Amino acid dipepetide frequency for Acidothermus cellulolyticus (strain ATCC 43068 / 11B)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.426AlaAla: 23.426 ± 0.298	1.118AlaCys: 1.118 ± 0.042	8.228AlaAsp: 8.228 ± 0.117	8.202AlaGlu: 8.202 ± 0.141	3.639AlaPhe: 3.639 ± 0.081	12.798AlaGly: 12.798 ± 0.15	2.692AlaHis: 2.692 ± 0.068	5.182AlaIle: 5.182 ± 0.087	2.517AlaLys: 2.517 ± 0.066	13.526AlaLeu: 13.526 ± 0.157	2.547AlaMet: 2.547 ± 0.06	2.302AlaAsn: 2.302 ± 0.058	6.156AlaPro: 6.156 ± 0.123	3.856AlaGln: 3.856 ± 0.087	10.32AlaArg: 10.32 ± 0.149	6.307AlaSer: 6.307 ± 0.105	7.409AlaThr: 7.409 ± 0.112	12.947AlaVal: 12.947 ± 0.165	1.65AlaTrp: 1.65 ± 0.059	2.492AlaTyr: 2.492 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.106CysAla: 1.106 ± 0.043	0.108CysCys: 0.108 ± 0.011	0.508CysAsp: 0.508 ± 0.024	0.414CysGlu: 0.414 ± 0.025	0.264CysPhe: 0.264 ± 0.022	0.993CysGly: 0.993 ± 0.039	0.211CysHis: 0.211 ± 0.018	0.274CysIle: 0.274 ± 0.02	0.089CysLys: 0.089 ± 0.01	0.715CysLeu: 0.715 ± 0.031	0.101CysMet: 0.101 ± 0.013	0.174CysAsn: 0.174 ± 0.016	0.58CysPro: 0.58 ± 0.031	0.236CysGln: 0.236 ± 0.017	0.788CysArg: 0.788 ± 0.033	0.414CysSer: 0.414 ± 0.026	0.51CysThr: 0.51 ± 0.031	0.706CysVal: 0.706 ± 0.038	0.123CysTrp: 0.123 ± 0.015	0.197CysTyr: 0.197 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	7.896AspAla: 7.896 ± 0.127	0.37AspCys: 0.37 ± 0.024	3.806AspAsp: 3.806 ± 0.096	3.582AspGlu: 3.582 ± 0.08	1.618AspPhe: 1.618 ± 0.047	5.653AspGly: 5.653 ± 0.103	1.225AspHis: 1.225 ± 0.048	2.517AspIle: 2.517 ± 0.065	0.756AspLys: 0.756 ± 0.036	5.799AspLeu: 5.799 ± 0.096	0.728AspMet: 0.728 ± 0.031	0.829AspAsn: 0.829 ± 0.037	4.337AspPro: 4.337 ± 0.091	1.511AspGln: 1.511 ± 0.043	4.522AspArg: 4.522 ± 0.088	1.865AspSer: 1.865 ± 0.052	2.758AspThr: 2.758 ± 0.069	6.127AspVal: 6.127 ± 0.104	0.767AspTrp: 0.767 ± 0.037	1.104AspTyr: 1.104 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.226GluAla: 6.226 ± 0.116	0.429GluCys: 0.429 ± 0.023	2.05GluAsp: 2.05 ± 0.061	2.953GluGlu: 2.953 ± 0.078	1.71GluPhe: 1.71 ± 0.056	2.946GluGly: 2.946 ± 0.066	1.332GluHis: 1.332 ± 0.047	2.916GluIle: 2.916 ± 0.07	1.248GluLys: 1.248 ± 0.051	6.096GluLeu: 6.096 ± 0.108	0.928GluMet: 0.928 ± 0.033	1.096GluAsn: 1.096 ± 0.043	3.214GluPro: 3.214 ± 0.072	1.929GluGln: 1.929 ± 0.06	5.03GluArg: 5.03 ± 0.093	2.246GluSer: 2.246 ± 0.053	2.891GluThr: 2.891 ± 0.068	4.305GluVal: 4.305 ± 0.096	0.711GluTrp: 0.711 ± 0.032	1.081GluTyr: 1.081 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.261PheAla: 4.261 ± 0.068	0.327PheCys: 0.327 ± 0.02	1.974PheAsp: 1.974 ± 0.053	1.288PheGlu: 1.288 ± 0.048	1.003PhePhe: 1.003 ± 0.04	3.099PheGly: 3.099 ± 0.074	0.685PheHis: 0.685 ± 0.032	0.896PheIle: 0.896 ± 0.031	0.381PheLys: 0.381 ± 0.025	2.918PheLeu: 2.918 ± 0.072	0.344PheMet: 0.344 ± 0.023	0.558PheAsn: 0.558 ± 0.029	1.58PhePro: 1.58 ± 0.045	0.61PheGln: 0.61 ± 0.026	2.094PheArg: 2.094 ± 0.059	1.61PheSer: 1.61 ± 0.042	1.881PheThr: 1.881 ± 0.062	2.718PheVal: 2.718 ± 0.066	0.377PheTrp: 0.377 ± 0.021	0.68PheTyr: 0.68 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.587GlyAla: 9.587 ± 0.138	0.937GlyCys: 0.937 ± 0.043	4.589GlyAsp: 4.589 ± 0.084	4.356GlyGlu: 4.356 ± 0.084	2.973GlyPhe: 2.973 ± 0.074	7.831GlyGly: 7.831 ± 0.143	1.991GlyHis: 1.991 ± 0.052	4.219GlyIle: 4.219 ± 0.077	1.925GlyLys: 1.925 ± 0.062	8.569GlyLeu: 8.569 ± 0.121	1.88GlyMet: 1.88 ± 0.049	1.718GlyAsn: 1.718 ± 0.057	4.398GlyPro: 4.398 ± 0.093	2.388GlyGln: 2.388 ± 0.061	7.563GlyArg: 7.563 ± 0.117	5.17GlySer: 5.17 ± 0.09	5.478GlyThr: 5.478 ± 0.101	8.075GlyVal: 8.075 ± 0.103	1.578GlyTrp: 1.578 ± 0.057	2.451GlyTyr: 2.451 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	2.801HisAla: 2.801 ± 0.058	0.196HisCys: 0.196 ± 0.018	1.321HisAsp: 1.321 ± 0.041	1.036HisGlu: 1.036 ± 0.037	0.582HisPhe: 0.582 ± 0.029	2.153HisGly: 2.153 ± 0.055	0.582HisHis: 0.582 ± 0.024	0.862HisIle: 0.862 ± 0.036	0.27HisLys: 0.27 ± 0.02	2.196HisLeu: 2.196 ± 0.06	0.3HisMet: 0.3 ± 0.02	0.393HisAsn: 0.393 ± 0.025	1.807HisPro: 1.807 ± 0.055	0.597HisGln: 0.597 ± 0.03	2.018HisArg: 2.018 ± 0.055	0.848HisSer: 0.848 ± 0.04	1.021HisThr: 1.021 ± 0.038	1.951HisVal: 1.951 ± 0.051	0.319HisTrp: 0.319 ± 0.023	0.525HisTyr: 0.525 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.243IleAla: 6.243 ± 0.092	0.443IleCys: 0.443 ± 0.023	3.071IleAsp: 3.071 ± 0.074	2.355IleGlu: 2.355 ± 0.066	1.214IlePhe: 1.214 ± 0.044	4.205IleGly: 4.205 ± 0.086	0.774IleHis: 0.774 ± 0.034	1.452IleIle: 1.452 ± 0.055	0.692IleLys: 0.692 ± 0.036	3.473IleLeu: 3.473 ± 0.076	0.467IleMet: 0.467 ± 0.024	0.924IleAsn: 0.924 ± 0.039	2.446IlePro: 2.446 ± 0.061	0.976IleGln: 0.976 ± 0.034	3.388IleArg: 3.388 ± 0.072	2.114IleSer: 2.114 ± 0.05	2.487IleThr: 2.487 ± 0.059	4.067IleVal: 4.067 ± 0.078	0.474IleTrp: 0.474 ± 0.027	0.703IleTyr: 0.703 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	2.127LysAla: 2.127 ± 0.071	0.123LysCys: 0.123 ± 0.013	0.825LysAsp: 0.825 ± 0.041	0.88LysGlu: 0.88 ± 0.04	0.433LysPhe: 0.433 ± 0.027	1.291LysGly: 1.291 ± 0.046	0.344LysHis: 0.344 ± 0.018	0.93LysIle: 0.93 ± 0.039	0.54LysLys: 0.54 ± 0.033	1.709LysLeu: 1.709 ± 0.051	0.292LysMet: 0.292 ± 0.02	0.417LysAsn: 0.417 ± 0.027	1.154LysPro: 1.154 ± 0.044	0.551LysGln: 0.551 ± 0.029	1.35LysArg: 1.35 ± 0.048	0.903LysSer: 0.903 ± 0.04	1.165LysThr: 1.165 ± 0.044	1.5LysVal: 1.5 ± 0.052	0.185LysTrp: 0.185 ± 0.016	0.392LysTyr: 0.392 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.044LeuAla: 16.044 ± 0.209	0.728LeuCys: 0.728 ± 0.033	6.286LeuAsp: 6.286 ± 0.106	4.493LeuGlu: 4.493 ± 0.099	2.731LeuPhe: 2.731 ± 0.068	8.738LeuGly: 8.738 ± 0.134	2.12LeuHis: 2.12 ± 0.057	3.776LeuIle: 3.776 ± 0.071	1.359LeuLys: 1.359 ± 0.054	10.583LeuLeu: 10.583 ± 0.126	1.192LeuMet: 1.192 ± 0.043	1.618LeuAsn: 1.618 ± 0.053	6.252LeuPro: 6.252 ± 0.105	2.453LeuGln: 2.453 ± 0.061	9.408LeuArg: 9.408 ± 0.13	4.742LeuSer: 4.742 ± 0.094	5.941LeuThr: 5.941 ± 0.097	9.199LeuVal: 9.199 ± 0.122	1.124LeuTrp: 1.124 ± 0.049	1.713LeuTyr: 1.713 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.025MetAla: 2.025 ± 0.054	0.121MetCys: 0.121 ± 0.013	0.739MetAsp: 0.739 ± 0.035	0.654MetGlu: 0.654 ± 0.027	0.408MetPhe: 0.408 ± 0.022	1.128MetGly: 1.128 ± 0.039	0.355MetHis: 0.355 ± 0.02	0.633MetIle: 0.633 ± 0.038	0.338MetLys: 0.338 ± 0.021	1.543MetLeu: 1.543 ± 0.047	0.264MetMet: 0.264 ± 0.018	0.388MetAsn: 0.388 ± 0.025	1.2MetPro: 1.2 ± 0.039	0.397MetGln: 0.397 ± 0.022	1.481MetArg: 1.481 ± 0.045	1.192MetSer: 1.192 ± 0.042	1.629MetThr: 1.629 ± 0.042	1.266MetVal: 1.266 ± 0.037	0.171MetTrp: 0.171 ± 0.022	0.301MetTyr: 0.301 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.403AsnAla: 2.403 ± 0.057	0.203AsnCys: 0.203 ± 0.02	0.969AsnAsp: 0.969 ± 0.04	0.741AsnGlu: 0.741 ± 0.032	0.632AsnPhe: 0.632 ± 0.032	1.933AsnGly: 1.933 ± 0.064	0.377AsnHis: 0.377 ± 0.022	0.732AsnIle: 0.732 ± 0.036	0.359AsnLys: 0.359 ± 0.027	1.863AsnLeu: 1.863 ± 0.053	0.28AsnMet: 0.28 ± 0.02	0.452AsnAsn: 0.452 ± 0.028	1.615AsnPro: 1.615 ± 0.058	0.586AsnGln: 0.586 ± 0.034	1.43AsnArg: 1.43 ± 0.047	0.91AsnSer: 0.91 ± 0.04	1.136AsnThr: 1.136 ± 0.046	1.725AsnVal: 1.725 ± 0.055	0.277AsnTrp: 0.277 ± 0.018	0.462AsnTyr: 0.462 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.427ProAla: 8.427 ± 0.16	0.388ProCys: 0.388 ± 0.023	4.289ProAsp: 4.289 ± 0.09	3.543ProGlu: 3.543 ± 0.08	1.595ProPhe: 1.595 ± 0.048	5.849ProGly: 5.849 ± 0.099	1.355ProHis: 1.355 ± 0.042	2.272ProIle: 2.272 ± 0.063	0.992ProLys: 0.992 ± 0.043	5.188ProLeu: 5.188 ± 0.078	1.033ProMet: 1.033 ± 0.037	1.202ProAsn: 1.202 ± 0.042	4.223ProPro: 4.223 ± 0.106	1.657ProGln: 1.657 ± 0.049	4.364ProArg: 4.364 ± 0.094	4.213ProSer: 4.213 ± 0.174	3.805ProThr: 3.805 ± 0.094	5.315ProVal: 5.315 ± 0.089	0.856ProTrp: 0.856 ± 0.033	1.199ProTyr: 1.199 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.81GlnAla: 3.81 ± 0.087	0.218GlnCys: 0.218 ± 0.016	0.974GlnAsp: 0.974 ± 0.035	1.147GlnGlu: 1.147 ± 0.046	0.714GlnPhe: 0.714 ± 0.029	1.74GlnGly: 1.74 ± 0.056	0.644GlnHis: 0.644 ± 0.029	1.376GlnIle: 1.376 ± 0.045	0.469GlnLys: 0.469 ± 0.029	3.288GlnLeu: 3.288 ± 0.084	0.463GlnMet: 0.463 ± 0.025	0.518GlnAsn: 0.518 ± 0.03	2.091GlnPro: 2.091 ± 0.053	1.21GlnGln: 1.21 ± 0.049	2.721GlnArg: 2.721 ± 0.071	1.173GlnSer: 1.173 ± 0.047	1.535GlnThr: 1.535 ± 0.05	2.513GlnVal: 2.513 ± 0.058	0.421GlnTrp: 0.421 ± 0.026	0.614GlnTyr: 0.614 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.78ArgAla: 9.78 ± 0.147	0.714ArgCys: 0.714 ± 0.033	4.681ArgAsp: 4.681 ± 0.086	4.363ArgGlu: 4.363 ± 0.089	2.631ArgPhe: 2.631 ± 0.062	5.884ArgGly: 5.884 ± 0.1	2.129ArgHis: 2.129 ± 0.05	4.097ArgIle: 4.097 ± 0.073	1.328ArgLys: 1.328 ± 0.048	9.501ArgLeu: 9.501 ± 0.137	1.765ArgMet: 1.765 ± 0.048	1.577ArgAsn: 1.577 ± 0.048	5.022ArgPro: 5.022 ± 0.092	2.483ArgGln: 2.483 ± 0.059	9.831ArgArg: 9.831 ± 0.16	4.415ArgSer: 4.415 ± 0.088	4.487ArgThr: 4.487 ± 0.076	6.534ArgVal: 6.534 ± 0.108	1.458ArgTrp: 1.458 ± 0.044	2.313ArgTyr: 2.313 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	6.9SerAla: 6.9 ± 0.11	0.464SerCys: 0.464 ± 0.024	2.577SerAsp: 2.577 ± 0.061	2.118SerGlu: 2.118 ± 0.055	1.48SerPhe: 1.48 ± 0.043	5.556SerGly: 5.556 ± 0.105	0.929SerHis: 0.929 ± 0.039	1.962SerIle: 1.962 ± 0.057	0.754SerLys: 0.754 ± 0.034	4.476SerLeu: 4.476 ± 0.069	0.978SerMet: 0.978 ± 0.037	0.976SerAsn: 0.976 ± 0.039	3.941SerPro: 3.941 ± 0.171	1.281SerGln: 1.281 ± 0.046	3.979SerArg: 3.979 ± 0.074	3.227SerSer: 3.227 ± 0.111	2.972SerThr: 2.972 ± 0.07	4.191SerVal: 4.191 ± 0.085	0.871SerTrp: 0.871 ± 0.039	1.198SerTyr: 1.198 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	8.224ThrAla: 8.224 ± 0.149	0.459ThrCys: 0.459 ± 0.029	3.123ThrAsp: 3.123 ± 0.075	2.724ThrGlu: 2.724 ± 0.063	1.721ThrPhe: 1.721 ± 0.055	5.911ThrGly: 5.911 ± 0.101	1.082ThrHis: 1.082 ± 0.037	2.453ThrIle: 2.453 ± 0.065	1.022ThrLys: 1.022 ± 0.039	5.597ThrLeu: 5.597 ± 0.078	0.95ThrMet: 0.95 ± 0.035	1.28ThrAsn: 1.28 ± 0.055	4.452ThrPro: 4.452 ± 0.091	1.356ThrGln: 1.356 ± 0.047	3.826ThrArg: 3.826 ± 0.064	3.19ThrSer: 3.19 ± 0.077	3.847ThrThr: 3.847 ± 0.077	5.867ThrVal: 5.867 ± 0.094	0.802ThrTrp: 0.802 ± 0.036	1.256ThrTyr: 1.256 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	11.933ValAla: 11.933 ± 0.16	0.819ValCys: 0.819 ± 0.034	5.845ValAsp: 5.845 ± 0.096	4.876ValGlu: 4.876 ± 0.098	2.766ValPhe: 2.766 ± 0.064	7.093ValGly: 7.093 ± 0.108	2.072ValHis: 2.072 ± 0.057	4.235ValIle: 4.235 ± 0.084	1.495ValLys: 1.495 ± 0.047	9.447ValLeu: 9.447 ± 0.13	1.269ValMet: 1.269 ± 0.043	1.887ValAsn: 1.887 ± 0.052	5.3ValPro: 5.3 ± 0.09	2.157ValGln: 2.157 ± 0.058	7.399ValArg: 7.399 ± 0.116	4.482ValSer: 4.482 ± 0.079	6.201ValThr: 6.201 ± 0.099	9.885ValVal: 9.885 ± 0.162	1.024ValTrp: 1.024 ± 0.039	1.728ValTyr: 1.728 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.284TrpAla: 1.284 ± 0.044	0.141TrpCys: 0.141 ± 0.018	0.611TrpAsp: 0.611 ± 0.03	0.565TrpGlu: 0.565 ± 0.033	0.48TrpPhe: 0.48 ± 0.024	0.85TrpGly: 0.85 ± 0.041	0.393TrpHis: 0.393 ± 0.019	0.567TrpIle: 0.567 ± 0.031	0.229TrpLys: 0.229 ± 0.017	1.678TrpLeu: 1.678 ± 0.056	0.245TrpMet: 0.245 ± 0.02	0.356TrpAsn: 0.356 ± 0.022	0.81TrpPro: 0.81 ± 0.033	0.686TrpGln: 0.686 ± 0.03	1.436TrpArg: 1.436 ± 0.055	0.9TrpSer: 0.9 ± 0.038	0.881TrpThr: 0.881 ± 0.036	1.078TrpVal: 1.078 ± 0.042	0.344TrpTrp: 0.344 ± 0.024	0.344TrpTyr: 0.344 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.812TyrAla: 2.812 ± 0.066	0.206TyrCys: 0.206 ± 0.017	1.306TyrAsp: 1.306 ± 0.042	1.048TyrGlu: 1.048 ± 0.04	0.691TyrPhe: 0.691 ± 0.031	2.028TyrGly: 2.028 ± 0.051	0.486TyrHis: 0.486 ± 0.025	0.617TyrIle: 0.617 ± 0.027	0.345TyrLys: 0.345 ± 0.021	2.331TyrLeu: 2.331 ± 0.053	0.207TyrMet: 0.207 ± 0.017	0.422TyrAsn: 0.422 ± 0.027	1.187TyrPro: 1.187 ± 0.041	0.718TyrGln: 0.718 ± 0.034	2.043TyrArg: 2.043 ± 0.054	0.911TyrSer: 0.911 ± 0.036	1.107TyrThr: 1.107 ± 0.041	1.943TyrVal: 1.943 ± 0.065	0.347TyrTrp: 0.347 ± 0.023	0.521TyrTyr: 0.521 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2157 proteins (729829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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