Amino acid dipepetide frequency for Streptococcus satellite phage Javan165

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.86AlaCys: 0.86 ± 0.406
2.866AlaAsp: 2.866 ± 0.856
6.019AlaGlu: 6.019 ± 1.169
3.153AlaPhe: 3.153 ± 1.086
0.86AlaGly: 0.86 ± 0.535
0.287AlaHis: 0.287 ± 0.297
5.732AlaIle: 5.732 ± 1.133
4.586AlaLys: 4.586 ± 1.228
4.586AlaLeu: 4.586 ± 1.075
1.146AlaMet: 1.146 ± 0.619
5.159AlaAsn: 5.159 ± 1.227
1.146AlaPro: 1.146 ± 0.499
2.866AlaGln: 2.866 ± 0.588
2.293AlaArg: 2.293 ± 0.665
2.293AlaSer: 2.293 ± 0.966
3.726AlaThr: 3.726 ± 0.691
2.58AlaVal: 2.58 ± 0.821
0.86AlaTrp: 0.86 ± 0.613
1.146AlaTyr: 1.146 ± 0.545
0.0AlaXaa: 0.0 ± 0.0
Cys
1.146CysAla: 1.146 ± 0.452
0.287CysCys: 0.287 ± 0.255
0.573CysAsp: 0.573 ± 0.353
0.287CysGlu: 0.287 ± 0.255
0.0CysPhe: 0.0 ± 0.0
1.146CysGly: 1.146 ± 0.662
0.287CysHis: 0.287 ± 0.258
0.287CysIle: 0.287 ± 0.245
0.0CysLys: 0.0 ± 0.0
1.146CysLeu: 1.146 ± 0.405
0.0CysMet: 0.0 ± 0.0
0.86CysAsn: 0.86 ± 0.438
0.573CysPro: 0.573 ± 0.352
0.287CysGln: 0.287 ± 0.255
0.287CysArg: 0.287 ± 0.255
0.287CysSer: 0.287 ± 0.292
0.287CysThr: 0.287 ± 0.269
0.573CysVal: 0.573 ± 0.366
0.0CysTrp: 0.0 ± 0.0
0.573CysTyr: 0.573 ± 0.403
0.0CysXaa: 0.0 ± 0.0
Asp
1.433AspAla: 1.433 ± 0.585
1.433AspCys: 1.433 ± 0.617
3.439AspAsp: 3.439 ± 0.91
3.726AspGlu: 3.726 ± 1.29
2.866AspPhe: 2.866 ± 0.963
2.293AspGly: 2.293 ± 0.919
0.0AspHis: 0.0 ± 0.0
4.586AspIle: 4.586 ± 1.2
6.306AspLys: 6.306 ± 1.126
6.019AspLeu: 6.019 ± 1.18
0.573AspMet: 0.573 ± 0.497
2.293AspAsn: 2.293 ± 0.763
1.146AspPro: 1.146 ± 0.564
2.006AspGln: 2.006 ± 0.572
3.153AspArg: 3.153 ± 0.834
4.586AspSer: 4.586 ± 1.301
2.58AspThr: 2.58 ± 0.879
2.293AspVal: 2.293 ± 0.787
0.0AspTrp: 0.0 ± 0.0
5.446AspTyr: 5.446 ± 1.546
0.0AspXaa: 0.0 ± 0.0
Glu
5.446GluAla: 5.446 ± 0.961
1.72GluCys: 1.72 ± 0.798
4.299GluAsp: 4.299 ± 1.057
6.879GluGlu: 6.879 ± 2.434
3.439GluPhe: 3.439 ± 1.32
2.866GluGly: 2.866 ± 0.906
2.293GluHis: 2.293 ± 0.653
6.019GluIle: 6.019 ± 1.258
6.592GluLys: 6.592 ± 1.203
9.172GluLeu: 9.172 ± 1.21
2.006GluMet: 2.006 ± 0.785
2.58GluAsn: 2.58 ± 0.579
2.006GluPro: 2.006 ± 0.701
4.299GluGln: 4.299 ± 1.406
3.726GluArg: 3.726 ± 1.179
1.72GluSer: 1.72 ± 0.593
5.446GluThr: 5.446 ± 1.183
3.439GluVal: 3.439 ± 0.963
1.146GluTrp: 1.146 ± 0.558
3.439GluTyr: 3.439 ± 0.963
0.0GluXaa: 0.0 ± 0.0
Phe
2.293PheAla: 2.293 ± 0.63
0.0PheCys: 0.0 ± 0.0
2.58PheAsp: 2.58 ± 0.835
2.58PheGlu: 2.58 ± 0.874
1.72PhePhe: 1.72 ± 0.555
1.146PheGly: 1.146 ± 0.397
1.433PheHis: 1.433 ± 0.555
4.872PheIle: 4.872 ± 1.387
3.439PheLys: 3.439 ± 0.765
2.866PheLeu: 2.866 ± 0.928
0.573PheMet: 0.573 ± 0.331
3.439PheAsn: 3.439 ± 0.721
1.433PhePro: 1.433 ± 0.613
1.433PheGln: 1.433 ± 0.462
1.72PheArg: 1.72 ± 0.763
2.58PheSer: 2.58 ± 0.85
2.58PheThr: 2.58 ± 0.977
2.58PheVal: 2.58 ± 0.776
0.0PheTrp: 0.0 ± 0.0
1.433PheTyr: 1.433 ± 0.552
0.0PheXaa: 0.0 ± 0.0
Gly
2.58GlyAla: 2.58 ± 1.27
0.287GlyCys: 0.287 ± 0.245
3.439GlyAsp: 3.439 ± 1.183
2.293GlyGlu: 2.293 ± 1.039
2.293GlyPhe: 2.293 ± 0.628
2.006GlyGly: 2.006 ± 0.574
0.86GlyHis: 0.86 ± 0.714
3.153GlyIle: 3.153 ± 0.712
3.726GlyLys: 3.726 ± 1.165
6.879GlyLeu: 6.879 ± 1.517
0.86GlyMet: 0.86 ± 0.434
2.006GlyAsn: 2.006 ± 0.772
0.287GlyPro: 0.287 ± 0.284
1.72GlyGln: 1.72 ± 0.777
1.146GlyArg: 1.146 ± 0.386
1.72GlySer: 1.72 ± 0.807
2.293GlyThr: 2.293 ± 0.982
3.153GlyVal: 3.153 ± 0.886
0.86GlyTrp: 0.86 ± 0.538
3.153GlyTyr: 3.153 ± 1.171
0.0GlyXaa: 0.0 ± 0.0
His
1.146HisAla: 1.146 ± 0.573
0.287HisCys: 0.287 ± 0.245
0.287HisAsp: 0.287 ± 0.313
0.0HisGlu: 0.0 ± 0.0
0.573HisPhe: 0.573 ± 0.387
1.433HisGly: 1.433 ± 0.585
0.0HisHis: 0.0 ± 0.0
2.58HisIle: 2.58 ± 0.718
1.433HisLys: 1.433 ± 0.716
2.006HisLeu: 2.006 ± 0.885
0.287HisMet: 0.287 ± 0.297
0.287HisAsn: 0.287 ± 0.3
1.146HisPro: 1.146 ± 0.768
0.86HisGln: 0.86 ± 0.593
0.573HisArg: 0.573 ± 0.409
0.287HisSer: 0.287 ± 0.258
0.86HisThr: 0.86 ± 0.416
0.573HisVal: 0.573 ± 0.399
0.287HisTrp: 0.287 ± 0.255
1.72HisTyr: 1.72 ± 0.814
0.0HisXaa: 0.0 ± 0.0
Ile
5.446IleAla: 5.446 ± 0.927
0.86IleCys: 0.86 ± 0.386
6.592IleAsp: 6.592 ± 1.374
6.879IleGlu: 6.879 ± 1.472
2.58IlePhe: 2.58 ± 0.965
2.006IleGly: 2.006 ± 0.561
0.573IleHis: 0.573 ± 0.511
3.726IleIle: 3.726 ± 0.826
9.745IleLys: 9.745 ± 1.655
4.586IleLeu: 4.586 ± 0.939
1.433IleMet: 1.433 ± 0.576
2.866IleAsn: 2.866 ± 0.766
1.72IlePro: 1.72 ± 0.837
2.866IleGln: 2.866 ± 0.615
3.153IleArg: 3.153 ± 0.726
6.019IleSer: 6.019 ± 1.476
5.446IleThr: 5.446 ± 0.981
3.153IleVal: 3.153 ± 0.742
0.0IleTrp: 0.0 ± 0.0
3.439IleTyr: 3.439 ± 0.813
0.0IleXaa: 0.0 ± 0.0
Lys
8.312LysAla: 8.312 ± 1.561
0.287LysCys: 0.287 ± 0.269
4.013LysAsp: 4.013 ± 1.317
9.172LysGlu: 9.172 ± 1.971
3.726LysPhe: 3.726 ± 0.806
4.299LysGly: 4.299 ± 1.161
2.006LysHis: 2.006 ± 0.629
5.446LysIle: 5.446 ± 1.077
9.458LysLys: 9.458 ± 2.273
6.592LysLeu: 6.592 ± 1.391
1.72LysMet: 1.72 ± 0.763
4.586LysAsn: 4.586 ± 0.952
4.299LysPro: 4.299 ± 1.271
4.013LysGln: 4.013 ± 0.982
4.586LysArg: 4.586 ± 1.141
4.586LysSer: 4.586 ± 1.796
4.872LysThr: 4.872 ± 1.446
6.879LysVal: 6.879 ± 1.447
0.86LysTrp: 0.86 ± 0.361
4.299LysTyr: 4.299 ± 1.549
0.0LysXaa: 0.0 ± 0.0
Leu
4.586LeuAla: 4.586 ± 1.42
0.86LeuCys: 0.86 ± 0.463
5.732LeuAsp: 5.732 ± 1.381
10.605LeuGlu: 10.605 ± 1.672
4.586LeuPhe: 4.586 ± 1.087
5.732LeuGly: 5.732 ± 1.376
0.573LeuHis: 0.573 ± 0.437
7.739LeuIle: 7.739 ± 2.183
8.885LeuLys: 8.885 ± 1.638
8.025LeuLeu: 8.025 ± 1.683
2.293LeuMet: 2.293 ± 0.831
6.019LeuAsn: 6.019 ± 1.156
4.586LeuPro: 4.586 ± 1.111
2.866LeuGln: 2.866 ± 0.549
2.866LeuArg: 2.866 ± 0.719
7.739LeuSer: 7.739 ± 1.329
3.726LeuThr: 3.726 ± 0.779
3.726LeuVal: 3.726 ± 1.098
1.146LeuTrp: 1.146 ± 0.386
4.586LeuTyr: 4.586 ± 0.946
0.0LeuXaa: 0.0 ± 0.0
Met
1.146MetAla: 1.146 ± 0.412
0.0MetCys: 0.0 ± 0.0
1.146MetAsp: 1.146 ± 0.552
1.146MetGlu: 1.146 ± 0.458
0.573MetPhe: 0.573 ± 0.452
0.287MetGly: 0.287 ± 0.258
0.0MetHis: 0.0 ± 0.0
1.146MetIle: 1.146 ± 0.543
2.866MetLys: 2.866 ± 0.769
3.153MetLeu: 3.153 ± 0.785
0.0MetMet: 0.0 ± 0.0
2.006MetAsn: 2.006 ± 0.872
0.573MetPro: 0.573 ± 0.345
0.0MetGln: 0.0 ± 0.0
1.72MetArg: 1.72 ± 0.54
1.146MetSer: 1.146 ± 0.492
3.153MetThr: 3.153 ± 1.047
0.573MetVal: 0.573 ± 0.376
0.0MetTrp: 0.0 ± 0.0
0.287MetTyr: 0.287 ± 0.269
0.0MetXaa: 0.0 ± 0.0
Asn
4.299AsnAla: 4.299 ± 0.823
0.0AsnCys: 0.0 ± 0.0
2.006AsnAsp: 2.006 ± 0.824
3.439AsnGlu: 3.439 ± 0.915
1.72AsnPhe: 1.72 ± 0.641
3.439AsnGly: 3.439 ± 1.189
1.72AsnHis: 1.72 ± 0.61
4.299AsnIle: 4.299 ± 1.272
4.586AsnLys: 4.586 ± 1.038
4.299AsnLeu: 4.299 ± 1.086
1.433AsnMet: 1.433 ± 0.614
2.293AsnAsn: 2.293 ± 0.889
2.866AsnPro: 2.866 ± 0.763
3.726AsnGln: 3.726 ± 0.914
4.299AsnArg: 4.299 ± 0.836
2.006AsnSer: 2.006 ± 0.473
2.58AsnThr: 2.58 ± 0.972
2.58AsnVal: 2.58 ± 0.786
0.287AsnTrp: 0.287 ± 0.274
4.299AsnTyr: 4.299 ± 1.081
0.0AsnXaa: 0.0 ± 0.0
Pro
1.146ProAla: 1.146 ± 0.53
0.287ProCys: 0.287 ± 0.292
0.86ProAsp: 0.86 ± 0.413
2.866ProGlu: 2.866 ± 1.11
1.433ProPhe: 1.433 ± 0.63
0.86ProGly: 0.86 ± 0.491
0.287ProHis: 0.287 ± 0.245
2.866ProIle: 2.866 ± 0.811
2.293ProLys: 2.293 ± 1.022
3.439ProLeu: 3.439 ± 0.996
0.86ProMet: 0.86 ± 0.37
2.58ProAsn: 2.58 ± 0.95
0.573ProPro: 0.573 ± 0.386
0.573ProGln: 0.573 ± 0.324
2.293ProArg: 2.293 ± 0.9
2.293ProSer: 2.293 ± 0.955
3.439ProThr: 3.439 ± 0.638
1.72ProVal: 1.72 ± 0.718
0.287ProTrp: 0.287 ± 0.245
1.433ProTyr: 1.433 ± 0.621
0.0ProXaa: 0.0 ± 0.0
Gln
3.439GlnAla: 3.439 ± 0.941
0.287GlnCys: 0.287 ± 0.306
1.72GlnAsp: 1.72 ± 0.677
2.866GlnGlu: 2.866 ± 0.918
1.146GlnPhe: 1.146 ± 0.548
2.58GlnGly: 2.58 ± 0.734
0.86GlnHis: 0.86 ± 0.376
2.293GlnIle: 2.293 ± 0.761
4.013GlnLys: 4.013 ± 0.875
5.446GlnLeu: 5.446 ± 1.022
1.146GlnMet: 1.146 ± 0.755
3.153GlnAsn: 3.153 ± 1.078
1.146GlnPro: 1.146 ± 0.466
1.72GlnGln: 1.72 ± 0.508
3.726GlnArg: 3.726 ± 0.742
2.58GlnSer: 2.58 ± 0.556
1.433GlnThr: 1.433 ± 0.573
3.153GlnVal: 3.153 ± 0.82
0.287GlnTrp: 0.287 ± 0.269
1.146GlnTyr: 1.146 ± 0.628
0.0GlnXaa: 0.0 ± 0.0
Arg
1.72ArgAla: 1.72 ± 0.702
0.287ArgCys: 0.287 ± 0.255
3.153ArgAsp: 3.153 ± 0.7
2.006ArgGlu: 2.006 ± 0.65
1.72ArgPhe: 1.72 ± 0.606
2.006ArgGly: 2.006 ± 0.631
1.433ArgHis: 1.433 ± 0.48
2.293ArgIle: 2.293 ± 0.93
6.019ArgLys: 6.019 ± 1.31
6.879ArgLeu: 6.879 ± 0.82
0.573ArgMet: 0.573 ± 0.4
2.006ArgAsn: 2.006 ± 0.814
1.433ArgPro: 1.433 ± 0.747
2.866ArgGln: 2.866 ± 0.795
2.006ArgArg: 2.006 ± 0.756
3.726ArgSer: 3.726 ± 1.069
2.58ArgThr: 2.58 ± 0.644
3.153ArgVal: 3.153 ± 0.926
0.86ArgTrp: 0.86 ± 0.576
4.299ArgTyr: 4.299 ± 1.079
0.0ArgXaa: 0.0 ± 0.0
Ser
1.72SerAla: 1.72 ± 0.749
0.287SerCys: 0.287 ± 0.255
5.159SerAsp: 5.159 ± 1.061
4.013SerGlu: 4.013 ± 1.132
1.72SerPhe: 1.72 ± 0.614
2.58SerGly: 2.58 ± 0.763
1.146SerHis: 1.146 ± 0.487
4.872SerIle: 4.872 ± 1.378
5.446SerLys: 5.446 ± 1.209
4.872SerLeu: 4.872 ± 0.834
1.72SerMet: 1.72 ± 0.77
1.433SerAsn: 1.433 ± 0.518
1.433SerPro: 1.433 ± 0.595
4.013SerGln: 4.013 ± 1.207
2.58SerArg: 2.58 ± 0.872
2.58SerSer: 2.58 ± 0.769
3.439SerThr: 3.439 ± 1.013
4.013SerVal: 4.013 ± 1.292
0.573SerTrp: 0.573 ± 0.409
3.726SerTyr: 3.726 ± 1.098
0.0SerXaa: 0.0 ± 0.0
Thr
3.439ThrAla: 3.439 ± 0.942
0.0ThrCys: 0.0 ± 0.0
1.72ThrAsp: 1.72 ± 0.622
3.153ThrGlu: 3.153 ± 0.748
1.146ThrPhe: 1.146 ± 0.504
4.299ThrGly: 4.299 ± 1.004
1.146ThrHis: 1.146 ± 0.662
4.872ThrIle: 4.872 ± 1.309
4.586ThrLys: 4.586 ± 1.054
6.306ThrLeu: 6.306 ± 1.192
1.146ThrMet: 1.146 ± 0.438
2.58ThrAsn: 2.58 ± 1.188
3.153ThrPro: 3.153 ± 1.078
2.293ThrGln: 2.293 ± 0.665
4.299ThrArg: 4.299 ± 0.844
2.866ThrSer: 2.866 ± 0.826
2.58ThrThr: 2.58 ± 1.331
3.153ThrVal: 3.153 ± 0.878
1.146ThrTrp: 1.146 ± 0.531
4.299ThrTyr: 4.299 ± 1.007
0.0ThrXaa: 0.0 ± 0.0
Val
1.433ValAla: 1.433 ± 0.404
0.287ValCys: 0.287 ± 0.255
3.153ValAsp: 3.153 ± 0.958
4.299ValGlu: 4.299 ± 1.081
3.153ValPhe: 3.153 ± 0.936
2.58ValGly: 2.58 ± 0.779
0.287ValHis: 0.287 ± 0.255
4.013ValIle: 4.013 ± 0.951
5.446ValLys: 5.446 ± 0.944
6.019ValLeu: 6.019 ± 1.102
1.72ValMet: 1.72 ± 0.542
4.299ValAsn: 4.299 ± 0.91
1.146ValPro: 1.146 ± 0.489
1.146ValGln: 1.146 ± 0.791
1.433ValArg: 1.433 ± 0.634
4.586ValSer: 4.586 ± 1.198
4.013ValThr: 4.013 ± 1.012
3.439ValVal: 3.439 ± 0.75
0.86ValTrp: 0.86 ± 0.567
1.146ValTyr: 1.146 ± 0.44
0.0ValXaa: 0.0 ± 0.0
Trp
0.287TrpAla: 0.287 ± 0.282
0.0TrpCys: 0.0 ± 0.0
1.433TrpAsp: 1.433 ± 0.624
0.86TrpGlu: 0.86 ± 0.418
0.287TrpPhe: 0.287 ± 0.245
0.287TrpGly: 0.287 ± 0.239
0.0TrpHis: 0.0 ± 0.0
0.287TrpIle: 0.287 ± 0.274
0.287TrpLys: 0.287 ± 0.245
2.006TrpLeu: 2.006 ± 0.551
0.0TrpMet: 0.0 ± 0.0
0.573TrpAsn: 0.573 ± 0.388
0.0TrpPro: 0.0 ± 0.0
0.86TrpGln: 0.86 ± 0.484
0.287TrpArg: 0.287 ± 0.255
0.573TrpSer: 0.573 ± 0.308
0.287TrpThr: 0.287 ± 0.245
1.146TrpVal: 1.146 ± 0.547
0.573TrpTrp: 0.573 ± 0.388
0.573TrpTyr: 0.573 ± 0.387
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.146TyrAla: 1.146 ± 0.608
0.573TyrCys: 0.573 ± 0.352
2.006TyrAsp: 2.006 ± 0.769
5.446TyrGlu: 5.446 ± 1.115
2.866TyrPhe: 2.866 ± 0.574
2.006TyrGly: 2.006 ± 0.823
1.433TyrHis: 1.433 ± 0.665
2.006TyrIle: 2.006 ± 0.809
4.586TyrLys: 4.586 ± 1.233
2.58TyrLeu: 2.58 ± 0.723
1.146TyrMet: 1.146 ± 0.611
5.159TyrAsn: 5.159 ± 0.952
1.72TyrPro: 1.72 ± 0.794
3.726TyrGln: 3.726 ± 0.862
4.872TyrArg: 4.872 ± 1.136
3.153TyrSer: 3.153 ± 1.289
2.866TyrThr: 2.866 ± 0.579
2.58TyrVal: 2.58 ± 0.654
0.573TyrTrp: 0.573 ± 0.511
2.58TyrTyr: 2.58 ± 1.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (3490 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski