Amino acid dipepetide frequency for Streptococcus phage Javan266

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.835AlaAla: 1.835 ± 0.406
0.29AlaCys: 0.29 ± 0.166
5.214AlaAsp: 5.214 ± 0.467
4.732AlaGlu: 4.732 ± 0.795
2.607AlaPhe: 2.607 ± 0.764
4.925AlaGly: 4.925 ± 1.095
0.676AlaHis: 0.676 ± 0.251
5.214AlaIle: 5.214 ± 1.041
6.47AlaLys: 6.47 ± 0.909
5.89AlaLeu: 5.89 ± 0.758
1.931AlaMet: 1.931 ± 0.462
3.38AlaAsn: 3.38 ± 0.436
1.931AlaPro: 1.931 ± 0.481
1.931AlaGln: 1.931 ± 0.308
2.317AlaArg: 2.317 ± 0.502
2.414AlaSer: 2.414 ± 0.53
3.187AlaThr: 3.187 ± 0.54
4.152AlaVal: 4.152 ± 0.99
0.772AlaTrp: 0.772 ± 0.269
2.8AlaTyr: 2.8 ± 0.593
0.0AlaXaa: 0.0 ± 0.0
Cys
0.29CysAla: 0.29 ± 0.158
0.097CysCys: 0.097 ± 0.093
0.29CysAsp: 0.29 ± 0.17
0.386CysGlu: 0.386 ± 0.177
0.29CysPhe: 0.29 ± 0.159
0.483CysGly: 0.483 ± 0.219
0.0CysHis: 0.0 ± 0.0
0.483CysIle: 0.483 ± 0.224
0.386CysLys: 0.386 ± 0.177
0.097CysLeu: 0.097 ± 0.095
0.097CysMet: 0.097 ± 0.078
0.29CysAsn: 0.29 ± 0.144
0.097CysPro: 0.097 ± 0.103
0.29CysGln: 0.29 ± 0.174
0.483CysArg: 0.483 ± 0.211
0.29CysSer: 0.29 ± 0.157
0.097CysThr: 0.097 ± 0.106
0.193CysVal: 0.193 ± 0.133
0.193CysTrp: 0.193 ± 0.132
0.483CysTyr: 0.483 ± 0.174
0.0CysXaa: 0.0 ± 0.0
Asp
4.442AspAla: 4.442 ± 0.594
0.386AspCys: 0.386 ± 0.219
3.573AspAsp: 3.573 ± 0.826
5.118AspGlu: 5.118 ± 1.017
3.38AspPhe: 3.38 ± 0.587
4.925AspGly: 4.925 ± 0.884
0.579AspHis: 0.579 ± 0.315
4.925AspIle: 4.925 ± 0.631
6.566AspLys: 6.566 ± 0.92
5.794AspLeu: 5.794 ± 0.99
2.414AspMet: 2.414 ± 0.544
3.09AspAsn: 3.09 ± 0.319
1.738AspPro: 1.738 ± 0.43
1.931AspGln: 1.931 ± 0.355
2.317AspArg: 2.317 ± 0.503
3.766AspSer: 3.766 ± 0.471
2.8AspThr: 2.8 ± 0.452
4.732AspVal: 4.732 ± 0.687
0.579AspTrp: 0.579 ± 0.235
2.124AspTyr: 2.124 ± 0.55
0.0AspXaa: 0.0 ± 0.0
Glu
5.407GluAla: 5.407 ± 0.669
0.097GluCys: 0.097 ± 0.095
3.862GluAsp: 3.862 ± 0.523
6.759GluGlu: 6.759 ± 1.036
2.704GluPhe: 2.704 ± 0.629
3.669GluGly: 3.669 ± 0.698
1.062GluHis: 1.062 ± 0.349
6.277GluIle: 6.277 ± 0.698
6.373GluLys: 6.373 ± 1.019
8.497GluLeu: 8.497 ± 1.074
2.028GluMet: 2.028 ± 0.391
4.056GluAsn: 4.056 ± 0.624
1.352GluPro: 1.352 ± 0.435
4.925GluGln: 4.925 ± 0.914
6.277GluArg: 6.277 ± 0.779
4.732GluSer: 4.732 ± 0.56
3.862GluThr: 3.862 ± 0.663
5.311GluVal: 5.311 ± 0.921
1.255GluTrp: 1.255 ± 0.326
