Amino acid dipepetide frequency for Vibrio maritimus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.895AlaAla: 7.895 ± 0.082
0.896AlaCys: 0.896 ± 0.025
4.469AlaAsp: 4.469 ± 0.053
5.449AlaGlu: 5.449 ± 0.063
3.536AlaPhe: 3.536 ± 0.05
5.879AlaGly: 5.879 ± 0.062
1.632AlaHis: 1.632 ± 0.037
6.241AlaIle: 6.241 ± 0.075
4.915AlaLys: 4.915 ± 0.062
9.869AlaLeu: 9.869 ± 0.096
2.951AlaMet: 2.951 ± 0.046
3.649AlaAsn: 3.649 ± 0.055
3.074AlaPro: 3.074 ± 0.051
3.687AlaGln: 3.687 ± 0.062
3.505AlaArg: 3.505 ± 0.053
5.767AlaSer: 5.767 ± 0.062
4.92AlaThr: 4.92 ± 0.05
6.003AlaVal: 6.003 ± 0.062
0.991AlaTrp: 0.991 ± 0.027
2.297AlaTyr: 2.297 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
0.776CysAla: 0.776 ± 0.022
0.18CysCys: 0.18 ± 0.012
0.6CysAsp: 0.6 ± 0.021
0.59CysGlu: 0.59 ± 0.02
0.45CysPhe: 0.45 ± 0.017
0.906CysGly: 0.906 ± 0.029
0.348CysHis: 0.348 ± 0.018
0.595CysIle: 0.595 ± 0.021
0.404CysLys: 0.404 ± 0.018
0.962CysLeu: 0.962 ± 0.023
0.295CysMet: 0.295 ± 0.013
0.327CysAsn: 0.327 ± 0.016
0.415CysPro: 0.415 ± 0.019
0.442CysGln: 0.442 ± 0.019
0.462CysArg: 0.462 ± 0.018
0.727CysSer: 0.727 ± 0.024
0.492CysThr: 0.492 ± 0.017
0.682CysVal: 0.682 ± 0.021
0.139CysTrp: 0.139 ± 0.009
0.316CysTyr: 0.316 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.552AspAla: 4.552 ± 0.06
0.501AspCys: 0.501 ± 0.018
3.032AspAsp: 3.032 ± 0.055
3.806AspGlu: 3.806 ± 0.061
2.447AspPhe: 2.447 ± 0.039
4.036AspGly: 4.036 ± 0.109
1.081AspHis: 1.081 ± 0.028
3.971AspIle: 3.971 ± 0.055
3.123AspLys: 3.123 ± 0.047
5.053AspLeu: 5.053 ± 0.073
1.449AspMet: 1.449 ± 0.031
2.595AspAsn: 2.595 ± 0.05
2.027AspPro: 2.027 ± 0.037
1.828AspGln: 1.828 ± 0.034
2.19AspArg: 2.19 ± 0.041
3.51AspSer: 3.51 ± 0.053
2.874AspThr: 2.874 ± 0.048
4.22AspVal: 4.22 ± 0.074
0.886AspTrp: 0.886 ± 0.024
2.133AspTyr: 2.133 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.419GluAla: 5.419 ± 0.074
0.511GluCys: 0.511 ± 0.021
2.938GluAsp: 2.938 ± 0.063
3.767GluGlu: 3.767 ± 0.051
2.523GluPhe: 2.523 ± 0.043
3.708GluGly: 3.708 ± 0.051
1.626GluHis: 1.626 ± 0.034
3.525GluIle: 3.525 ± 0.06
3.594GluLys: 3.594 ± 0.052
7.11GluLeu: 7.11 ± 0.066
1.668GluMet: 1.668 ± 0.031
2.567GluAsn: 2.567 ± 0.043
2.131GluPro: 2.131 ± 0.042
3.98GluGln: 3.98 ± 0.056
3.466GluArg: 3.466 ± 0.055
3.933GluSer: 3.933 ± 0.057
3.254GluThr: 3.254 ± 0.044
4.481GluVal: 4.481 ± 0.053
0.808GluTrp: 0.808 ± 0.026
1.726GluTyr: 1.726 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.775PheAla: 3.775 ± 0.054
0.485PheCys: 0.485 ± 0.016
2.858PheAsp: 2.858 ± 0.047
2.701PheGlu: 2.701 ± 0.039
1.647PhePhe: 1.647 ± 0.039
3.443PheGly: 3.443 ± 0.05
0.853PheHis: 0.853 ± 0.023
2.619PheIle: 2.619 ± 0.048
1.843PheLys: 1.843 ± 0.036
3.353PheLeu: 3.353 ± 0.058
1.086PheMet: 1.086 ± 0.03
1.976PheAsn: 1.976 ± 0.038
1.376PhePro: 1.376 ± 0.024
1.323PheGln: 1.323 ± 0.029
1.468PheArg: 1.468 ± 0.031
3.227PheSer: 3.227 ± 0.049
2.449PheThr: 2.449 ± 0.055
3.113PheVal: 3.113 ± 0.052
0.553PheTrp: 0.553 ± 0.022
1.295PheTyr: 1.295 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.598GlyAla: 5.598 ± 0.06
0.884GlyCys: 0.884 ± 0.025
3.8GlyAsp: 3.8 ± 0.079
4.476GlyGlu: 4.476 ± 0.05
3.338GlyPhe: 3.338 ± 0.049
4.979GlyGly: 4.979 ± 0.072
1.576GlyHis: 1.576 ± 0.037
4.616GlyIle: 4.616 ± 0.059
3.81GlyLys: 3.81 ± 0.055
6.912GlyLeu: 6.912 ± 0.078
2.19GlyMet: 2.19 ± 0.043
2.641GlyAsn: 2.641 ± 0.046
1.496GlyPro: 1.496 ± 0.031
2.835GlyGln: 2.835 ± 0.041
2.964GlyArg: 2.964 ± 0.044
4.339GlySer: 4.339 ± 0.049
3.687GlyThr: 3.687 ± 0.071
5.501GlyVal: 5.501 ± 0.059
0.98GlyTrp: 0.98 ± 0.028
2.647GlyTyr: 2.647 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.641HisAla: 1.641 ± 0.026
0.306HisCys: 0.306 ± 0.014
1.158HisAsp: 1.158 ± 0.034
1.094HisGlu: 1.094 ± 0.027
1.051HisPhe: 1.051 ± 0.025
1.533HisGly: 1.533 ± 0.032
0.737HisHis: 0.737 ± 0.025
1.349HisIle: 1.349 ± 0.028
1.037HisLys: 1.037 ± 0.027
2.224HisLeu: 2.224 ± 0.043
0.559HisMet: 0.559 ± 0.019
0.821HisAsn: 0.821 ± 0.024
1.094HisPro: 1.094 ± 0.027
1.16HisGln: 1.16 ± 0.027
1.053HisArg: 1.053 ± 0.025
1.432HisSer: 1.432 ± 0.029
1.103HisThr: 1.103 ± 0.027
1.351HisVal: 1.351 ± 0.03
0.359HisTrp: 0.359 ± 0.016
0.857HisTyr: 0.857 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.564IleAla: 6.564 ± 0.07
0.628IleCys: 0.628 ± 0.021
4.206IleAsp: 4.206 ± 0.056
4.767IleGlu: 4.767 ± 0.058
2.067IlePhe: 2.067 ± 0.043
4.772IleGly: 4.772 ± 0.06
1.188IleHis: 1.188 ± 0.026
3.4IleIle: 3.4 ± 0.056
2.982IleLys: 2.982 ± 0.044
4.983IleLeu: 4.983 ± 0.066
1.379IleMet: 1.379 ± 0.033
2.742IleAsn: 2.742 ± 0.042
2.634IlePro: 2.634 ± 0.039
2.238IleGln: 2.238 ± 0.036
2.624IleArg: 2.624 ± 0.042
4.278IleSer: 4.278 ± 0.05
3.713IleThr: 3.713 ± 0.054
4.309IleVal: 4.309 ± 0.059
0.648IleTrp: 0.648 ± 0.023
1.67IleTyr: 1.67 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.797LysAla: 4.797 ± 0.057
0.344LysCys: 0.344 ± 0.015
2.588LysAsp: 2.588 ± 0.048
3.114LysGlu: 3.114 ± 0.048
1.547LysPhe: 1.547 ± 0.03
3.3LysGly: 3.3 ± 0.052
1.311LysHis: 1.311 ± 0.031
2.497LysIle: 2.497 ± 0.039
2.668LysLys: 2.668 ± 0.045
5.288LysLeu: 5.288 ± 0.062
1.468LysMet: 1.468 ± 0.03
1.841LysAsn: 1.841 ± 0.038
2.48LysPro: 2.48 ± 0.048
3.009LysGln: 3.009 ± 0.049
2.807LysArg: 2.807 ± 0.041
3.048LysSer: 3.048 ± 0.049
2.819LysThr: 2.819 ± 0.047
3.87LysVal: 3.87 ± 0.053
0.626LysTrp: 0.626 ± 0.021
1.32LysTyr: 1.32 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
9.668LeuAla: 9.668 ± 0.091
1.101LeuCys: 1.101 ± 0.025
5.719LeuAsp: 5.719 ± 0.062
6.197LeuGlu: 6.197 ± 0.07
4.283LeuPhe: 4.283 ± 0.067
7.1LeuGly: 7.1 ± 0.072
1.898LeuHis: 1.898 ± 0.034
5.909LeuIle: 5.909 ± 0.072
5.091LeuLys: 5.091 ± 0.055
9.932LeuLeu: 9.932 ± 0.11
2.868LeuMet: 2.868 ± 0.048
4.473LeuAsn: 4.473 ± 0.053
4.604LeuPro: 4.604 ± 0.059
3.336LeuGln: 3.336 ± 0.054
4.127LeuArg: 4.127 ± 0.044
8.106LeuSer: 8.106 ± 0.086
6.151LeuThr: 6.151 ± 0.066
7.386LeuVal: 7.386 ± 0.077
1.049LeuTrp: 1.049 ± 0.027
2.536LeuTyr: 2.536 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.776MetAla: 2.776 ± 0.045
0.234MetCys: 0.234 ± 0.011
1.37MetAsp: 1.37 ± 0.03
1.374MetGlu: 1.374 ± 0.029
1.064MetPhe: 1.064 ± 0.029
1.907MetGly: 1.907 ± 0.039
0.519MetHis: 0.519 ± 0.02
1.616MetIle: 1.616 ± 0.033
1.58MetLys: 1.58 ± 0.033
3.015MetLeu: 3.015 ± 0.045
0.946MetMet: 0.946 ± 0.024
1.214MetAsn: 1.214 ± 0.029
1.314MetPro: 1.314 ± 0.027
1.133MetGln: 1.133 ± 0.027
1.233MetArg: 1.233 ± 0.026
2.209MetSer: 2.209 ± 0.041
1.885MetThr: 1.885 ± 0.041
2.127MetVal: 2.127 ± 0.042
0.284MetTrp: 0.284 ± 0.014
0.6MetTyr: 0.6 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.498AsnAla: 3.498 ± 0.053
0.36AsnCys: 0.36 ± 0.017
2.415AsnAsp: 2.415 ± 0.048
2.405AsnGlu: 2.405 ± 0.05
1.551AsnPhe: 1.551 ± 0.039
3.084AsnGly: 3.084 ± 0.063
0.998AsnHis: 0.998 ± 0.027
2.592AsnIle: 2.592 ± 0.042
2.101AsnLys: 2.101 ± 0.04
3.809AsnLeu: 3.809 ± 0.046
1.069AsnMet: 1.069 ± 0.025
1.841AsnAsn: 1.841 ± 0.04
2.057AsnPro: 2.057 ± 0.033
2.161AsnGln: 2.161 ± 0.034
1.921AsnArg: 1.921 ± 0.034
2.539AsnSer: 2.539 ± 0.042
2.231AsnThr: 2.231 ± 0.039
2.86AsnVal: 2.86 ± 0.04
0.602AsnTrp: 0.602 ± 0.019
1.365AsnTyr: 1.365 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
2.94ProAla: 2.94 ± 0.048
0.325ProCys: 0.325 ± 0.015
2.151ProAsp: 2.151 ± 0.038
3.192ProGlu: 3.192 ± 0.052
1.738ProPhe: 1.738 ± 0.04
2.16ProGly: 2.16 ± 0.038
0.818ProHis: 0.818 ± 0.023
2.558ProIle: 2.558 ± 0.049
1.98ProLys: 1.98 ± 0.037
3.975ProLeu: 3.975 ± 0.055
1.172ProMet: 1.172 ± 0.031
1.795ProAsn: 1.795 ± 0.039
1.128ProPro: 1.128 ± 0.026
1.52ProGln: 1.52 ± 0.031
1.318ProArg: 1.318 ± 0.031
2.663ProSer: 2.663 ± 0.041
2.358ProThr: 2.358 ± 0.039
3.046ProVal: 3.046 ± 0.045
0.506ProTrp: 0.506 ± 0.023
1.303ProTyr: 1.303 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.128GlnAla: 4.128 ± 0.062
0.395GlnCys: 0.395 ± 0.015
2.072GlnAsp: 2.072 ± 0.034
2.449GlnGlu: 2.449 ± 0.044
1.792GlnPhe: 1.792 ± 0.033
2.917GlnGly: 2.917 ± 0.053
1.115GlnHis: 1.115 ± 0.031
2.486GlnIle: 2.486 ± 0.039
2.072GlnLys: 2.072 ± 0.039
4.636GlnLeu: 4.636 ± 0.064
1.187GlnMet: 1.187 ± 0.027
1.58GlnAsn: 1.58 ± 0.03
1.647GlnPro: 1.647 ± 0.028
2.744GlnGln: 2.744 ± 0.056
2.232GlnArg: 2.232 ± 0.045
2.988GlnSer: 2.988 ± 0.052
2.427GlnThr: 2.427 ± 0.043
3.225GlnVal: 3.225 ± 0.046
0.647GlnTrp: 0.647 ± 0.019
1.453GlnTyr: 1.453 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.411ArgAla: 3.411 ± 0.053
0.517ArgCys: 0.517 ± 0.018
2.462ArgAsp: 2.462 ± 0.034
2.863ArgGlu: 2.863 ± 0.047
2.197ArgPhe: 2.197 ± 0.038
2.536ArgGly: 2.536 ± 0.041
1.055ArgHis: 1.055 ± 0.026
2.827ArgIle: 2.827 ± 0.043
2.175ArgLys: 2.175 ± 0.037
4.713ArgLeu: 4.713 ± 0.059
1.308ArgMet: 1.308 ± 0.029
1.771ArgAsn: 1.771 ± 0.033
1.503ArgPro: 1.503 ± 0.032
2.067ArgGln: 2.067 ± 0.039
2.21ArgArg: 2.21 ± 0.041
2.712ArgSer: 2.712 ± 0.044
2.146ArgThr: 2.146 ± 0.037
3.282ArgVal: 3.282 ± 0.05
0.655ArgTrp: 0.655 ± 0.02
1.743ArgTyr: 1.743 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
5.6SerAla: 5.6 ± 0.06
0.651SerCys: 0.651 ± 0.024
3.786SerAsp: 3.786 ± 0.075
4.208SerGlu: 4.208 ± 0.058
2.926SerPhe: 2.926 ± 0.051
4.974SerGly: 4.974 ± 0.067
1.539SerHis: 1.539 ± 0.035
4.314SerIle: 4.314 ± 0.05
3.402SerLys: 3.402 ± 0.047
7.289SerLeu: 7.289 ± 0.082
2.051SerMet: 2.051 ± 0.035
2.809SerAsn: 2.809 ± 0.046
2.423SerPro: 2.423 ± 0.037
3.142SerGln: 3.142 ± 0.049
2.934SerArg: 2.934 ± 0.044
4.76SerSer: 4.76 ± 0.06
3.631SerThr: 3.631 ± 0.053
4.941SerVal: 4.941 ± 0.061
0.899SerTrp: 0.899 ± 0.024
2.092SerTyr: 2.092 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
4.63ThrAla: 4.63 ± 0.069
0.469ThrCys: 0.469 ± 0.019
3.012ThrAsp: 3.012 ± 0.059
3.302ThrGlu: 3.302 ± 0.042
2.272ThrPhe: 2.272 ± 0.046
4.039ThrGly: 4.039 ± 0.066
1.201ThrHis: 1.201 ± 0.03
3.62ThrIle: 3.62 ± 0.055
2.55ThrLys: 2.55 ± 0.041
6.485ThrLeu: 6.485 ± 0.067
1.442ThrMet: 1.442 ± 0.033
2.135ThrAsn: 2.135 ± 0.042
2.745ThrPro: 2.745 ± 0.042
2.515ThrGln: 2.515 ± 0.036
2.234ThrArg: 2.234 ± 0.039
3.776ThrSer: 3.776 ± 0.049
3.205ThrThr: 3.205 ± 0.051
4.119ThrVal: 4.119 ± 0.063
0.667ThrTrp: 0.667 ± 0.021
1.563ThrTyr: 1.563 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
6.802ValAla: 6.802 ± 0.069
0.783ValCys: 0.783 ± 0.022
4.371ValAsp: 4.371 ± 0.07
4.893ValGlu: 4.893 ± 0.058
3.011ValPhe: 3.011 ± 0.054
5.044ValGly: 5.044 ± 0.057
1.274ValHis: 1.274 ± 0.024
4.749ValIle: 4.749 ± 0.05
3.599ValLys: 3.599 ± 0.05
6.964ValLeu: 6.964 ± 0.08
2.182ValMet: 2.182 ± 0.035
3.017ValAsn: 3.017 ± 0.053
2.71ValPro: 2.71 ± 0.046
2.29ValGln: 2.29 ± 0.037
2.987ValArg: 2.987 ± 0.043
5.409ValSer: 5.409 ± 0.068
4.469ValThr: 4.469 ± 0.06
5.839ValVal: 5.839 ± 0.069
0.839ValTrp: 0.839 ± 0.021
1.942ValTyr: 1.942 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
0.844TrpAla: 0.844 ± 0.022
0.146TrpCys: 0.146 ± 0.01
0.617TrpAsp: 0.617 ± 0.022
0.55TrpGlu: 0.55 ± 0.021
0.632TrpPhe: 0.632 ± 0.02
0.808TrpGly: 0.808 ± 0.02
0.364TrpHis: 0.364 ± 0.017
0.7TrpIle: 0.7 ± 0.021
0.554TrpLys: 0.554 ± 0.02
1.754TrpLeu: 1.754 ± 0.037
0.44TrpMet: 0.44 ± 0.017
0.532TrpAsn: 0.532 ± 0.021
0.47TrpPro: 0.47 ± 0.02
0.831TrpGln: 0.831 ± 0.027
0.696TrpArg: 0.696 ± 0.021
0.845TrpSer: 0.845 ± 0.023
0.567TrpThr: 0.567 ± 0.019
0.881TrpVal: 0.881 ± 0.023
0.213TrpTrp: 0.213 ± 0.011
0.403TrpTyr: 0.403 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.311TyrAla: 2.311 ± 0.042
0.393TyrCys: 0.393 ± 0.016
1.688TyrAsp: 1.688 ± 0.029
1.539TyrGlu: 1.539 ± 0.031
1.369TyrPhe: 1.369 ± 0.03
2.144TyrGly: 2.144 ± 0.039
0.786TyrHis: 0.786 ± 0.025
1.609TyrIle: 1.609 ± 0.034
1.264TyrLys: 1.264 ± 0.029
3.207TyrLeu: 3.207 ± 0.045
0.687TyrMet: 0.687 ± 0.022
1.131TyrAsn: 1.131 ± 0.028
1.319TyrPro: 1.319 ± 0.031
1.954TyrGln: 1.954 ± 0.038
1.723TyrArg: 1.723 ± 0.031
2.107TyrSer: 2.107 ± 0.048
1.598TyrThr: 1.598 ± 0.037
1.936TyrVal: 1.936 ± 0.037
0.496TyrTrp: 0.496 ± 0.017
1.029TyrTyr: 1.029 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6793 proteins (1574031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski