Amino acid dipepetide frequency for Brevundimonas sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.945AlaAla: 20.945 ± 0.234	1.175AlaCys: 1.175 ± 0.042	8.3AlaAsp: 8.3 ± 0.127	8.314AlaGlu: 8.314 ± 0.126	4.796AlaPhe: 4.796 ± 0.085	11.993AlaGly: 11.993 ± 0.136	2.304AlaHis: 2.304 ± 0.056	5.45AlaIle: 5.45 ± 0.088	3.258AlaLys: 3.258 ± 0.072	14.957AlaLeu: 14.957 ± 0.144	3.647AlaMet: 3.647 ± 0.066	2.745AlaAsn: 2.745 ± 0.062	7.671AlaPro: 7.671 ± 0.123	4.446AlaGln: 4.446 ± 0.081	11.146AlaArg: 11.146 ± 0.141	6.448AlaSer: 6.448 ± 0.096	6.617AlaThr: 6.617 ± 0.098	10.713AlaVal: 10.713 ± 0.133	1.934AlaTrp: 1.934 ± 0.056	2.736AlaTyr: 2.736 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.04	0.067CysCys: 0.067 ± 0.009	0.483CysAsp: 0.483 ± 0.022	0.382CysGlu: 0.382 ± 0.021	0.24CysPhe: 0.24 ± 0.016	0.818CysGly: 0.818 ± 0.032	0.168CysHis: 0.168 ± 0.014	0.282CysIle: 0.282 ± 0.019	0.136CysLys: 0.136 ± 0.014	0.622CysLeu: 0.622 ± 0.027	0.109CysMet: 0.109 ± 0.011	0.157CysAsn: 0.157 ± 0.015	0.406CysPro: 0.406 ± 0.021	0.19CysGln: 0.19 ± 0.014	0.507CysArg: 0.507 ± 0.028	0.365CysSer: 0.365 ± 0.02	0.306CysThr: 0.306 ± 0.02	0.596CysVal: 0.596 ± 0.028	0.099CysTrp: 0.099 ± 0.011	0.126CysTyr: 0.126 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.426AspAla: 8.426 ± 0.123	0.407AspCys: 0.407 ± 0.026	3.645AspAsp: 3.645 ± 0.083	3.444AspGlu: 3.444 ± 0.069	2.103AspPhe: 2.103 ± 0.045	5.969AspGly: 5.969 ± 0.092	1.406AspHis: 1.406 ± 0.046	2.586AspIle: 2.586 ± 0.057	1.531AspLys: 1.531 ± 0.049	6.416AspLeu: 6.416 ± 0.093	1.313AspMet: 1.313 ± 0.034	1.211AspAsn: 1.211 ± 0.039	3.866AspPro: 3.866 ± 0.061	2.141AspGln: 2.141 ± 0.048	5.119AspArg: 5.119 ± 0.079	2.143AspSer: 2.143 ± 0.05	2.641AspThr: 2.641 ± 0.065	4.252AspVal: 4.252 ± 0.075	1.184AspTrp: 1.184 ± 0.04	1.568AspTyr: 1.568 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.791GluAla: 8.791 ± 0.105	0.247GluCys: 0.247 ± 0.018	2.796GluAsp: 2.796 ± 0.061	2.568GluGlu: 2.568 ± 0.066	1.449GluPhe: 1.449 ± 0.045	4.928GluGly: 4.928 ± 0.084	0.992GluHis: 0.992 ± 0.036	2.876GluIle: 2.876 ± 0.064	1.685GluLys: 1.685 ± 0.054	4.739GluLeu: 4.739 ± 0.086	1.312GluMet: 1.312 ± 0.04	1.165GluAsn: 1.165 ± 0.034	2.876GluPro: 2.876 ± 0.069	2.131GluGln: 2.131 ± 0.051	5.068GluArg: 5.068 ± 0.083	2.133GluSer: 2.133 ± 0.051	3.762GluThr: 3.762 ± 0.063	4.04GluVal: 4.04 ± 0.08	0.713GluTrp: 0.713 ± 0.03	0.871GluTyr: 0.871 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.483PheAla: 4.483 ± 0.08	0.312PheCys: 0.312 ± 0.019	2.758PheAsp: 2.758 ± 0.07	2.083PheGlu: 2.083 ± 0.046	1.114PhePhe: 1.114 ± 0.043	3.576PheGly: 3.576 ± 0.073	0.655PheHis: 0.655 ± 0.031	1.501PheIle: 1.501 ± 0.05	0.867PheLys: 0.867 ± 0.034	2.828PheLeu: 2.828 ± 0.063	0.787PheMet: 0.787 ± 0.029	0.945PheAsn: 0.945 ± 0.036	1.308PhePro: 1.308 ± 0.037	1.053PheGln: 1.053 ± 0.035	2.143PheArg: 2.143 ± 0.06	1.75PheSer: 1.75 ± 0.046	1.876PheThr: 1.876 ± 0.049	2.615PheVal: 2.615 ± 0.059	0.535PheTrp: 0.535 ± 0.028	0.83PheTyr: 0.83 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.915GlyAla: 11.915 ± 0.133	0.758GlyCys: 0.758 ± 0.03	5.314GlyAsp: 5.314 ± 0.101	5.216GlyGlu: 5.216 ± 0.095	3.525GlyPhe: 3.525 ± 0.074	8.676GlyGly: 8.676 ± 0.133	1.67GlyHis: 1.67 ± 0.049	2.872GlyIle: 2.872 ± 0.069	2.623GlyLys: 2.623 ± 0.064	9.753GlyLeu: 9.753 ± 0.124	2.268GlyMet: 2.268 ± 0.05	1.5GlyAsn: 1.5 ± 0.048	4.158GlyPro: 4.158 ± 0.074	3.4GlyGln: 3.4 ± 0.071	7.212GlyArg: 7.212 ± 0.103	4.33GlySer: 4.33 ± 0.083	3.391GlyThr: 3.391 ± 0.07	8.231GlyVal: 8.231 ± 0.106	1.742GlyTrp: 1.742 ± 0.051	2.173GlyTyr: 2.173 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.392HisAla: 2.392 ± 0.055	0.159HisCys: 0.159 ± 0.016	1.223HisAsp: 1.223 ± 0.046	1.04HisGlu: 1.04 ± 0.033	0.611HisPhe: 0.611 ± 0.028	1.821HisGly: 1.821 ± 0.045	0.439HisHis: 0.439 ± 0.022	0.719HisIle: 0.719 ± 0.027	0.387HisLys: 0.387 ± 0.022	1.731HisLeu: 1.731 ± 0.051	0.404HisMet: 0.404 ± 0.024	0.384HisAsn: 0.384 ± 0.022	1.243HisPro: 1.243 ± 0.039	0.553HisGln: 0.553 ± 0.022	1.285HisArg: 1.285 ± 0.046	0.76HisSer: 0.76 ± 0.03	0.76HisThr: 0.76 ± 0.031	1.342HisVal: 1.342 ± 0.039	0.276HisTrp: 0.276 ± 0.017	0.402HisTyr: 0.402 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.213IleAla: 6.213 ± 0.086	0.354IleCys: 0.354 ± 0.02	3.565IleAsp: 3.565 ± 0.067	3.278IleGlu: 3.278 ± 0.068	1.254IlePhe: 1.254 ± 0.05	4.413IleGly: 4.413 ± 0.084	0.847IleHis: 0.847 ± 0.034	1.712IleIle: 1.712 ± 0.047	1.129IleLys: 1.129 ± 0.038	3.809IleLeu: 3.809 ± 0.073	0.799IleMet: 0.799 ± 0.031	1.101IleAsn: 1.101 ± 0.037	1.874IlePro: 1.874 ± 0.044	1.306IleGln: 1.306 ± 0.042	2.967IleArg: 2.967 ± 0.059	2.177IleSer: 2.177 ± 0.058	2.285IleThr: 2.285 ± 0.053	3.573IleVal: 3.573 ± 0.073	0.513IleTrp: 0.513 ± 0.024	0.805IleTyr: 0.805 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.208LysAla: 4.208 ± 0.085	0.098LysCys: 0.098 ± 0.01	1.505LysAsp: 1.505 ± 0.047	1.083LysGlu: 1.083 ± 0.039	0.684LysPhe: 0.684 ± 0.028	2.436LysGly: 2.436 ± 0.059	0.506LysHis: 0.506 ± 0.025	1.225LysIle: 1.225 ± 0.045	0.956LysLys: 0.956 ± 0.044	2.496LysLeu: 2.496 ± 0.059	0.542LysMet: 0.542 ± 0.03	0.581LysAsn: 0.581 ± 0.027	1.771LysPro: 1.771 ± 0.054	0.762LysGln: 0.762 ± 0.033	2.017LysArg: 2.017 ± 0.045	1.406LysSer: 1.406 ± 0.049	1.75LysThr: 1.75 ± 0.053	2.108LysVal: 2.108 ± 0.062	0.321LysTrp: 0.321 ± 0.02	0.519LysTyr: 0.519 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.769LeuAla: 13.769 ± 0.17	0.716LeuCys: 0.716 ± 0.031	6.377LeuAsp: 6.377 ± 0.098	5.118LeuGlu: 5.118 ± 0.086	3.438LeuPhe: 3.438 ± 0.076	8.163LeuGly: 8.163 ± 0.094	1.652LeuHis: 1.652 ± 0.049	5.234LeuIle: 5.234 ± 0.09	3.667LeuLys: 3.667 ± 0.06	8.538LeuLeu: 8.538 ± 0.129	2.423LeuMet: 2.423 ± 0.052	2.896LeuAsn: 2.896 ± 0.06	5.057LeuPro: 5.057 ± 0.099	2.664LeuGln: 2.664 ± 0.058	6.533LeuArg: 6.533 ± 0.1	6.1LeuSer: 6.1 ± 0.079	6.765LeuThr: 6.765 ± 0.093	6.413LeuVal: 6.413 ± 0.086	1.271LeuTrp: 1.271 ± 0.044	1.961LeuTyr: 1.961 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.424MetAla: 3.424 ± 0.072	0.106MetCys: 0.106 ± 0.011	1.232MetAsp: 1.232 ± 0.039	1.004MetGlu: 1.004 ± 0.034	0.663MetPhe: 0.663 ± 0.03	2.01MetGly: 2.01 ± 0.051	0.351MetHis: 0.351 ± 0.02	1.243MetIle: 1.243 ± 0.039	0.938MetLys: 0.938 ± 0.034	2.089MetLeu: 2.089 ± 0.055	0.557MetMet: 0.557 ± 0.029	0.669MetAsn: 0.669 ± 0.028	1.166MetPro: 1.166 ± 0.034	0.725MetGln: 0.725 ± 0.029	1.81MetArg: 1.81 ± 0.044	1.483MetSer: 1.483 ± 0.044	2.029MetThr: 2.029 ± 0.041	1.494MetVal: 1.494 ± 0.048	0.205MetTrp: 0.205 ± 0.017	0.237MetTyr: 0.237 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.144AsnAla: 3.144 ± 0.072	0.169AsnCys: 0.169 ± 0.014	1.321AsnAsp: 1.321 ± 0.044	1.009AsnGlu: 1.009 ± 0.034	0.695AsnPhe: 0.695 ± 0.031	2.192AsnGly: 2.192 ± 0.053	0.431AsnHis: 0.431 ± 0.025	1.049AsnIle: 1.049 ± 0.042	0.467AsnLys: 0.467 ± 0.022	2.321AsnLeu: 2.321 ± 0.051	0.457AsnMet: 0.457 ± 0.025	0.587AsnAsn: 0.587 ± 0.033	1.777AsnPro: 1.777 ± 0.05	0.667AsnGln: 0.667 ± 0.032	1.688AsnArg: 1.688 ± 0.047	1.02AsnSer: 1.02 ± 0.038	1.168AsnThr: 1.168 ± 0.044	1.822AsnVal: 1.822 ± 0.053	0.343AsnTrp: 0.343 ± 0.024	0.544AsnTyr: 0.544 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.506ProAla: 7.506 ± 0.106	0.351ProCys: 0.351 ± 0.02	4.069ProAsp: 4.069 ± 0.078	3.498ProGlu: 3.498 ± 0.079	1.985ProPhe: 1.985 ± 0.049	5.051ProGly: 5.051 ± 0.086	0.984ProHis: 0.984 ± 0.036	2.195ProIle: 2.195 ± 0.048	1.279ProLys: 1.279 ± 0.043	4.689ProLeu: 4.689 ± 0.08	1.179ProMet: 1.179 ± 0.042	1.284ProAsn: 1.284 ± 0.039	2.913ProPro: 2.913 ± 0.079	1.719ProGln: 1.719 ± 0.047	3.448ProArg: 3.448 ± 0.074	2.809ProSer: 2.809 ± 0.058	2.966ProThr: 2.966 ± 0.057	4.574ProVal: 4.574 ± 0.095	0.813ProTrp: 0.813 ± 0.03	1.113ProTyr: 1.113 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	5.132GlnAla: 5.132 ± 0.083	0.146GlnCys: 0.146 ± 0.014	1.607GlnAsp: 1.607 ± 0.054	1.306GlnGlu: 1.306 ± 0.041	0.902GlnPhe: 0.902 ± 0.034	2.834GlnGly: 2.834 ± 0.068	0.524GlnHis: 0.524 ± 0.025	1.552GlnIle: 1.552 ± 0.045	0.864GlnLys: 0.864 ± 0.033	2.698GlnLeu: 2.698 ± 0.06	0.851GlnMet: 0.851 ± 0.03	0.794GlnAsn: 0.794 ± 0.037	1.963GlnPro: 1.963 ± 0.049	1.056GlnGln: 1.056 ± 0.045	2.38GlnArg: 2.38 ± 0.064	1.672GlnSer: 1.672 ± 0.044	2.062GlnThr: 2.062 ± 0.055	2.406GlnVal: 2.406 ± 0.057	0.407GlnTrp: 0.407 ± 0.023	0.536GlnTyr: 0.536 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	9.761ArgAla: 9.761 ± 0.135	0.433ArgCys: 0.433 ± 0.026	4.488ArgAsp: 4.488 ± 0.071	4.012ArgGlu: 4.012 ± 0.082	3.009ArgPhe: 3.009 ± 0.065	5.507ArgGly: 5.507 ± 0.092	1.367ArgHis: 1.367 ± 0.037	3.824ArgIle: 3.824 ± 0.067	1.935ArgLys: 1.935 ± 0.05	9.068ArgLeu: 9.068 ± 0.131	1.985ArgMet: 1.985 ± 0.046	1.571ArgAsn: 1.571 ± 0.048	4.446ArgPro: 4.446 ± 0.073	2.494ArgGln: 2.494 ± 0.057	6.629ArgArg: 6.629 ± 0.114	3.45ArgSer: 3.45 ± 0.07	3.822ArgThr: 3.822 ± 0.074	5.305ArgVal: 5.305 ± 0.086	1.277ArgTrp: 1.277 ± 0.042	1.738ArgTyr: 1.738 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.542SerAla: 6.542 ± 0.086	0.299SerCys: 0.299 ± 0.018	2.968SerAsp: 2.968 ± 0.061	2.392SerGlu: 2.392 ± 0.051	1.69SerPhe: 1.69 ± 0.044	5.191SerGly: 5.191 ± 0.094	0.903SerHis: 0.903 ± 0.031	2.168SerIle: 2.168 ± 0.058	1.2SerLys: 1.2 ± 0.041	4.929SerLeu: 4.929 ± 0.078	1.129SerMet: 1.129 ± 0.036	1.254SerAsn: 1.254 ± 0.041	2.973SerPro: 2.973 ± 0.06	1.522SerGln: 1.522 ± 0.048	3.549SerArg: 3.549 ± 0.07	2.503SerSer: 2.503 ± 0.064	2.478SerThr: 2.478 ± 0.066	3.667SerVal: 3.667 ± 0.072	0.69SerTrp: 0.69 ± 0.028	1.088SerTyr: 1.088 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	7.2ThrAla: 7.2 ± 0.099	0.351ThrCys: 0.351 ± 0.022	3.17ThrAsp: 3.17 ± 0.061	2.468ThrGlu: 2.468 ± 0.054	1.824ThrPhe: 1.824 ± 0.046	5.638ThrGly: 5.638 ± 0.095	0.928ThrHis: 0.928 ± 0.035	2.107ThrIle: 2.107 ± 0.048	1.082ThrLys: 1.082 ± 0.03	5.995ThrLeu: 5.995 ± 0.08	0.987ThrMet: 0.987 ± 0.038	1.226ThrAsn: 1.226 ± 0.045	4.159ThrPro: 4.159 ± 0.063	1.495ThrGln: 1.495 ± 0.042	3.766ThrArg: 3.766 ± 0.081	2.45ThrSer: 2.45 ± 0.062	3.002ThrThr: 3.002 ± 0.086	4.637ThrVal: 4.637 ± 0.073	0.675ThrTrp: 0.675 ± 0.032	1.178ThrTyr: 1.178 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	10.412ValAla: 10.412 ± 0.115	0.655ValCys: 0.655 ± 0.029	4.297ValAsp: 4.297 ± 0.074	5.092ValGlu: 5.092 ± 0.08	2.745ValPhe: 2.745 ± 0.06	6.241ValGly: 6.241 ± 0.092	1.24ValHis: 1.24 ± 0.037	3.939ValIle: 3.939 ± 0.074	2.072ValLys: 2.072 ± 0.054	7.338ValLeu: 7.338 ± 0.095	1.905ValMet: 1.905 ± 0.052	1.891ValAsn: 1.891 ± 0.058	3.044ValPro: 3.044 ± 0.061	2.311ValGln: 2.311 ± 0.053	5.692ValArg: 5.692 ± 0.078	4.161ValSer: 4.161 ± 0.081	4.813ValThr: 4.813 ± 0.083	6.709ValVal: 6.709 ± 0.103	1.154ValTrp: 1.154 ± 0.039	1.407ValTyr: 1.407 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.682TrpAla: 1.682 ± 0.045	0.119TrpCys: 0.119 ± 0.012	0.697TrpAsp: 0.697 ± 0.031	0.576TrpGlu: 0.576 ± 0.028	0.537TrpPhe: 0.537 ± 0.027	1.114TrpGly: 1.114 ± 0.045	0.212TrpHis: 0.212 ± 0.015	0.758TrpIle: 0.758 ± 0.033	0.464TrpLys: 0.464 ± 0.022	1.74TrpLeu: 1.74 ± 0.044	0.41TrpMet: 0.41 ± 0.023	0.427TrpAsn: 0.427 ± 0.024	0.785TrpPro: 0.785 ± 0.03	0.394TrpGln: 0.394 ± 0.024	1.476TrpArg: 1.476 ± 0.049	0.941TrpSer: 0.941 ± 0.033	1.022TrpThr: 1.022 ± 0.038	0.89TrpVal: 0.89 ± 0.035	0.27TrpTrp: 0.27 ± 0.019	0.231TrpTyr: 0.231 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.609TyrAla: 2.609 ± 0.058	0.178TyrCys: 0.178 ± 0.014	1.557TyrAsp: 1.557 ± 0.051	1.257TyrGlu: 1.257 ± 0.043	0.753TyrPhe: 0.753 ± 0.03	2.158TyrGly: 2.158 ± 0.051	0.353TyrHis: 0.353 ± 0.02	0.687TyrIle: 0.687 ± 0.029	0.432TyrLys: 0.432 ± 0.02	1.998TyrLeu: 1.998 ± 0.056	0.372TyrMet: 0.372 ± 0.02	0.483TyrAsn: 0.483 ± 0.026	0.971TyrPro: 0.971 ± 0.034	0.663TyrGln: 0.663 ± 0.031	1.684TyrArg: 1.684 ± 0.051	1.036TyrSer: 1.036 ± 0.034	0.821TyrThr: 0.821 ± 0.032	1.73TyrVal: 1.73 ± 0.046	0.321TyrTrp: 0.321 ± 0.023	0.465TyrTyr: 0.465 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2819 proteins (847357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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