Amino acid dipepetide frequency for Paracoccus sulfuroxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.823AlaAla: 16.823 ± 0.197
0.974AlaCys: 0.974 ± 0.031
6.769AlaAsp: 6.769 ± 0.076
8.595AlaGlu: 8.595 ± 0.104
3.96AlaPhe: 3.96 ± 0.07
11.013AlaGly: 11.013 ± 0.107
2.237AlaHis: 2.237 ± 0.045
6.144AlaIle: 6.144 ± 0.085
3.502AlaLys: 3.502 ± 0.064
13.656AlaLeu: 13.656 ± 0.128
3.897AlaMet: 3.897 ± 0.06
2.869AlaAsn: 2.869 ± 0.058
6.183AlaPro: 6.183 ± 0.106
4.78AlaGln: 4.78 ± 0.068
9.332AlaArg: 9.332 ± 0.101
5.914AlaSer: 5.914 ± 0.075
6.102AlaThr: 6.102 ± 0.064
8.089AlaVal: 8.089 ± 0.085
1.414AlaTrp: 1.414 ± 0.035
2.324AlaTyr: 2.324 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.91CysAla: 0.91 ± 0.029
0.093CysCys: 0.093 ± 0.01
0.524CysAsp: 0.524 ± 0.024
0.399CysGlu: 0.399 ± 0.019
0.319CysPhe: 0.319 ± 0.017
0.86CysGly: 0.86 ± 0.029
0.223CysHis: 0.223 ± 0.013
0.363CysIle: 0.363 ± 0.017
0.184CysLys: 0.184 ± 0.012
0.773CysLeu: 0.773 ± 0.026
0.159CysMet: 0.159 ± 0.012
0.21CysAsn: 0.21 ± 0.014
0.485CysPro: 0.485 ± 0.022
0.233CysGln: 0.233 ± 0.016
0.499CysArg: 0.499 ± 0.024
0.434CysSer: 0.434 ± 0.017
0.387CysThr: 0.387 ± 0.021
0.504CysVal: 0.504 ± 0.02
0.123CysTrp: 0.123 ± 0.01
0.17CysTyr: 0.17 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.087AspAla: 7.087 ± 0.087
0.459AspCys: 0.459 ± 0.02
3.324AspAsp: 3.324 ± 0.065
3.641AspGlu: 3.641 ± 0.061
2.213AspPhe: 2.213 ± 0.047
5.404AspGly: 5.404 ± 0.092
1.314AspHis: 1.314 ± 0.032
2.756AspIle: 2.756 ± 0.047
1.545AspLys: 1.545 ± 0.037
6.558AspLeu: 6.558 ± 0.084
1.538AspMet: 1.538 ± 0.035
1.27AspAsn: 1.27 ± 0.036
3.799AspPro: 3.799 ± 0.059
2.173AspGln: 2.173 ± 0.042
4.39AspArg: 4.39 ± 0.062
2.358AspSer: 2.358 ± 0.05
2.606AspThr: 2.606 ± 0.067
3.717AspVal: 3.717 ± 0.057
1.201AspTrp: 1.201 ± 0.03
1.532AspTyr: 1.532 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.955GluAla: 7.955 ± 0.094
0.36GluCys: 0.36 ± 0.017
3.038GluAsp: 3.038 ± 0.053
3.092GluGlu: 3.092 ± 0.054
1.947GluPhe: 1.947 ± 0.042
4.852GluGly: 4.852 ± 0.064
1.115GluHis: 1.115 ± 0.032
3.56GluIle: 3.56 ± 0.062
2.039GluLys: 2.039 ± 0.052
5.359GluLeu: 5.359 ± 0.071
1.763GluMet: 1.763 ± 0.037
1.654GluAsn: 1.654 ± 0.036
2.632GluPro: 2.632 ± 0.057
1.997GluGln: 1.997 ± 0.046
4.194GluArg: 4.194 ± 0.071
2.216GluSer: 2.216 ± 0.05
3.385GluThr: 3.385 ± 0.054
4.229GluVal: 4.229 ± 0.056
0.828GluTrp: 0.828 ± 0.027
1.062GluTyr: 1.062 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.197PheAla: 4.197 ± 0.058
0.386PheCys: 0.386 ± 0.018
2.651PheAsp: 2.651 ± 0.048
1.814PheGlu: 1.814 ± 0.045
1.263PhePhe: 1.263 ± 0.038
3.583PheGly: 3.583 ± 0.064
0.782PheHis: 0.782 ± 0.027
1.694PheIle: 1.694 ± 0.042
0.821PheLys: 0.821 ± 0.032
3.391PheLeu: 3.391 ± 0.058
0.847PheMet: 0.847 ± 0.026
0.981PheAsn: 0.981 ± 0.03
1.586PhePro: 1.586 ± 0.038
1.131PheGln: 1.131 ± 0.03
2.218PheArg: 2.218 ± 0.042
2.118PheSer: 2.118 ± 0.043
1.957PheThr: 1.957 ± 0.048
2.434PheVal: 2.434 ± 0.044
0.592PheTrp: 0.592 ± 0.023
0.825PheTyr: 0.825 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.886GlyAla: 9.886 ± 0.103
0.747GlyCys: 0.747 ± 0.028
4.716GlyAsp: 4.716 ± 0.083
4.704GlyGlu: 4.704 ± 0.068
3.564GlyPhe: 3.564 ± 0.056
7.655GlyGly: 7.655 ± 0.122
1.954GlyHis: 1.954 ± 0.044
4.644GlyIle: 4.644 ± 0.069
3.23GlyLys: 3.23 ± 0.061
9.178GlyLeu: 9.178 ± 0.106
2.768GlyMet: 2.768 ± 0.046
2.545GlyAsn: 2.545 ± 0.093
3.913GlyPro: 3.913 ± 0.063
3.667GlyGln: 3.667 ± 0.068
6.154GlyArg: 6.154 ± 0.073
4.294GlySer: 4.294 ± 0.06
4.694GlyThr: 4.694 ± 0.086
6.122GlyVal: 6.122 ± 0.071
1.573GlyTrp: 1.573 ± 0.038
2.195GlyTyr: 2.195 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.308HisAla: 2.308 ± 0.042
0.207HisCys: 0.207 ± 0.013
1.316HisAsp: 1.316 ± 0.035
1.068HisGlu: 1.068 ± 0.027
0.849HisPhe: 0.849 ± 0.03
1.908HisGly: 1.908 ± 0.043
0.53HisHis: 0.53 ± 0.026
0.919HisIle: 0.919 ± 0.028
0.432HisLys: 0.432 ± 0.021
2.119HisLeu: 2.119 ± 0.05
0.548HisMet: 0.548 ± 0.021
0.43HisAsn: 0.43 ± 0.02
1.396HisPro: 1.396 ± 0.039
0.653HisGln: 0.653 ± 0.021
1.394HisArg: 1.394 ± 0.042
0.916HisSer: 0.916 ± 0.029
0.696HisThr: 0.696 ± 0.022
1.414HisVal: 1.414 ± 0.034
0.334HisTrp: 0.334 ± 0.015
0.513HisTyr: 0.513 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.371IleAla: 7.371 ± 0.084
0.593IleCys: 0.593 ± 0.024
3.583IleAsp: 3.583 ± 0.056
3.419IleGlu: 3.419 ± 0.055
1.771IlePhe: 1.771 ± 0.04
5.011IleGly: 5.011 ± 0.08
0.946IleHis: 0.946 ± 0.033
2.318IleIle: 2.318 ± 0.053
1.239IleLys: 1.239 ± 0.032
4.894IleLeu: 4.894 ± 0.074
1.17IleMet: 1.17 ± 0.036
1.385IleAsn: 1.385 ± 0.035
2.4IlePro: 2.4 ± 0.045
1.296IleGln: 1.296 ± 0.034
3.597IleArg: 3.597 ± 0.051
3.168IleSer: 3.168 ± 0.054
2.853IleThr: 2.853 ± 0.052
3.75IleVal: 3.75 ± 0.055
0.747IleTrp: 0.747 ± 0.028
1.138IleTyr: 1.138 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
3.814LysAla: 3.814 ± 0.07
0.155LysCys: 0.155 ± 0.011
1.684LysAsp: 1.684 ± 0.047
1.333LysGlu: 1.333 ± 0.038
0.861LysPhe: 0.861 ± 0.026
2.678LysGly: 2.678 ± 0.057
0.517LysHis: 0.517 ± 0.023
1.527LysIle: 1.527 ± 0.038
0.984LysLys: 0.984 ± 0.035
2.967LysLeu: 2.967 ± 0.054
0.821LysMet: 0.821 ± 0.03
0.788LysAsn: 0.788 ± 0.027
1.735LysPro: 1.735 ± 0.046
0.897LysGln: 0.897 ± 0.031
1.951LysArg: 1.951 ± 0.04
1.597LysSer: 1.597 ± 0.041
1.661LysThr: 1.661 ± 0.038
2.169LysVal: 2.169 ± 0.052
0.375LysTrp: 0.375 ± 0.016
0.572LysTyr: 0.572 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.591LeuAla: 13.591 ± 0.134
0.844LeuCys: 0.844 ± 0.025
5.827LeuAsp: 5.827 ± 0.068
4.946LeuGlu: 4.946 ± 0.068
3.235LeuPhe: 3.235 ± 0.055
8.604LeuGly: 8.604 ± 0.097
1.832LeuHis: 1.832 ± 0.043
5.605LeuIle: 5.605 ± 0.082
3.037LeuLys: 3.037 ± 0.047
9.33LeuLeu: 9.33 ± 0.135
2.671LeuMet: 2.671 ± 0.046
2.716LeuAsn: 2.716 ± 0.052
6.104LeuPro: 6.104 ± 0.078
3.095LeuGln: 3.095 ± 0.05
7.57LeuArg: 7.57 ± 0.083
6.686LeuSer: 6.686 ± 0.078
6.348LeuThr: 6.348 ± 0.087
6.824LeuVal: 6.824 ± 0.096
1.265LeuTrp: 1.265 ± 0.037
1.936LeuTyr: 1.936 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.585MetAla: 3.585 ± 0.059
0.139MetCys: 0.139 ± 0.011
1.335MetAsp: 1.335 ± 0.037
1.191MetGlu: 1.191 ± 0.028
0.766MetPhe: 0.766 ± 0.03
2.287MetGly: 2.287 ± 0.045
0.439MetHis: 0.439 ± 0.019
1.612MetIle: 1.612 ± 0.038
1.002MetLys: 1.002 ± 0.029
2.723MetLeu: 2.723 ± 0.043
0.77MetMet: 0.77 ± 0.03
0.895MetAsn: 0.895 ± 0.029
1.57MetPro: 1.57 ± 0.043
1.135MetGln: 1.135 ± 0.027
2.055MetArg: 2.055 ± 0.045
1.848MetSer: 1.848 ± 0.038
2.172MetThr: 2.172 ± 0.041
1.826MetVal: 1.826 ± 0.042
0.232MetTrp: 0.232 ± 0.014
0.336MetTyr: 0.336 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.198AsnAla: 3.198 ± 0.056
0.237AsnCys: 0.237 ± 0.015
1.749AsnAsp: 1.749 ± 0.073
1.223AsnGlu: 1.223 ± 0.032
0.964AsnPhe: 0.964 ± 0.03
2.485AsnGly: 2.485 ± 0.057
0.528AsnHis: 0.528 ± 0.018
1.336AsnIle: 1.336 ± 0.036
0.608AsnLys: 0.608 ± 0.025
2.655AsnLeu: 2.655 ± 0.051
0.701AsnMet: 0.701 ± 0.028
0.686AsnAsn: 0.686 ± 0.034
1.921AsnPro: 1.921 ± 0.039
0.804AsnGln: 0.804 ± 0.025
1.901AsnArg: 1.901 ± 0.044
1.308AsnSer: 1.308 ± 0.04
1.271AsnThr: 1.271 ± 0.035
1.749AsnVal: 1.749 ± 0.048
0.466AsnTrp: 0.466 ± 0.019
0.636AsnTyr: 0.636 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.707ProAla: 6.707 ± 0.107
0.329ProCys: 0.329 ± 0.015
3.956ProAsp: 3.956 ± 0.064
4.4ProGlu: 4.4 ± 0.074
1.91ProPhe: 1.91 ± 0.039
4.799ProGly: 4.799 ± 0.069
1.016ProHis: 1.016 ± 0.029
2.294ProIle: 2.294 ± 0.047
1.505ProLys: 1.505 ± 0.035
4.842ProLeu: 4.842 ± 0.07
1.368ProMet: 1.368 ± 0.032
1.363ProAsn: 1.363 ± 0.035
2.605ProPro: 2.605 ± 0.059
2.052ProGln: 2.052 ± 0.051
3.171ProArg: 3.171 ± 0.063
2.717ProSer: 2.717 ± 0.053
2.447ProThr: 2.447 ± 0.047
4.401ProVal: 4.401 ± 0.064
0.72ProTrp: 0.72 ± 0.025
1.101ProTyr: 1.101 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.332GlnAla: 4.332 ± 0.067
0.189GlnCys: 0.189 ± 0.013
1.871GlnAsp: 1.871 ± 0.042
1.601GlnGlu: 1.601 ± 0.036
1.084GlnPhe: 1.084 ± 0.03
3.078GlnGly: 3.078 ± 0.049
0.676GlnHis: 0.676 ± 0.025
2.393GlnIle: 2.393 ± 0.049
1.177GlnLys: 1.177 ± 0.034
3.104GlnLeu: 3.104 ± 0.043
1.204GlnMet: 1.204 ± 0.031
1.098GlnAsn: 1.098 ± 0.036
2.153GlnPro: 2.153 ± 0.053
1.486GlnGln: 1.486 ± 0.065
2.534GlnArg: 2.534 ± 0.049
1.83GlnSer: 1.83 ± 0.04
1.933GlnThr: 1.933 ± 0.038
2.529GlnVal: 2.529 ± 0.047
0.406GlnTrp: 0.406 ± 0.019
0.608GlnTyr: 0.608 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.286ArgAla: 8.286 ± 0.11
0.448ArgCys: 0.448 ± 0.018
4.41ArgAsp: 4.41 ± 0.069
4.062ArgGlu: 4.062 ± 0.071
2.682ArgPhe: 2.682 ± 0.046
4.864ArgGly: 4.864 ± 0.077
1.664ArgHis: 1.664 ± 0.042
4.246ArgIle: 4.246 ± 0.054
2.26ArgLys: 2.26 ± 0.047
8.002ArgLeu: 8.002 ± 0.101
2.202ArgMet: 2.202 ± 0.045
1.921ArgAsn: 1.921 ± 0.043
3.636ArgPro: 3.636 ± 0.057
2.721ArgGln: 2.721 ± 0.046
5.433ArgArg: 5.433 ± 0.086
3.321ArgSer: 3.321 ± 0.057
2.964ArgThr: 2.964 ± 0.052
4.825ArgVal: 4.825 ± 0.065
1.018ArgTrp: 1.018 ± 0.027
1.473ArgTyr: 1.473 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.043SerAla: 6.043 ± 0.066
0.432SerCys: 0.432 ± 0.019
3.22SerAsp: 3.22 ± 0.06
2.724SerGlu: 2.724 ± 0.047
2.183SerPhe: 2.183 ± 0.05
5.551SerGly: 5.551 ± 0.074
1.049SerHis: 1.049 ± 0.026
2.652SerIle: 2.652 ± 0.052
1.337SerLys: 1.337 ± 0.038
5.175SerLeu: 5.175 ± 0.079
1.317SerMet: 1.317 ± 0.036
1.329SerAsn: 1.329 ± 0.036
2.735SerPro: 2.735 ± 0.047
1.781SerGln: 1.781 ± 0.044
3.442SerArg: 3.442 ± 0.058
2.664SerSer: 2.664 ± 0.056
2.626SerThr: 2.626 ± 0.044
3.724SerVal: 3.724 ± 0.057
0.791SerTrp: 0.791 ± 0.026
1.253SerTyr: 1.253 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.088ThrAla: 6.088 ± 0.067
0.407ThrCys: 0.407 ± 0.018
3.013ThrAsp: 3.013 ± 0.043
3.078ThrGlu: 3.078 ± 0.049
1.758ThrPhe: 1.758 ± 0.039
5.378ThrGly: 5.378 ± 0.065
1.087ThrHis: 1.087 ± 0.032
2.801ThrIle: 2.801 ± 0.054
1.237ThrLys: 1.237 ± 0.036
5.605ThrLeu: 5.605 ± 0.078
1.22ThrMet: 1.22 ± 0.035
1.284ThrAsn: 1.284 ± 0.039
3.585ThrPro: 3.585 ± 0.063
1.694ThrGln: 1.694 ± 0.042
3.661ThrArg: 3.661 ± 0.05
2.725ThrSer: 2.725 ± 0.054
2.762ThrThr: 2.762 ± 0.058
4.094ThrVal: 4.094 ± 0.066
0.641ThrTrp: 0.641 ± 0.023
1.142ThrTyr: 1.142 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
8.682ValAla: 8.682 ± 0.1
0.517ValCys: 0.517 ± 0.021
3.666ValAsp: 3.666 ± 0.061
4.241ValGlu: 4.241 ± 0.057
2.523ValPhe: 2.523 ± 0.052
5.11ValGly: 5.11 ± 0.061
1.237ValHis: 1.237 ± 0.032
4.205ValIle: 4.205 ± 0.058
1.971ValLys: 1.971 ± 0.049
7.601ValLeu: 7.601 ± 0.093
2.111ValMet: 2.111 ± 0.043
1.992ValAsn: 1.992 ± 0.048
3.52ValPro: 3.52 ± 0.056
2.228ValGln: 2.228 ± 0.04
4.144ValArg: 4.144 ± 0.056
3.992ValSer: 3.992 ± 0.057
4.648ValThr: 4.648 ± 0.067
5.261ValVal: 5.261 ± 0.074
0.963ValTrp: 0.963 ± 0.026
1.305ValTyr: 1.305 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.333TrpAla: 1.333 ± 0.033
0.117TrpCys: 0.117 ± 0.01
0.746TrpAsp: 0.746 ± 0.022
0.574TrpGlu: 0.574 ± 0.021
0.6TrpPhe: 0.6 ± 0.025
1.059TrpGly: 1.059 ± 0.028
0.352TrpHis: 0.352 ± 0.015
0.737TrpIle: 0.737 ± 0.026
0.465TrpLys: 0.465 ± 0.017
1.863TrpLeu: 1.863 ± 0.038
0.4TrpMet: 0.4 ± 0.018
0.456TrpAsn: 0.456 ± 0.019
0.709TrpPro: 0.709 ± 0.024
0.742TrpGln: 0.742 ± 0.025
1.192TrpArg: 1.192 ± 0.03
0.797TrpSer: 0.797 ± 0.028
0.797TrpThr: 0.797 ± 0.024
0.853TrpVal: 0.853 ± 0.03
0.248TrpTrp: 0.248 ± 0.013
0.248TrpTyr: 0.248 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.382TyrAla: 2.382 ± 0.044
0.22TyrCys: 0.22 ± 0.013
1.487TyrAsp: 1.487 ± 0.036
1.173TyrGlu: 1.173 ± 0.036
0.822TyrPhe: 0.822 ± 0.028
2.019TyrGly: 2.019 ± 0.041
0.454TyrHis: 0.454 ± 0.02
0.844TyrIle: 0.844 ± 0.029
0.511TyrLys: 0.511 ± 0.024
2.271TyrLeu: 2.271 ± 0.049
0.444TyrMet: 0.444 ± 0.017
0.555TyrAsn: 0.555 ± 0.022
1.034TyrPro: 1.034 ± 0.029
0.719TyrGln: 0.719 ± 0.029
1.606TyrArg: 1.606 ± 0.034
1.126TyrSer: 1.126 ± 0.03
0.949TyrThr: 0.949 ± 0.028
1.401TyrVal: 1.401 ± 0.035
0.351TyrTrp: 0.351 ± 0.016
0.554TyrTyr: 0.554 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3917 proteins (1217529 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski