Amino acid dipepetide frequency for Desulfotomaculum nigrificans (strain DSM 14880 / VKM B-2319 / CO-1-SRB) (Desulfotomaculum carboxydivorans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.18AlaAla: 9.18 ± 0.167	0.992AlaCys: 0.992 ± 0.047	4.034AlaAsp: 4.034 ± 0.076	5.601AlaGlu: 5.601 ± 0.088	2.643AlaPhe: 2.643 ± 0.061	7.386AlaGly: 7.386 ± 0.108	1.439AlaHis: 1.439 ± 0.046	5.767AlaIle: 5.767 ± 0.099	5.177AlaLys: 5.177 ± 0.095	8.773AlaLeu: 8.773 ± 0.139	2.403AlaMet: 2.403 ± 0.057	3.119AlaAsn: 3.119 ± 0.066	2.732AlaPro: 2.732 ± 0.072	3.016AlaGln: 3.016 ± 0.063	5.241AlaArg: 5.241 ± 0.092	3.605AlaSer: 3.605 ± 0.061	4.006AlaThr: 4.006 ± 0.077	7.168AlaVal: 7.168 ± 0.103	0.701AlaTrp: 0.701 ± 0.032	2.246AlaTyr: 2.246 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.823CysAla: 0.823 ± 0.034	0.257CysCys: 0.257 ± 0.02	0.52CysAsp: 0.52 ± 0.026	0.562CysGlu: 0.562 ± 0.032	0.396CysPhe: 0.396 ± 0.021	1.341CysGly: 1.341 ± 0.054	0.316CysHis: 0.316 ± 0.023	0.648CysIle: 0.648 ± 0.031	0.533CysLys: 0.533 ± 0.026	1.149CysLeu: 1.149 ± 0.043	0.268CysMet: 0.268 ± 0.02	0.441CysAsn: 0.441 ± 0.023	0.873CysPro: 0.873 ± 0.041	0.585CysGln: 0.585 ± 0.028	0.776CysArg: 0.776 ± 0.033	0.758CysSer: 0.758 ± 0.038	0.581CysThr: 0.581 ± 0.029	0.68CysVal: 0.68 ± 0.035	0.12CysTrp: 0.12 ± 0.015	0.362CysTyr: 0.362 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.257AspAla: 3.257 ± 0.066	0.596AspCys: 0.596 ± 0.028	1.982AspAsp: 1.982 ± 0.049	3.139AspGlu: 3.139 ± 0.062	2.052AspPhe: 2.052 ± 0.05	3.309AspGly: 3.309 ± 0.07	0.957AspHis: 0.957 ± 0.038	4.111AspIle: 4.111 ± 0.068	3.141AspLys: 3.141 ± 0.073	5.225AspLeu: 5.225 ± 0.086	1.337AspMet: 1.337 ± 0.04	1.899AspAsn: 1.899 ± 0.054	2.378AspPro: 2.378 ± 0.058	1.944AspGln: 1.944 ± 0.052	2.696AspArg: 2.696 ± 0.062	2.034AspSer: 2.034 ± 0.049	2.22AspThr: 2.22 ± 0.052	3.561AspVal: 3.561 ± 0.071	0.556AspTrp: 0.556 ± 0.029	1.865AspTyr: 1.865 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.508GluAla: 5.508 ± 0.097	0.542GluCys: 0.542 ± 0.029	2.882GluAsp: 2.882 ± 0.067	5.139GluGlu: 5.139 ± 0.093	2.256GluPhe: 2.256 ± 0.049	4.005GluGly: 4.005 ± 0.066	1.173GluHis: 1.173 ± 0.037	5.339GluIle: 5.339 ± 0.123	4.652GluLys: 4.652 ± 0.084	7.108GluLeu: 7.108 ± 0.111	1.881GluMet: 1.881 ± 0.045	2.551GluAsn: 2.551 ± 0.056	2.111GluPro: 2.111 ± 0.055	3.225GluGln: 3.225 ± 0.07	3.553GluArg: 3.553 ± 0.1	2.387GluSer: 2.387 ± 0.056	3.022GluThr: 3.022 ± 0.056	5.406GluVal: 5.406 ± 0.088	0.496GluTrp: 0.496 ± 0.029	1.846GluTyr: 1.846 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.918PheAla: 2.918 ± 0.068	0.516PheCys: 0.516 ± 0.025	1.839PheAsp: 1.839 ± 0.044	1.835PheGlu: 1.835 ± 0.053	1.539PhePhe: 1.539 ± 0.047	3.089PheGly: 3.089 ± 0.072	0.686PheHis: 0.686 ± 0.031	2.691PheIle: 2.691 ± 0.058	2.191PheLys: 2.191 ± 0.058	3.652PheLeu: 3.652 ± 0.087	0.994PheMet: 0.994 ± 0.033	1.756PheAsn: 1.756 ± 0.047	1.547PhePro: 1.547 ± 0.051	1.038PheGln: 1.038 ± 0.04	1.785PheArg: 1.785 ± 0.043	2.218PheSer: 2.218 ± 0.056	2.252PheThr: 2.252 ± 0.055	2.461PheVal: 2.461 ± 0.058	0.422PheTrp: 0.422 ± 0.027	1.246PheTyr: 1.246 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.133GlyAla: 6.133 ± 0.098	1.208GlyCys: 1.208 ± 0.044	3.482GlyAsp: 3.482 ± 0.073	4.568GlyGlu: 4.568 ± 0.069	2.986GlyPhe: 2.986 ± 0.069	5.828GlyGly: 5.828 ± 0.106	1.556GlyHis: 1.556 ± 0.049	5.833GlyIle: 5.833 ± 0.094	4.948GlyLys: 4.948 ± 0.092	8.391GlyLeu: 8.391 ± 0.131	2.191GlyMet: 2.191 ± 0.053	2.709GlyAsn: 2.709 ± 0.063	2.543GlyPro: 2.543 ± 0.061	3.43GlyGln: 3.43 ± 0.068	3.934GlyArg: 3.934 ± 0.085	3.935GlySer: 3.935 ± 0.071	4.252GlyThr: 4.252 ± 0.071	6.192GlyVal: 6.192 ± 0.096	0.851GlyTrp: 0.851 ± 0.033	2.843GlyTyr: 2.843 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.211HisAla: 1.211 ± 0.049	0.341HisCys: 0.341 ± 0.019	0.877HisAsp: 0.877 ± 0.034	0.923HisGlu: 0.923 ± 0.031	0.791HisPhe: 0.791 ± 0.031	1.471HisGly: 1.471 ± 0.043	0.509HisHis: 0.509 ± 0.026	1.349HisIle: 1.349 ± 0.04	0.994HisLys: 0.994 ± 0.036	2.013HisLeu: 2.013 ± 0.053	0.473HisMet: 0.473 ± 0.023	0.771HisAsn: 0.771 ± 0.031	1.163HisPro: 1.163 ± 0.044	0.834HisGln: 0.834 ± 0.037	1.242HisArg: 1.242 ± 0.041	0.948HisSer: 0.948 ± 0.032	0.924HisThr: 0.924 ± 0.035	1.137HisVal: 1.137 ± 0.046	0.241HisTrp: 0.241 ± 0.019	0.675HisTyr: 0.675 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.558IleAla: 5.558 ± 0.091	0.811IleCys: 0.811 ± 0.029	3.609IleAsp: 3.609 ± 0.071	4.149IleGlu: 4.149 ± 0.084	2.677IlePhe: 2.677 ± 0.067	5.252IleGly: 5.252 ± 0.087	1.158IleHis: 1.158 ± 0.038	5.305IleIle: 5.305 ± 0.095	5.133IleLys: 5.133 ± 0.098	6.857IleLeu: 6.857 ± 0.092	1.772IleMet: 1.772 ± 0.051	3.366IleAsn: 3.366 ± 0.078	3.404IlePro: 3.404 ± 0.068	1.958IleGln: 1.958 ± 0.056	3.249IleArg: 3.249 ± 0.066	4.192IleSer: 4.192 ± 0.078	4.118IleThr: 4.118 ± 0.078	4.6IleVal: 4.6 ± 0.086	0.552IleTrp: 0.552 ± 0.025	2.1IleTyr: 2.1 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.754LysAla: 4.754 ± 0.101	0.635LysCys: 0.635 ± 0.032	3.258LysAsp: 3.258 ± 0.072	5.07LysGlu: 5.07 ± 0.091	2.015LysPhe: 2.015 ± 0.052	4.046LysGly: 4.046 ± 0.083	1.072LysHis: 1.072 ± 0.033	4.348LysIle: 4.348 ± 0.082	4.116LysLys: 4.116 ± 0.098	6.0LysLeu: 6.0 ± 0.086	1.635LysMet: 1.635 ± 0.044	2.491LysAsn: 2.491 ± 0.061	2.62LysPro: 2.62 ± 0.057	2.589LysGln: 2.589 ± 0.063	2.791LysArg: 2.791 ± 0.065	2.78LysSer: 2.78 ± 0.078	3.014LysThr: 3.014 ± 0.061	4.922LysVal: 4.922 ± 0.098	0.514LysTrp: 0.514 ± 0.024	2.07LysTyr: 2.07 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	10.873LeuAla: 10.873 ± 0.145	1.015LeuCys: 1.015 ± 0.041	5.168LeuAsp: 5.168 ± 0.097	6.62LeuGlu: 6.62 ± 0.094	3.463LeuPhe: 3.463 ± 0.066	8.042LeuGly: 8.042 ± 0.123	1.776LeuHis: 1.776 ± 0.048	6.187LeuIle: 6.187 ± 0.094	6.429LeuLys: 6.429 ± 0.091	10.284LeuLeu: 10.284 ± 0.161	2.568LeuMet: 2.568 ± 0.061	4.135LeuAsn: 4.135 ± 0.073	4.854LeuPro: 4.854 ± 0.093	3.591LeuGln: 3.591 ± 0.078	4.943LeuArg: 4.943 ± 0.088	5.675LeuSer: 5.675 ± 0.091	5.868LeuThr: 5.868 ± 0.084	8.18LeuVal: 8.18 ± 0.117	0.899LeuTrp: 0.899 ± 0.036	2.824LeuTyr: 2.824 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.862MetAla: 2.862 ± 0.065	0.239MetCys: 0.239 ± 0.02	1.349MetAsp: 1.349 ± 0.039	1.785MetGlu: 1.785 ± 0.05	0.81MetPhe: 0.81 ± 0.033	2.111MetGly: 2.111 ± 0.063	0.448MetHis: 0.448 ± 0.024	1.561MetIle: 1.561 ± 0.045	1.499MetLys: 1.499 ± 0.047	2.575MetLeu: 2.575 ± 0.054	0.687MetMet: 0.687 ± 0.027	0.977MetAsn: 0.977 ± 0.032	1.175MetPro: 1.175 ± 0.04	1.042MetGln: 1.042 ± 0.036	1.163MetArg: 1.163 ± 0.037	1.432MetSer: 1.432 ± 0.041	1.375MetThr: 1.375 ± 0.046	2.371MetVal: 2.371 ± 0.048	0.176MetTrp: 0.176 ± 0.015	0.553MetTyr: 0.553 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.542AsnAla: 2.542 ± 0.064	0.599AsnCys: 0.599 ± 0.029	1.528AsnAsp: 1.528 ± 0.045	2.066AsnGlu: 2.066 ± 0.052	1.529AsnPhe: 1.529 ± 0.047	2.713AsnGly: 2.713 ± 0.065	0.877AsnHis: 0.877 ± 0.036	3.197AsnIle: 3.197 ± 0.069	2.466AsnLys: 2.466 ± 0.058	4.447AsnLeu: 4.447 ± 0.086	1.099AsnMet: 1.099 ± 0.038	1.877AsnAsn: 1.877 ± 0.057	2.316AsnPro: 2.316 ± 0.056	1.832AsnGln: 1.832 ± 0.055	2.215AsnArg: 2.215 ± 0.056	2.025AsnSer: 2.025 ± 0.053	1.933AsnThr: 1.933 ± 0.048	2.524AsnVal: 2.524 ± 0.055	0.477AsnTrp: 0.477 ± 0.026	1.447AsnTyr: 1.447 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.699ProAla: 3.699 ± 0.074	0.454ProCys: 0.454 ± 0.028	2.596ProAsp: 2.596 ± 0.055	3.715ProGlu: 3.715 ± 0.076	1.608ProPhe: 1.608 ± 0.04	4.179ProGly: 4.179 ± 0.077	0.881ProHis: 0.881 ± 0.032	2.32ProIle: 2.32 ± 0.056	2.171ProLys: 2.171 ± 0.052	4.116ProLeu: 4.116 ± 0.073	1.005ProMet: 1.005 ± 0.038	1.549ProAsn: 1.549 ± 0.049	1.725ProPro: 1.725 ± 0.056	1.608ProGln: 1.608 ± 0.05	1.948ProArg: 1.948 ± 0.048	1.818ProSer: 1.818 ± 0.051	2.191ProThr: 2.191 ± 0.07	4.243ProVal: 4.243 ± 0.077	0.478ProTrp: 0.478 ± 0.024	1.328ProTyr: 1.328 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.779GlnAla: 3.779 ± 0.085	0.366GlnCys: 0.366 ± 0.023	1.805GlnAsp: 1.805 ± 0.049	2.924GlnGlu: 2.924 ± 0.058	1.216GlnPhe: 1.216 ± 0.04	2.924GlnGly: 2.924 ± 0.065	0.705GlnHis: 0.705 ± 0.029	2.734GlnIle: 2.734 ± 0.063	2.305GlnLys: 2.305 ± 0.059	3.943GlnLeu: 3.943 ± 0.099	1.075GlnMet: 1.075 ± 0.034	1.477GlnAsn: 1.477 ± 0.051	1.677GlnPro: 1.677 ± 0.052	2.138GlnGln: 2.138 ± 0.07	2.271GlnArg: 2.271 ± 0.061	1.738GlnSer: 1.738 ± 0.049	1.748GlnThr: 1.748 ± 0.057	3.58GlnVal: 3.58 ± 0.08	0.444GlnTrp: 0.444 ± 0.027	1.189GlnTyr: 1.189 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.918ArgAla: 3.918 ± 0.081	0.62ArgCys: 0.62 ± 0.027	2.552ArgAsp: 2.552 ± 0.056	4.246ArgGlu: 4.246 ± 0.084	1.922ArgPhe: 1.922 ± 0.049	3.561ArgGly: 3.561 ± 0.069	0.978ArgHis: 0.978 ± 0.039	3.387ArgIle: 3.387 ± 0.067	2.916ArgLys: 2.916 ± 0.062	5.606ArgLeu: 5.606 ± 0.087	1.394ArgMet: 1.394 ± 0.038	1.891ArgAsn: 1.891 ± 0.056	2.2ArgPro: 2.2 ± 0.052	2.847ArgGln: 2.847 ± 0.064	3.089ArgArg: 3.089 ± 0.079	2.332ArgSer: 2.332 ± 0.054	2.276ArgThr: 2.276 ± 0.053	4.096ArgVal: 4.096 ± 0.093	0.572ArgTrp: 0.572 ± 0.027	1.827ArgTyr: 1.827 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.673SerAla: 3.673 ± 0.075	0.659SerCys: 0.659 ± 0.033	2.138SerAsp: 2.138 ± 0.056	2.656SerGlu: 2.656 ± 0.071	2.187SerPhe: 2.187 ± 0.057	4.329SerGly: 4.329 ± 0.079	1.029SerHis: 1.029 ± 0.037	3.314SerIle: 3.314 ± 0.072	2.599SerLys: 2.599 ± 0.061	5.608SerLeu: 5.608 ± 0.093	1.313SerMet: 1.313 ± 0.044	1.734SerAsn: 1.734 ± 0.048	2.42SerPro: 2.42 ± 0.063	1.971SerGln: 1.971 ± 0.056	2.727SerArg: 2.727 ± 0.06	2.72SerSer: 2.72 ± 0.077	2.605SerThr: 2.605 ± 0.062	3.561SerVal: 3.561 ± 0.062	0.567SerTrp: 0.567 ± 0.027	1.551SerTyr: 1.551 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.533ThrAla: 4.533 ± 0.075	0.627ThrCys: 0.627 ± 0.029	2.478ThrAsp: 2.478 ± 0.054	2.852ThrGlu: 2.852 ± 0.068	2.032ThrPhe: 2.032 ± 0.068	5.347ThrGly: 5.347 ± 0.082	0.941ThrHis: 0.941 ± 0.038	3.543ThrIle: 3.543 ± 0.061	2.609ThrLys: 2.609 ± 0.057	5.008ThrLeu: 5.008 ± 0.091	1.267ThrMet: 1.267 ± 0.044	2.014ThrAsn: 2.014 ± 0.052	2.599ThrPro: 2.599 ± 0.062	1.373ThrGln: 1.373 ± 0.039	2.548ThrArg: 2.548 ± 0.054	2.505ThrSer: 2.505 ± 0.063	2.918ThrThr: 2.918 ± 0.072	4.572ThrVal: 4.572 ± 0.083	0.451ThrTrp: 0.451 ± 0.023	1.496ThrTyr: 1.496 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	7.125ValAla: 7.125 ± 0.097	0.92ValCys: 0.92 ± 0.036	4.114ValAsp: 4.114 ± 0.083	5.043ValGlu: 5.043 ± 0.083	2.738ValPhe: 2.738 ± 0.068	5.663ValGly: 5.663 ± 0.096	1.33ValHis: 1.33 ± 0.041	5.672ValIle: 5.672 ± 0.091	4.813ValLys: 4.813 ± 0.081	7.88ValLeu: 7.88 ± 0.116	1.97ValMet: 1.97 ± 0.051	3.299ValAsn: 3.299 ± 0.066	3.448ValPro: 3.448 ± 0.056	2.719ValGln: 2.719 ± 0.063	3.652ValArg: 3.652 ± 0.071	4.208ValSer: 4.208 ± 0.071	4.422ValThr: 4.422 ± 0.086	6.71ValVal: 6.71 ± 0.135	0.647ValTrp: 0.647 ± 0.034	2.157ValTyr: 2.157 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.727TrpAla: 0.727 ± 0.034	0.13TrpCys: 0.13 ± 0.014	0.514TrpAsp: 0.514 ± 0.028	0.614TrpGlu: 0.614 ± 0.034	0.411TrpPhe: 0.411 ± 0.029	0.692TrpGly: 0.692 ± 0.031	0.252TrpHis: 0.252 ± 0.017	0.518TrpIle: 0.518 ± 0.03	0.385TrpLys: 0.385 ± 0.023	1.196TrpLeu: 1.196 ± 0.043	0.224TrpMet: 0.224 ± 0.02	0.343TrpAsn: 0.343 ± 0.025	0.408TrpPro: 0.408 ± 0.026	0.746TrpGln: 0.746 ± 0.036	0.497TrpArg: 0.497 ± 0.025	0.553TrpSer: 0.553 ± 0.029	0.37TrpThr: 0.37 ± 0.022	0.642TrpVal: 0.642 ± 0.025	0.132TrpTrp: 0.132 ± 0.015	0.285TrpTyr: 0.285 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.158TyrAla: 2.158 ± 0.05	0.461TyrCys: 0.461 ± 0.025	1.532TyrAsp: 1.532 ± 0.049	1.575TyrGlu: 1.575 ± 0.05	1.401TyrPhe: 1.401 ± 0.044	2.528TyrGly: 2.528 ± 0.056	0.801TyrHis: 0.801 ± 0.031	1.995TyrIle: 1.995 ± 0.049	1.665TyrLys: 1.665 ± 0.044	3.567TyrLeu: 3.567 ± 0.071	0.633TyrMet: 0.633 ± 0.024	1.31TyrAsn: 1.31 ± 0.045	1.438TyrPro: 1.438 ± 0.048	1.552TyrGln: 1.552 ± 0.045	1.909TyrArg: 1.909 ± 0.048	1.497TyrSer: 1.497 ± 0.047	1.618TyrThr: 1.618 ± 0.046	1.924TyrVal: 1.924 ± 0.052	0.343TyrTrp: 0.343 ± 0.021	1.157TyrTyr: 1.157 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2620 proteins (789997 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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