Amino acid dipepetide frequency for Pauljensenia hongkongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.262AlaAla: 18.262 ± 0.245
1.175AlaCys: 1.175 ± 0.055
8.274AlaAsp: 8.274 ± 0.143
6.752AlaGlu: 6.752 ± 0.136
3.959AlaPhe: 3.959 ± 0.101
11.709AlaGly: 11.709 ± 0.178
2.758AlaHis: 2.758 ± 0.091
4.923AlaIle: 4.923 ± 0.113
2.831AlaLys: 2.831 ± 0.083
14.757AlaLeu: 14.757 ± 0.22
2.991AlaMet: 2.991 ± 0.083
2.443AlaAsn: 2.443 ± 0.068
7.72AlaPro: 7.72 ± 0.135
4.579AlaGln: 4.579 ± 0.102
10.262AlaArg: 10.262 ± 0.181
8.518AlaSer: 8.518 ± 0.147
6.611AlaThr: 6.611 ± 0.133
11.056AlaVal: 11.056 ± 0.164
2.068AlaTrp: 2.068 ± 0.071
2.59AlaTyr: 2.59 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
1.309CysAla: 1.309 ± 0.05
0.102CysCys: 0.102 ± 0.014
0.441CysAsp: 0.441 ± 0.027
0.439CysGlu: 0.439 ± 0.029
0.251CysPhe: 0.251 ± 0.022
0.985CysGly: 0.985 ± 0.048
0.145CysHis: 0.145 ± 0.018
0.234CysIle: 0.234 ± 0.021
0.093CysLys: 0.093 ± 0.012
0.756CysLeu: 0.756 ± 0.039
0.135CysMet: 0.135 ± 0.014
0.141CysAsn: 0.141 ± 0.017
0.523CysPro: 0.523 ± 0.036
0.207CysGln: 0.207 ± 0.02
0.454CysArg: 0.454 ± 0.032
0.511CysSer: 0.511 ± 0.035
0.372CysThr: 0.372 ± 0.032
0.745CysVal: 0.745 ± 0.04
0.115CysTrp: 0.115 ± 0.015
0.181CysTyr: 0.181 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
7.566AspAla: 7.566 ± 0.13
0.467AspCys: 0.467 ± 0.028
3.637AspAsp: 3.637 ± 0.099
4.116AspGlu: 4.116 ± 0.114
1.792AspPhe: 1.792 ± 0.056
6.585AspGly: 6.585 ± 0.15
1.162AspHis: 1.162 ± 0.047
2.385AspIle: 2.385 ± 0.073
1.221AspLys: 1.221 ± 0.048
5.498AspLeu: 5.498 ± 0.115
1.184AspMet: 1.184 ± 0.046
1.206AspAsn: 1.206 ± 0.053
4.55AspPro: 4.55 ± 0.119
2.083AspGln: 2.083 ± 0.062
3.876AspArg: 3.876 ± 0.091
3.463AspSer: 3.463 ± 0.092
2.773AspThr: 2.773 ± 0.075
4.522AspVal: 4.522 ± 0.096
0.966AspTrp: 0.966 ± 0.043
1.543AspTyr: 1.543 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
8.018GluAla: 8.018 ± 0.123
0.441GluCys: 0.441 ± 0.031
3.368GluAsp: 3.368 ± 0.087
3.776GluGlu: 3.776 ± 0.111
1.484GluPhe: 1.484 ± 0.052
5.141GluGly: 5.141 ± 0.092
1.126GluHis: 1.126 ± 0.048
2.306GluIle: 2.306 ± 0.078
1.369GluLys: 1.369 ± 0.054
5.007GluLeu: 5.007 ± 0.116
1.138GluMet: 1.138 ± 0.038
1.133GluAsn: 1.133 ± 0.052
2.676GluPro: 2.676 ± 0.071
1.914GluGln: 1.914 ± 0.055
4.843GluArg: 4.843 ± 0.125
2.802GluSer: 2.802 ± 0.074
2.271GluThr: 2.271 ± 0.059
4.25GluVal: 4.25 ± 0.096
0.84GluTrp: 0.84 ± 0.04
1.265GluTyr: 1.265 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.664PheAla: 3.664 ± 0.086
0.256PheCys: 0.256 ± 0.022
2.156PheAsp: 2.156 ± 0.071
1.557PheGlu: 1.557 ± 0.054
1.072PhePhe: 1.072 ± 0.049
2.919PheGly: 2.919 ± 0.08
0.619PheHis: 0.619 ± 0.034
1.159PheIle: 1.159 ± 0.05
0.719PheLys: 0.719 ± 0.035
2.619PheLeu: 2.619 ± 0.082
0.611PheMet: 0.611 ± 0.039
0.805PheAsn: 0.805 ± 0.042
1.424PhePro: 1.424 ± 0.057
0.781PheGln: 0.781 ± 0.039
1.453PheArg: 1.453 ± 0.054
1.956PheSer: 1.956 ± 0.06
2.13PheThr: 2.13 ± 0.07
2.423PheVal: 2.423 ± 0.076
0.395PheTrp: 0.395 ± 0.029
0.703PheTyr: 0.703 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
14.356GlyAla: 14.356 ± 0.224
0.728GlyCys: 0.728 ± 0.04
5.024GlyAsp: 5.024 ± 0.102
4.987GlyGlu: 4.987 ± 0.105
2.956GlyPhe: 2.956 ± 0.08
8.957GlyGly: 8.957 ± 0.175
1.816GlyHis: 1.816 ± 0.064
4.129GlyIle: 4.129 ± 0.094
2.454GlyLys: 2.454 ± 0.086
8.477GlyLeu: 8.477 ± 0.145
2.244GlyMet: 2.244 ± 0.069
1.772GlyAsn: 1.772 ± 0.071
4.59GlyPro: 4.59 ± 0.116
3.234GlyGln: 3.234 ± 0.102
6.819GlyArg: 6.819 ± 0.129
5.747GlySer: 5.747 ± 0.114
5.708GlyThr: 5.708 ± 0.125
7.941GlyVal: 7.941 ± 0.128
1.715GlyTrp: 1.715 ± 0.077
2.242GlyTyr: 2.242 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
2.09HisAla: 2.09 ± 0.064
0.209HisCys: 0.209 ± 0.02
1.175HisAsp: 1.175 ± 0.047
1.063HisGlu: 1.063 ± 0.043
0.496HisPhe: 0.496 ± 0.026
1.77HisGly: 1.77 ± 0.062
0.478HisHis: 0.478 ± 0.033
0.792HisIle: 0.792 ± 0.041
0.324HisLys: 0.324 ± 0.025
1.687HisLeu: 1.687 ± 0.057
0.434HisMet: 0.434 ± 0.026
0.425HisAsn: 0.425 ± 0.028
1.398HisPro: 1.398 ± 0.053
0.613HisGln: 0.613 ± 0.034
1.481HisArg: 1.481 ± 0.055
1.148HisSer: 1.148 ± 0.041
0.955HisThr: 0.955 ± 0.043
1.654HisVal: 1.654 ± 0.063
0.361HisTrp: 0.361 ± 0.028
0.509HisTyr: 0.509 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.977IleAla: 5.977 ± 0.118
0.315IleCys: 0.315 ± 0.027
3.488IleAsp: 3.488 ± 0.091
2.551IleGlu: 2.551 ± 0.077
0.833IlePhe: 0.833 ± 0.043
4.442IleGly: 4.442 ± 0.108
0.822IleHis: 0.822 ± 0.037
1.728IleIle: 1.728 ± 0.058
0.893IleLys: 0.893 ± 0.042
3.073IleLeu: 3.073 ± 0.083
0.805IleMet: 0.805 ± 0.037
1.03IleAsn: 1.03 ± 0.044
2.257IlePro: 2.257 ± 0.066
0.93IleGln: 0.93 ± 0.044
2.593IleArg: 2.593 ± 0.069
2.041IleSer: 2.041 ± 0.058
2.74IleThr: 2.74 ± 0.073
3.648IleVal: 3.648 ± 0.081
0.393IleTrp: 0.393 ± 0.025
0.663IleTyr: 0.663 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
2.84LysAla: 2.84 ± 0.086
0.156LysCys: 0.156 ± 0.016
1.462LysAsp: 1.462 ± 0.058
1.406LysGlu: 1.406 ± 0.058
0.48LysPhe: 0.48 ± 0.036
2.165LysGly: 2.165 ± 0.071
0.434LysHis: 0.434 ± 0.029
0.919LysIle: 0.919 ± 0.043
0.955LysLys: 0.955 ± 0.059
1.554LysLeu: 1.554 ± 0.06
0.49LysMet: 0.49 ± 0.039
0.681LysAsn: 0.681 ± 0.038
1.245LysPro: 1.245 ± 0.062
0.71LysGln: 0.71 ± 0.038
1.883LysArg: 1.883 ± 0.058
1.318LysSer: 1.318 ± 0.053
1.276LysThr: 1.276 ± 0.051
1.719LysVal: 1.719 ± 0.073
0.414LysTrp: 0.414 ± 0.028
0.511LysTyr: 0.511 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
13.329LeuAla: 13.329 ± 0.187
0.675LeuCys: 0.675 ± 0.037
5.732LeuAsp: 5.732 ± 0.104
4.929LeuGlu: 4.929 ± 0.109
2.668LeuPhe: 2.668 ± 0.084
8.659LeuGly: 8.659 ± 0.159
1.587LeuHis: 1.587 ± 0.055
3.785LeuIle: 3.785 ± 0.081
1.856LeuLys: 1.856 ± 0.071
8.305LeuLeu: 8.305 ± 0.162
1.933LeuMet: 1.933 ± 0.06
1.72LeuAsn: 1.72 ± 0.056
5.079LeuPro: 5.079 ± 0.096
1.925LeuGln: 1.925 ± 0.058
6.832LeuArg: 6.832 ± 0.131
5.666LeuSer: 5.666 ± 0.097
5.599LeuThr: 5.599 ± 0.105
9.312LeuVal: 9.312 ± 0.155
1.14LeuTrp: 1.14 ± 0.047
1.669LeuTyr: 1.669 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
2.872MetAla: 2.872 ± 0.081
0.172MetCys: 0.172 ± 0.018
1.23MetAsp: 1.23 ± 0.051
1.094MetGlu: 1.094 ± 0.043
0.54MetPhe: 0.54 ± 0.036
2.066MetGly: 2.066 ± 0.063
0.322MetHis: 0.322 ± 0.026
0.869MetIle: 0.869 ± 0.037
0.478MetLys: 0.478 ± 0.034
1.746MetLeu: 1.746 ± 0.053
0.481MetMet: 0.481 ± 0.032
0.591MetAsn: 0.591 ± 0.034
1.235MetPro: 1.235 ± 0.05
0.426MetGln: 0.426 ± 0.026
1.896MetArg: 1.896 ± 0.055
1.713MetSer: 1.713 ± 0.059
1.587MetThr: 1.587 ± 0.058
1.77MetVal: 1.77 ± 0.055
0.28MetTrp: 0.28 ± 0.022
0.379MetTyr: 0.379 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.679AsnAla: 2.679 ± 0.081
0.163AsnCys: 0.163 ± 0.019
1.107AsnAsp: 1.107 ± 0.051
1.067AsnGlu: 1.067 ± 0.047
0.571AsnPhe: 0.571 ± 0.033
2.211AsnGly: 2.211 ± 0.078
0.39AsnHis: 0.39 ± 0.028
0.873AsnIle: 0.873 ± 0.036
0.481AsnLys: 0.481 ± 0.031
1.814AsnLeu: 1.814 ± 0.057
0.399AsnMet: 0.399 ± 0.026
0.527AsnAsn: 0.527 ± 0.036
1.649AsnPro: 1.649 ± 0.057
0.661AsnGln: 0.661 ± 0.038
1.277AsnArg: 1.277 ± 0.049
1.124AsnSer: 1.124 ± 0.049
1.314AsnThr: 1.314 ± 0.058
1.59AsnVal: 1.59 ± 0.052
0.353AsnTrp: 0.353 ± 0.025
0.529AsnTyr: 0.529 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
7.264ProAla: 7.264 ± 0.128
0.322ProCys: 0.322 ± 0.028
3.885ProAsp: 3.885 ± 0.091
3.318ProGlu: 3.318 ± 0.091
1.493ProPhe: 1.493 ± 0.055
6.104ProGly: 6.104 ± 0.132
1.076ProHis: 1.076 ± 0.049
1.859ProIle: 1.859 ± 0.062
1.23ProLys: 1.23 ± 0.052
4.799ProLeu: 4.799 ± 0.1
1.052ProMet: 1.052 ± 0.043
1.052ProAsn: 1.052 ± 0.051
2.506ProPro: 2.506 ± 0.09
1.847ProGln: 1.847 ± 0.077
3.644ProArg: 3.644 ± 0.095
3.767ProSer: 3.767 ± 0.099
3.375ProThr: 3.375 ± 0.092
4.894ProVal: 4.894 ± 0.091
0.902ProTrp: 0.902 ± 0.044
1.208ProTyr: 1.208 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.62GlnAla: 3.62 ± 0.104
0.231GlnCys: 0.231 ± 0.021
1.578GlnAsp: 1.578 ± 0.058
1.479GlnGlu: 1.479 ± 0.052
0.818GlnPhe: 0.818 ± 0.038
2.784GlnGly: 2.784 ± 0.079
0.474GlnHis: 0.474 ± 0.032
1.561GlnIle: 1.561 ± 0.05
0.652GlnLys: 0.652 ± 0.04
2.656GlnLeu: 2.656 ± 0.068
0.91GlnMet: 0.91 ± 0.041
0.646GlnAsn: 0.646 ± 0.036
1.363GlnPro: 1.363 ± 0.064
1.138GlnGln: 1.138 ± 0.076
2.229GlnArg: 2.229 ± 0.063
1.801GlnSer: 1.801 ± 0.065
1.471GlnThr: 1.471 ± 0.06
2.676GlnVal: 2.676 ± 0.065
0.75GlnTrp: 0.75 ± 0.042
0.738GlnTyr: 0.738 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
10.06ArgAla: 10.06 ± 0.187
0.577ArgCys: 0.577 ± 0.037
3.629ArgAsp: 3.629 ± 0.081
4.041ArgGlu: 4.041 ± 0.093
2.24ArgPhe: 2.24 ± 0.07
5.802ArgGly: 5.802 ± 0.123
1.316ArgHis: 1.316 ± 0.054
3.6ArgIle: 3.6 ± 0.088
1.614ArgLys: 1.614 ± 0.06
6.81ArgLeu: 6.81 ± 0.143
1.867ArgMet: 1.867 ± 0.061
1.34ArgAsn: 1.34 ± 0.052
3.871ArgPro: 3.871 ± 0.102
2.107ArgGln: 2.107 ± 0.061
6.369ArgArg: 6.369 ± 0.143
4.339ArgSer: 4.339 ± 0.089
4.155ArgThr: 4.155 ± 0.092
6.032ArgVal: 6.032 ± 0.122
1.122ArgTrp: 1.122 ± 0.053
1.528ArgTyr: 1.528 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
8.166SerAla: 8.166 ± 0.16
0.476SerCys: 0.476 ± 0.036
3.419SerAsp: 3.419 ± 0.092
2.853SerGlu: 2.853 ± 0.07
2.059SerPhe: 2.059 ± 0.065
6.636SerGly: 6.636 ± 0.143
1.151SerHis: 1.151 ± 0.048
2.419SerIle: 2.419 ± 0.07
1.385SerLys: 1.385 ± 0.051
5.628SerLeu: 5.628 ± 0.103
1.351SerMet: 1.351 ± 0.056
1.296SerAsn: 1.296 ± 0.058
3.437SerPro: 3.437 ± 0.09
1.837SerGln: 1.837 ± 0.063
3.9SerArg: 3.9 ± 0.09
3.95SerSer: 3.95 ± 0.106
3.551SerThr: 3.551 ± 0.097
4.91SerVal: 4.91 ± 0.112
0.968SerTrp: 0.968 ± 0.042
1.393SerTyr: 1.393 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
7.163ThrAla: 7.163 ± 0.151
0.414ThrCys: 0.414 ± 0.029
3.217ThrAsp: 3.217 ± 0.079
2.506ThrGlu: 2.506 ± 0.072
1.471ThrPhe: 1.471 ± 0.053
6.01ThrGly: 6.01 ± 0.125
1.142ThrHis: 1.142 ± 0.045
2.696ThrIle: 2.696 ± 0.081
1.257ThrLys: 1.257 ± 0.052
4.777ThrLeu: 4.777 ± 0.098
1.217ThrMet: 1.217 ± 0.047
1.283ThrAsn: 1.283 ± 0.054
3.503ThrPro: 3.503 ± 0.104
1.532ThrGln: 1.532 ± 0.047
3.739ThrArg: 3.739 ± 0.086
3.073ThrSer: 3.073 ± 0.084
3.818ThrThr: 3.818 ± 0.096
5.211ThrVal: 5.211 ± 0.117
0.975ThrTrp: 0.975 ± 0.045
1.294ThrTyr: 1.294 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
10.58ValAla: 10.58 ± 0.152
0.877ValCys: 0.877 ± 0.043
5.545ValAsp: 5.545 ± 0.121
5.073ValGlu: 5.073 ± 0.105
2.954ValPhe: 2.954 ± 0.082
7.659ValGly: 7.659 ± 0.133
1.548ValHis: 1.548 ± 0.058
3.624ValIle: 3.624 ± 0.084
1.916ValLys: 1.916 ± 0.07
8.86ValLeu: 8.86 ± 0.153
1.667ValMet: 1.667 ± 0.055
1.773ValAsn: 1.773 ± 0.062
4.833ValPro: 4.833 ± 0.103
1.832ValGln: 1.832 ± 0.052
6.078ValArg: 6.078 ± 0.114
5.39ValSer: 5.39 ± 0.114
4.301ValThr: 4.301 ± 0.103
9.204ValVal: 9.204 ± 0.158
1.146ValTrp: 1.146 ± 0.052
1.675ValTyr: 1.675 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.847TrpAla: 1.847 ± 0.061
0.172TrpCys: 0.172 ± 0.019
0.948TrpAsp: 0.948 ± 0.04
0.864TrpGlu: 0.864 ± 0.038
0.511TrpPhe: 0.511 ± 0.035
1.23TrpGly: 1.23 ± 0.052
0.269TrpHis: 0.269 ± 0.023
0.631TrpIle: 0.631 ± 0.034
0.454TrpLys: 0.454 ± 0.036
1.567TrpLeu: 1.567 ± 0.065
0.377TrpMet: 0.377 ± 0.023
0.443TrpAsn: 0.443 ± 0.029
0.591TrpPro: 0.591 ± 0.034
0.518TrpGln: 0.518 ± 0.027
1.21TrpArg: 1.21 ± 0.051
1.008TrpSer: 1.008 ± 0.045
0.935TrpThr: 0.935 ± 0.048
1.276TrpVal: 1.276 ± 0.057
0.441TrpTrp: 0.441 ± 0.033
0.441TrpTyr: 0.441 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.573TyrAla: 2.573 ± 0.063
0.212TyrCys: 0.212 ± 0.021
1.277TyrAsp: 1.277 ± 0.058
1.296TyrGlu: 1.296 ± 0.051
0.776TyrPhe: 0.776 ± 0.037
2.063TyrGly: 2.063 ± 0.084
0.428TyrHis: 0.428 ± 0.028
0.728TyrIle: 0.728 ± 0.035
0.432TyrLys: 0.432 ± 0.033
2.011TyrLeu: 2.011 ± 0.06
0.459TyrMet: 0.459 ± 0.033
0.472TyrAsn: 0.472 ± 0.032
1.149TyrPro: 1.149 ± 0.051
0.699TyrGln: 0.699 ± 0.042
1.579TyrArg: 1.579 ± 0.057
1.453TyrSer: 1.453 ± 0.049
1.358TyrThr: 1.358 ± 0.058
1.704TyrVal: 1.704 ± 0.052
0.386TyrTrp: 0.386 ± 0.031
0.719TyrTyr: 0.719 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1597 proteins (546396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski