Amino acid dipepetide frequency for Flavobacterium phage VK20

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.13AlaAla: 2.13 ± 0.573
0.55AlaCys: 0.55 ± 0.196
2.611AlaAsp: 2.611 ± 0.37
3.366AlaGlu: 3.366 ± 0.583
2.611AlaPhe: 2.611 ± 0.45
2.954AlaGly: 2.954 ± 0.519
0.344AlaHis: 0.344 ± 0.145
3.916AlaIle: 3.916 ± 0.524
4.946AlaLys: 4.946 ± 0.744
3.779AlaLeu: 3.779 ± 0.753
1.168AlaMet: 1.168 ± 0.277
3.916AlaAsn: 3.916 ± 0.588
1.511AlaPro: 1.511 ± 0.343
1.718AlaGln: 1.718 ± 0.373
1.992AlaArg: 1.992 ± 0.424
4.053AlaSer: 4.053 ± 0.572
3.641AlaThr: 3.641 ± 0.544
3.298AlaVal: 3.298 ± 0.498
0.618AlaTrp: 0.618 ± 0.193
2.198AlaTyr: 2.198 ± 0.402
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.207
0.069CysCys: 0.069 ± 0.067
0.756CysAsp: 0.756 ± 0.221
0.481CysGlu: 0.481 ± 0.156
0.618CysPhe: 0.618 ± 0.254
0.344CysGly: 0.344 ± 0.156
0.206CysHis: 0.206 ± 0.12
0.618CysIle: 0.618 ± 0.204
1.099CysLys: 1.099 ± 0.325
0.893CysLeu: 0.893 ± 0.299
0.206CysMet: 0.206 ± 0.095
0.55CysAsn: 0.55 ± 0.196
0.206CysPro: 0.206 ± 0.102
0.206CysGln: 0.206 ± 0.11
0.412CysArg: 0.412 ± 0.192
0.481CysSer: 0.481 ± 0.181
0.824CysThr: 0.824 ± 0.228
0.618CysVal: 0.618 ± 0.228
0.0CysTrp: 0.0 ± 0.0
0.344CysTyr: 0.344 ± 0.163
0.0CysXaa: 0.0 ± 0.0
Asp
4.053AspAla: 4.053 ± 0.56
0.618AspCys: 0.618 ± 0.228
2.748AspAsp: 2.748 ± 0.444
4.053AspGlu: 4.053 ± 0.476
3.779AspPhe: 3.779 ± 0.449
3.229AspGly: 3.229 ± 0.442
0.618AspHis: 0.618 ± 0.226
3.985AspIle: 3.985 ± 0.428
3.779AspLys: 3.779 ± 0.511
7.214AspLeu: 7.214 ± 0.538
0.824AspMet: 0.824 ± 0.212
4.328AspAsn: 4.328 ± 0.591
1.649AspPro: 1.649 ± 0.372
1.305AspGln: 1.305 ± 0.321
1.374AspArg: 1.374 ± 0.288
3.985AspSer: 3.985 ± 0.676
2.336AspThr: 2.336 ± 0.392
3.779AspVal: 3.779 ± 0.611
0.824AspTrp: 0.824 ± 0.262
3.023AspTyr: 3.023 ± 0.428
0.0AspXaa: 0.0 ± 0.0
Glu
3.435GluAla: 3.435 ± 0.557
0.412GluCys: 0.412 ± 0.197
2.817GluAsp: 2.817 ± 0.415
4.534GluGlu: 4.534 ± 0.807
3.572GluPhe: 3.572 ± 0.472
1.992GluGly: 1.992 ± 0.464
1.099GluHis: 1.099 ± 0.262
6.046GluIle: 6.046 ± 0.612
7.488GluLys: 7.488 ± 0.968
7.969GluLeu: 7.969 ± 0.808
2.611GluMet: 2.611 ± 0.472
5.771GluAsn: 5.771 ± 0.745
1.511GluPro: 1.511 ± 0.331
2.473GluGln: 2.473 ± 0.416
3.16GluArg: 3.16 ± 0.554
4.672GluSer: 4.672 ± 0.593
4.122GluThr: 4.122 ± 0.638
3.298GluVal: 3.298 ± 0.44
0.756GluTrp: 0.756 ± 0.196
2.748GluTyr: 2.748 ± 0.473
0.0GluXaa: 0.0 ± 0.0
Phe
1.786PheAla: 1.786 ± 0.365
0.687PheCys: 0.687 ± 0.225
4.053PheAsp: 4.053 ± 0.512
3.847PheGlu: 3.847 ± 0.563
1.924PhePhe: 1.924 ± 0.346
3.504PheGly: 3.504 ± 0.535
0.412PheHis: 0.412 ± 0.152
3.71PheIle: 3.71 ± 0.513
5.084PheLys: 5.084 ± 0.575
3.71PheLeu: 3.71 ± 0.439
1.168PheMet: 1.168 ± 0.238
3.572PheAsn: 3.572 ± 0.509
1.099PhePro: 1.099 ± 0.219
1.305PheGln: 1.305 ± 0.27
1.374PheArg: 1.374 ± 0.279
2.405PheSer: 2.405 ± 0.376
2.817PheThr: 2.817 ± 0.439
2.748PheVal: 2.748 ± 0.45
0.55PheTrp: 0.55 ± 0.172
2.13PheTyr: 2.13 ± 0.34
0.0PheXaa: 0.0 ± 0.0
Gly
2.954GlyAla: 2.954 ± 0.494
0.344GlyCys: 0.344 ± 0.127
3.641GlyAsp: 3.641 ± 0.607
3.435GlyGlu: 3.435 ± 0.482
3.229GlyPhe: 3.229 ± 0.521
4.397GlyGly: 4.397 ± 0.673
0.206GlyHis: 0.206 ± 0.107
4.466GlyIle: 4.466 ± 0.479
5.015GlyLys: 5.015 ± 0.611
4.672GlyLeu: 4.672 ± 0.499
0.687GlyMet: 0.687 ± 0.21
3.298GlyAsn: 3.298 ± 0.402
0.55GlyPro: 0.55 ± 0.156
1.718GlyGln: 1.718 ± 0.351
1.855GlyArg: 1.855 ± 0.332
4.191GlySer: 4.191 ± 0.49
3.023GlyThr: 3.023 ± 0.528
3.916GlyVal: 3.916 ± 0.591
0.687GlyTrp: 0.687 ± 0.207
2.611GlyTyr: 2.611 ± 0.472
0.0GlyXaa: 0.0 ± 0.0
His
0.275HisAla: 0.275 ± 0.154
0.275HisCys: 0.275 ± 0.17
0.756HisAsp: 0.756 ± 0.213
0.893HisGlu: 0.893 ± 0.26
0.687HisPhe: 0.687 ± 0.227
0.962HisGly: 0.962 ± 0.354
0.069HisHis: 0.069 ± 0.073
1.237HisIle: 1.237 ± 0.326
1.168HisLys: 1.168 ± 0.246
0.756HisLeu: 0.756 ± 0.223
0.137HisMet: 0.137 ± 0.089
1.031HisAsn: 1.031 ± 0.307
0.687HisPro: 0.687 ± 0.179
0.618HisGln: 0.618 ± 0.185
0.824HisArg: 0.824 ± 0.229
0.687HisSer: 0.687 ± 0.185
0.412HisThr: 0.412 ± 0.152
0.481HisVal: 0.481 ± 0.187
0.412HisTrp: 0.412 ± 0.177
0.481HisTyr: 0.481 ± 0.161
0.0HisXaa: 0.0 ± 0.0
Ile
4.672IleAla: 4.672 ± 0.646
0.412IleCys: 0.412 ± 0.147
5.359IleAsp: 5.359 ± 0.52
6.389IleGlu: 6.389 ± 0.7
2.542IlePhe: 2.542 ± 0.423
4.328IleGly: 4.328 ± 0.487
1.168IleHis: 1.168 ± 0.276
6.114IleIle: 6.114 ± 0.556
7.557IleLys: 7.557 ± 0.804
6.32IleLeu: 6.32 ± 0.605
1.58IleMet: 1.58 ± 0.291
5.153IleAsn: 5.153 ± 0.507
2.748IlePro: 2.748 ± 0.464
4.053IleGln: 4.053 ± 0.531
2.542IleArg: 2.542 ± 0.4
5.221IleSer: 5.221 ± 0.684
4.672IleThr: 4.672 ± 0.51
4.328IleVal: 4.328 ± 0.542
0.687IleTrp: 0.687 ± 0.225
2.817IleTyr: 2.817 ± 0.402
0.0IleXaa: 0.0 ± 0.0
Lys
5.153LysAla: 5.153 ± 0.7
0.824LysCys: 0.824 ± 0.291
4.74LysAsp: 4.74 ± 0.539
7.214LysGlu: 7.214 ± 1.023
3.641LysPhe: 3.641 ± 0.598
5.771LysGly: 5.771 ± 0.557
1.443LysHis: 1.443 ± 0.295
6.458LysIle: 6.458 ± 0.666
8.313LysLys: 8.313 ± 0.902
8.794LysLeu: 8.794 ± 0.713
2.679LysMet: 2.679 ± 0.427
6.595LysAsn: 6.595 ± 0.676
3.435LysPro: 3.435 ± 0.484
3.779LysGln: 3.779 ± 0.523
4.397LysArg: 4.397 ± 0.559
6.183LysSer: 6.183 ± 0.652
5.633LysThr: 5.633 ± 0.559
4.466LysVal: 4.466 ± 0.563
1.168LysTrp: 1.168 ± 0.256
4.122LysTyr: 4.122 ± 0.69
0.0LysXaa: 0.0 ± 0.0
Leu
4.74LeuAla: 4.74 ± 0.587
0.687LeuCys: 0.687 ± 0.192
5.565LeuAsp: 5.565 ± 0.784
8.107LeuGlu: 8.107 ± 0.822
4.191LeuPhe: 4.191 ± 0.564
4.603LeuGly: 4.603 ± 0.533
1.031LeuHis: 1.031 ± 0.298
7.763LeuIle: 7.763 ± 0.748
8.794LeuLys: 8.794 ± 0.658
6.733LeuLeu: 6.733 ± 0.648
2.267LeuMet: 2.267 ± 0.421
6.046LeuAsn: 6.046 ± 0.622
3.16LeuPro: 3.16 ± 0.465
2.817LeuGln: 2.817 ± 0.325
3.298LeuArg: 3.298 ± 0.442
5.771LeuSer: 5.771 ± 0.703
5.633LeuThr: 5.633 ± 0.756
5.221LeuVal: 5.221 ± 0.583
0.893LeuTrp: 0.893 ± 0.276
2.748LeuTyr: 2.748 ± 0.361
0.0LeuXaa: 0.0 ± 0.0
Met
1.786MetAla: 1.786 ± 0.374
0.275MetCys: 0.275 ± 0.14
0.962MetAsp: 0.962 ± 0.321
0.962MetGlu: 0.962 ± 0.214
0.756MetPhe: 0.756 ± 0.224
1.099MetGly: 1.099 ± 0.261
0.137MetHis: 0.137 ± 0.098
2.061MetIle: 2.061 ± 0.425
2.336MetLys: 2.336 ± 0.394
1.374MetLeu: 1.374 ± 0.278
0.069MetMet: 0.069 ± 0.063
1.786MetAsn: 1.786 ± 0.38
0.618MetPro: 0.618 ± 0.224
1.443MetGln: 1.443 ± 0.28
1.168MetArg: 1.168 ± 0.344
1.511MetSer: 1.511 ± 0.389
1.031MetThr: 1.031 ± 0.258
0.962MetVal: 0.962 ± 0.283
0.275MetTrp: 0.275 ± 0.135
1.031MetTyr: 1.031 ± 0.255
0.0MetXaa: 0.0 ± 0.0
Asn
3.504AsnAla: 3.504 ± 0.591
0.893AsnCys: 0.893 ± 0.236
3.71AsnAsp: 3.71 ± 0.538
6.046AsnGlu: 6.046 ± 0.611
3.023AsnPhe: 3.023 ± 0.481
4.672AsnGly: 4.672 ± 0.844
1.099AsnHis: 1.099 ± 0.251
5.633AsnIle: 5.633 ± 0.651
6.664AsnLys: 6.664 ± 0.852
6.733AsnLeu: 6.733 ± 0.671
1.099AsnMet: 1.099 ± 0.215
6.389AsnAsn: 6.389 ± 0.642
2.13AsnPro: 2.13 ± 0.368
2.542AsnGln: 2.542 ± 0.445
2.13AsnArg: 2.13 ± 0.335
5.427AsnSer: 5.427 ± 0.581
4.466AsnThr: 4.466 ± 0.457
3.298AsnVal: 3.298 ± 0.653
0.412AsnTrp: 0.412 ± 0.164
3.229AsnTyr: 3.229 ± 0.459
0.0AsnXaa: 0.0 ± 0.0
Pro
1.305ProAla: 1.305 ± 0.311
0.344ProCys: 0.344 ± 0.138
2.405ProAsp: 2.405 ± 0.545
1.718ProGlu: 1.718 ± 0.362
1.649ProPhe: 1.649 ± 0.335
0.618ProGly: 0.618 ± 0.222
0.618ProHis: 0.618 ± 0.15
2.198ProIle: 2.198 ± 0.347
2.885ProLys: 2.885 ± 0.492
2.267ProLeu: 2.267 ± 0.414
0.206ProMet: 0.206 ± 0.161
2.336ProAsn: 2.336 ± 0.345
0.412ProPro: 0.412 ± 0.15
1.168ProGln: 1.168 ± 0.347
0.687ProArg: 0.687 ± 0.231
1.855ProSer: 1.855 ± 0.34
2.336ProThr: 2.336 ± 0.386
2.267ProVal: 2.267 ± 0.367
0.206ProTrp: 0.206 ± 0.099
1.374ProTyr: 1.374 ± 0.303
0.0ProXaa: 0.0 ± 0.0
Gln
1.924GlnAla: 1.924 ± 0.387
0.206GlnCys: 0.206 ± 0.118
1.443GlnAsp: 1.443 ± 0.252
2.748GlnGlu: 2.748 ± 0.468
1.718GlnPhe: 1.718 ± 0.268
2.13GlnGly: 2.13 ± 0.283
0.687GlnHis: 0.687 ± 0.337
2.748GlnIle: 2.748 ± 0.345
3.435GlnLys: 3.435 ± 0.521
3.985GlnLeu: 3.985 ± 0.466
1.099GlnMet: 1.099 ± 0.271
2.13GlnAsn: 2.13 ± 0.422
1.031GlnPro: 1.031 ± 0.29
1.855GlnGln: 1.855 ± 0.453
1.031GlnArg: 1.031 ± 0.247
2.817GlnSer: 2.817 ± 0.482
1.786GlnThr: 1.786 ± 0.266
1.786GlnVal: 1.786 ± 0.348
0.412GlnTrp: 0.412 ± 0.185
1.649GlnTyr: 1.649 ± 0.282
0.0GlnXaa: 0.0 ± 0.0
Arg
1.511ArgAla: 1.511 ± 0.292
0.412ArgCys: 0.412 ± 0.154
2.13ArgAsp: 2.13 ± 0.455
2.336ArgGlu: 2.336 ± 0.443
2.336ArgPhe: 2.336 ± 0.463
1.031ArgGly: 1.031 ± 0.24
0.618ArgHis: 0.618 ± 0.196
3.023ArgIle: 3.023 ± 0.368
3.641ArgLys: 3.641 ± 0.55
3.641ArgLeu: 3.641 ± 0.574
0.687ArgMet: 0.687 ± 0.196
2.198ArgAsn: 2.198 ± 0.382
0.55ArgPro: 0.55 ± 0.164
1.031ArgGln: 1.031 ± 0.269
0.962ArgArg: 0.962 ± 0.295
1.786ArgSer: 1.786 ± 0.319
2.198ArgThr: 2.198 ± 0.429
2.748ArgVal: 2.748 ± 0.395
0.206ArgTrp: 0.206 ± 0.117
1.786ArgTyr: 1.786 ± 0.319
0.0ArgXaa: 0.0 ± 0.0
Ser
3.298SerAla: 3.298 ± 0.604
0.344SerCys: 0.344 ± 0.153
3.504SerAsp: 3.504 ± 0.4
4.053SerGlu: 4.053 ± 0.56
3.16SerPhe: 3.16 ± 0.504
4.259SerGly: 4.259 ± 0.483
0.824SerHis: 0.824 ± 0.243
5.633SerIle: 5.633 ± 0.642
7.832SerLys: 7.832 ± 0.681
6.046SerLeu: 6.046 ± 0.692
1.718SerMet: 1.718 ± 0.29
4.534SerAsn: 4.534 ± 0.596
1.305SerPro: 1.305 ± 0.36
2.611SerGln: 2.611 ± 0.377
1.855SerArg: 1.855 ± 0.368
2.748SerSer: 2.748 ± 0.522
3.779SerThr: 3.779 ± 0.442
4.672SerVal: 4.672 ± 0.468
0.756SerTrp: 0.756 ± 0.182
3.023SerTyr: 3.023 ± 0.459
0.0SerXaa: 0.0 ± 0.0
Thr
3.779ThrAla: 3.779 ± 0.748
0.481ThrCys: 0.481 ± 0.21
3.504ThrAsp: 3.504 ± 0.501
3.504ThrGlu: 3.504 ± 0.565
2.885ThrPhe: 2.885 ± 0.426
3.985ThrGly: 3.985 ± 0.538
0.756ThrHis: 0.756 ± 0.228
5.29ThrIle: 5.29 ± 0.466
4.053ThrLys: 4.053 ± 0.611
5.015ThrLeu: 5.015 ± 0.556
1.237ThrMet: 1.237 ± 0.351
4.397ThrAsn: 4.397 ± 0.694
2.748ThrPro: 2.748 ± 0.442
1.718ThrGln: 1.718 ± 0.366
1.855ThrArg: 1.855 ± 0.384
3.229ThrSer: 3.229 ± 0.448
3.092ThrThr: 3.092 ± 0.554
4.053ThrVal: 4.053 ± 0.713
0.893ThrTrp: 0.893 ± 0.207
2.267ThrTyr: 2.267 ± 0.414
0.0ThrXaa: 0.0 ± 0.0
Val
2.679ValAla: 2.679 ± 0.514
0.756ValCys: 0.756 ± 0.262
3.572ValAsp: 3.572 ± 0.413
3.985ValGlu: 3.985 ± 0.506
2.473ValPhe: 2.473 ± 0.362
2.336ValGly: 2.336 ± 0.377
0.687ValHis: 0.687 ± 0.249
4.603ValIle: 4.603 ± 0.673
5.153ValLys: 5.153 ± 0.639
5.153ValLeu: 5.153 ± 0.639
1.031ValMet: 1.031 ± 0.222
5.221ValAsn: 5.221 ± 0.594
1.374ValPro: 1.374 ± 0.352
1.855ValGln: 1.855 ± 0.343
2.473ValArg: 2.473 ± 0.349
4.328ValSer: 4.328 ± 0.624
3.71ValThr: 3.71 ± 0.591
3.229ValVal: 3.229 ± 0.319
0.481ValTrp: 0.481 ± 0.183
3.229ValTyr: 3.229 ± 0.445
0.0ValXaa: 0.0 ± 0.0
Trp
0.824TrpAla: 0.824 ± 0.224
0.137TrpCys: 0.137 ± 0.084
0.55TrpAsp: 0.55 ± 0.149
0.55TrpGlu: 0.55 ± 0.172
0.55TrpPhe: 0.55 ± 0.172
0.824TrpGly: 0.824 ± 0.225
0.137TrpHis: 0.137 ± 0.094
0.893TrpIle: 0.893 ± 0.262
1.168TrpLys: 1.168 ± 0.286
0.618TrpLeu: 0.618 ± 0.19
0.412TrpMet: 0.412 ± 0.166
0.687TrpAsn: 0.687 ± 0.16
0.137TrpPro: 0.137 ± 0.088
0.344TrpGln: 0.344 ± 0.173
0.275TrpArg: 0.275 ± 0.133
0.756TrpSer: 0.756 ± 0.242
0.756TrpThr: 0.756 ± 0.179
0.481TrpVal: 0.481 ± 0.185
0.137TrpTrp: 0.137 ± 0.09
0.618TrpTyr: 0.618 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.099TyrAla: 1.099 ± 0.245
0.618TyrCys: 0.618 ± 0.202
2.679TyrAsp: 2.679 ± 0.47
2.336TyrGlu: 2.336 ± 0.374
2.542TyrPhe: 2.542 ± 0.394
1.855TyrGly: 1.855 ± 0.388
0.687TyrHis: 0.687 ± 0.217
2.267TyrIle: 2.267 ± 0.399
4.397TyrLys: 4.397 ± 0.556
4.397TyrLeu: 4.397 ± 0.517
0.687TyrMet: 0.687 ± 0.244
3.16TyrAsn: 3.16 ± 0.518
1.992TyrPro: 1.992 ± 0.41
2.061TyrGln: 2.061 ± 0.466
1.168TyrArg: 1.168 ± 0.31
3.847TyrSer: 3.847 ± 0.641
2.473TyrThr: 2.473 ± 0.422
2.679TyrVal: 2.679 ± 0.451
0.481TyrTrp: 0.481 ± 0.17
1.855TyrTyr: 1.855 ± 0.38
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (14557 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski