Amino acid dipepetide frequency for Macaca fuscata rhadinovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.498AlaAla: 7.498 ± 0.508
2.322AlaCys: 2.322 ± 0.275
3.03AlaAsp: 3.03 ± 0.239
3.34AlaGlu: 3.34 ± 0.334
3.207AlaPhe: 3.207 ± 0.249
4.733AlaGly: 4.733 ± 0.399
2.079AlaHis: 2.079 ± 0.241
3.472AlaIle: 3.472 ± 0.313
2.698AlaLys: 2.698 ± 0.298
6.901AlaLeu: 6.901 ± 0.425
1.814AlaMet: 1.814 ± 0.211
2.698AlaAsn: 2.698 ± 0.272
5.64AlaPro: 5.64 ± 0.4
2.411AlaGln: 2.411 ± 0.218
5.264AlaArg: 5.264 ± 0.441
5.861AlaSer: 5.861 ± 0.447
5.574AlaThr: 5.574 ± 0.43
5.64AlaVal: 5.64 ± 0.367
1.261AlaTrp: 1.261 ± 0.186
2.168AlaTyr: 2.168 ± 0.208
0.0AlaXaa: 0.0 ± 0.0
Cys
1.659CysAla: 1.659 ± 0.2
0.796CysCys: 0.796 ± 0.119
1.128CysAsp: 1.128 ± 0.173
1.283CysGlu: 1.283 ± 0.184
1.283CysPhe: 1.283 ± 0.165
1.57CysGly: 1.57 ± 0.202
0.575CysHis: 0.575 ± 0.105
1.172CysIle: 1.172 ± 0.157
0.907CysLys: 0.907 ± 0.133
3.074CysLeu: 3.074 ± 0.245
0.686CysMet: 0.686 ± 0.125
1.04CysAsn: 1.04 ± 0.131
1.659CysPro: 1.659 ± 0.231
1.128CysGln: 1.128 ± 0.147
1.836CysArg: 1.836 ± 0.191
1.725CysSer: 1.725 ± 0.248
1.128CysThr: 1.128 ± 0.16
2.256CysVal: 2.256 ± 0.216
0.31CysTrp: 0.31 ± 0.076
0.575CysTyr: 0.575 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
3.915AspAla: 3.915 ± 0.305
0.951AspCys: 0.951 ± 0.146
3.03AspAsp: 3.03 ± 0.364
2.367AspGlu: 2.367 ± 0.252
1.946AspPhe: 1.946 ± 0.234
2.698AspGly: 2.698 ± 0.24
1.062AspHis: 1.062 ± 0.145
2.367AspIle: 2.367 ± 0.219
1.592AspLys: 1.592 ± 0.218
4.18AspLeu: 4.18 ± 0.37
1.084AspMet: 1.084 ± 0.162
1.88AspAsn: 1.88 ± 0.205
2.676AspPro: 2.676 ± 0.25
1.283AspGln: 1.283 ± 0.127
2.743AspArg: 2.743 ± 0.284
2.809AspSer: 2.809 ± 0.315
2.698AspThr: 2.698 ± 0.253
3.384AspVal: 3.384 ± 0.248
0.73AspTrp: 0.73 ± 0.128
1.128AspTyr: 1.128 ± 0.179
0.0AspXaa: 0.0 ± 0.0
Glu
3.406GluAla: 3.406 ± 0.302
1.239GluCys: 1.239 ± 0.182
1.991GluAsp: 1.991 ± 0.27
2.256GluGlu: 2.256 ± 0.256
1.393GluPhe: 1.393 ± 0.171
2.566GluGly: 2.566 ± 0.197
1.526GluHis: 1.526 ± 0.188
2.521GluIle: 2.521 ± 0.234
1.924GluLys: 1.924 ± 0.195
4.224GluLeu: 4.224 ± 0.279
1.349GluMet: 1.349 ± 0.166
2.256GluAsn: 2.256 ± 0.228
2.278GluPro: 2.278 ± 0.233
1.924GluGln: 1.924 ± 0.23
2.566GluArg: 2.566 ± 0.232
3.362GluSer: 3.362 ± 0.269
3.583GluThr: 3.583 ± 0.342
2.72GluVal: 2.72 ± 0.264
0.42GluTrp: 0.42 ± 0.098
1.482GluTyr: 1.482 ± 0.187
0.0GluXaa: 0.0 ± 0.0
Phe
2.212PheAla: 2.212 ± 0.218
1.106PheCys: 1.106 ± 0.168
1.725PheAsp: 1.725 ± 0.213
1.725PheGlu: 1.725 ± 0.191
2.566PhePhe: 2.566 ± 0.263
2.521PheGly: 2.521 ± 0.22
0.951PheHis: 0.951 ± 0.16
2.521PheIle: 2.521 ± 0.248
2.588PheLys: 2.588 ± 0.279
5.242PheLeu: 5.242 ± 0.32
1.15PheMet: 1.15 ± 0.165
1.703PheAsn: 1.703 ± 0.159
2.72PhePro: 2.72 ± 0.245
1.592PheGln: 1.592 ± 0.176
2.278PheArg: 2.278 ± 0.249
3.251PheSer: 3.251 ± 0.318
2.521PheThr: 2.521 ± 0.227
3.008PheVal: 3.008 ± 0.264
0.796PheTrp: 0.796 ± 0.147
1.836PheTyr: 1.836 ± 0.192
0.0PheXaa: 0.0 ± 0.0
Gly
5.574GlyAla: 5.574 ± 0.408
1.305GlyCys: 1.305 ± 0.215
3.163GlyAsp: 3.163 ± 0.325
2.499GlyGlu: 2.499 ± 0.235
2.92GlyPhe: 2.92 ± 0.227
5.264GlyGly: 5.264 ± 0.557
1.592GlyHis: 1.592 ± 0.203
2.765GlyIle: 2.765 ± 0.27
2.035GlyLys: 2.035 ± 0.224
6.259GlyLeu: 6.259 ± 0.423
1.017GlyMet: 1.017 ± 0.157
2.433GlyAsn: 2.433 ± 0.289
4.092GlyPro: 4.092 ± 0.352
2.322GlyGln: 2.322 ± 0.247
4.976GlyArg: 4.976 ± 0.449
5.176GlySer: 5.176 ± 0.418
4.468GlyThr: 4.468 ± 0.335
5.131GlyVal: 5.131 ± 0.414
0.885GlyTrp: 0.885 ± 0.174
1.327GlyTyr: 1.327 ± 0.166
0.0GlyXaa: 0.0 ± 0.0
His
2.123HisAla: 2.123 ± 0.196
0.664HisCys: 0.664 ± 0.126
1.062HisAsp: 1.062 ± 0.163
1.57HisGlu: 1.57 ± 0.197
1.04HisPhe: 1.04 ± 0.123
2.367HisGly: 2.367 ± 0.215
0.929HisHis: 0.929 ± 0.132
1.106HisIle: 1.106 ± 0.157
1.194HisLys: 1.194 ± 0.16
2.809HisLeu: 2.809 ± 0.274
0.509HisMet: 0.509 ± 0.124
0.973HisAsn: 0.973 ± 0.151
1.924HisPro: 1.924 ± 0.279
0.885HisGln: 0.885 ± 0.124
2.035HisArg: 2.035 ± 0.192
1.482HisSer: 1.482 ± 0.164
1.504HisThr: 1.504 ± 0.224
2.544HisVal: 2.544 ± 0.249
0.31HisTrp: 0.31 ± 0.074
0.73HisTyr: 0.73 ± 0.122
0.022HisXaa: 0.022 ± 0.023
Ile
3.362IleAla: 3.362 ± 0.307
1.57IleCys: 1.57 ± 0.182
1.769IleAsp: 1.769 ± 0.22
1.902IleGlu: 1.902 ± 0.243
2.212IlePhe: 2.212 ± 0.203
2.411IleGly: 2.411 ± 0.209
0.995IleHis: 0.995 ± 0.149
2.389IleIle: 2.389 ± 0.23
2.035IleLys: 2.035 ± 0.222
5.087IleLeu: 5.087 ± 0.349
1.327IleMet: 1.327 ± 0.178
2.654IleAsn: 2.654 ± 0.346
2.544IlePro: 2.544 ± 0.288
1.836IleGln: 1.836 ± 0.213
3.03IleArg: 3.03 ± 0.285
4.003IleSer: 4.003 ± 0.373
3.096IleThr: 3.096 ± 0.297
3.251IleVal: 3.251 ± 0.316
0.354IleTrp: 0.354 ± 0.081
1.526IleTyr: 1.526 ± 0.224
0.0IleXaa: 0.0 ± 0.0
Lys
2.079LysAla: 2.079 ± 0.221
0.664LysCys: 0.664 ± 0.157
1.747LysAsp: 1.747 ± 0.239
1.526LysGlu: 1.526 ± 0.173
1.482LysPhe: 1.482 ± 0.146
1.924LysGly: 1.924 ± 0.2
1.548LysHis: 1.548 ± 0.199
2.698LysIle: 2.698 ± 0.322
2.123LysLys: 2.123 ± 0.312
4.136LysLeu: 4.136 ± 0.347
1.062LysMet: 1.062 ± 0.14
2.035LysAsn: 2.035 ± 0.217
2.035LysPro: 2.035 ± 0.243
1.902LysGln: 1.902 ± 0.212
2.499LysArg: 2.499 ± 0.254
2.499LysSer: 2.499 ± 0.231
3.406LysThr: 3.406 ± 0.263
1.946LysVal: 1.946 ± 0.195
0.265LysTrp: 0.265 ± 0.07
0.885LysTyr: 0.885 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
7.232LeuAla: 7.232 ± 0.367
2.61LeuCys: 2.61 ± 0.25
3.826LeuAsp: 3.826 ± 0.332
4.866LeuGlu: 4.866 ± 0.352
4.976LeuPhe: 4.976 ± 0.404
6.326LeuGly: 6.326 ± 0.412
2.743LeuHis: 2.743 ± 0.267
3.649LeuIle: 3.649 ± 0.292
4.357LeuLys: 4.357 ± 0.405
8.25LeuLeu: 8.25 ± 0.485
1.88LeuMet: 1.88 ± 0.209
4.822LeuAsn: 4.822 ± 0.294
6.215LeuPro: 6.215 ± 0.366
3.296LeuGln: 3.296 ± 0.278
6.657LeuArg: 6.657 ± 0.426
7.984LeuSer: 7.984 ± 0.392
6.591LeuThr: 6.591 ± 0.349
6.038LeuVal: 6.038 ± 0.426
1.239LeuTrp: 1.239 ± 0.159
3.119LeuTyr: 3.119 ± 0.248
0.0LeuXaa: 0.0 ± 0.0
Met
2.013MetAla: 2.013 ± 0.189
0.398MetCys: 0.398 ± 0.074
1.194MetAsp: 1.194 ± 0.14
1.062MetGlu: 1.062 ± 0.156
1.416MetPhe: 1.416 ± 0.195
1.393MetGly: 1.393 ± 0.162
0.553MetHis: 0.553 ± 0.131
0.995MetIle: 0.995 ± 0.144
0.686MetLys: 0.686 ± 0.13
2.256MetLeu: 2.256 ± 0.217
0.42MetMet: 0.42 ± 0.097
0.619MetAsn: 0.619 ± 0.122
0.951MetPro: 0.951 ± 0.134
0.641MetGln: 0.641 ± 0.117
1.46MetArg: 1.46 ± 0.203
1.858MetSer: 1.858 ± 0.203
1.349MetThr: 1.349 ± 0.156
1.57MetVal: 1.57 ± 0.175
0.398MetTrp: 0.398 ± 0.091
0.796MetTyr: 0.796 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
3.273AsnAla: 3.273 ± 0.241
0.708AsnCys: 0.708 ± 0.14
1.615AsnAsp: 1.615 ± 0.174
1.615AsnGlu: 1.615 ± 0.211
1.637AsnPhe: 1.637 ± 0.208
2.743AsnGly: 2.743 ± 0.249
1.128AsnHis: 1.128 ± 0.159
2.743AsnIle: 2.743 ± 0.247
1.57AsnLys: 1.57 ± 0.16
3.848AsnLeu: 3.848 ± 0.263
0.796AsnMet: 0.796 ± 0.131
1.814AsnAsn: 1.814 ± 0.232
2.367AsnPro: 2.367 ± 0.202
1.371AsnGln: 1.371 ± 0.21
2.234AsnArg: 2.234 ± 0.226
3.163AsnSer: 3.163 ± 0.247
2.809AsnThr: 2.809 ± 0.227
3.362AsnVal: 3.362 ± 0.315
0.509AsnTrp: 0.509 ± 0.112
1.371AsnTyr: 1.371 ± 0.176
0.0AsnXaa: 0.0 ± 0.0
Pro
4.534ProAla: 4.534 ± 0.334
1.416ProCys: 1.416 ± 0.202
2.809ProAsp: 2.809 ± 0.226
3.119ProGlu: 3.119 ± 0.258
2.433ProPhe: 2.433 ± 0.199
5.375ProGly: 5.375 ± 0.435
2.19ProHis: 2.19 ± 0.213
2.787ProIle: 2.787 ± 0.233
2.234ProLys: 2.234 ± 0.202
5.308ProLeu: 5.308 ± 0.343
1.084ProMet: 1.084 ± 0.185
1.902ProAsn: 1.902 ± 0.227
5.662ProPro: 5.662 ± 0.613
2.101ProGln: 2.101 ± 0.234
4.976ProArg: 4.976 ± 0.43
4.777ProSer: 4.777 ± 0.411
4.224ProThr: 4.224 ± 0.309
4.822ProVal: 4.822 ± 0.272
1.305ProTrp: 1.305 ± 0.189
1.327ProTyr: 1.327 ± 0.188
0.0ProXaa: 0.0 ± 0.0
Gln
2.676GlnAla: 2.676 ± 0.359
0.907GlnCys: 0.907 ± 0.146
1.504GlnAsp: 1.504 ± 0.216
1.371GlnGlu: 1.371 ± 0.195
1.216GlnPhe: 1.216 ± 0.23
2.168GlnGly: 2.168 ± 0.17
1.04GlnHis: 1.04 ± 0.15
1.858GlnIle: 1.858 ± 0.178
1.637GlnLys: 1.637 ± 0.191
3.296GlnLeu: 3.296 ± 0.279
0.708GlnMet: 0.708 ± 0.124
1.482GlnAsn: 1.482 ± 0.189
2.278GlnPro: 2.278 ± 0.254
1.393GlnGln: 1.393 ± 0.222
2.212GlnArg: 2.212 ± 0.262
2.477GlnSer: 2.477 ± 0.249
2.676GlnThr: 2.676 ± 0.295
2.322GlnVal: 2.322 ± 0.253
0.464GlnTrp: 0.464 ± 0.109
0.995GlnTyr: 0.995 ± 0.167
0.0GlnXaa: 0.0 ± 0.0
Arg
5.552ArgAla: 5.552 ± 0.36
1.991ArgCys: 1.991 ± 0.207
3.517ArgAsp: 3.517 ± 0.333
3.229ArgGlu: 3.229 ± 0.3
2.389ArgPhe: 2.389 ± 0.243
5.242ArgGly: 5.242 ± 0.408
2.145ArgHis: 2.145 ± 0.24
2.544ArgIle: 2.544 ± 0.249
2.3ArgLys: 2.3 ± 0.207
6.879ArgLeu: 6.879 ± 0.45
1.239ArgMet: 1.239 ± 0.205
2.212ArgAsn: 2.212 ± 0.201
4.357ArgPro: 4.357 ± 0.38
2.3ArgGln: 2.3 ± 0.213
6.127ArgArg: 6.127 ± 0.578
5.087ArgSer: 5.087 ± 0.4
3.782ArgThr: 3.782 ± 0.287
4.755ArgVal: 4.755 ± 0.364
1.239ArgTrp: 1.239 ± 0.145
1.526ArgTyr: 1.526 ± 0.211
0.0ArgXaa: 0.0 ± 0.0
Ser
6.259SerAla: 6.259 ± 0.38
1.924SerCys: 1.924 ± 0.231
3.517SerAsp: 3.517 ± 0.311
3.384SerGlu: 3.384 ± 0.261
3.141SerPhe: 3.141 ± 0.28
5.507SerGly: 5.507 ± 0.472
2.123SerHis: 2.123 ± 0.274
3.627SerIle: 3.627 ± 0.269
2.566SerLys: 2.566 ± 0.297
7.564SerLeu: 7.564 ± 0.461
1.924SerMet: 1.924 ± 0.216
2.72SerAsn: 2.72 ± 0.236
5.087SerPro: 5.087 ± 0.519
2.521SerGln: 2.521 ± 0.268
5.463SerArg: 5.463 ± 0.402
7.033SerSer: 7.033 ± 0.624
4.401SerThr: 4.401 ± 0.301
5.397SerVal: 5.397 ± 0.376
1.04SerTrp: 1.04 ± 0.163
1.681SerTyr: 1.681 ± 0.186
0.0SerXaa: 0.0 ± 0.0
Thr
5.021ThrAla: 5.021 ± 0.379
1.637ThrCys: 1.637 ± 0.226
2.964ThrAsp: 2.964 ± 0.301
3.207ThrGlu: 3.207 ± 0.23
2.654ThrPhe: 2.654 ± 0.23
4.291ThrGly: 4.291 ± 0.344
1.858ThrHis: 1.858 ± 0.199
2.853ThrIle: 2.853 ± 0.246
1.703ThrLys: 1.703 ± 0.226
5.817ThrLeu: 5.817 ± 0.317
1.305ThrMet: 1.305 ± 0.186
2.278ThrAsn: 2.278 ± 0.222
4.976ThrPro: 4.976 ± 0.392
2.079ThrGln: 2.079 ± 0.197
4.357ThrArg: 4.357 ± 0.32
5.574ThrSer: 5.574 ± 0.437
4.556ThrThr: 4.556 ± 0.441
5.308ThrVal: 5.308 ± 0.329
1.239ThrTrp: 1.239 ± 0.18
2.19ThrTyr: 2.19 ± 0.219
0.0ThrXaa: 0.0 ± 0.0
Val
5.618ValAla: 5.618 ± 0.338
2.101ValCys: 2.101 ± 0.272
3.273ValAsp: 3.273 ± 0.305
2.809ValGlu: 2.809 ± 0.241
4.048ValPhe: 4.048 ± 0.304
3.34ValGly: 3.34 ± 0.316
1.725ValHis: 1.725 ± 0.204
3.251ValIle: 3.251 ± 0.327
2.72ValLys: 2.72 ± 0.287
6.569ValLeu: 6.569 ± 0.411
1.57ValMet: 1.57 ± 0.155
3.273ValAsn: 3.273 ± 0.259
4.755ValPro: 4.755 ± 0.367
2.212ValGln: 2.212 ± 0.238
4.866ValArg: 4.866 ± 0.376
5.618ValSer: 5.618 ± 0.456
5.198ValThr: 5.198 ± 0.388
5.22ValVal: 5.22 ± 0.437
0.863ValTrp: 0.863 ± 0.159
2.787ValTyr: 2.787 ± 0.293
0.0ValXaa: 0.0 ± 0.0
Trp
1.172TrpAla: 1.172 ± 0.17
0.42TrpCys: 0.42 ± 0.093
0.442TrpAsp: 0.442 ± 0.106
0.597TrpGlu: 0.597 ± 0.114
0.619TrpPhe: 0.619 ± 0.142
0.84TrpGly: 0.84 ± 0.129
0.376TrpHis: 0.376 ± 0.096
0.641TrpIle: 0.641 ± 0.107
0.575TrpLys: 0.575 ± 0.105
1.681TrpLeu: 1.681 ± 0.208
0.376TrpMet: 0.376 ± 0.099
0.641TrpAsn: 0.641 ± 0.1
0.951TrpPro: 0.951 ± 0.142
0.597TrpGln: 0.597 ± 0.103
1.128TrpArg: 1.128 ± 0.187
0.907TrpSer: 0.907 ± 0.159
0.796TrpThr: 0.796 ± 0.124
0.796TrpVal: 0.796 ± 0.144
0.111TrpTrp: 0.111 ± 0.052
0.354TrpTyr: 0.354 ± 0.069
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.433TyrAla: 2.433 ± 0.225
1.062TyrCys: 1.062 ± 0.129
1.216TyrAsp: 1.216 ± 0.223
1.261TyrGlu: 1.261 ± 0.183
1.438TyrPhe: 1.438 ± 0.156
1.924TyrGly: 1.924 ± 0.21
0.641TyrHis: 0.641 ± 0.12
1.393TyrIle: 1.393 ± 0.168
1.017TyrLys: 1.017 ± 0.159
3.296TyrLeu: 3.296 ± 0.254
0.708TyrMet: 0.708 ± 0.138
1.239TyrAsn: 1.239 ± 0.182
1.216TyrPro: 1.216 ± 0.137
0.885TyrGln: 0.885 ± 0.157
1.703TyrArg: 1.703 ± 0.204
2.234TyrSer: 2.234 ± 0.219
1.504TyrThr: 1.504 ± 0.178
2.344TyrVal: 2.344 ± 0.288
0.288TyrTrp: 0.288 ± 0.095
1.017TyrTyr: 1.017 ± 0.188
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.022XaaPro: 0.022 ± 0.023
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 170 proteins (45214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski