Amino acid dipepetide frequency for Mesoplasma lactucae ATCC 49193

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.868AlaAla: 3.868 ± 0.184
0.441AlaCys: 0.441 ± 0.04
3.515AlaAsp: 3.515 ± 0.137
3.325AlaGlu: 3.325 ± 0.21
2.738AlaPhe: 2.738 ± 0.127
3.774AlaGly: 3.774 ± 0.155
0.814AlaHis: 0.814 ± 0.063
5.945AlaIle: 5.945 ± 0.168
6.346AlaLys: 6.346 ± 0.189
5.731AlaLeu: 5.731 ± 0.159
1.758AlaMet: 1.758 ± 0.088
3.904AlaAsn: 3.904 ± 0.126
1.648AlaPro: 1.648 ± 0.084
1.847AlaGln: 1.847 ± 0.119
1.952AlaArg: 1.952 ± 0.101
3.487AlaSer: 3.487 ± 0.131
3.56AlaThr: 3.56 ± 0.131
3.556AlaVal: 3.556 ± 0.155
0.616AlaTrp: 0.616 ± 0.055
2.179AlaTyr: 2.179 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
0.316CysAla: 0.316 ± 0.037
0.057CysCys: 0.057 ± 0.016
0.336CysAsp: 0.336 ± 0.04
0.373CysGlu: 0.373 ± 0.042
0.283CysPhe: 0.283 ± 0.035
0.522CysGly: 0.522 ± 0.042
0.121CysHis: 0.121 ± 0.023
0.312CysIle: 0.312 ± 0.032
0.373CysLys: 0.373 ± 0.037
0.583CysLeu: 0.583 ± 0.048
0.101CysMet: 0.101 ± 0.019
0.207CysAsn: 0.207 ± 0.026
0.126CysPro: 0.126 ± 0.023
0.138CysGln: 0.138 ± 0.024
0.097CysArg: 0.097 ± 0.02
0.316CysSer: 0.316 ± 0.046
0.19CysThr: 0.19 ± 0.025
0.373CysVal: 0.373 ± 0.044
0.073CysTrp: 0.073 ± 0.017
0.275CysTyr: 0.275 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.783AspAla: 3.783 ± 0.127
0.308AspCys: 0.308 ± 0.043
4.066AspAsp: 4.066 ± 0.17
4.953AspGlu: 4.953 ± 0.168
3.479AspPhe: 3.479 ± 0.157
3.811AspGly: 3.811 ± 0.156
0.867AspHis: 0.867 ± 0.057
4.884AspIle: 4.884 ± 0.15
6.464AspLys: 6.464 ± 0.17
6.686AspLeu: 6.686 ± 0.197
1.523AspMet: 1.523 ± 0.082
4.208AspAsn: 4.208 ± 0.133
1.936AspPro: 1.936 ± 0.114
1.988AspGln: 1.988 ± 0.098
1.754AspArg: 1.754 ± 0.098
3.365AspSer: 3.365 ± 0.129
2.665AspThr: 2.665 ± 0.116
3.957AspVal: 3.957 ± 0.14
0.774AspTrp: 0.774 ± 0.061
3.305AspTyr: 3.305 ± 0.135
0.0AspXaa: 0.0 ± 0.0
Glu
4.05GluAla: 4.05 ± 0.205
0.255GluCys: 0.255 ± 0.033
3.491GluAsp: 3.491 ± 0.136
5.03GluGlu: 5.03 ± 0.18
2.835GluPhe: 2.835 ± 0.125
2.867GluGly: 2.867 ± 0.124
0.98GluHis: 0.98 ± 0.069
6.257GluIle: 6.257 ± 0.214
6.383GluLys: 6.383 ± 0.206
6.455GluLeu: 6.455 ± 0.222
1.766GluMet: 1.766 ± 0.089
4.665GluAsn: 4.665 ± 0.147
1.685GluPro: 1.685 ± 0.094
2.762GluGln: 2.762 ± 0.113
2.296GluArg: 2.296 ± 0.119
2.705GluSer: 2.705 ± 0.094
3.398GluThr: 3.398 ± 0.13
4.289GluVal: 4.289 ± 0.141
0.676GluTrp: 0.676 ± 0.051
2.592GluTyr: 2.592 ± 0.102
0.0GluXaa: 0.0 ± 0.0
Phe
3.09PheAla: 3.09 ± 0.126
0.255PheCys: 0.255 ± 0.036
3.608PheAsp: 3.608 ± 0.138
2.807PheGlu: 2.807 ± 0.113
2.353PhePhe: 2.353 ± 0.136
2.94PheGly: 2.94 ± 0.128
0.514PheHis: 0.514 ± 0.042
3.827PheIle: 3.827 ± 0.18
4.074PheLys: 4.074 ± 0.147
4.236PheLeu: 4.236 ± 0.182
1.029PheMet: 1.029 ± 0.075
3.604PheAsn: 3.604 ± 0.139
1.162PhePro: 1.162 ± 0.072
1.13PheGln: 1.13 ± 0.064
1.191PheArg: 1.191 ± 0.062
3.143PheSer: 3.143 ± 0.13
2.596PheThr: 2.596 ± 0.109
3.037PheVal: 3.037 ± 0.125
0.514PheTrp: 0.514 ± 0.052
1.98PheTyr: 1.98 ± 0.111
0.0PheXaa: 0.0 ± 0.0
Gly
3.503GlyAla: 3.503 ± 0.168
0.316GlyCys: 0.316 ± 0.039
3.199GlyAsp: 3.199 ± 0.126
3.28GlyGlu: 3.28 ± 0.123
2.964GlyPhe: 2.964 ± 0.146
3.195GlyGly: 3.195 ± 0.156
1.025GlyHis: 1.025 ± 0.068
5.058GlyIle: 5.058 ± 0.142
4.831GlyLys: 4.831 ± 0.154
5.058GlyLeu: 5.058 ± 0.15
1.725GlyMet: 1.725 ± 0.094
3.143GlyAsn: 3.143 ± 0.114
1.219GlyPro: 1.219 ± 0.066
1.891GlyGln: 1.891 ± 0.114
1.758GlyArg: 1.758 ± 0.09
3.301GlySer: 3.301 ± 0.134
3.365GlyThr: 3.365 ± 0.14
4.236GlyVal: 4.236 ± 0.141
0.818GlyTrp: 0.818 ± 0.073
2.616GlyTyr: 2.616 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.774HisAla: 0.774 ± 0.055
0.085HisCys: 0.085 ± 0.017
0.992HisAsp: 0.992 ± 0.074
0.956HisGlu: 0.956 ± 0.066
0.599HisPhe: 0.599 ± 0.048
0.927HisGly: 0.927 ± 0.068
0.328HisHis: 0.328 ± 0.042
0.988HisIle: 0.988 ± 0.062
1.065HisLys: 1.065 ± 0.072
1.118HisLeu: 1.118 ± 0.067
0.263HisMet: 0.263 ± 0.033
0.879HisAsn: 0.879 ± 0.065
0.648HisPro: 0.648 ± 0.048
0.583HisGln: 0.583 ± 0.047
0.506HisArg: 0.506 ± 0.044
0.753HisSer: 0.753 ± 0.06
0.644HisThr: 0.644 ± 0.054
0.842HisVal: 0.842 ± 0.056
0.101HisTrp: 0.101 ± 0.022
0.567HisTyr: 0.567 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.812IleAla: 5.812 ± 0.204
0.656IleCys: 0.656 ± 0.058
5.856IleAsp: 5.856 ± 0.166
4.876IleGlu: 4.876 ± 0.161
3.928IlePhe: 3.928 ± 0.182
4.657IleGly: 4.657 ± 0.148
0.98IleHis: 0.98 ± 0.067
6.783IleIle: 6.783 ± 0.208
7.201IleLys: 7.201 ± 0.188
7.148IleLeu: 7.148 ± 0.18
1.681IleMet: 1.681 ± 0.088
6.289IleAsn: 6.289 ± 0.205
2.956IlePro: 2.956 ± 0.122
2.393IleGln: 2.393 ± 0.102
2.474IleArg: 2.474 ± 0.094
5.641IleSer: 5.641 ± 0.18
4.929IleThr: 4.929 ± 0.239
5.544IleVal: 5.544 ± 0.178
0.644IleTrp: 0.644 ± 0.066
2.993IleTyr: 2.993 ± 0.117
0.0IleXaa: 0.0 ± 0.0
Lys
5.56LysAla: 5.56 ± 0.192
0.263LysCys: 0.263 ± 0.036
6.484LysAsp: 6.484 ± 0.192
7.994LysGlu: 7.994 ± 0.213
3.094LysPhe: 3.094 ± 0.117
4.098LysGly: 4.098 ± 0.141
1.215LysHis: 1.215 ± 0.076
7.156LysIle: 7.156 ± 0.201
9.205LysLys: 9.205 ± 0.238
6.792LysLeu: 6.792 ± 0.179
2.916LysMet: 2.916 ± 0.109
6.909LysAsn: 6.909 ± 0.2
3.252LysPro: 3.252 ± 0.131
4.107LysGln: 4.107 ± 0.149
3.179LysArg: 3.179 ± 0.127
4.479LysSer: 4.479 ± 0.138
6.14LysThr: 6.14 ± 0.158
5.479LysVal: 5.479 ± 0.144
1.162LysTrp: 1.162 ± 0.077
3.689LysTyr: 3.689 ± 0.117
0.0LysXaa: 0.0 ± 0.0
Leu
5.577LeuAla: 5.577 ± 0.169
0.369LeuCys: 0.369 ± 0.041
5.795LeuAsp: 5.795 ± 0.176
5.577LeuGlu: 5.577 ± 0.187
4.382LeuPhe: 4.382 ± 0.18
4.973LeuGly: 4.973 ± 0.164
1.0LeuHis: 1.0 ± 0.066
7.444LeuIle: 7.444 ± 0.214
8.294LeuLys: 8.294 ± 0.198
7.156LeuLeu: 7.156 ± 0.232
2.26LeuMet: 2.26 ± 0.104
6.686LeuAsn: 6.686 ± 0.2
2.713LeuPro: 2.713 ± 0.122
2.697LeuGln: 2.697 ± 0.119
2.576LeuArg: 2.576 ± 0.099
5.767LeuSer: 5.767 ± 0.17
6.136LeuThr: 6.136 ± 0.282
5.872LeuVal: 5.872 ± 0.18
0.887LeuTrp: 0.887 ± 0.065
2.778LeuTyr: 2.778 ± 0.12
0.0LeuXaa: 0.0 ± 0.0
Met
1.733MetAla: 1.733 ± 0.091
0.101MetCys: 0.101 ± 0.02
1.604MetAsp: 1.604 ± 0.091
1.126MetGlu: 1.126 ± 0.083
1.247MetPhe: 1.247 ± 0.071
1.405MetGly: 1.405 ± 0.085
0.312MetHis: 0.312 ± 0.038
2.223MetIle: 2.223 ± 0.086
2.353MetLys: 2.353 ± 0.105
1.984MetLeu: 1.984 ± 0.082
0.717MetMet: 0.717 ± 0.059
1.79MetAsn: 1.79 ± 0.106
0.834MetPro: 0.834 ± 0.052
0.741MetGln: 0.741 ± 0.062
0.765MetArg: 0.765 ± 0.055
1.543MetSer: 1.543 ± 0.068
1.47MetThr: 1.47 ± 0.085
1.644MetVal: 1.644 ± 0.09
0.19MetTrp: 0.19 ± 0.028
0.725MetTyr: 0.725 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.811AsnAla: 3.811 ± 0.132
0.312AsnCys: 0.312 ± 0.037
4.783AsnAsp: 4.783 ± 0.162
4.641AsnGlu: 4.641 ± 0.153
3.203AsnPhe: 3.203 ± 0.147
4.175AsnGly: 4.175 ± 0.167
1.13AsnHis: 1.13 ± 0.071
5.119AsnIle: 5.119 ± 0.175
7.29AsnLys: 7.29 ± 0.227
6.087AsnLeu: 6.087 ± 0.189
1.373AsnMet: 1.373 ± 0.072
5.479AsnAsn: 5.479 ± 0.235
2.632AsnPro: 2.632 ± 0.114
2.956AsnGln: 2.956 ± 0.12
2.155AsnArg: 2.155 ± 0.133
3.592AsnSer: 3.592 ± 0.144
3.151AsnThr: 3.151 ± 0.102
3.908AsnVal: 3.908 ± 0.139
0.859AsnTrp: 0.859 ± 0.059
3.163AsnTyr: 3.163 ± 0.148
0.0AsnXaa: 0.0 ± 0.0
Pro
1.559ProAla: 1.559 ± 0.095
0.121ProCys: 0.121 ± 0.02
2.029ProAsp: 2.029 ± 0.103
2.353ProGlu: 2.353 ± 0.095
1.466ProPhe: 1.466 ± 0.083
1.92ProGly: 1.92 ± 0.082
0.462ProHis: 0.462 ± 0.049
2.551ProIle: 2.551 ± 0.1
2.689ProLys: 2.689 ± 0.122
2.539ProLeu: 2.539 ± 0.105
0.66ProMet: 0.66 ± 0.051
2.26ProAsn: 2.26 ± 0.11
0.486ProPro: 0.486 ± 0.055
1.122ProGln: 1.122 ± 0.074
0.745ProArg: 0.745 ± 0.052
2.11ProSer: 2.11 ± 0.102
1.96ProThr: 1.96 ± 0.099
1.826ProVal: 1.826 ± 0.106
0.369ProTrp: 0.369 ± 0.04
1.393ProTyr: 1.393 ± 0.078
0.0ProXaa: 0.0 ± 0.0
Gln
2.219GlnAla: 2.219 ± 0.096
0.085GlnCys: 0.085 ± 0.018
1.859GlnAsp: 1.859 ± 0.092
2.551GlnGlu: 2.551 ± 0.13
1.592GlnPhe: 1.592 ± 0.075
1.66GlnGly: 1.66 ± 0.077
0.381GlnHis: 0.381 ± 0.037
2.981GlnIle: 2.981 ± 0.14
3.422GlnLys: 3.422 ± 0.142
3.167GlnLeu: 3.167 ± 0.145
0.915GlnMet: 0.915 ± 0.058
2.357GlnAsn: 2.357 ± 0.087
1.093GlnPro: 1.093 ± 0.081
1.454GlnGln: 1.454 ± 0.08
1.174GlnArg: 1.174 ± 0.079
1.66GlnSer: 1.66 ± 0.074
2.292GlnThr: 2.292 ± 0.121
2.341GlnVal: 2.341 ± 0.113
0.336GlnTrp: 0.336 ± 0.035
1.324GlnTyr: 1.324 ± 0.08
0.0GlnXaa: 0.0 ± 0.0
Arg
1.798ArgAla: 1.798 ± 0.086
0.142ArgCys: 0.142 ± 0.025
2.013ArgAsp: 2.013 ± 0.139
2.195ArgGlu: 2.195 ± 0.115
1.446ArgPhe: 1.446 ± 0.084
1.519ArgGly: 1.519 ± 0.094
0.373ArgHis: 0.373 ± 0.038
2.604ArgIle: 2.604 ± 0.093
2.932ArgLys: 2.932 ± 0.123
2.705ArgLeu: 2.705 ± 0.128
0.907ArgMet: 0.907 ± 0.068
2.033ArgAsn: 2.033 ± 0.104
1.0ArgPro: 1.0 ± 0.067
1.308ArgGln: 1.308 ± 0.067
1.328ArgArg: 1.328 ± 0.086
1.543ArgSer: 1.543 ± 0.084
1.814ArgThr: 1.814 ± 0.092
1.883ArgVal: 1.883 ± 0.083
0.324ArgTrp: 0.324 ± 0.04
1.345ArgTyr: 1.345 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
3.337SerAla: 3.337 ± 0.127
0.369SerCys: 0.369 ± 0.038
3.681SerAsp: 3.681 ± 0.133
3.329SerGlu: 3.329 ± 0.136
3.098SerPhe: 3.098 ± 0.136
3.608SerGly: 3.608 ± 0.118
0.818SerHis: 0.818 ± 0.062
4.584SerIle: 4.584 ± 0.155
5.079SerLys: 5.079 ± 0.151
5.645SerLeu: 5.645 ± 0.164
1.203SerMet: 1.203 ± 0.057
3.479SerAsn: 3.479 ± 0.154
1.652SerPro: 1.652 ± 0.083
2.159SerGln: 2.159 ± 0.096
1.806SerArg: 1.806 ± 0.099
3.637SerSer: 3.637 ± 0.157
3.313SerThr: 3.313 ± 0.12
3.499SerVal: 3.499 ± 0.122
0.705SerTrp: 0.705 ± 0.055
2.6SerTyr: 2.6 ± 0.126
0.0SerXaa: 0.0 ± 0.0
Thr
3.256ThrAla: 3.256 ± 0.132
0.243ThrCys: 0.243 ± 0.035
3.495ThrAsp: 3.495 ± 0.123
2.843ThrGlu: 2.843 ± 0.136
2.786ThrPhe: 2.786 ± 0.11
3.536ThrGly: 3.536 ± 0.148
0.741ThrHis: 0.741 ± 0.05
5.463ThrIle: 5.463 ± 0.181
5.18ThrLys: 5.18 ± 0.165
5.083ThrLeu: 5.083 ± 0.139
1.154ThrMet: 1.154 ± 0.067
4.22ThrAsn: 4.22 ± 0.159
2.357ThrPro: 2.357 ± 0.103
1.79ThrGln: 1.79 ± 0.099
1.916ThrArg: 1.916 ± 0.109
3.673ThrSer: 3.673 ± 0.153
3.847ThrThr: 3.847 ± 0.146
3.309ThrVal: 3.309 ± 0.162
0.559ThrTrp: 0.559 ± 0.058
2.118ThrTyr: 2.118 ± 0.094
0.0ThrXaa: 0.0 ± 0.0
Val
4.305ValAla: 4.305 ± 0.143
0.381ValCys: 0.381 ± 0.042
4.378ValAsp: 4.378 ± 0.13
4.115ValGlu: 4.115 ± 0.161
2.738ValPhe: 2.738 ± 0.121
3.928ValGly: 3.928 ± 0.117
0.79ValHis: 0.79 ± 0.054
5.471ValIle: 5.471 ± 0.162
5.605ValLys: 5.605 ± 0.173
5.751ValLeu: 5.751 ± 0.156
1.466ValMet: 1.466 ± 0.081
4.2ValAsn: 4.2 ± 0.142
1.899ValPro: 1.899 ± 0.098
1.656ValGln: 1.656 ± 0.09
1.741ValArg: 1.741 ± 0.081
3.673ValSer: 3.673 ± 0.133
3.564ValThr: 3.564 ± 0.165
4.742ValVal: 4.742 ± 0.153
0.688ValTrp: 0.688 ± 0.055
2.385ValTyr: 2.385 ± 0.11
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.05
0.097TrpCys: 0.097 ± 0.021
0.628TrpAsp: 0.628 ± 0.054
0.62TrpGlu: 0.62 ± 0.056
0.656TrpPhe: 0.656 ± 0.057
0.543TrpGly: 0.543 ± 0.054
0.178TrpHis: 0.178 ± 0.025
0.96TrpIle: 0.96 ± 0.073
0.931TrpLys: 0.931 ± 0.074
1.069TrpLeu: 1.069 ± 0.067
0.324TrpMet: 0.324 ± 0.04
0.794TrpAsn: 0.794 ± 0.066
0.243TrpPro: 0.243 ± 0.034
0.324TrpGln: 0.324 ± 0.037
0.352TrpArg: 0.352 ± 0.038
0.628TrpSer: 0.628 ± 0.051
0.656TrpThr: 0.656 ± 0.048
0.725TrpVal: 0.725 ± 0.055
0.263TrpTrp: 0.263 ± 0.034
0.51TrpTyr: 0.51 ± 0.052
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.098TyrAla: 2.098 ± 0.104
0.316TyrCys: 0.316 ± 0.04
2.96TyrAsp: 2.96 ± 0.116
2.495TyrGlu: 2.495 ± 0.107
2.203TyrPhe: 2.203 ± 0.108
2.442TyrGly: 2.442 ± 0.123
0.591TyrHis: 0.591 ± 0.046
2.831TyrIle: 2.831 ± 0.1
3.459TyrLys: 3.459 ± 0.119
3.945TyrLeu: 3.945 ± 0.15
0.765TyrMet: 0.765 ± 0.053
2.713TyrAsn: 2.713 ± 0.129
1.077TyrPro: 1.077 ± 0.078
1.818TyrGln: 1.818 ± 0.107
1.446TyrArg: 1.446 ± 0.087
2.584TyrSer: 2.584 ± 0.138
1.879TyrThr: 1.879 ± 0.104
2.414TyrVal: 2.414 ± 0.1
0.498TyrTrp: 0.498 ± 0.05
1.579TyrTyr: 1.579 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 689 proteins (246924 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski