Amino acid dipepetide frequency for Streptococcus satellite phage Javan195

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.667AlaAla: 0.667 ± 0.401
0.333AlaCys: 0.333 ± 0.327
7.002AlaAsp: 7.002 ± 2.271
6.669AlaGlu: 6.669 ± 1.598
3.334AlaPhe: 3.334 ± 1.082
2.001AlaGly: 2.001 ± 0.739
0.667AlaHis: 0.667 ± 0.451
4.335AlaIle: 4.335 ± 0.878
4.668AlaLys: 4.668 ± 1.382
8.003AlaLeu: 8.003 ± 1.344
3.001AlaMet: 3.001 ± 0.982
3.001AlaAsn: 3.001 ± 0.63
1.334AlaPro: 1.334 ± 0.576
3.001AlaGln: 3.001 ± 0.854
3.334AlaArg: 3.334 ± 0.893
2.668AlaSer: 2.668 ± 0.792
3.334AlaThr: 3.334 ± 1.1
3.001AlaVal: 3.001 ± 0.919
0.333AlaTrp: 0.333 ± 0.329
2.334AlaTyr: 2.334 ± 0.908
0.0AlaXaa: 0.0 ± 0.0
Cys
0.667CysAla: 0.667 ± 0.391
0.0CysCys: 0.0 ± 0.0
0.333CysAsp: 0.333 ± 0.327
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.667CysGly: 0.667 ± 0.769
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.333CysLeu: 0.333 ± 0.328
0.0CysMet: 0.0 ± 0.0
0.333CysAsn: 0.333 ± 0.307
0.667CysPro: 0.667 ± 0.481
1.334CysGln: 1.334 ± 0.876
0.667CysArg: 0.667 ± 0.423
0.667CysSer: 0.667 ± 0.452
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.333CysTyr: 0.333 ± 0.327
0.0CysXaa: 0.0 ± 0.0
Asp
2.001AspAla: 2.001 ± 0.748
0.667AspCys: 0.667 ± 0.769
3.001AspAsp: 3.001 ± 0.989
2.334AspGlu: 2.334 ± 0.709
3.334AspPhe: 3.334 ± 1.163
2.334AspGly: 2.334 ± 0.974
0.333AspHis: 0.333 ± 0.245
6.669AspIle: 6.669 ± 1.773
7.336AspLys: 7.336 ± 1.538
5.669AspLeu: 5.669 ± 1.115
2.001AspMet: 2.001 ± 1.001
3.668AspAsn: 3.668 ± 1.113
0.667AspPro: 0.667 ± 0.484
1.0AspGln: 1.0 ± 0.549
2.334AspArg: 2.334 ± 0.657
3.668AspSer: 3.668 ± 0.903
3.334AspThr: 3.334 ± 1.206
1.0AspVal: 1.0 ± 0.45
1.334AspTrp: 1.334 ± 0.54
3.001AspTyr: 3.001 ± 0.994
0.0AspXaa: 0.0 ± 0.0
Glu
6.002GluAla: 6.002 ± 1.588
0.667GluCys: 0.667 ± 0.428
3.668GluAsp: 3.668 ± 0.7
6.335GluGlu: 6.335 ± 1.796
2.668GluPhe: 2.668 ± 0.95
2.334GluGly: 2.334 ± 1.229
0.667GluHis: 0.667 ± 0.412
5.002GluIle: 5.002 ± 1.195
7.669GluLys: 7.669 ± 1.908
12.671GluLeu: 12.671 ± 1.695
1.0GluMet: 1.0 ± 0.443
3.668GluAsn: 3.668 ± 0.997
2.334GluPro: 2.334 ± 0.805
8.336GluGln: 8.336 ± 1.941
2.001GluArg: 2.001 ± 0.837
3.001GluSer: 3.001 ± 0.829
4.335GluThr: 4.335 ± 1.189
3.334GluVal: 3.334 ± 1.516
0.667GluTrp: 0.667 ± 0.401
2.334GluTyr: 2.334 ± 0.723
0.0GluXaa: 0.0 ± 0.0
Phe
1.334PheAla: 1.334 ± 0.667
0.667PheCys: 0.667 ± 0.464
1.667PheAsp: 1.667 ± 0.766
4.001PheGlu: 4.001 ± 1.112
2.334PhePhe: 2.334 ± 0.791
2.668PheGly: 2.668 ± 0.793
1.667PheHis: 1.667 ± 0.969
4.668PheIle: 4.668 ± 1.592
3.001PheLys: 3.001 ± 0.973
2.001PheLeu: 2.001 ± 0.813
0.667PheMet: 0.667 ± 0.399
1.334PheAsn: 1.334 ± 0.56
2.001PhePro: 2.001 ± 0.968
0.333PheGln: 0.333 ± 0.331
1.667PheArg: 1.667 ± 0.751
2.668PheSer: 2.668 ± 0.838
1.667PheThr: 1.667 ± 0.885
1.334PheVal: 1.334 ± 0.722
0.0PheTrp: 0.0 ± 0.0
1.667PheTyr: 1.667 ± 0.758
0.0PheXaa: 0.0 ± 0.0
Gly
4.335GlyAla: 4.335 ± 1.515
1.0GlyCys: 1.0 ± 0.522
2.001GlyAsp: 2.001 ± 0.832
3.334GlyGlu: 3.334 ± 0.917
1.667GlyPhe: 1.667 ± 0.974
1.334GlyGly: 1.334 ± 0.831
1.334GlyHis: 1.334 ± 0.682
3.668GlyIle: 3.668 ± 0.772
2.668GlyLys: 2.668 ± 0.75
3.334GlyLeu: 3.334 ± 0.952
1.667GlyMet: 1.667 ± 0.592
1.667GlyAsn: 1.667 ± 0.942
0.333GlyPro: 0.333 ± 0.307
2.001GlyGln: 2.001 ± 0.613
2.334GlyArg: 2.334 ± 0.925
1.334GlySer: 1.334 ± 0.627
2.334GlyThr: 2.334 ± 0.945
4.001GlyVal: 4.001 ± 1.145
1.0GlyTrp: 1.0 ± 0.557
2.668GlyTyr: 2.668 ± 1.024
0.0GlyXaa: 0.0 ± 0.0
His
2.001HisAla: 2.001 ± 1.236
0.0HisCys: 0.0 ± 0.0
0.333HisAsp: 0.333 ± 0.329
1.0HisGlu: 1.0 ± 0.645
0.0HisPhe: 0.0 ± 0.0
0.333HisGly: 0.333 ± 0.4
0.333HisHis: 0.333 ± 0.329
0.667HisIle: 0.667 ± 0.412
2.001HisLys: 2.001 ± 0.89
2.334HisLeu: 2.334 ± 1.037
0.0HisMet: 0.0 ± 0.0
0.333HisAsn: 0.333 ± 0.329
1.667HisPro: 1.667 ± 0.726
1.334HisGln: 1.334 ± 0.623
2.001HisArg: 2.001 ± 0.927
0.333HisSer: 0.333 ± 0.289
1.0HisThr: 1.0 ± 0.481
0.333HisVal: 0.333 ± 0.245
0.0HisTrp: 0.0 ± 0.0
0.667HisTyr: 0.667 ± 0.423
0.0HisXaa: 0.0 ± 0.0
Ile
5.002IleAla: 5.002 ± 1.057
0.0IleCys: 0.0 ± 0.0
4.001IleAsp: 4.001 ± 1.183
5.669IleGlu: 5.669 ± 1.135
1.334IlePhe: 1.334 ± 0.694
2.001IleGly: 2.001 ± 0.735
2.668IleHis: 2.668 ± 0.897
5.335IleIle: 5.335 ± 1.617
6.335IleLys: 6.335 ± 1.583
4.001IleLeu: 4.001 ± 1.019
0.667IleMet: 0.667 ± 0.426
6.002IleAsn: 6.002 ± 1.648
4.001IlePro: 4.001 ± 0.858
2.001IleGln: 2.001 ± 0.619
2.334IleArg: 2.334 ± 0.869
6.002IleSer: 6.002 ± 1.078
5.669IleThr: 5.669 ± 1.224
1.667IleVal: 1.667 ± 0.607
0.333IleTrp: 0.333 ± 0.348
3.001IleTyr: 3.001 ± 1.078
0.0IleXaa: 0.0 ± 0.0
Lys
7.002LysAla: 7.002 ± 1.505
0.333LysCys: 0.333 ± 0.307
3.668LysAsp: 3.668 ± 1.021
12.004LysGlu: 12.004 ± 1.467
1.334LysPhe: 1.334 ± 0.654
5.002LysGly: 5.002 ± 1.611
3.668LysHis: 3.668 ± 1.065
4.001LysIle: 4.001 ± 0.859
9.003LysLys: 9.003 ± 1.891
8.67LysLeu: 8.67 ± 1.409
2.668LysMet: 2.668 ± 1.307
6.002LysAsn: 6.002 ± 1.103
4.668LysPro: 4.668 ± 0.83
4.668LysGln: 4.668 ± 1.112
3.668LysArg: 3.668 ± 1.321
4.001LysSer: 4.001 ± 1.302
6.335LysThr: 6.335 ± 1.316
6.002LysVal: 6.002 ± 1.244
0.333LysTrp: 0.333 ± 0.348
1.334LysTyr: 1.334 ± 0.567
0.0LysXaa: 0.0 ± 0.0
Leu
7.002LeuAla: 7.002 ± 1.356
1.0LeuCys: 1.0 ± 0.549
5.669LeuAsp: 5.669 ± 1.329
8.336LeuGlu: 8.336 ± 1.925
2.668LeuPhe: 2.668 ± 0.755
7.669LeuGly: 7.669 ± 1.462
0.667LeuHis: 0.667 ± 0.391
5.002LeuIle: 5.002 ± 1.333
12.337LeuLys: 12.337 ± 1.835
12.337LeuLeu: 12.337 ± 1.767
2.668LeuMet: 2.668 ± 0.644
8.336LeuAsn: 8.336 ± 1.647
3.668LeuPro: 3.668 ± 0.886
4.001LeuGln: 4.001 ± 0.953
3.334LeuArg: 3.334 ± 0.799
6.669LeuSer: 6.669 ± 1.617
6.002LeuThr: 6.002 ± 1.379
3.001LeuVal: 3.001 ± 0.983
1.334LeuTrp: 1.334 ± 0.505
4.335LeuTyr: 4.335 ± 0.948
0.0LeuXaa: 0.0 ± 0.0
Met
6.335MetAla: 6.335 ± 1.179
0.333MetCys: 0.333 ± 0.384
1.334MetAsp: 1.334 ± 0.687
1.0MetGlu: 1.0 ± 0.466
0.667MetPhe: 0.667 ± 0.43
0.667MetGly: 0.667 ± 0.43
0.0MetHis: 0.0 ± 0.0
1.667MetIle: 1.667 ± 0.67
1.334MetLys: 1.334 ± 0.522
2.668MetLeu: 2.668 ± 0.802
0.0MetMet: 0.0 ± 0.0
1.667MetAsn: 1.667 ± 0.567
0.0MetPro: 0.0 ± 0.0
0.333MetGln: 0.333 ± 0.347
1.334MetArg: 1.334 ± 0.655
2.334MetSer: 2.334 ± 1.11
3.001MetThr: 3.001 ± 0.755
2.334MetVal: 2.334 ± 0.881
0.333MetTrp: 0.333 ± 0.245
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.001AsnAla: 3.001 ± 0.942
0.0AsnCys: 0.0 ± 0.0
3.001AsnAsp: 3.001 ± 0.901
3.001AsnGlu: 3.001 ± 1.294
2.668AsnPhe: 2.668 ± 1.042
2.668AsnGly: 2.668 ± 0.952
0.667AsnHis: 0.667 ± 0.426
4.001AsnIle: 4.001 ± 1.294
3.668AsnLys: 3.668 ± 0.994
8.003AsnLeu: 8.003 ± 1.527
2.001AsnMet: 2.001 ± 0.911
5.002AsnAsn: 5.002 ± 1.164
3.001AsnPro: 3.001 ± 0.944
4.335AsnGln: 4.335 ± 1.606
3.668AsnArg: 3.668 ± 1.2
3.668AsnSer: 3.668 ± 0.798
2.334AsnThr: 2.334 ± 0.806
2.001AsnVal: 2.001 ± 0.549
0.333AsnTrp: 0.333 ± 0.347
1.667AsnTyr: 1.667 ± 0.636
0.0AsnXaa: 0.0 ± 0.0
Pro
2.334ProAla: 2.334 ± 0.744
0.0ProCys: 0.0 ± 0.0
2.668ProAsp: 2.668 ± 0.809
2.001ProGlu: 2.001 ± 0.632
2.334ProPhe: 2.334 ± 0.707
0.667ProGly: 0.667 ± 0.533
0.0ProHis: 0.0 ± 0.0
2.001ProIle: 2.001 ± 0.743
6.335ProLys: 6.335 ± 1.325
2.668ProLeu: 2.668 ± 0.898
0.333ProMet: 0.333 ± 0.312
1.0ProAsn: 1.0 ± 0.635
1.667ProPro: 1.667 ± 0.808
1.334ProGln: 1.334 ± 0.59
1.667ProArg: 1.667 ± 0.565
2.668ProSer: 2.668 ± 0.938
2.334ProThr: 2.334 ± 1.096
2.334ProVal: 2.334 ± 0.619
0.0ProTrp: 0.0 ± 0.0
1.667ProTyr: 1.667 ± 0.616
0.0ProXaa: 0.0 ± 0.0
Gln
5.669GlnAla: 5.669 ± 1.81
0.333GlnCys: 0.333 ± 0.307
3.334GlnAsp: 3.334 ± 1.023
4.668GlnGlu: 4.668 ± 0.978
1.334GlnPhe: 1.334 ± 0.592
2.001GlnGly: 2.001 ± 0.781
1.0GlnHis: 1.0 ± 0.497
3.334GlnIle: 3.334 ± 1.085
5.335GlnLys: 5.335 ± 1.201
5.002GlnLeu: 5.002 ± 1.544
2.001GlnMet: 2.001 ± 0.713
2.668GlnAsn: 2.668 ± 1.219
1.667GlnPro: 1.667 ± 0.754
3.668GlnGln: 3.668 ± 1.107
3.334GlnArg: 3.334 ± 0.973
1.667GlnSer: 1.667 ± 0.704
2.334GlnThr: 2.334 ± 0.568
2.334GlnVal: 2.334 ± 0.683
0.0GlnTrp: 0.0 ± 0.0
3.001GlnTyr: 3.001 ± 1.029
0.0GlnXaa: 0.0 ± 0.0
Arg
2.001ArgAla: 2.001 ± 0.58
0.333ArgCys: 0.333 ± 0.384
3.334ArgAsp: 3.334 ± 0.869
4.668ArgGlu: 4.668 ± 1.229
2.001ArgPhe: 2.001 ± 0.644
2.668ArgGly: 2.668 ± 1.061
0.667ArgHis: 0.667 ± 0.436
1.667ArgIle: 1.667 ± 0.592
5.002ArgLys: 5.002 ± 1.193
7.002ArgLeu: 7.002 ± 1.532
1.0ArgMet: 1.0 ± 0.416
1.334ArgAsn: 1.334 ± 0.784
0.333ArgPro: 0.333 ± 0.384
3.668ArgGln: 3.668 ± 1.02
2.001ArgArg: 2.001 ± 0.706
0.333ArgSer: 0.333 ± 0.384
2.668ArgThr: 2.668 ± 0.732
2.334ArgVal: 2.334 ± 0.947
0.667ArgTrp: 0.667 ± 0.381
2.001ArgTyr: 2.001 ± 0.896
0.0ArgXaa: 0.0 ± 0.0
Ser
2.334SerAla: 2.334 ± 0.757
0.333SerCys: 0.333 ± 0.364
3.001SerAsp: 3.001 ± 0.763
3.001SerGlu: 3.001 ± 1.074
1.0SerPhe: 1.0 ± 0.499
1.667SerGly: 1.667 ± 0.637
0.333SerHis: 0.333 ± 0.307
4.001SerIle: 4.001 ± 0.818
6.002SerLys: 6.002 ± 1.385
6.335SerLeu: 6.335 ± 1.106
2.334SerMet: 2.334 ± 0.814
3.668SerAsn: 3.668 ± 1.096
2.001SerPro: 2.001 ± 0.916
3.668SerGln: 3.668 ± 0.857
2.001SerArg: 2.001 ± 0.89
1.667SerSer: 1.667 ± 0.662
2.334SerThr: 2.334 ± 0.634
3.001SerVal: 3.001 ± 1.284
0.0SerTrp: 0.0 ± 0.0
4.001SerTyr: 4.001 ± 1.714
0.0SerXaa: 0.0 ± 0.0
Thr
1.667ThrAla: 1.667 ± 1.068
0.0ThrCys: 0.0 ± 0.0
3.668ThrAsp: 3.668 ± 1.066
5.002ThrGlu: 5.002 ± 1.103
2.001ThrPhe: 2.001 ± 0.855
4.001ThrGly: 4.001 ± 1.104
1.0ThrHis: 1.0 ± 0.512
6.335ThrIle: 6.335 ± 1.121
4.335ThrLys: 4.335 ± 1.386
4.668ThrLeu: 4.668 ± 1.368
1.334ThrMet: 1.334 ± 0.7
2.668ThrAsn: 2.668 ± 1.235
3.001ThrPro: 3.001 ± 0.877
2.668ThrGln: 2.668 ± 0.753
1.667ThrArg: 1.667 ± 0.906
3.334ThrSer: 3.334 ± 1.007
2.334ThrThr: 2.334 ± 0.671
4.668ThrVal: 4.668 ± 0.856
0.667ThrTrp: 0.667 ± 0.489
3.001ThrTyr: 3.001 ± 0.93
0.0ThrXaa: 0.0 ± 0.0
Val
2.334ValAla: 2.334 ± 0.598
0.0ValCys: 0.0 ± 0.0
2.334ValAsp: 2.334 ± 0.837
3.334ValGlu: 3.334 ± 1.012
2.001ValPhe: 2.001 ± 0.85
1.334ValGly: 1.334 ± 0.449
0.667ValHis: 0.667 ± 0.579
3.001ValIle: 3.001 ± 1.066
3.334ValLys: 3.334 ± 0.847
4.668ValLeu: 4.668 ± 1.267
1.667ValMet: 1.667 ± 0.675
2.001ValAsn: 2.001 ± 0.843
1.667ValPro: 1.667 ± 0.654
1.667ValGln: 1.667 ± 0.92
3.668ValArg: 3.668 ± 1.064
3.668ValSer: 3.668 ± 1.011
4.001ValThr: 4.001 ± 1.172
3.001ValVal: 3.001 ± 1.168
0.0ValTrp: 0.0 ± 0.0
2.334ValTyr: 2.334 ± 0.657
0.0ValXaa: 0.0 ± 0.0
Trp
1.334TrpAla: 1.334 ± 0.623
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.0TrpGlu: 1.0 ± 0.455
0.333TrpPhe: 0.333 ± 0.245
0.0TrpGly: 0.0 ± 0.0
0.333TrpHis: 0.333 ± 0.347
0.0TrpIle: 0.0 ± 0.0
0.667TrpLys: 0.667 ± 0.417
1.0TrpLeu: 1.0 ± 0.514
0.0TrpMet: 0.0 ± 0.0
0.667TrpAsn: 0.667 ± 0.425
0.0TrpPro: 0.0 ± 0.0
0.667TrpGln: 0.667 ± 0.337
0.667TrpArg: 0.667 ± 0.489
0.667TrpSer: 0.667 ± 0.356
0.333TrpThr: 0.333 ± 0.348
0.0TrpVal: 0.0 ± 0.0
0.333TrpTrp: 0.333 ± 0.245
0.667TrpTyr: 0.667 ± 0.427
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.0TyrCys: 0.0 ± 0.0
2.001TyrAsp: 2.001 ± 1.045
1.334TyrGlu: 1.334 ± 0.773
4.335TyrPhe: 4.335 ± 1.285
2.001TyrGly: 2.001 ± 0.71
0.0TyrHis: 0.0 ± 0.0
2.668TyrIle: 2.668 ± 0.683
3.334TyrLys: 3.334 ± 1.095
4.668TyrLeu: 4.668 ± 1.188
2.001TyrMet: 2.001 ± 0.733
3.668TyrAsn: 3.668 ± 0.741
1.334TyrPro: 1.334 ± 0.645
4.668TyrGln: 4.668 ± 1.19
2.001TyrArg: 2.001 ± 0.732
1.667TyrSer: 1.667 ± 0.946
2.334TyrThr: 2.334 ± 0.672
1.0TyrVal: 1.0 ± 0.416
1.0TyrTrp: 1.0 ± 0.811
1.667TyrTyr: 1.667 ± 0.855
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (3000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski