Amino acid dipepetide frequency for Ammoniphilus oxalaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.802AlaAla: 6.802 ± 0.126	0.655AlaCys: 0.655 ± 0.025	4.118AlaAsp: 4.118 ± 0.077	5.583AlaGlu: 5.583 ± 0.086	3.233AlaPhe: 3.233 ± 0.064	5.543AlaGly: 5.543 ± 0.092	1.433AlaHis: 1.433 ± 0.036	5.78AlaIle: 5.78 ± 0.087	4.406AlaLys: 4.406 ± 0.088	8.214AlaLeu: 8.214 ± 0.102	2.213AlaMet: 2.213 ± 0.053	2.783AlaAsn: 2.783 ± 0.05	2.439AlaPro: 2.439 ± 0.056	3.262AlaGln: 3.262 ± 0.062	3.833AlaArg: 3.833 ± 0.072	4.129AlaSer: 4.129 ± 0.066	3.924AlaThr: 3.924 ± 0.068	5.643AlaVal: 5.643 ± 0.096	0.768AlaTrp: 0.768 ± 0.029	2.384AlaTyr: 2.384 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.537CysAla: 0.537 ± 0.024	0.11CysCys: 0.11 ± 0.013	0.371CysAsp: 0.371 ± 0.023	0.444CysGlu: 0.444 ± 0.021	0.367CysPhe: 0.367 ± 0.02	0.7CysGly: 0.7 ± 0.03	0.175CysHis: 0.175 ± 0.014	0.476CysIle: 0.476 ± 0.023	0.324CysLys: 0.324 ± 0.017	0.755CysLeu: 0.755 ± 0.033	0.168CysMet: 0.168 ± 0.014	0.269CysAsn: 0.269 ± 0.018	0.394CysPro: 0.394 ± 0.023	0.314CysGln: 0.314 ± 0.02	0.377CysArg: 0.377 ± 0.019	0.578CysSer: 0.578 ± 0.025	0.276CysThr: 0.276 ± 0.018	0.479CysVal: 0.479 ± 0.024	0.07CysTrp: 0.07 ± 0.009	0.269CysTyr: 0.269 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.505AspAla: 3.505 ± 0.068	0.422AspCys: 0.422 ± 0.021	2.59AspAsp: 2.59 ± 0.065	4.481AspGlu: 4.481 ± 0.078	2.264AspPhe: 2.264 ± 0.05	3.61AspGly: 3.61 ± 0.076	1.289AspHis: 1.289 ± 0.042	3.548AspIle: 3.548 ± 0.063	2.61AspLys: 2.61 ± 0.063	5.313AspLeu: 5.313 ± 0.075	1.201AspMet: 1.201 ± 0.033	1.547AspAsn: 1.547 ± 0.045	2.477AspPro: 2.477 ± 0.056	2.834AspGln: 2.834 ± 0.059	3.059AspArg: 3.059 ± 0.058	2.607AspSer: 2.607 ± 0.058	2.395AspThr: 2.395 ± 0.051	3.829AspVal: 3.829 ± 0.076	0.708AspTrp: 0.708 ± 0.031	1.954AspTyr: 1.954 ± 0.045	0.001AspXaa: 0.001 ± 0.001
Glu	5.99GluAla: 5.99 ± 0.08	0.408GluCys: 0.408 ± 0.024	3.544GluAsp: 3.544 ± 0.07	6.224GluGlu: 6.224 ± 0.101	2.238GluPhe: 2.238 ± 0.049	4.148GluGly: 4.148 ± 0.068	1.578GluHis: 1.578 ± 0.041	5.552GluIle: 5.552 ± 0.079	5.119GluLys: 5.119 ± 0.09	7.25GluLeu: 7.25 ± 0.113	2.362GluMet: 2.362 ± 0.057	2.702GluAsn: 2.702 ± 0.062	2.134GluPro: 2.134 ± 0.056	5.148GluGln: 5.148 ± 0.103	4.488GluArg: 4.488 ± 0.076	3.418GluSer: 3.418 ± 0.062	3.804GluThr: 3.804 ± 0.061	4.948GluVal: 4.948 ± 0.077	0.88GluTrp: 0.88 ± 0.029	1.959GluTyr: 1.959 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.09PheAla: 3.09 ± 0.057	0.395PheCys: 0.395 ± 0.023	2.265PheAsp: 2.265 ± 0.045	2.872PheGlu: 2.872 ± 0.053	2.078PhePhe: 2.078 ± 0.061	3.176PheGly: 3.176 ± 0.057	0.88PheHis: 0.88 ± 0.031	3.455PheIle: 3.455 ± 0.076	2.083PheLys: 2.083 ± 0.049	4.354PheLeu: 4.354 ± 0.094	1.132PheMet: 1.132 ± 0.039	1.568PheAsn: 1.568 ± 0.048	1.62PhePro: 1.62 ± 0.039	1.642PheGln: 1.642 ± 0.045	1.794PheArg: 1.794 ± 0.048	3.018PheSer: 3.018 ± 0.062	2.496PheThr: 2.496 ± 0.051	3.044PheVal: 3.044 ± 0.057	0.51PheTrp: 0.51 ± 0.027	1.537PheTyr: 1.537 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	5.339GlyAla: 5.339 ± 0.101	0.681GlyCys: 0.681 ± 0.026	3.372GlyAsp: 3.372 ± 0.066	4.515GlyGlu: 4.515 ± 0.073	3.298GlyPhe: 3.298 ± 0.076	5.141GlyGly: 5.141 ± 0.098	1.453GlyHis: 1.453 ± 0.038	5.511GlyIle: 5.511 ± 0.084	4.449GlyLys: 4.449 ± 0.064	7.099GlyLeu: 7.099 ± 0.097	2.148GlyMet: 2.148 ± 0.052	2.487GlyAsn: 2.487 ± 0.059	1.928GlyPro: 1.928 ± 0.042	2.867GlyGln: 2.867 ± 0.055	3.393GlyArg: 3.393 ± 0.053	4.075GlySer: 4.075 ± 0.069	3.587GlyThr: 3.587 ± 0.066	5.311GlyVal: 5.311 ± 0.092	0.882GlyTrp: 0.882 ± 0.034	2.595GlyTyr: 2.595 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.45HisAla: 1.45 ± 0.043	0.201HisCys: 0.201 ± 0.014	1.074HisAsp: 1.074 ± 0.03	1.258HisGlu: 1.258 ± 0.036	1.064HisPhe: 1.064 ± 0.037	1.441HisGly: 1.441 ± 0.037	0.604HisHis: 0.604 ± 0.028	1.299HisIle: 1.299 ± 0.039	0.828HisLys: 0.828 ± 0.033	2.338HisLeu: 2.338 ± 0.065	0.483HisMet: 0.483 ± 0.024	0.648HisAsn: 0.648 ± 0.027	1.188HisPro: 1.188 ± 0.039	0.986HisGln: 0.986 ± 0.031	1.147HisArg: 1.147 ± 0.042	1.124HisSer: 1.124 ± 0.041	0.983HisThr: 0.983 ± 0.035	1.419HisVal: 1.419 ± 0.041	0.236HisTrp: 0.236 ± 0.016	0.812HisTyr: 0.812 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.165IleAla: 6.165 ± 0.092	0.639IleCys: 0.639 ± 0.025	4.351IleAsp: 4.351 ± 0.081	5.902IleGlu: 5.902 ± 0.081	2.812IlePhe: 2.812 ± 0.071	5.855IleGly: 5.855 ± 0.098	1.653IleHis: 1.653 ± 0.04	4.92IleIle: 4.92 ± 0.098	3.832IleLys: 3.832 ± 0.061	6.457IleLeu: 6.457 ± 0.103	1.676IleMet: 1.676 ± 0.049	2.685IleAsn: 2.685 ± 0.057	3.277IlePro: 3.277 ± 0.058	3.066IleGln: 3.066 ± 0.055	3.647IleArg: 3.647 ± 0.062	4.579IleSer: 4.579 ± 0.07	4.016IleThr: 4.016 ± 0.072	5.495IleVal: 5.495 ± 0.088	0.645IleTrp: 0.645 ± 0.029	2.181IleTyr: 2.181 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.082LysAla: 4.082 ± 0.073	0.26LysCys: 0.26 ± 0.014	2.961LysAsp: 2.961 ± 0.063	5.23LysGlu: 5.23 ± 0.102	1.639LysPhe: 1.639 ± 0.04	3.855LysGly: 3.855 ± 0.062	0.998LysHis: 0.998 ± 0.036	3.881LysIle: 3.881 ± 0.069	4.14LysLys: 4.14 ± 0.081	5.19LysLeu: 5.19 ± 0.088	1.954LysMet: 1.954 ± 0.042	2.306LysAsn: 2.306 ± 0.055	2.001LysPro: 2.001 ± 0.043	3.316LysGln: 3.316 ± 0.068	3.625LysArg: 3.625 ± 0.066	2.754LysSer: 2.754 ± 0.064	3.017LysThr: 3.017 ± 0.064	4.181LysVal: 4.181 ± 0.073	0.753LysTrp: 0.753 ± 0.027	1.67LysTyr: 1.67 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	8.462LeuAla: 8.462 ± 0.099	0.732LeuCys: 0.732 ± 0.028	5.309LeuAsp: 5.309 ± 0.087	6.837LeuGlu: 6.837 ± 0.092	4.71LeuPhe: 4.71 ± 0.095	6.932LeuGly: 6.932 ± 0.103	1.907LeuHis: 1.907 ± 0.053	7.161LeuIle: 7.161 ± 0.109	5.81LeuLys: 5.81 ± 0.087	10.298LeuLeu: 10.298 ± 0.143	2.379LeuMet: 2.379 ± 0.053	3.849LeuAsn: 3.849 ± 0.07	4.094LeuPro: 4.094 ± 0.072	4.067LeuGln: 4.067 ± 0.079	4.853LeuArg: 4.853 ± 0.083	6.599LeuSer: 6.599 ± 0.094	5.779LeuThr: 5.779 ± 0.076	6.341LeuVal: 6.341 ± 0.085	0.883LeuTrp: 0.883 ± 0.032	2.902LeuTyr: 2.902 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	2.115MetAla: 2.115 ± 0.053	0.127MetCys: 0.127 ± 0.012	1.508MetAsp: 1.508 ± 0.041	1.969MetGlu: 1.969 ± 0.046	1.067MetPhe: 1.067 ± 0.033	1.928MetGly: 1.928 ± 0.053	0.338MetHis: 0.338 ± 0.017	2.296MetIle: 2.296 ± 0.054	2.086MetLys: 2.086 ± 0.05	2.486MetLeu: 2.486 ± 0.06	0.92MetMet: 0.92 ± 0.034	1.387MetAsn: 1.387 ± 0.039	1.0MetPro: 1.0 ± 0.033	0.975MetGln: 0.975 ± 0.031	1.448MetArg: 1.448 ± 0.039	1.821MetSer: 1.821 ± 0.041	1.553MetThr: 1.553 ± 0.04	1.687MetVal: 1.687 ± 0.048	0.21MetTrp: 0.21 ± 0.016	0.682MetTyr: 0.682 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.539AsnAla: 2.539 ± 0.055	0.251AsnCys: 0.251 ± 0.017	1.853AsnAsp: 1.853 ± 0.045	2.922AsnGlu: 2.922 ± 0.07	1.329AsnPhe: 1.329 ± 0.038	2.787AsnGly: 2.787 ± 0.066	0.881AsnHis: 0.881 ± 0.028	2.528AsnIle: 2.528 ± 0.059	2.214AsnLys: 2.214 ± 0.048	3.49AsnLeu: 3.49 ± 0.056	1.022AsnMet: 1.022 ± 0.032	1.534AsnAsn: 1.534 ± 0.042	1.939AsnPro: 1.939 ± 0.045	2.015AsnGln: 2.015 ± 0.046	2.325AsnArg: 2.325 ± 0.053	1.862AsnSer: 1.862 ± 0.05	1.79AsnThr: 1.79 ± 0.045	2.525AsnVal: 2.525 ± 0.048	0.484AsnTrp: 0.484 ± 0.026	1.261AsnTyr: 1.261 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.528ProAla: 2.528 ± 0.059	0.262ProCys: 0.262 ± 0.019	2.038ProAsp: 2.038 ± 0.051	2.723ProGlu: 2.723 ± 0.068	2.007ProPhe: 2.007 ± 0.05	2.433ProGly: 2.433 ± 0.059	0.912ProHis: 0.912 ± 0.035	3.105ProIle: 3.105 ± 0.053	1.915ProLys: 1.915 ± 0.05	4.006ProLeu: 4.006 ± 0.062	0.916ProMet: 0.916 ± 0.033	1.621ProAsn: 1.621 ± 0.042	1.336ProPro: 1.336 ± 0.045	1.556ProGln: 1.556 ± 0.041	1.57ProArg: 1.57 ± 0.048	2.27ProSer: 2.27 ± 0.055	2.357ProThr: 2.357 ± 0.052	2.547ProVal: 2.547 ± 0.057	0.337ProTrp: 0.337 ± 0.022	1.341ProTyr: 1.341 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	4.143GlnAla: 4.143 ± 0.074	0.219GlnCys: 0.219 ± 0.017	1.87GlnAsp: 1.87 ± 0.049	3.11GlnGlu: 3.11 ± 0.067	1.795GlnPhe: 1.795 ± 0.044	2.785GlnGly: 2.785 ± 0.057	0.947GlnHis: 0.947 ± 0.032	3.212GlnIle: 3.212 ± 0.058	2.469GlnLys: 2.469 ± 0.053	5.135GlnLeu: 5.135 ± 0.1	1.338GlnMet: 1.338 ± 0.037	1.488GlnAsn: 1.488 ± 0.046	1.627GlnPro: 1.627 ± 0.045	2.892GlnGln: 2.892 ± 0.065	2.465GlnArg: 2.465 ± 0.059	2.369GlnSer: 2.369 ± 0.062	2.655GlnThr: 2.655 ± 0.057	3.061GlnVal: 3.061 ± 0.066	0.547GlnTrp: 0.547 ± 0.025	1.281GlnTyr: 1.281 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.586ArgAla: 3.586 ± 0.073	0.338ArgCys: 0.338 ± 0.02	2.655ArgAsp: 2.655 ± 0.058	4.055ArgGlu: 4.055 ± 0.062	2.386ArgPhe: 2.386 ± 0.05	3.209ArgGly: 3.209 ± 0.059	1.012ArgHis: 1.012 ± 0.034	3.723ArgIle: 3.723 ± 0.065	3.283ArgLys: 3.283 ± 0.06	5.332ArgLeu: 5.332 ± 0.079	1.63ArgMet: 1.63 ± 0.037	2.001ArgAsn: 2.001 ± 0.047	1.752ArgPro: 1.752 ± 0.046	2.432ArgGln: 2.432 ± 0.053	2.92ArgArg: 2.92 ± 0.073	2.878ArgSer: 2.878 ± 0.06	2.34ArgThr: 2.34 ± 0.054	3.447ArgVal: 3.447 ± 0.074	0.667ArgTrp: 0.667 ± 0.028	1.917ArgTyr: 1.917 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.16SerAla: 4.16 ± 0.079	0.404SerCys: 0.404 ± 0.024	2.891SerAsp: 2.891 ± 0.061	3.865SerGlu: 3.865 ± 0.073	3.152SerPhe: 3.152 ± 0.059	4.408SerGly: 4.408 ± 0.069	1.175SerHis: 1.175 ± 0.033	4.711SerIle: 4.711 ± 0.077	3.241SerLys: 3.241 ± 0.066	5.947SerLeu: 5.947 ± 0.084	1.662SerMet: 1.662 ± 0.05	2.162SerAsn: 2.162 ± 0.053	2.122SerPro: 2.122 ± 0.049	2.051SerGln: 2.051 ± 0.051	2.745SerArg: 2.745 ± 0.05	3.674SerSer: 3.674 ± 0.078	2.692SerThr: 2.692 ± 0.054	4.074SerVal: 4.074 ± 0.07	0.631SerTrp: 0.631 ± 0.026	1.92SerTyr: 1.92 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.155ThrAla: 4.155 ± 0.077	0.383ThrCys: 0.383 ± 0.022	2.819ThrAsp: 2.819 ± 0.064	3.538ThrGlu: 3.538 ± 0.064	2.465ThrPhe: 2.465 ± 0.059	4.16ThrGly: 4.16 ± 0.069	1.118ThrHis: 1.118 ± 0.033	4.219ThrIle: 4.219 ± 0.066	2.732ThrLys: 2.732 ± 0.059	5.393ThrLeu: 5.393 ± 0.076	1.407ThrMet: 1.407 ± 0.042	1.983ThrAsn: 1.983 ± 0.044	2.381ThrPro: 2.381 ± 0.056	1.671ThrGln: 1.671 ± 0.043	2.386ThrArg: 2.386 ± 0.053	2.921ThrSer: 2.921 ± 0.058	2.995ThrThr: 2.995 ± 0.055	4.088ThrVal: 4.088 ± 0.07	0.571ThrTrp: 0.571 ± 0.026	1.734ThrTyr: 1.734 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.538ValAla: 5.538 ± 0.085	0.618ValCys: 0.618 ± 0.027	4.217ValAsp: 4.217 ± 0.07	5.273ValGlu: 5.273 ± 0.075	3.021ValPhe: 3.021 ± 0.063	4.998ValGly: 4.998 ± 0.075	1.273ValHis: 1.273 ± 0.036	5.496ValIle: 5.496 ± 0.081	4.07ValLys: 4.07 ± 0.071	6.139ValLeu: 6.139 ± 0.083	1.889ValMet: 1.889 ± 0.045	2.844ValAsn: 2.844 ± 0.055	2.412ValPro: 2.412 ± 0.047	2.356ValGln: 2.356 ± 0.059	3.03ValArg: 3.03 ± 0.073	4.621ValSer: 4.621 ± 0.072	4.198ValThr: 4.198 ± 0.073	5.204ValVal: 5.204 ± 0.086	0.673ValTrp: 0.673 ± 0.027	2.305ValTyr: 2.305 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.028	0.069TrpCys: 0.069 ± 0.008	0.632TrpAsp: 0.632 ± 0.028	0.699TrpGlu: 0.699 ± 0.026	0.509TrpPhe: 0.509 ± 0.024	0.758TrpGly: 0.758 ± 0.029	0.188TrpHis: 0.188 ± 0.013	0.9TrpIle: 0.9 ± 0.035	0.713TrpLys: 0.713 ± 0.028	1.325TrpLeu: 1.325 ± 0.047	0.361TrpMet: 0.361 ± 0.02	0.502TrpAsn: 0.502 ± 0.024	0.265TrpPro: 0.265 ± 0.017	0.419TrpGln: 0.419 ± 0.024	0.542TrpArg: 0.542 ± 0.025	0.581TrpSer: 0.581 ± 0.028	0.598TrpThr: 0.598 ± 0.025	0.74TrpVal: 0.74 ± 0.028	0.145TrpTrp: 0.145 ± 0.013	0.272TrpTyr: 0.272 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.05	0.282TyrCys: 0.282 ± 0.018	1.807TyrAsp: 1.807 ± 0.047	2.397TyrGlu: 2.397 ± 0.055	1.578TyrPhe: 1.578 ± 0.042	2.262TyrGly: 2.262 ± 0.052	0.767TyrHis: 0.767 ± 0.026	2.079TyrIle: 2.079 ± 0.051	1.488TyrLys: 1.488 ± 0.039	3.382TyrLeu: 3.382 ± 0.063	0.74TyrMet: 0.74 ± 0.029	1.183TyrAsn: 1.183 ± 0.043	1.39TyrPro: 1.39 ± 0.042	1.538TyrGln: 1.538 ± 0.044	1.913TyrArg: 1.913 ± 0.051	1.808TyrSer: 1.808 ± 0.043	1.663TyrThr: 1.663 ± 0.046	2.113TyrVal: 2.113 ± 0.05	0.341TyrTrp: 0.341 ± 0.021	1.167TyrTyr: 1.167 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3305 proteins (923978 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---