Amino acid dipepetide frequency for Corynebacterium vitaeruminis DSM 20294

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.201AlaAla: 16.201 ± 0.196	1.091AlaCys: 1.091 ± 0.036	6.541AlaAsp: 6.541 ± 0.105	7.757AlaGlu: 7.757 ± 0.126	3.905AlaPhe: 3.905 ± 0.075	10.354AlaGly: 10.354 ± 0.119	2.342AlaHis: 2.342 ± 0.054	5.95AlaIle: 5.95 ± 0.098	4.1AlaLys: 4.1 ± 0.076	11.97AlaLeu: 11.97 ± 0.153	2.942AlaMet: 2.942 ± 0.066	2.896AlaAsn: 2.896 ± 0.055	5.344AlaPro: 5.344 ± 0.104	4.161AlaGln: 4.161 ± 0.072	7.363AlaArg: 7.363 ± 0.116	6.924AlaSer: 6.924 ± 0.104	7.302AlaThr: 7.302 ± 0.098	9.606AlaVal: 9.606 ± 0.118	1.66AlaTrp: 1.66 ± 0.046	2.448AlaTyr: 2.448 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.038	0.103CysCys: 0.103 ± 0.011	0.47CysAsp: 0.47 ± 0.022	0.494CysGlu: 0.494 ± 0.023	0.283CysPhe: 0.283 ± 0.02	0.813CysGly: 0.813 ± 0.035	0.179CysHis: 0.179 ± 0.014	0.355CysIle: 0.355 ± 0.02	0.164CysLys: 0.164 ± 0.017	0.628CysLeu: 0.628 ± 0.027	0.167CysMet: 0.167 ± 0.015	0.194CysAsn: 0.194 ± 0.014	0.41CysPro: 0.41 ± 0.026	0.246CysGln: 0.246 ± 0.017	0.368CysArg: 0.368 ± 0.024	0.52CysSer: 0.52 ± 0.024	0.426CysThr: 0.426 ± 0.025	0.609CysVal: 0.609 ± 0.027	0.097CysTrp: 0.097 ± 0.011	0.152CysTyr: 0.152 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.985AspAla: 6.985 ± 0.105	0.393AspCys: 0.393 ± 0.025	3.32AspAsp: 3.32 ± 0.084	4.424AspGlu: 4.424 ± 0.091	2.077AspPhe: 2.077 ± 0.05	4.925AspGly: 4.925 ± 0.088	1.141AspHis: 1.141 ± 0.042	2.768AspIle: 2.768 ± 0.062	2.002AspLys: 2.002 ± 0.05	5.605AspLeu: 5.605 ± 0.088	1.125AspMet: 1.125 ± 0.037	1.624AspAsn: 1.624 ± 0.049	3.752AspPro: 3.752 ± 0.071	1.762AspGln: 1.762 ± 0.058	3.358AspArg: 3.358 ± 0.067	3.13AspSer: 3.13 ± 0.066	3.052AspThr: 3.052 ± 0.067	4.587AspVal: 4.587 ± 0.077	0.77AspTrp: 0.77 ± 0.033	1.513AspTyr: 1.513 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	7.402GluAla: 7.402 ± 0.119	0.399GluCys: 0.399 ± 0.022	3.361GluAsp: 3.361 ± 0.069	4.613GluGlu: 4.613 ± 0.1	2.067GluPhe: 2.067 ± 0.05	4.651GluGly: 4.651 ± 0.082	1.47GluHis: 1.47 ± 0.045	3.301GluIle: 3.301 ± 0.071	2.693GluLys: 2.693 ± 0.071	6.883GluLeu: 6.883 ± 0.105	1.273GluMet: 1.273 ± 0.041	1.807GluAsn: 1.807 ± 0.049	2.711GluPro: 2.711 ± 0.073	2.476GluGln: 2.476 ± 0.06	4.084GluArg: 4.084 ± 0.083	3.151GluSer: 3.151 ± 0.063	3.046GluThr: 3.046 ± 0.062	5.259GluVal: 5.259 ± 0.089	0.75GluTrp: 0.75 ± 0.032	1.398GluTyr: 1.398 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.039PheAla: 4.039 ± 0.072	0.282PheCys: 0.282 ± 0.017	2.565PheAsp: 2.565 ± 0.06	1.93PheGlu: 1.93 ± 0.052	1.336PhePhe: 1.336 ± 0.044	3.541PheGly: 3.541 ± 0.074	0.734PheHis: 0.734 ± 0.035	1.631PheIle: 1.631 ± 0.052	0.846PheLys: 0.846 ± 0.03	3.187PheLeu: 3.187 ± 0.086	0.664PheMet: 0.664 ± 0.026	0.966PheAsn: 0.966 ± 0.029	1.568PhePro: 1.568 ± 0.044	0.84PheGln: 0.84 ± 0.033	1.714PheArg: 1.714 ± 0.048	2.215PheSer: 2.215 ± 0.06	2.03PheThr: 2.03 ± 0.056	2.73PheVal: 2.73 ± 0.067	0.397PheTrp: 0.397 ± 0.024	0.874PheTyr: 0.874 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.22GlyAla: 9.22 ± 0.132	0.728GlyCys: 0.728 ± 0.032	4.373GlyAsp: 4.373 ± 0.077	5.261GlyGlu: 5.261 ± 0.088	3.404GlyPhe: 3.404 ± 0.064	6.954GlyGly: 6.954 ± 0.138	1.942GlyHis: 1.942 ± 0.053	4.862GlyIle: 4.862 ± 0.086	3.244GlyLys: 3.244 ± 0.067	8.464GlyLeu: 8.464 ± 0.109	2.257GlyMet: 2.257 ± 0.057	2.237GlyAsn: 2.237 ± 0.043	3.195GlyPro: 3.195 ± 0.069	2.808GlyGln: 2.808 ± 0.054	5.022GlyArg: 5.022 ± 0.084	5.068GlySer: 5.068 ± 0.085	5.428GlyThr: 5.428 ± 0.083	7.291GlyVal: 7.291 ± 0.098	1.417GlyTrp: 1.417 ± 0.041	2.263GlyTyr: 2.263 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.195HisAla: 2.195 ± 0.052	0.183HisCys: 0.183 ± 0.015	1.203HisAsp: 1.203 ± 0.037	1.237HisGlu: 1.237 ± 0.041	0.664HisPhe: 0.664 ± 0.026	1.853HisGly: 1.853 ± 0.051	0.58HisHis: 0.58 ± 0.032	0.946HisIle: 0.946 ± 0.029	0.502HisLys: 0.502 ± 0.024	1.997HisLeu: 1.997 ± 0.052	0.466HisMet: 0.466 ± 0.026	0.574HisAsn: 0.574 ± 0.026	1.477HisPro: 1.477 ± 0.045	0.64HisGln: 0.64 ± 0.03	1.41HisArg: 1.41 ± 0.044	1.133HisSer: 1.133 ± 0.038	1.189HisThr: 1.189 ± 0.04	1.579HisVal: 1.579 ± 0.047	0.264HisTrp: 0.264 ± 0.017	0.53HisTyr: 0.53 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.802IleAla: 6.802 ± 0.094	0.407IleCys: 0.407 ± 0.022	3.766IleAsp: 3.766 ± 0.066	3.247IleGlu: 3.247 ± 0.067	1.453IlePhe: 1.453 ± 0.052	4.519IleGly: 4.519 ± 0.086	0.997IleHis: 0.997 ± 0.041	2.457IleIle: 2.457 ± 0.072	1.464IleLys: 1.464 ± 0.039	4.049IleLeu: 4.049 ± 0.076	0.968IleMet: 0.968 ± 0.035	1.554IleAsn: 1.554 ± 0.041	2.649IlePro: 2.649 ± 0.067	1.202IleGln: 1.202 ± 0.04	2.575IleArg: 2.575 ± 0.057	2.777IleSer: 2.777 ± 0.062	3.3IleThr: 3.3 ± 0.07	4.454IleVal: 4.454 ± 0.086	0.423IleTrp: 0.423 ± 0.022	0.987IleTyr: 0.987 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.086LysAla: 4.086 ± 0.084	0.138LysCys: 0.138 ± 0.013	2.02LysAsp: 2.02 ± 0.046	2.233LysGlu: 2.233 ± 0.058	0.862LysPhe: 0.862 ± 0.038	2.408LysGly: 2.408 ± 0.056	0.66LysHis: 0.66 ± 0.029	1.57LysIle: 1.57 ± 0.051	1.771LysLys: 1.771 ± 0.053	3.236LysLeu: 3.236 ± 0.061	0.807LysMet: 0.807 ± 0.031	1.075LysAsn: 1.075 ± 0.038	1.637LysPro: 1.637 ± 0.044	1.296LysGln: 1.296 ± 0.04	2.184LysArg: 2.184 ± 0.049	1.704LysSer: 1.704 ± 0.04	1.847LysThr: 1.847 ± 0.05	2.942LysVal: 2.942 ± 0.066	0.425LysTrp: 0.425 ± 0.024	0.742LysTyr: 0.742 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.854LeuAla: 12.854 ± 0.159	0.753LeuCys: 0.753 ± 0.032	6.041LeuAsp: 6.041 ± 0.102	5.331LeuGlu: 5.331 ± 0.087	2.971LeuPhe: 2.971 ± 0.077	9.086LeuGly: 9.086 ± 0.134	1.828LeuHis: 1.828 ± 0.052	4.926LeuIle: 4.926 ± 0.084	3.052LeuLys: 3.052 ± 0.064	9.055LeuLeu: 9.055 ± 0.155	1.941LeuMet: 1.941 ± 0.046	2.522LeuAsn: 2.522 ± 0.059	5.151LeuPro: 5.151 ± 0.068	2.374LeuGln: 2.374 ± 0.059	6.223LeuArg: 6.223 ± 0.103	6.218LeuSer: 6.218 ± 0.085	5.693LeuThr: 5.693 ± 0.096	8.432LeuVal: 8.432 ± 0.116	1.194LeuTrp: 1.194 ± 0.041	1.824LeuTyr: 1.824 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.693MetAla: 2.693 ± 0.056	0.176MetCys: 0.176 ± 0.014	1.092MetAsp: 1.092 ± 0.037	1.042MetGlu: 1.042 ± 0.037	0.71MetPhe: 0.71 ± 0.03	1.829MetGly: 1.829 ± 0.053	0.457MetHis: 0.457 ± 0.025	1.186MetIle: 1.186 ± 0.04	0.768MetLys: 0.768 ± 0.033	2.148MetLeu: 2.148 ± 0.052	0.49MetMet: 0.49 ± 0.025	0.786MetAsn: 0.786 ± 0.032	1.16MetPro: 1.16 ± 0.034	0.726MetGln: 0.726 ± 0.027	1.448MetArg: 1.448 ± 0.038	1.77MetSer: 1.77 ± 0.046	1.641MetThr: 1.641 ± 0.045	1.698MetVal: 1.698 ± 0.05	0.287MetTrp: 0.287 ± 0.019	0.372MetTyr: 0.372 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.043AsnAla: 3.043 ± 0.064	0.207AsnCys: 0.207 ± 0.017	1.49AsnAsp: 1.49 ± 0.046	1.605AsnGlu: 1.605 ± 0.049	0.871AsnPhe: 0.871 ± 0.031	2.195AsnGly: 2.195 ± 0.06	0.575AsnHis: 0.575 ± 0.022	1.259AsnIle: 1.259 ± 0.038	0.972AsnLys: 0.972 ± 0.037	2.739AsnLeu: 2.739 ± 0.061	0.576AsnMet: 0.576 ± 0.027	0.87AsnAsn: 0.87 ± 0.034	1.991AsnPro: 1.991 ± 0.049	0.921AsnGln: 0.921 ± 0.032	1.599AsnArg: 1.599 ± 0.048	1.551AsnSer: 1.551 ± 0.045	1.53AsnThr: 1.53 ± 0.043	1.995AsnVal: 1.995 ± 0.052	0.411AsnTrp: 0.411 ± 0.024	0.72AsnTyr: 0.72 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.042ProAla: 6.042 ± 0.103	0.231ProCys: 0.231 ± 0.019	3.059ProAsp: 3.059 ± 0.065	4.05ProGlu: 4.05 ± 0.072	1.654ProPhe: 1.654 ± 0.041	4.501ProGly: 4.501 ± 0.089	1.033ProHis: 1.033 ± 0.036	2.174ProIle: 2.174 ± 0.053	1.606ProLys: 1.606 ± 0.05	4.404ProLeu: 4.404 ± 0.084	1.031ProMet: 1.031 ± 0.035	1.355ProAsn: 1.355 ± 0.04	1.627ProPro: 1.627 ± 0.049	1.709ProGln: 1.709 ± 0.055	2.795ProArg: 2.795 ± 0.066	2.854ProSer: 2.854 ± 0.061	3.248ProThr: 3.248 ± 0.07	4.285ProVal: 4.285 ± 0.074	0.742ProTrp: 0.742 ± 0.029	1.041ProTyr: 1.041 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.18GlnAla: 4.18 ± 0.08	0.161GlnCys: 0.161 ± 0.014	1.459GlnAsp: 1.459 ± 0.045	1.849GlnGlu: 1.849 ± 0.051	0.988GlnPhe: 0.988 ± 0.037	2.38GlnGly: 2.38 ± 0.053	0.63GlnHis: 0.63 ± 0.03	1.683GlnIle: 1.683 ± 0.047	1.06GlnLys: 1.06 ± 0.039	3.685GlnLeu: 3.685 ± 0.072	0.782GlnMet: 0.782 ± 0.028	0.71GlnAsn: 0.71 ± 0.029	1.475GlnPro: 1.475 ± 0.039	1.356GlnGln: 1.356 ± 0.048	2.281GlnArg: 2.281 ± 0.06	1.573GlnSer: 1.573 ± 0.046	1.508GlnThr: 1.508 ± 0.05	2.789GlnVal: 2.789 ± 0.058	0.52GlnTrp: 0.52 ± 0.027	0.64GlnTyr: 0.64 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.616ArgAla: 6.616 ± 0.111	0.404ArgCys: 0.404 ± 0.021	3.27ArgAsp: 3.27 ± 0.075	4.373ArgGlu: 4.373 ± 0.08	2.327ArgPhe: 2.327 ± 0.053	4.746ArgGly: 4.746 ± 0.083	1.258ArgHis: 1.258 ± 0.04	3.138ArgIle: 3.138 ± 0.061	2.219ArgLys: 2.219 ± 0.054	5.988ArgLeu: 5.988 ± 0.104	1.557ArgMet: 1.557 ± 0.041	1.689ArgAsn: 1.689 ± 0.05	2.866ArgPro: 2.866 ± 0.065	2.092ArgGln: 2.092 ± 0.053	4.914ArgArg: 4.914 ± 0.103	3.256ArgSer: 3.256 ± 0.062	3.34ArgThr: 3.34 ± 0.063	4.509ArgVal: 4.509 ± 0.076	0.89ArgTrp: 0.89 ± 0.032	1.572ArgTyr: 1.572 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.504SerAla: 6.504 ± 0.098	0.407SerCys: 0.407 ± 0.022	3.245SerAsp: 3.245 ± 0.075	3.212SerGlu: 3.212 ± 0.068	2.238SerPhe: 2.238 ± 0.051	5.475SerGly: 5.475 ± 0.094	1.206SerHis: 1.206 ± 0.036	2.764SerIle: 2.764 ± 0.056	1.926SerLys: 1.926 ± 0.054	5.7SerLeu: 5.7 ± 0.099	1.609SerMet: 1.609 ± 0.047	1.503SerAsn: 1.503 ± 0.043	2.915SerPro: 2.915 ± 0.058	2.03SerGln: 2.03 ± 0.05	3.416SerArg: 3.416 ± 0.076	4.008SerSer: 4.008 ± 0.129	3.794SerThr: 3.794 ± 0.077	4.486SerVal: 4.486 ± 0.077	0.891SerTrp: 0.891 ± 0.034	1.445SerTyr: 1.445 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.607ThrAla: 6.607 ± 0.11	0.5ThrCys: 0.5 ± 0.026	3.367ThrAsp: 3.367 ± 0.074	2.989ThrGlu: 2.989 ± 0.069	2.037ThrPhe: 2.037 ± 0.054	5.429ThrGly: 5.429 ± 0.08	1.222ThrHis: 1.222 ± 0.036	3.056ThrIle: 3.056 ± 0.059	1.869ThrLys: 1.869 ± 0.051	5.782ThrLeu: 5.782 ± 0.086	1.269ThrMet: 1.269 ± 0.039	1.597ThrAsn: 1.597 ± 0.039	3.709ThrPro: 3.709 ± 0.063	1.744ThrGln: 1.744 ± 0.048	3.185ThrArg: 3.185 ± 0.059	3.65ThrSer: 3.65 ± 0.088	3.898ThrThr: 3.898 ± 0.079	5.239ThrVal: 5.239 ± 0.093	0.903ThrTrp: 0.903 ± 0.03	1.458ThrTyr: 1.458 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.532ValAla: 10.532 ± 0.139	0.731ValCys: 0.731 ± 0.028	5.577ValAsp: 5.577 ± 0.079	5.036ValGlu: 5.036 ± 0.091	2.813ValPhe: 2.813 ± 0.07	6.761ValGly: 6.761 ± 0.106	1.574ValHis: 1.574 ± 0.046	4.437ValIle: 4.437 ± 0.082	2.336ValLys: 2.336 ± 0.069	7.915ValLeu: 7.915 ± 0.109	1.726ValMet: 1.726 ± 0.047	2.121ValAsn: 2.121 ± 0.052	4.027ValPro: 4.027 ± 0.07	1.973ValGln: 1.973 ± 0.05	4.693ValArg: 4.693 ± 0.082	4.955ValSer: 4.955 ± 0.078	5.282ValThr: 5.282 ± 0.09	7.521ValVal: 7.521 ± 0.108	1.072ValTrp: 1.072 ± 0.039	1.676ValTyr: 1.676 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.524TrpAla: 1.524 ± 0.044	0.144TrpCys: 0.144 ± 0.014	0.708TrpAsp: 0.708 ± 0.032	0.752TrpGlu: 0.752 ± 0.032	0.545TrpPhe: 0.545 ± 0.031	0.974TrpGly: 0.974 ± 0.035	0.327TrpHis: 0.327 ± 0.02	0.689TrpIle: 0.689 ± 0.034	0.456TrpLys: 0.456 ± 0.026	1.6TrpLeu: 1.6 ± 0.054	0.404TrpMet: 0.404 ± 0.023	0.39TrpAsn: 0.39 ± 0.02	0.594TrpPro: 0.594 ± 0.024	0.548TrpGln: 0.548 ± 0.025	0.93TrpArg: 0.93 ± 0.034	0.776TrpSer: 0.776 ± 0.03	0.736TrpThr: 0.736 ± 0.031	1.056TrpVal: 1.056 ± 0.04	0.317TrpTrp: 0.317 ± 0.02	0.299TrpTyr: 0.299 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.406TyrAla: 2.406 ± 0.054	0.167TyrCys: 0.167 ± 0.015	1.386TyrAsp: 1.386 ± 0.038	1.361TyrGlu: 1.361 ± 0.044	0.885TyrPhe: 0.885 ± 0.038	2.044TyrGly: 2.044 ± 0.048	0.465TyrHis: 0.465 ± 0.023	0.895TyrIle: 0.895 ± 0.036	0.594TyrLys: 0.594 ± 0.028	2.434TyrLeu: 2.434 ± 0.059	0.423TyrMet: 0.423 ± 0.024	0.652TyrAsn: 0.652 ± 0.029	1.183TyrPro: 1.183 ± 0.041	0.806TyrGln: 0.806 ± 0.03	1.462TyrArg: 1.462 ± 0.045	1.539TyrSer: 1.539 ± 0.041	1.22TyrThr: 1.22 ± 0.038	1.69TyrVal: 1.69 ± 0.047	0.338TyrTrp: 0.338 ± 0.017	0.586TyrTyr: 0.586 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2565 proteins (836113 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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