Amino acid dipepetide frequency for Izhakiella capsodis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.474AlaAla: 9.474 ± 0.129	1.087AlaCys: 1.087 ± 0.037	4.902AlaAsp: 4.902 ± 0.079	5.512AlaGlu: 5.512 ± 0.098	3.369AlaPhe: 3.369 ± 0.067	7.507AlaGly: 7.507 ± 0.109	1.786AlaHis: 1.786 ± 0.042	5.969AlaIle: 5.969 ± 0.08	3.474AlaLys: 3.474 ± 0.066	11.685AlaLeu: 11.685 ± 0.144	2.815AlaMet: 2.815 ± 0.056	3.122AlaAsn: 3.122 ± 0.064	3.353AlaPro: 3.353 ± 0.052	4.241AlaGln: 4.241 ± 0.067	5.655AlaArg: 5.655 ± 0.098	5.707AlaSer: 5.707 ± 0.076	4.513AlaThr: 4.513 ± 0.075	6.241AlaVal: 6.241 ± 0.079	1.367AlaTrp: 1.367 ± 0.043	2.03AlaTyr: 2.03 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.975CysAla: 0.975 ± 0.036	0.186CysCys: 0.186 ± 0.014	0.644CysAsp: 0.644 ± 0.025	0.61CysGlu: 0.61 ± 0.027	0.477CysPhe: 0.477 ± 0.023	1.086CysGly: 1.086 ± 0.034	0.337CysHis: 0.337 ± 0.021	0.613CysIle: 0.613 ± 0.026	0.352CysLys: 0.352 ± 0.02	1.071CysLeu: 1.071 ± 0.036	0.251CysMet: 0.251 ± 0.017	0.356CysAsn: 0.356 ± 0.02	0.516CysPro: 0.516 ± 0.026	0.538CysGln: 0.538 ± 0.024	0.636CysArg: 0.636 ± 0.025	0.681CysSer: 0.681 ± 0.03	0.485CysThr: 0.485 ± 0.023	0.684CysVal: 0.684 ± 0.028	0.233CysTrp: 0.233 ± 0.016	0.333CysTyr: 0.333 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.074AspAla: 5.074 ± 0.086	0.511AspCys: 0.511 ± 0.026	2.988AspAsp: 2.988 ± 0.065	3.511AspGlu: 3.511 ± 0.07	2.184AspPhe: 2.184 ± 0.048	3.707AspGly: 3.707 ± 0.066	1.038AspHis: 1.038 ± 0.033	3.702AspIle: 3.702 ± 0.06	2.535AspLys: 2.535 ± 0.063	4.83AspLeu: 4.83 ± 0.075	1.367AspMet: 1.367 ± 0.038	2.447AspAsn: 2.447 ± 0.056	2.244AspPro: 2.244 ± 0.054	1.662AspGln: 1.662 ± 0.043	2.877AspArg: 2.877 ± 0.056	3.177AspSer: 3.177 ± 0.052	2.483AspThr: 2.483 ± 0.05	3.721AspVal: 3.721 ± 0.066	0.807AspTrp: 0.807 ± 0.03	1.928AspTyr: 1.928 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.94GluAla: 4.94 ± 0.08	0.483GluCys: 0.483 ± 0.022	2.356GluAsp: 2.356 ± 0.061	2.996GluGlu: 2.996 ± 0.064	1.673GluPhe: 1.673 ± 0.047	3.31GluGly: 3.31 ± 0.07	1.298GluHis: 1.298 ± 0.039	3.574GluIle: 3.574 ± 0.065	3.274GluLys: 3.274 ± 0.072	5.656GluLeu: 5.656 ± 0.096	1.736GluMet: 1.736 ± 0.046	2.504GluAsn: 2.504 ± 0.056	1.861GluPro: 1.861 ± 0.047	3.241GluGln: 3.241 ± 0.068	3.698GluArg: 3.698 ± 0.063	3.061GluSer: 3.061 ± 0.059	2.806GluThr: 2.806 ± 0.06	3.701GluVal: 3.701 ± 0.073	0.684GluTrp: 0.684 ± 0.027	1.427GluTyr: 1.427 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.291PheAla: 3.291 ± 0.064	0.56PheCys: 0.56 ± 0.025	2.286PheAsp: 2.286 ± 0.048	1.75PheGlu: 1.75 ± 0.05	1.648PhePhe: 1.648 ± 0.052	2.93PheGly: 2.93 ± 0.058	0.831PheHis: 0.831 ± 0.033	2.678PheIle: 2.678 ± 0.06	1.291PheLys: 1.291 ± 0.046	3.239PheLeu: 3.239 ± 0.075	0.948PheMet: 0.948 ± 0.032	1.918PheAsn: 1.918 ± 0.04	1.458PhePro: 1.458 ± 0.041	1.204PheGln: 1.204 ± 0.035	1.879PheArg: 1.879 ± 0.042	3.358PheSer: 3.358 ± 0.058	2.229PheThr: 2.229 ± 0.046	2.258PheVal: 2.258 ± 0.053	0.576PheTrp: 0.576 ± 0.028	1.245PheTyr: 1.245 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.085GlyAla: 6.085 ± 0.085	1.039GlyCys: 1.039 ± 0.032	3.735GlyAsp: 3.735 ± 0.073	4.316GlyGlu: 4.316 ± 0.072	3.123GlyPhe: 3.123 ± 0.057	5.265GlyGly: 5.265 ± 0.112	1.621GlyHis: 1.621 ± 0.041	4.918GlyIle: 4.918 ± 0.073	3.973GlyLys: 3.973 ± 0.067	7.172GlyLeu: 7.172 ± 0.093	2.27GlyMet: 2.27 ± 0.049	2.953GlyAsn: 2.953 ± 0.062	1.976GlyPro: 1.976 ± 0.04	2.973GlyGln: 2.973 ± 0.066	4.009GlyArg: 4.009 ± 0.079	4.372GlySer: 4.372 ± 0.074	3.47GlyThr: 3.47 ± 0.074	5.438GlyVal: 5.438 ± 0.087	1.241GlyTrp: 1.241 ± 0.043	2.494GlyTyr: 2.494 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.907HisAla: 1.907 ± 0.043	0.358HisCys: 0.358 ± 0.017	1.162HisAsp: 1.162 ± 0.039	1.064HisGlu: 1.064 ± 0.031	1.067HisPhe: 1.067 ± 0.034	1.643HisGly: 1.643 ± 0.043	0.773HisHis: 0.773 ± 0.033	1.371HisIle: 1.371 ± 0.036	0.785HisLys: 0.785 ± 0.028	2.368HisLeu: 2.368 ± 0.056	0.542HisMet: 0.542 ± 0.023	0.903HisAsn: 0.903 ± 0.026	1.347HisPro: 1.347 ± 0.037	1.348HisGln: 1.348 ± 0.041	1.369HisArg: 1.369 ± 0.037	1.392HisSer: 1.392 ± 0.036	1.028HisThr: 1.028 ± 0.033	1.246HisVal: 1.246 ± 0.037	0.419HisTrp: 0.419 ± 0.02	0.924HisTyr: 0.924 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.383IleAla: 6.383 ± 0.09	0.767IleCys: 0.767 ± 0.031	3.887IleAsp: 3.887 ± 0.06	3.523IleGlu: 3.523 ± 0.07	2.103IlePhe: 2.103 ± 0.057	4.649IleGly: 4.649 ± 0.086	1.275IleHis: 1.275 ± 0.035	3.658IleIle: 3.658 ± 0.068	2.666IleLys: 2.666 ± 0.056	5.183IleLeu: 5.183 ± 0.079	1.376IleMet: 1.376 ± 0.039	3.023IleAsn: 3.023 ± 0.059	2.786IlePro: 2.786 ± 0.057	1.972IleGln: 1.972 ± 0.043	3.239IleArg: 3.239 ± 0.053	4.439IleSer: 4.439 ± 0.075	3.61IleThr: 3.61 ± 0.076	3.843IleVal: 3.843 ± 0.071	0.714IleTrp: 0.714 ± 0.03	1.606IleTyr: 1.606 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.979LysAla: 3.979 ± 0.085	0.269LysCys: 0.269 ± 0.018	2.124LysAsp: 2.124 ± 0.05	2.402LysGlu: 2.402 ± 0.065	1.174LysPhe: 1.174 ± 0.039	2.889LysGly: 2.889 ± 0.057	0.856LysHis: 0.856 ± 0.036	2.528LysIle: 2.528 ± 0.06	2.49LysLys: 2.49 ± 0.061	4.372LysLeu: 4.372 ± 0.074	1.272LysMet: 1.272 ± 0.04	2.034LysAsn: 2.034 ± 0.055	2.097LysPro: 2.097 ± 0.049	2.136LysGln: 2.136 ± 0.059	2.635LysArg: 2.635 ± 0.055	2.596LysSer: 2.596 ± 0.064	2.523LysThr: 2.523 ± 0.049	2.858LysVal: 2.858 ± 0.055	0.417LysTrp: 0.417 ± 0.024	1.18LysTyr: 1.18 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.986LeuAla: 10.986 ± 0.13	1.274LeuCys: 1.274 ± 0.037	5.487LeuAsp: 5.487 ± 0.083	5.242LeuGlu: 5.242 ± 0.089	4.13LeuPhe: 4.13 ± 0.084	6.795LeuGly: 6.795 ± 0.089	2.361LeuHis: 2.361 ± 0.047	6.55LeuIle: 6.55 ± 0.108	4.716LeuLys: 4.716 ± 0.077	11.895LeuLeu: 11.895 ± 0.181	3.073LeuMet: 3.073 ± 0.055	4.699LeuAsn: 4.699 ± 0.083	5.684LeuPro: 5.684 ± 0.09	4.619LeuGln: 4.619 ± 0.08	6.467LeuArg: 6.467 ± 0.098	7.976LeuSer: 7.976 ± 0.102	6.33LeuThr: 6.33 ± 0.088	6.709LeuVal: 6.709 ± 0.105	1.372LeuTrp: 1.372 ± 0.039	2.667LeuTyr: 2.667 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.761MetAla: 2.761 ± 0.05	0.194MetCys: 0.194 ± 0.014	1.148MetAsp: 1.148 ± 0.036	1.22MetGlu: 1.22 ± 0.036	0.832MetPhe: 0.832 ± 0.029	1.76MetGly: 1.76 ± 0.039	0.577MetHis: 0.577 ± 0.024	1.512MetIle: 1.512 ± 0.041	1.372MetLys: 1.372 ± 0.035	3.333MetLeu: 3.333 ± 0.069	0.897MetMet: 0.897 ± 0.033	1.121MetAsn: 1.121 ± 0.031	1.343MetPro: 1.343 ± 0.033	1.309MetGln: 1.309 ± 0.038	1.633MetArg: 1.633 ± 0.043	1.948MetSer: 1.948 ± 0.044	1.7MetThr: 1.7 ± 0.041	1.85MetVal: 1.85 ± 0.045	0.21MetTrp: 0.21 ± 0.014	0.457MetTyr: 0.457 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.795AsnAla: 3.795 ± 0.069	0.378AsnCys: 0.378 ± 0.02	2.217AsnAsp: 2.217 ± 0.048	2.068AsnGlu: 2.068 ± 0.058	1.455AsnPhe: 1.455 ± 0.037	3.181AsnGly: 3.181 ± 0.068	0.943AsnHis: 0.943 ± 0.032	2.509AsnIle: 2.509 ± 0.053	1.814AsnLys: 1.814 ± 0.047	3.873AsnLeu: 3.873 ± 0.063	1.005AsnMet: 1.005 ± 0.03	2.034AsnAsn: 2.034 ± 0.073	2.172AsnPro: 2.172 ± 0.048	1.904AsnGln: 1.904 ± 0.051	2.194AsnArg: 2.194 ± 0.049	2.465AsnSer: 2.465 ± 0.065	2.102AsnThr: 2.102 ± 0.059	2.689AsnVal: 2.689 ± 0.06	0.577AsnTrp: 0.577 ± 0.025	1.266AsnTyr: 1.266 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.213ProAla: 4.213 ± 0.072	0.425ProCys: 0.425 ± 0.021	2.864ProAsp: 2.864 ± 0.058	3.067ProGlu: 3.067 ± 0.059	1.738ProPhe: 1.738 ± 0.044	3.614ProGly: 3.614 ± 0.079	1.035ProHis: 1.035 ± 0.033	1.89ProIle: 1.89 ± 0.043	1.383ProLys: 1.383 ± 0.042	5.118ProLeu: 5.118 ± 0.085	1.013ProMet: 1.013 ± 0.035	1.266ProAsn: 1.266 ± 0.037	1.725ProPro: 1.725 ± 0.047	2.281ProGln: 2.281 ± 0.054	2.017ProArg: 2.017 ± 0.057	2.236ProSer: 2.236 ± 0.049	2.064ProThr: 2.064 ± 0.041	3.745ProVal: 3.745 ± 0.068	0.736ProTrp: 0.736 ± 0.028	1.185ProTyr: 1.185 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.708GlnAla: 4.708 ± 0.088	0.395GlnCys: 0.395 ± 0.022	1.921GlnAsp: 1.921 ± 0.049	2.041GlnGlu: 2.041 ± 0.053	1.493GlnPhe: 1.493 ± 0.038	3.177GlnGly: 3.177 ± 0.057	1.38GlnHis: 1.38 ± 0.038	2.588GlnIle: 2.588 ± 0.046	1.794GlnLys: 1.794 ± 0.041	5.499GlnLeu: 5.499 ± 0.093	1.266GlnMet: 1.266 ± 0.033	1.588GlnAsn: 1.588 ± 0.044	2.346GlnPro: 2.346 ± 0.054	3.723GlnGln: 3.723 ± 0.098	3.466GlnArg: 3.466 ± 0.077	2.596GlnSer: 2.596 ± 0.06	2.216GlnThr: 2.216 ± 0.052	3.022GlnVal: 3.022 ± 0.062	0.6GlnTrp: 0.6 ± 0.021	1.174GlnTyr: 1.174 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.689ArgAla: 4.689 ± 0.08	0.661ArgCys: 0.661 ± 0.028	3.213ArgAsp: 3.213 ± 0.066	3.641ArgGlu: 3.641 ± 0.07	2.662ArgPhe: 2.662 ± 0.051	3.497ArgGly: 3.497 ± 0.071	1.637ArgHis: 1.637 ± 0.047	3.617ArgIle: 3.617 ± 0.064	2.492ArgLys: 2.492 ± 0.051	6.971ArgLeu: 6.971 ± 0.112	1.567ArgMet: 1.567 ± 0.042	2.186ArgAsn: 2.186 ± 0.046	2.276ArgPro: 2.276 ± 0.051	3.508ArgGln: 3.508 ± 0.071	3.882ArgArg: 3.882 ± 0.086	3.079ArgSer: 3.079 ± 0.07	2.545ArgThr: 2.545 ± 0.052	3.879ArgVal: 3.879 ± 0.064	1.024ArgTrp: 1.024 ± 0.035	2.195ArgTyr: 2.195 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	6.147SerAla: 6.147 ± 0.084	0.637SerCys: 0.637 ± 0.028	3.476SerAsp: 3.476 ± 0.064	3.486SerGlu: 3.486 ± 0.06	2.345SerPhe: 2.345 ± 0.054	5.558SerGly: 5.558 ± 0.094	1.599SerHis: 1.599 ± 0.037	3.322SerIle: 3.322 ± 0.059	2.298SerLys: 2.298 ± 0.06	7.278SerLeu: 7.278 ± 0.094	1.553SerMet: 1.553 ± 0.038	2.247SerAsn: 2.247 ± 0.054	2.557SerPro: 2.557 ± 0.052	2.839SerGln: 2.839 ± 0.055	3.661SerArg: 3.661 ± 0.067	4.045SerSer: 4.045 ± 0.082	3.208SerThr: 3.208 ± 0.065	4.419SerVal: 4.419 ± 0.067	1.055SerTrp: 1.055 ± 0.033	1.776SerTyr: 1.776 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.764ThrAla: 4.764 ± 0.074	0.511ThrCys: 0.511 ± 0.022	2.464ThrAsp: 2.464 ± 0.053	2.415ThrGlu: 2.415 ± 0.052	1.98ThrPhe: 1.98 ± 0.044	4.43ThrGly: 4.43 ± 0.071	1.212ThrHis: 1.212 ± 0.034	2.913ThrIle: 2.913 ± 0.058	1.545ThrLys: 1.545 ± 0.048	7.288ThrLeu: 7.288 ± 0.097	1.111ThrMet: 1.111 ± 0.035	1.737ThrAsn: 1.737 ± 0.049	3.054ThrPro: 3.054 ± 0.053	2.205ThrGln: 2.205 ± 0.049	3.053ThrArg: 3.053 ± 0.056	3.133ThrSer: 3.133 ± 0.064	2.702ThrThr: 2.702 ± 0.06	3.623ThrVal: 3.623 ± 0.07	0.661ThrTrp: 0.661 ± 0.028	1.111ThrTyr: 1.111 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.358ValAla: 6.358 ± 0.091	0.732ValCys: 0.732 ± 0.029	3.726ValAsp: 3.726 ± 0.072	3.703ValGlu: 3.703 ± 0.069	2.35ValPhe: 2.35 ± 0.056	4.497ValGly: 4.497 ± 0.088	1.23ValHis: 1.23 ± 0.038	4.58ValIle: 4.58 ± 0.073	3.102ValLys: 3.102 ± 0.066	6.89ValLeu: 6.89 ± 0.108	2.124ValMet: 2.124 ± 0.047	2.867ValAsn: 2.867 ± 0.063	2.855ValPro: 2.855 ± 0.062	2.367ValGln: 2.367 ± 0.059	3.773ValArg: 3.773 ± 0.072	4.659ValSer: 4.659 ± 0.073	4.073ValThr: 4.073 ± 0.069	4.939ValVal: 4.939 ± 0.08	0.851ValTrp: 0.851 ± 0.031	1.611ValTyr: 1.611 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.914TrpAla: 0.914 ± 0.033	0.216TrpCys: 0.216 ± 0.015	0.612TrpAsp: 0.612 ± 0.027	0.502TrpGlu: 0.502 ± 0.021	0.646TrpPhe: 0.646 ± 0.027	0.795TrpGly: 0.795 ± 0.031	0.467TrpHis: 0.467 ± 0.023	0.738TrpIle: 0.738 ± 0.031	0.504TrpLys: 0.504 ± 0.023	2.258TrpLeu: 2.258 ± 0.068	0.401TrpMet: 0.401 ± 0.019	0.48TrpAsn: 0.48 ± 0.024	0.644TrpPro: 0.644 ± 0.027	1.211TrpGln: 1.211 ± 0.044	1.131TrpArg: 1.131 ± 0.037	0.789TrpSer: 0.789 ± 0.027	0.441TrpThr: 0.441 ± 0.024	0.807TrpVal: 0.807 ± 0.029	0.203TrpTrp: 0.203 ± 0.014	0.411TrpTyr: 0.411 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.369TyrAla: 2.369 ± 0.052	0.382TyrCys: 0.382 ± 0.02	1.58TyrAsp: 1.58 ± 0.052	1.208TyrGlu: 1.208 ± 0.037	1.131TyrPhe: 1.131 ± 0.035	2.155TyrGly: 2.155 ± 0.046	0.756TyrHis: 0.756 ± 0.029	1.472TyrIle: 1.472 ± 0.043	0.972TyrLys: 0.972 ± 0.039	3.052TyrLeu: 3.052 ± 0.058	0.59TyrMet: 0.59 ± 0.025	1.157TyrAsn: 1.157 ± 0.04	1.321TyrPro: 1.321 ± 0.04	1.71TyrGln: 1.71 ± 0.047	1.949TyrArg: 1.949 ± 0.047	1.795TyrSer: 1.795 ± 0.044	1.384TyrThr: 1.384 ± 0.039	1.616TyrVal: 1.616 ± 0.043	0.42TyrTrp: 0.42 ± 0.023	0.921TyrTyr: 0.921 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3234 proteins (978745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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