3.09GluTyr: 3.09 ± 0.574
0.0GluXaa: 0.0 ± 0.0
Phe
3.38PheAla: 3.38 ± 0.585
0.0PheCys: 0.0 ± 0.0
3.187PheAsp: 3.187 ± 0.474
4.152PheGlu: 4.152 ± 0.607
2.414PhePhe: 2.414 ± 0.475
3.187PheGly: 3.187 ± 0.611
0.676PheHis: 0.676 ± 0.235
2.028PheIle: 2.028 ± 0.461
2.704PheLys: 2.704 ± 0.522
2.414PheLeu: 2.414 ± 0.426
0.772PheMet: 0.772 ± 0.292
2.704PheAsn: 2.704 ± 0.541
0.772PhePro: 0.772 ± 0.286
2.028PheGln: 2.028 ± 0.416
1.448PheArg: 1.448 ± 0.271
2.704PheSer: 2.704 ± 0.514
2.317PheThr: 2.317 ± 0.408
2.317PheVal: 2.317 ± 0.401
0.676PheTrp: 0.676 ± 0.284
1.835PheTyr: 1.835 ± 0.474
0.0PheXaa: 0.0 ± 0.0
Gly
3.959GlyAla: 3.959 ± 0.574
0.097GlyCys: 0.097 ± 0.119
4.635GlyAsp: 4.635 ± 0.655
5.794GlyGlu: 5.794 ± 0.813
2.897GlyPhe: 2.897 ± 0.774
4.538GlyGly: 4.538 ± 1.68
1.062GlyHis: 1.062 ± 0.252
5.407GlyIle: 5.407 ± 0.874
4.635GlyLys: 4.635 ± 0.763
6.18GlyLeu: 6.18 ± 0.63
1.642GlyMet: 1.642 ± 0.391
4.152GlyAsn: 4.152 ± 0.632
1.835GlyPro: 1.835 ± 0.802
3.283GlyGln: 3.283 ± 0.464
2.511GlyArg: 2.511 ± 0.395
2.897GlySer: 2.897 ± 0.58
3.38GlyThr: 3.38 ± 0.786
4.538GlyVal: 4.538 ± 0.76
1.255GlyTrp: 1.255 ± 0.396
3.283GlyTyr: 3.283 ± 0.738
0.0GlyXaa: 0.0 ± 0.0
His
0.579HisAla: 0.579 ± 0.268
0.386HisCys: 0.386 ± 0.199
1.352HisAsp: 1.352 ± 0.368
1.255HisGlu: 1.255 ± 0.333
0.579HisPhe: 0.579 ± 0.237
1.255HisGly: 1.255 ± 0.374
0.193HisHis: 0.193 ± 0.115
1.062HisIle: 1.062 ± 0.284
1.062HisLys: 1.062 ± 0.336
0.966HisLeu: 0.966 ± 0.305
0.193HisMet: 0.193 ± 0.135
0.772HisAsn: 0.772 ± 0.286
0.579HisPro: 0.579 ± 0.246
0.29HisGln: 0.29 ± 0.159
0.483HisArg: 0.483 ± 0.203
0.869HisSer: 0.869 ± 0.27
0.966HisThr: 0.966 ± 0.271
0.772HisVal: 0.772 ± 0.273
0.386HisTrp: 0.386 ± 0.187
0.483HisTyr: 0.483 ± 0.258
0.0HisXaa: 0.0 ± 0.0
Ile
4.249IleAla: 4.249 ± 0.662
0.483IleCys: 0.483 ± 0.236
3.766IleAsp: 3.766 ± 0.652
7.242IleGlu: 7.242 ± 0.898
2.704IlePhe: 2.704 ± 0.603
4.345IleGly: 4.345 ± 0.95
0.869IleHis: 0.869 ± 0.244
3.38IleIle: 3.38 ± 0.502
5.794IleLys: 5.794 ± 0.734
4.925IleLeu: 4.925 ± 0.774
1.352IleMet: 1.352 ± 0.386
3.766IleAsn: 3.766 ± 0.455
1.931IlePro: 1.931 ± 0.442
3.283IleGln: 3.283 ± 0.529
2.993IleArg: 2.993 ± 0.542
4.249IleSer: 4.249 ± 0.62
4.249IleThr: 4.249 ± 0.863
4.538IleVal: 4.538 ± 0.848
0.386IleTrp: 0.386 ± 0.181
2.414IleTyr: 2.414 ± 0.513
0.0IleXaa: 0.0 ± 0.0
Lys
5.311LysAla: 5.311 ± 0.753
0.29LysCys: 0.29 ± 0.171
5.504LysAsp: 5.504 ± 0.755
7.049LysGlu: 7.049 ± 0.969
3.187LysPhe: 3.187 ± 0.471
5.021LysGly: 5.021 ± 0.66
1.159LysHis: 1.159 ± 0.352
5.311LysIle: 5.311 ± 0.712
5.504LysLys: 5.504 ± 0.698
6.759LysLeu: 6.759 ± 0.798
1.931LysMet: 1.931 ± 0.344
4.249LysAsn: 4.249 ± 0.687
3.09LysPro: 3.09 ± 0.638
4.152LysGln: 4.152 ± 0.727
4.249LysArg: 4.249 ± 0.678
4.538LysSer: 4.538 ± 0.673
5.504LysThr: 5.504 ± 0.831
5.214LysVal: 5.214 ± 0.894
0.869LysTrp: 0.869 ± 0.27
3.573LysTyr: 3.573 ± 0.547
0.0LysXaa: 0.0 ± 0.0
Leu
6.18LeuAla: 6.18 ± 0.928
0.386LeuCys: 0.386 ± 0.284
6.566LeuAsp: 6.566 ± 0.729
6.759LeuGlu: 6.759 ± 0.833
2.317LeuPhe: 2.317 ± 0.57
6.18LeuGly: 6.18 ± 0.88
1.255LeuHis: 1.255 ± 0.326
4.635LeuIle: 4.635 ± 0.749
7.822LeuLys: 7.822 ± 0.9
6.083LeuLeu: 6.083 ± 0.681
2.124LeuMet: 2.124 ± 0.521
3.959LeuAsn: 3.959 ± 0.585
2.511LeuPro: 2.511 ± 0.516
2.993LeuGln: 2.993 ± 0.57
4.056LeuArg: 4.056 ± 0.74
5.214LeuSer: 5.214 ± 0.65
5.697LeuThr: 5.697 ± 0.55
4.056LeuVal: 4.056 ± 0.698
0.386LeuTrp: 0.386 ± 0.213
3.09LeuTyr: 3.09 ± 0.624
0.0LeuXaa: 0.0 ± 0.0
Met
1.642MetAla: 1.642 ± 0.345
0.0MetCys: 0.0 ± 0.0
1.448MetAsp: 1.448 ± 0.34
2.124MetGlu: 2.124 ± 0.502
0.772MetPhe: 0.772 ± 0.292
1.642MetGly: 1.642 ± 0.454
0.676MetHis: 0.676 ± 0.252
1.738MetIle: 1.738 ± 0.65
2.414MetLys: 2.414 ± 0.615
2.124MetLeu: 2.124 ± 0.564
0.386MetMet: 0.386 ± 0.209
1.545MetAsn: 1.545 ± 0.364
0.966MetPro: 0.966 ± 0.362
0.579MetGln: 0.579 ± 0.218
0.869MetArg: 0.869 ± 0.25
1.642MetSer: 1.642 ± 0.374
1.642MetThr: 1.642 ± 0.356
0.869MetVal: 0.869 ± 0.235
0.0MetTrp: 0.0 ± 0.0
0.966MetTyr: 0.966 ± 0.289
0.0MetXaa: 0.0 ± 0.0
Asn
3.573AsnAla: 3.573 ± 1.041
0.193AsnCys: 0.193 ± 0.118
3.09AsnAsp: 3.09 ± 0.454
3.959AsnGlu: 3.959 ± 0.815
1.255AsnPhe: 1.255 ± 0.359
4.635AsnGly: 4.635 ± 0.683
1.062AsnHis: 1.062 ± 0.251
2.317AsnIle: 2.317 ± 0.323
6.083AsnLys: 6.083 ± 0.861
4.925AsnLeu: 4.925 ± 0.757
1.545AsnMet: 1.545 ± 0.337
2.704AsnAsn: 2.704 ± 0.468
1.159AsnPro: 1.159 ± 0.356
2.124AsnGln: 2.124 ± 0.385
2.897AsnArg: 2.897 ± 0.427
2.897AsnSer: 2.897 ± 0.476
2.897AsnThr: 2.897 ± 0.509
3.669AsnVal: 3.669 ± 0.685
1.352AsnTrp: 1.352 ± 0.524
1.738AsnTyr: 1.738 ± 0.354
0.0AsnXaa: 0.0 ± 0.0
Pro
2.317ProAla: 2.317 ± 0.482
0.29ProCys: 0.29 ± 0.174
2.414ProAsp: 2.414 ± 0.417
2.993ProGlu: 2.993 ± 0.603
0.869ProPhe: 0.869 ± 0.279
1.931ProGly: 1.931 ± 0.456
0.29ProHis: 0.29 ± 0.159
2.221ProIle: 2.221 ± 0.658
2.221ProLys: 2.221 ± 0.425
1.931ProLeu: 1.931 ± 0.426
0.579ProMet: 0.579 ± 0.247
1.159ProAsn: 1.159 ± 0.356
0.772ProPro: 0.772 ± 0.224
0.966ProGln: 0.966 ± 0.338
1.352ProArg: 1.352 ± 0.353
1.255ProSer: 1.255 ± 0.394
1.738ProThr: 1.738 ± 0.32
1.835ProVal: 1.835 ± 0.448
0.579ProTrp: 0.579 ± 0.227
1.159ProTyr: 1.159 ± 0.319
0.0ProXaa: 0.0 ± 0.0
Gln
3.09GlnAla: 3.09 ± 0.607
0.579GlnCys: 0.579 ± 0.228
2.704GlnAsp: 2.704 ± 0.5
3.766GlnGlu: 3.766 ± 0.655
2.511GlnPhe: 2.511 ± 0.552
2.607GlnGly: 2.607 ± 0.641
0.193GlnHis: 0.193 ± 0.124
3.283GlnIle: 3.283 ± 0.495
4.056GlnLys: 4.056 ± 0.471
3.09GlnLeu: 3.09 ± 0.601
1.448GlnMet: 1.448 ± 0.375
1.738GlnAsn: 1.738 ± 0.379
1.062GlnPro: 1.062 ± 0.394
1.642GlnGln: 1.642 ± 0.464
1.545GlnArg: 1.545 ± 0.364
1.931GlnSer: 1.931 ± 0.496
2.221GlnThr: 2.221 ± 0.422
2.993GlnVal: 2.993 ± 0.542
0.386GlnTrp: 0.386 ± 0.192
0.966GlnTyr: 0.966 ± 0.298
0.0GlnXaa: 0.0 ± 0.0
Arg
2.221ArgAla: 2.221 ± 0.345
0.097ArgCys: 0.097 ± 0.093
2.317ArgAsp: 2.317 ± 0.503
3.669ArgGlu: 3.669 ± 0.49
2.221ArgPhe: 2.221 ± 0.495
3.09ArgGly: 3.09 ± 0.495
0.869ArgHis: 0.869 ± 0.247
3.573ArgIle: 3.573 ± 0.595
3.283ArgLys: 3.283 ± 0.498
5.021ArgLeu: 5.021 ± 0.908
1.159ArgMet: 1.159 ± 0.39
2.511ArgAsn: 2.511 ± 0.471
0.579ArgPro: 0.579 ± 0.241
1.835ArgGln: 1.835 ± 0.41
2.8ArgArg: 2.8 ± 0.681
3.187ArgSer: 3.187 ± 0.547
1.835ArgThr: 1.835 ± 0.382
3.476ArgVal: 3.476 ± 0.525
0.579ArgTrp: 0.579 ± 0.247
1.738ArgTyr: 1.738 ± 0.507
0.0ArgXaa: 0.0 ± 0.0
Ser
3.09SerAla: 3.09 ± 0.611
0.386SerCys: 0.386 ± 0.209
5.214SerAsp: 5.214 ± 0.598
4.249SerGlu: 4.249 ± 0.826
2.897SerPhe: 2.897 ± 0.543
3.283SerGly: 3.283 ± 0.803
1.255SerHis: 1.255 ± 0.318
4.442SerIle: 4.442 ± 0.637
3.766SerLys: 3.766 ± 0.704
4.732SerLeu: 4.732 ± 0.6
1.062SerMet: 1.062 ± 0.271
2.993SerAsn: 2.993 ± 0.415
1.642SerPro: 1.642 ± 0.308
2.8SerGln: 2.8 ± 0.597
2.511SerArg: 2.511 ± 0.533
3.573SerSer: 3.573 ± 0.48
3.187SerThr: 3.187 ± 0.423
3.476SerVal: 3.476 ± 0.605
0.676SerTrp: 0.676 ± 0.248
3.476SerTyr: 3.476 ± 0.685
0.0SerXaa: 0.0 ± 0.0
Thr
3.669ThrAla: 3.669 ± 0.601
0.386ThrCys: 0.386 ± 0.231
3.573ThrAsp: 3.573 ± 0.536
2.511ThrGlu: 2.511 ± 0.504
2.414ThrPhe: 2.414 ± 0.888
4.925ThrGly: 4.925 ± 0.533
0.483ThrHis: 0.483 ± 0.179
4.152ThrIle: 4.152 ± 0.543
4.249ThrLys: 4.249 ± 0.58
4.345ThrLeu: 4.345 ± 0.815
0.772ThrMet: 0.772 ± 0.229
2.8ThrAsn: 2.8 ± 0.402
1.835ThrPro: 1.835 ± 0.469
2.993ThrGln: 2.993 ± 0.583
1.545ThrArg: 1.545 ± 0.373
3.669ThrSer: 3.669 ± 0.53
4.152ThrThr: 4.152 ± 0.604
4.442ThrVal: 4.442 ± 0.889
1.062ThrTrp: 1.062 ± 0.314
2.993ThrTyr: 2.993 ± 0.579
0.0ThrXaa: 0.0 ± 0.0
Val
4.635ValAla: 4.635 ± 1.122
0.193ValCys: 0.193 ± 0.118
3.38ValAsp: 3.38 ± 0.526
5.794ValGlu: 5.794 ± 0.725
2.317ValPhe: 2.317 ± 0.549
4.538ValGly: 4.538 ± 0.726
0.966ValHis: 0.966 ± 0.37
3.766ValIle: 3.766 ± 0.556
4.152ValLys: 4.152 ± 0.52
4.442ValLeu: 4.442 ± 0.727
1.738ValMet: 1.738 ± 0.409
4.635ValAsn: 4.635 ± 0.743
2.993ValPro: 2.993 ± 0.622
1.642ValGln: 1.642 ± 0.375
1.931ValArg: 1.931 ± 0.427
5.214ValSer: 5.214 ± 0.649
4.442ValThr: 4.442 ± 0.665
4.538ValVal: 4.538 ± 0.751
0.579ValTrp: 0.579 ± 0.181
2.897ValTyr: 2.897 ± 0.554
0.0ValXaa: 0.0 ± 0.0
Trp
0.579TrpAla: 0.579 ± 0.358
0.29TrpCys: 0.29 ± 0.16
0.869TrpAsp: 0.869 ± 0.409
0.676TrpGlu: 0.676 ± 0.289
1.159TrpPhe: 1.159 ± 0.436
0.676TrpGly: 0.676 ± 0.208
0.097TrpHis: 0.097 ± 0.095
0.579TrpIle: 0.579 ± 0.289
1.159TrpLys: 1.159 ± 0.416
0.966TrpLeu: 0.966 ± 0.376
0.386TrpMet: 0.386 ± 0.153
0.966TrpAsn: 0.966 ± 0.286
0.097TrpPro: 0.097 ± 0.078
0.386TrpGln: 0.386 ± 0.19
0.772TrpArg: 0.772 ± 0.23
0.966TrpSer: 0.966 ± 0.262
0.386TrpThr: 0.386 ± 0.225
1.352TrpVal: 1.352 ± 0.446
0.193TrpTrp: 0.193 ± 0.155
0.579TrpTyr: 0.579 ± 0.223
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.221TyrAla: 2.221 ± 0.531
0.386TyrCys: 0.386 ± 0.195
2.221TyrAsp: 2.221 ± 0.419
2.607TyrGlu: 2.607 ± 0.553
2.221TyrPhe: 2.221 ± 0.499
2.124TyrGly: 2.124 ± 0.45
1.062TyrHis: 1.062 ± 0.314
2.221TyrIle: 2.221 ± 0.363
3.766TyrLys: 3.766 ± 0.753
3.09TyrLeu: 3.09 ± 0.645
0.386TyrMet: 0.386 ± 0.209
2.607TyrAsn: 2.607 ± 0.394
1.931TyrPro: 1.931 ± 0.483
1.738TyrGln: 1.738 ± 0.435
2.704TyrArg: 2.704 ± 0.542
2.704TyrSer: 2.704 ± 0.517
2.414TyrThr: 2.414 ± 0.583
2.317TyrVal: 2.317 ± 0.534
0.966TyrTrp: 0.966 ± 0.324
1.255TyrTyr: 1.255 ± 0.392
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (10357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski