1.17 ± 0.417
3.216AlaGly: 3.216 ± 0.644
1.754AlaHis: 1.754 ± 0.879
5.263AlaIle: 5.263 ± 1.155
4.678AlaLys: 4.678 ± 1.428
10.234AlaLeu: 10.234 ± 2.339
1.462AlaMet: 1.462 ± 0.358
2.047AlaAsn: 2.047 ± 1.08
3.216AlaPro: 3.216 ± 1.118
3.216AlaGln: 3.216 ± 1.204
3.216AlaArg: 3.216 ± 2.249
3.216AlaSer: 3.216 ± 0.844
5.556AlaThr: 5.556 ± 0.506
3.801AlaVal: 3.801 ± 0.737
0.877AlaTrp: 0.877 ± 0.522
2.632AlaTyr: 2.632 ± 0.749
0.0AlaXaa: 0.0 ± 0.0
Cys
1.462CysAla: 1.462 ± 1.298
0.585CysCys: 0.585 ± 0.621
1.754CysAsp: 1.754 ± 0.652
0.585CysGlu: 0.585 ± 0.274
0.292CysPhe: 0.292 ± 0.174
0.585CysGly: 0.585 ± 0.621
0.0CysHis: 0.0 ± 0.0
0.292CysIle: 0.292 ± 0.502
0.292CysLys: 0.292 ± 0.174
0.877CysLeu: 0.877 ± 0.338
0.877CysMet: 0.877 ± 0.815
0.292CysAsn: 0.292 ± 0.174
1.17CysPro: 1.17 ± 0.463
1.462CysGln: 1.462 ± 0.842
0.0CysArg: 0.0 ± 0.0
1.462CysSer: 1.462 ± 0.612
1.462CysThr: 1.462 ± 0.59
0.585CysVal: 0.585 ± 0.348
0.292CysTrp: 0.292 ± 0.311
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.216AspAla: 3.216 ± 0.771
0.292AspCys: 0.292 ± 0.174
3.216AspAsp: 3.216 ± 1.924
4.678AspGlu: 4.678 ± 0.58
2.924AspPhe: 2.924 ± 0.839
4.094AspGly: 4.094 ± 1.315
0.585AspHis: 0.585 ± 0.42
4.094AspIle: 4.094 ± 0.932
3.216AspLys: 3.216 ± 0.62
9.357AspLeu: 9.357 ± 1.526
1.17AspMet: 1.17 ± 0.417
2.047AspAsn: 2.047 ± 0.57
3.509AspPro: 3.509 ± 1.434
2.047AspGln: 2.047 ± 0.843
3.216AspArg: 3.216 ± 0.721
3.216AspSer: 3.216 ± 1.217
3.801AspThr: 3.801 ± 1.08
2.047AspVal: 2.047 ± 0.575
0.292AspTrp: 0.292 ± 0.174
1.17AspTyr: 1.17 ± 0.534
0.0AspXaa: 0.0 ± 0.0
Glu
4.386GluAla: 4.386 ± 1.029
1.17GluCys: 1.17 ± 0.463
5.556GluAsp: 5.556 ± 1.73
6.433GluGlu: 6.433 ± 2.667
2.047GluPhe: 2.047 ± 0.621
5.263GluGly: 5.263 ± 1.924
1.17GluHis: 1.17 ± 0.909
5.263GluIle: 5.263 ± 0.85
6.433GluLys: 6.433 ± 2.378
6.433GluLeu: 6.433 ± 2.557
2.632GluMet: 2.632 ± 0.783
2.924GluAsn: 2.924 ± 0.56
1.754GluPro: 1.754 ± 0.7
2.632GluGln: 2.632 ± 1.116
4.386GluArg: 4.386 ± 1.352
6.14GluSer: 6.14 ± 1.291
3.801GluThr: 3.801 ± 1.391
2.339GluVal: 2.339 ± 0.857
1.462GluTrp: 1.462 ± 0.612
0.585GluTyr: 0.585 ± 0.756
0.0GluXaa: 0.0 ± 0.0
Phe
2.339PheAla: 2.339 ± 0.386
0.585PheCys: 0.585 ± 0.274
2.339PheAsp: 2.339 ± 0.672
0.877PheGlu: 0.877 ± 0.522
2.339PhePhe: 2.339 ± 0.778
3.509PheGly: 3.509 ± 1.209
1.17PheHis: 1.17 ± 0.381
1.754PheIle: 1.754 ± 0.772
1.754PheLys: 1.754 ± 1.014
3.216PheLeu: 3.216 ± 1.018
0.585PheMet: 0.585 ± 0.348
1.754PheAsn: 1.754 ± 0.815
1.754PhePro: 1.754 ± 0.676
0.877PheGln: 0.877 ± 0.49
2.339PheArg: 2.339 ± 0.469
2.924PheSer: 2.924 ± 0.769
3.509PheThr: 3.509 ± 0.927
2.047PheVal: 2.047 ± 0.841
0.292PheTrp: 0.292 ± 0.311
1.17PheTyr: 1.17 ± 0.463
0.0PheXaa: 0.0 ± 0.0
Gly
3.509GlyAla: 3.509 ± 1.593
0.877GlyCys: 0.877 ± 0.54
4.678GlyAsp: 4.678 ± 1.16
5.848GlyGlu: 5.848 ± 2.041
3.216GlyPhe: 3.216 ± 0.644
4.094GlyGly: 4.094 ± 0.565
1.462GlyHis: 1.462 ± 0.839
4.094GlyIle: 4.094 ± 1.784
2.339GlyLys: 2.339 ± 0.587
8.772GlyLeu: 8.772 ± 1.122
1.754GlyMet: 1.754 ± 0.525
1.754GlyAsn: 1.754 ± 1.119
0.877GlyPro: 0.877 ± 0.373
2.047GlyGln: 2.047 ± 1.08
2.632GlyArg: 2.632 ± 0.953
3.216GlySer: 3.216 ± 1.394
3.509GlyThr: 3.509 ± 1.452
4.094GlyVal: 4.094 ± 1.374
0.585GlyTrp: 0.585 ± 0.348
1.754GlyTyr: 1.754 ± 0.459
0.0GlyXaa: 0.0 ± 0.0
His
1.462HisAla: 1.462 ± 0.612
0.292HisCys: 0.292 ± 0.174
0.292HisAsp: 0.292 ± 0.174
0.877HisGlu: 0.877 ± 0.451
0.877HisPhe: 0.877 ± 0.522
1.462HisGly: 1.462 ± 0.947
0.585HisHis: 0.585 ± 0.274
1.462HisIle: 1.462 ± 0.612
1.17HisLys: 1.17 ± 0.548
3.509HisLeu: 3.509 ± 1.051
0.877HisMet: 0.877 ± 0.351
0.292HisAsn: 0.292 ± 0.174
1.462HisPro: 1.462 ± 0.971
1.17HisGln: 1.17 ± 0.447
2.339HisArg: 2.339 ± 0.661
0.877HisSer: 0.877 ± 0.451
0.585HisThr: 0.585 ± 0.274
0.877HisVal: 0.877 ± 0.49
0.877HisTrp: 0.877 ± 0.559
0.292HisTyr: 0.292 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
4.094IleAla: 4.094 ± 0.998
0.877IleCys: 0.877 ± 0.338
3.509IleAsp: 3.509 ± 1.703
4.971IleGlu: 4.971 ± 2.084
2.339IlePhe: 2.339 ± 0.639
3.216IleGly: 3.216 ± 0.814
1.754IleHis: 1.754 ± 0.676
3.801IleIle: 3.801 ± 1.221
5.556IleLys: 5.556 ± 0.614
7.31IleLeu: 7.31 ± 0.799
0.292IleMet: 0.292 ± 0.174
3.216IleAsn: 3.216 ± 0.997
3.801IlePro: 3.801 ± 1.16
1.462IleGln: 1.462 ± 0.871
4.094IleArg: 4.094 ± 1.174
4.386IleSer: 4.386 ± 1.508
6.433IleThr: 6.433 ± 1.457
3.216IleVal: 3.216 ± 1.063
0.585IleTrp: 0.585 ± 0.348
1.754IleTyr: 1.754 ± 0.463
0.0IleXaa: 0.0 ± 0.0
Lys
5.263LysAla: 5.263 ± 1.41
1.17LysCys: 1.17 ± 0.548
1.462LysAsp: 1.462 ± 0.683
5.556LysGlu: 5.556 ± 1.131
2.047LysPhe: 2.047 ± 0.937
4.678LysGly: 4.678 ± 1.057
0.292LysHis: 0.292 ± 0.174
3.801LysIle: 3.801 ± 0.925
3.216LysLys: 3.216 ± 1.306
7.018LysLeu: 7.018 ± 1.333
1.462LysMet: 1.462 ± 0.869
3.509LysAsn: 3.509 ± 1.524
1.462LysPro: 1.462 ± 0.683
1.462LysGln: 1.462 ± 0.615
4.678LysArg: 4.678 ± 1.198
4.678LysSer: 4.678 ± 0.58
4.094LysThr: 4.094 ± 0.739
4.094LysVal: 4.094 ± 1.569
0.877LysTrp: 0.877 ± 0.338
1.462LysTyr: 1.462 ± 1.681
0.0LysXaa: 0.0 ± 0.0
Leu
7.895LeuAla: 7.895 ± 1.106
2.632LeuCys: 2.632 ± 1.111
8.187LeuAsp: 8.187 ± 1.522
8.187LeuGlu: 8.187 ± 2.795
6.14LeuPhe: 6.14 ± 1.057
5.848LeuGly: 5.848 ± 1.0
3.216LeuHis: 3.216 ± 0.909
7.602LeuIle: 7.602 ± 1.454
4.678LeuLys: 4.678 ± 1.548
11.988LeuLeu: 11.988 ± 2.59
1.754LeuMet: 1.754 ± 0.746
2.632LeuAsn: 2.632 ± 1.116
4.386LeuPro: 4.386 ± 1.341
3.509LeuGln: 3.509 ± 0.902
6.433LeuArg: 6.433 ± 1.002
11.696LeuSer: 11.696 ± 1.669
4.971LeuThr: 4.971 ± 1.077
4.971LeuVal: 4.971 ± 1.041
0.292LeuTrp: 0.292 ± 0.174
2.339LeuTyr: 2.339 ± 1.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.17MetAla: 1.17 ± 0.813
0.292MetCys: 0.292 ± 0.311
2.632MetAsp: 2.632 ± 1.021
1.754MetGlu: 1.754 ± 0.652
0.292MetPhe: 0.292 ± 0.174
1.17MetGly: 1.17 ± 0.381
0.292MetHis: 0.292 ± 0.311
1.462MetIle: 1.462 ± 0.587
1.754MetLys: 1.754 ± 0.411
0.877MetLeu: 0.877 ± 0.373
0.585MetMet: 0.585 ± 0.601
1.754MetAsn: 1.754 ± 0.507
0.877MetPro: 0.877 ± 0.522
1.17MetGln: 1.17 ± 0.707
1.462MetArg: 1.462 ± 0.825
2.339MetSer: 2.339 ± 0.745
2.339MetThr: 2.339 ± 0.981
0.585MetVal: 0.585 ± 0.406
0.292MetTrp: 0.292 ± 0.174
0.292MetTyr: 0.292 ± 0.311
0.0MetXaa: 0.0 ± 0.0
Asn
2.339AsnAla: 2.339 ± 0.896
0.0AsnCys: 0.0 ± 0.0
2.339AsnAsp: 2.339 ± 0.816
2.632AsnGlu: 2.632 ± 0.42
1.462AsnPhe: 1.462 ± 0.519
0.292AsnGly: 0.292 ± 0.174
1.17AsnHis: 1.17 ± 0.447
2.924AsnIle: 2.924 ± 0.905
2.924AsnLys: 2.924 ± 0.75
4.971AsnLeu: 4.971 ± 1.585
1.17AsnMet: 1.17 ± 0.559
1.17AsnAsn: 1.17 ± 0.381
1.17AsnPro: 1.17 ± 0.447
0.292AsnGln: 0.292 ± 0.502
3.801AsnArg: 3.801 ± 0.627
2.632AsnSer: 2.632 ± 0.789
0.877AsnThr: 0.877 ± 0.473
2.047AsnVal: 2.047 ± 0.566
0.292AsnTrp: 0.292 ± 0.174
0.877AsnTyr: 0.877 ± 0.522
0.0AsnXaa: 0.0 ± 0.0
Pro
3.216ProAla: 3.216 ± 0.595
0.292ProCys: 0.292 ± 0.311
2.924ProAsp: 2.924 ± 1.617
3.509ProGlu: 3.509 ± 0.863
1.17ProPhe: 1.17 ± 0.689
1.754ProGly: 1.754 ± 1.311
1.17ProHis: 1.17 ± 0.721
1.17ProIle: 1.17 ± 0.697
1.754ProLys: 1.754 ± 0.859
5.848ProLeu: 5.848 ± 1.135
1.462ProMet: 1.462 ± 0.633
0.877ProAsn: 0.877 ± 0.373
2.339ProPro: 2.339 ± 0.892
1.17ProGln: 1.17 ± 0.793
4.678ProArg: 4.678 ± 1.321
2.924ProSer: 2.924 ± 0.682
2.924ProThr: 2.924 ± 1.066
2.047ProVal: 2.047 ± 1.219
0.585ProTrp: 0.585 ± 0.274
2.632ProTyr: 2.632 ± 1.071
0.0ProXaa: 0.0 ± 0.0
Gln
3.216GlnAla: 3.216 ± 1.713
0.292GlnCys: 0.292 ± 0.174
1.754GlnAsp: 1.754 ± 0.746
3.801GlnGlu: 3.801 ± 1.562
1.462GlnPhe: 1.462 ± 0.615
2.339GlnGly: 2.339 ± 0.469
0.877GlnHis: 0.877 ± 0.522
1.462GlnIle: 1.462 ± 0.615
2.047GlnLys: 2.047 ± 0.389
1.754GlnLeu: 1.754 ± 0.859
0.292GlnMet: 0.292 ± 0.425
0.877GlnAsn: 0.877 ± 0.473
1.17GlnPro: 1.17 ± 0.474
1.17GlnGln: 1.17 ± 0.447
2.632GlnArg: 2.632 ± 1.032
2.047GlnSer: 2.047 ± 0.792
3.509GlnThr: 3.509 ± 1.421
1.17GlnVal: 1.17 ± 0.925
0.877GlnTrp: 0.877 ± 0.559
0.877GlnTyr: 0.877 ± 0.338
0.0GlnXaa: 0.0 ± 0.0
Arg
5.263ArgAla: 5.263 ± 1.235
0.585ArgCys: 0.585 ± 0.621
4.094ArgAsp: 4.094 ± 1.084
6.433ArgGlu: 6.433 ± 1.606
0.877ArgPhe: 0.877 ± 0.754
6.14ArgGly: 6.14 ± 1.304
0.585ArgHis: 0.585 ± 0.42
3.801ArgIle: 3.801 ± 0.887
3.801ArgLys: 3.801 ± 0.798
7.31ArgLeu: 7.31 ± 1.607
2.047ArgMet: 2.047 ± 0.949
0.585ArgAsn: 0.585 ± 0.455
2.924ArgPro: 2.924 ± 0.89
1.17ArgGln: 1.17 ± 0.51
5.263ArgArg: 5.263 ± 1.491
4.094ArgSer: 4.094 ± 1.299
3.216ArgThr: 3.216 ± 0.753
3.801ArgVal: 3.801 ± 1.238
0.0ArgTrp: 0.0 ± 0.0
2.047ArgTyr: 2.047 ± 0.608
0.0ArgXaa: 0.0 ± 0.0
Ser
4.678SerAla: 4.678 ± 0.679
0.877SerCys: 0.877 ± 0.451
4.678SerAsp: 4.678 ± 0.837
4.971SerGlu: 4.971 ± 1.164
2.632SerPhe: 2.632 ± 1.33
3.801SerGly: 3.801 ± 0.677
1.17SerHis: 1.17 ± 0.692
5.263SerIle: 5.263 ± 1.569
3.509SerLys: 3.509 ± 0.62
7.018SerLeu: 7.018 ± 2.612
1.754SerMet: 1.754 ± 1.069
3.216SerAsn: 3.216 ± 0.753
3.801SerPro: 3.801 ± 1.144
4.678SerGln: 4.678 ± 1.133
4.678SerArg: 4.678 ± 0.739
6.433SerSer: 6.433 ± 1.936
4.386SerThr: 4.386 ± 0.827
4.678SerVal: 4.678 ± 1.355
0.877SerTrp: 0.877 ± 0.522
0.877SerTyr: 0.877 ± 0.54
0.0SerXaa: 0.0 ± 0.0
Thr
3.216ThrAla: 3.216 ± 0.699
1.17ThrCys: 1.17 ± 0.936
3.216ThrAsp: 3.216 ± 0.861
2.924ThrGlu: 2.924 ± 0.634
2.632ThrPhe: 2.632 ± 1.292
3.801ThrGly: 3.801 ± 2.859
1.754ThrHis: 1.754 ± 0.772
6.433ThrIle: 6.433 ± 1.015
6.725ThrLys: 6.725 ± 0.814
4.386ThrLeu: 4.386 ± 1.352
1.462ThrMet: 1.462 ± 0.358
2.047ThrAsn: 2.047 ± 0.729
3.509ThrPro: 3.509 ± 1.026
2.632ThrGln: 2.632 ± 0.924
3.509ThrArg: 3.509 ± 0.879
5.263ThrSer: 5.263 ± 0.596
3.509ThrThr: 3.509 ± 2.396
2.924ThrVal: 2.924 ± 0.964
1.754ThrTrp: 1.754 ± 0.603
2.339ThrTyr: 2.339 ± 1.7
0.0ThrXaa: 0.0 ± 0.0
Val
4.094ValAla: 4.094 ± 1.094
0.292ValCys: 0.292 ± 0.174
2.339ValAsp: 2.339 ± 0.519
3.216ValGlu: 3.216 ± 1.06
1.754ValPhe: 1.754 ± 0.746
2.924ValGly: 2.924 ± 1.164
1.17ValHis: 1.17 ± 0.697
3.509ValIle: 3.509 ± 1.065
4.386ValLys: 4.386 ± 1.463
5.848ValLeu: 5.848 ± 2.173
0.585ValMet: 0.585 ± 0.406
2.632ValAsn: 2.632 ± 0.512
2.632ValPro: 2.632 ± 0.658
0.585ValGln: 0.585 ± 0.274
1.462ValArg: 1.462 ± 0.518
3.216ValSer: 3.216 ± 0.726
4.094ValThr: 4.094 ± 1.281
2.632ValVal: 2.632 ± 1.063
1.17ValTrp: 1.17 ± 0.458
1.17ValTyr: 1.17 ± 0.721
0.0ValXaa: 0.0 ± 0.0
Trp
0.585TrpAla: 0.585 ± 0.348
0.292TrpCys: 0.292 ± 0.174
0.292TrpAsp: 0.292 ± 0.174
1.754TrpGlu: 1.754 ± 0.676
0.0TrpPhe: 0.0 ± 0.0
0.585TrpGly: 0.585 ± 0.274
0.0TrpHis: 0.0 ± 0.0
1.17TrpIle: 1.17 ± 0.463
1.17TrpLys: 1.17 ± 0.697
0.0TrpLeu: 0.0 ± 0.0
0.292TrpMet: 0.292 ± 0.311
0.585TrpAsn: 0.585 ± 0.348
1.17TrpPro: 1.17 ± 0.463
0.0TrpGln: 0.0 ± 0.0
1.754TrpArg: 1.754 ± 0.926
1.462TrpSer: 1.462 ± 1.169
0.585TrpThr: 0.585 ± 0.348
0.292TrpVal: 0.292 ± 0.174
0.0TrpTrp: 0.0 ± 0.0
0.585TrpTyr: 0.585 ± 0.274
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.877TyrAla: 0.877 ± 0.54
0.292TyrCys: 0.292 ± 0.502
1.17TyrAsp: 1.17 ± 1.55
0.292TyrGlu: 0.292 ± 0.52
1.462TyrPhe: 1.462 ± 0.358
2.339TyrGly: 2.339 ± 1.13
1.462TyrHis: 1.462 ± 0.59
2.047TyrIle: 2.047 ± 1.219
0.877TyrLys: 0.877 ± 0.947
2.632TyrLeu: 2.632 ± 0.924
0.585TyrMet: 0.585 ± 0.42
1.17TyrAsn: 1.17 ± 0.548
1.462TyrPro: 1.462 ± 0.631
1.17TyrGln: 1.17 ± 1.012
1.462TyrArg: 1.462 ± 0.842
1.754TyrSer: 1.754 ± 0.98
2.047TyrThr: 2.047 ± 0.856
1.462TyrVal: 1.462 ± 0.453
0.292TyrTrp: 0.292 ± 0.174
1.462TyrTyr: 1.462 ± 0.999
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski