Amino acid dipepetide frequency for Streptococcus phage Javan377

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.955AlaAla: 2.955 ± 1.29
0.174AlaCys: 0.174 ± 0.12
4.781AlaAsp: 4.781 ± 0.589
6.259AlaGlu: 6.259 ± 1.146
2.26AlaPhe: 2.26 ± 0.7
5.042AlaGly: 5.042 ± 0.891
1.043AlaHis: 1.043 ± 0.326
6.519AlaIle: 6.519 ± 0.78
5.824AlaLys: 5.824 ± 0.657
7.041AlaLeu: 7.041 ± 1.231
1.999AlaMet: 1.999 ± 0.407
4.607AlaAsn: 4.607 ± 0.761
2.782AlaPro: 2.782 ± 0.802
5.042AlaGln: 5.042 ± 0.931
3.651AlaArg: 3.651 ± 0.761
5.998AlaSer: 5.998 ± 1.859
4.607AlaThr: 4.607 ± 0.595
4.52AlaVal: 4.52 ± 0.768
0.956AlaTrp: 0.956 ± 0.325
2.434AlaTyr: 2.434 ± 0.514
0.0AlaXaa: 0.0 ± 0.0
Cys
0.087CysAla: 0.087 ± 0.102
0.0CysCys: 0.0 ± 0.0
0.261CysAsp: 0.261 ± 0.19
0.174CysGlu: 0.174 ± 0.115
0.608CysPhe: 0.608 ± 0.239
0.174CysGly: 0.174 ± 0.109
0.087CysHis: 0.087 ± 0.077
0.174CysIle: 0.174 ± 0.122
0.522CysLys: 0.522 ± 0.217
0.087CysLeu: 0.087 ± 0.077
0.261CysMet: 0.261 ± 0.169
0.348CysAsn: 0.348 ± 0.136
0.435CysPro: 0.435 ± 0.184
0.174CysGln: 0.174 ± 0.111
0.261CysArg: 0.261 ± 0.18
0.348CysSer: 0.348 ± 0.16
0.087CysThr: 0.087 ± 0.077
0.174CysVal: 0.174 ± 0.124
0.087CysTrp: 0.087 ± 0.085
0.261CysTyr: 0.261 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
3.999AspAla: 3.999 ± 0.695
0.348AspCys: 0.348 ± 0.202
2.521AspAsp: 2.521 ± 0.601
5.389AspGlu: 5.389 ± 0.748
3.129AspPhe: 3.129 ± 0.552
4.52AspGly: 4.52 ± 0.67
1.13AspHis: 1.13 ± 0.323
2.347AspIle: 2.347 ± 0.353
4.433AspLys: 4.433 ± 0.658
5.476AspLeu: 5.476 ± 0.835
1.217AspMet: 1.217 ± 0.386
2.869AspAsn: 2.869 ± 0.708
2.173AspPro: 2.173 ± 0.423
2.608AspGln: 2.608 ± 0.463
2.434AspArg: 2.434 ± 0.476
3.39AspSer: 3.39 ± 0.507
3.303AspThr: 3.303 ± 0.654
3.477AspVal: 3.477 ± 0.548
1.13AspTrp: 1.13 ± 0.272
2.695AspTyr: 2.695 ± 0.611
0.0AspXaa: 0.0 ± 0.0
Glu
6.259GluAla: 6.259 ± 0.863
0.348GluCys: 0.348 ± 0.186
3.999GluAsp: 3.999 ± 0.84
7.389GluGlu: 7.389 ± 1.411
3.129GluPhe: 3.129 ± 0.552
5.042GluGly: 5.042 ± 0.648
1.13GluHis: 1.13 ± 0.398
5.563GluIle: 5.563 ± 0.801
6.433GluLys: 6.433 ± 0.855
9.562GluLeu: 9.562 ± 1.177
2.521GluMet: 2.521 ± 0.523
4.433GluAsn: 4.433 ± 0.818
1.652GluPro: 1.652 ± 0.358
4.52GluGln: 4.52 ± 0.859
4.694GluArg: 4.694 ± 1.056
2.955GluSer: 2.955 ± 0.581
4.086GluThr: 4.086 ± 0.596
4.086GluVal: 4.086 ± 0.703
1.217GluTrp: 1.217 ± 0.281
3.39GluTyr: 3.39 ± 0.675
0.0GluXaa: 0.0 ± 0.0
Phe
2.521PheAla: 2.521 ± 0.478
0.348PheCys: 0.348 ± 0.208
3.477PheAsp: 3.477 ± 0.475
4.955PheGlu: 4.955 ± 0.864
1.652PhePhe: 1.652 ± 0.346
3.042PheGly: 3.042 ± 0.499
0.174PheHis: 0.174 ± 0.122
2.086PheIle: 2.086 ± 0.375
3.216PheLys: 3.216 ± 0.45
2.434PheLeu: 2.434 ± 0.472
0.695PheMet: 0.695 ± 0.346
2.608PheAsn: 2.608 ± 0.477
1.304PhePro: 1.304 ± 0.359
1.304PheGln: 1.304 ± 0.274
1.391PheArg: 1.391 ± 0.35
2.26PheSer: 2.26 ± 0.452
3.129PheThr: 3.129 ± 0.55
1.912PheVal: 1.912 ± 0.439
0.435PheTrp: 0.435 ± 0.264
1.043PheTyr: 1.043 ± 0.298
0.0PheXaa: 0.0 ± 0.0
Gly
5.389GlyAla: 5.389 ± 0.908
0.174GlyCys: 0.174 ± 0.11
3.042GlyAsp: 3.042 ± 0.472
4.346GlyGlu: 4.346 ± 0.452
3.216GlyPhe: 3.216 ± 0.568
3.825GlyGly: 3.825 ± 0.594
0.695GlyHis: 0.695 ± 0.218
4.433GlyIle: 4.433 ± 0.824
6.867GlyLys: 6.867 ± 0.701
6.346GlyLeu: 6.346 ± 0.885
1.825GlyMet: 1.825 ± 0.415
2.869GlyAsn: 2.869 ± 0.495
1.217GlyPro: 1.217 ± 0.259
3.39GlyGln: 3.39 ± 0.673
3.39GlyArg: 3.39 ± 0.699
4.346GlySer: 4.346 ± 0.604
4.607GlyThr: 4.607 ± 0.982
4.346GlyVal: 4.346 ± 0.509
1.13GlyTrp: 1.13 ± 0.34
2.26GlyTyr: 2.26 ± 0.398
0.0GlyXaa: 0.0 ± 0.0
His
1.043HisAla: 1.043 ± 0.3
0.0HisCys: 0.0 ± 0.0
0.435HisAsp: 0.435 ± 0.221
1.043HisGlu: 1.043 ± 0.271
0.956HisPhe: 0.956 ± 0.336
1.043HisGly: 1.043 ± 0.356
0.608HisHis: 0.608 ± 0.222
0.608HisIle: 0.608 ± 0.223
1.043HisLys: 1.043 ± 0.26
0.782HisLeu: 0.782 ± 0.225
0.0HisMet: 0.0 ± 0.0
0.869HisAsn: 0.869 ± 0.244
0.261HisPro: 0.261 ± 0.15
0.348HisGln: 0.348 ± 0.145
0.695HisArg: 0.695 ± 0.207
0.869HisSer: 0.869 ± 0.235
0.782HisThr: 0.782 ± 0.214
0.695HisVal: 0.695 ± 0.269
0.174HisTrp: 0.174 ± 0.194
0.348HisTyr: 0.348 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
5.563IleAla: 5.563 ± 0.7
0.608IleCys: 0.608 ± 0.213
4.781IleAsp: 4.781 ± 0.601
7.128IleGlu: 7.128 ± 1.15
1.912IlePhe: 1.912 ± 0.378
4.52IleGly: 4.52 ± 0.734
0.869IleHis: 0.869 ± 0.197
3.129IleIle: 3.129 ± 0.494
5.563IleLys: 5.563 ± 0.672
3.912IleLeu: 3.912 ± 0.588
1.13IleMet: 1.13 ± 0.363
3.651IleAsn: 3.651 ± 0.536
1.999IlePro: 1.999 ± 0.367
1.912IleGln: 1.912 ± 0.529
2.173IleArg: 2.173 ± 0.375
3.39IleSer: 3.39 ± 0.705
3.651IleThr: 3.651 ± 0.79
3.738IleVal: 3.738 ± 0.5
0.782IleTrp: 0.782 ± 0.245
2.782IleTyr: 2.782 ± 0.596
0.0IleXaa: 0.0 ± 0.0
Lys
7.65LysAla: 7.65 ± 1.255
0.348LysCys: 0.348 ± 0.169
4.781LysAsp: 4.781 ± 0.667
6.693LysGlu: 6.693 ± 0.856
2.26LysPhe: 2.26 ± 0.352
5.389LysGly: 5.389 ± 0.559
0.522LysHis: 0.522 ± 0.196
5.476LysIle: 5.476 ± 0.662
6.172LysLys: 6.172 ± 0.915
7.389LysLeu: 7.389 ± 0.839
1.912LysMet: 1.912 ± 0.384
4.433LysAsn: 4.433 ± 0.711
2.434LysPro: 2.434 ± 0.483
3.042LysGln: 3.042 ± 0.459
3.651LysArg: 3.651 ± 0.78
4.086LysSer: 4.086 ± 0.595
5.129LysThr: 5.129 ± 0.766
4.607LysVal: 4.607 ± 0.653
0.956LysTrp: 0.956 ± 0.294
3.042LysTyr: 3.042 ± 0.575
0.0LysXaa: 0.0 ± 0.0
Leu
7.041LeuAla: 7.041 ± 0.875
0.348LeuCys: 0.348 ± 0.224
5.389LeuAsp: 5.389 ± 0.844
6.606LeuGlu: 6.606 ± 0.979
3.129LeuPhe: 3.129 ± 0.462
5.998LeuGly: 5.998 ± 0.839
0.782LeuHis: 0.782 ± 0.211
4.172LeuIle: 4.172 ± 0.628
9.04LeuLys: 9.04 ± 1.039
5.911LeuLeu: 5.911 ± 0.626
2.173LeuMet: 2.173 ± 0.582
5.129LeuAsn: 5.129 ± 0.868
3.651LeuPro: 3.651 ± 0.588
3.912LeuGln: 3.912 ± 0.539
3.477LeuArg: 3.477 ± 0.797
5.303LeuSer: 5.303 ± 0.762
4.781LeuThr: 4.781 ± 0.796
4.868LeuVal: 4.868 ± 0.741
0.435LeuTrp: 0.435 ± 0.167
2.955LeuTyr: 2.955 ± 0.407
0.0LeuXaa: 0.0 ± 0.0
Met
2.782MetAla: 2.782 ± 0.747
0.0MetCys: 0.0 ± 0.0
1.478MetAsp: 1.478 ± 0.336
1.912MetGlu: 1.912 ± 0.485
0.782MetPhe: 0.782 ± 0.245
1.565MetGly: 1.565 ± 0.416
0.0MetHis: 0.0 ± 0.0
2.173MetIle: 2.173 ± 0.443
1.478MetLys: 1.478 ± 0.36
1.304MetLeu: 1.304 ± 0.343
0.261MetMet: 0.261 ± 0.159
1.565MetAsn: 1.565 ± 0.497
0.869MetPro: 0.869 ± 0.347
1.304MetGln: 1.304 ± 0.495
1.304MetArg: 1.304 ± 0.317
2.173MetSer: 2.173 ± 0.51
1.565MetThr: 1.565 ± 0.343
1.217MetVal: 1.217 ± 0.325
0.348MetTrp: 0.348 ± 0.15
0.522MetTyr: 0.522 ± 0.231
0.0MetXaa: 0.0 ± 0.0
Asn
4.433AsnAla: 4.433 ± 1.048
0.261AsnCys: 0.261 ± 0.125
2.782AsnAsp: 2.782 ± 0.514
4.172AsnGlu: 4.172 ± 0.66
2.434AsnPhe: 2.434 ± 0.404
4.433AsnGly: 4.433 ± 0.547
1.13AsnHis: 1.13 ± 0.303
3.999AsnIle: 3.999 ± 0.43
3.477AsnLys: 3.477 ± 0.74
4.172AsnLeu: 4.172 ± 0.57
1.652AsnMet: 1.652 ± 0.395
2.869AsnAsn: 2.869 ± 0.475
1.912AsnPro: 1.912 ± 0.546
2.869AsnGln: 2.869 ± 0.59
1.912AsnArg: 1.912 ± 0.51
3.564AsnSer: 3.564 ± 0.743
2.26AsnThr: 2.26 ± 0.402
3.564AsnVal: 3.564 ± 0.628
0.869AsnTrp: 0.869 ± 0.317
2.521AsnTyr: 2.521 ± 0.609
0.0AsnXaa: 0.0 ± 0.0
Pro
3.042ProAla: 3.042 ± 0.775
0.087ProCys: 0.087 ± 0.088
2.347ProAsp: 2.347 ± 0.482
2.434ProGlu: 2.434 ± 0.624
1.565ProPhe: 1.565 ± 0.376
1.217ProGly: 1.217 ± 0.313
0.261ProHis: 0.261 ± 0.143
1.478ProIle: 1.478 ± 0.327
2.347ProLys: 2.347 ± 0.394
2.26ProLeu: 2.26 ± 0.485
0.695ProMet: 0.695 ± 0.226
1.13ProAsn: 1.13 ± 0.296
0.695ProPro: 0.695 ± 0.244
2.173ProGln: 2.173 ± 0.603
0.695ProArg: 0.695 ± 0.248
1.825ProSer: 1.825 ± 0.348
1.478ProThr: 1.478 ± 0.302
2.26ProVal: 2.26 ± 0.448
0.261ProTrp: 0.261 ± 0.142
0.956ProTyr: 0.956 ± 0.297
0.0ProXaa: 0.0 ± 0.0
Gln
4.607GlnAla: 4.607 ± 0.848
0.087GlnCys: 0.087 ± 0.086
1.652GlnAsp: 1.652 ± 0.469
3.564GlnGlu: 3.564 ± 0.91
2.173GlnPhe: 2.173 ± 0.287
2.695GlnGly: 2.695 ± 0.473
0.261GlnHis: 0.261 ± 0.145
3.216GlnIle: 3.216 ± 0.545
4.346GlnLys: 4.346 ± 0.619
3.999GlnLeu: 3.999 ± 0.941
1.565GlnMet: 1.565 ± 0.553
2.695GlnAsn: 2.695 ± 0.645
1.652GlnPro: 1.652 ± 0.56
3.129GlnGln: 3.129 ± 0.686
2.26GlnArg: 2.26 ± 0.618
1.912GlnSer: 1.912 ± 0.46
3.477GlnThr: 3.477 ± 0.582
2.695GlnVal: 2.695 ± 0.464
0.087GlnTrp: 0.087 ± 0.083
1.565GlnTyr: 1.565 ± 0.484
0.0GlnXaa: 0.0 ± 0.0
Arg
3.477ArgAla: 3.477 ± 0.612
0.087ArgCys: 0.087 ± 0.097
2.347ArgAsp: 2.347 ± 0.441
2.869ArgGlu: 2.869 ± 0.639
1.825ArgPhe: 1.825 ± 0.519
3.216ArgGly: 3.216 ± 0.546
1.13ArgHis: 1.13 ± 0.306
2.695ArgIle: 2.695 ± 0.417
3.825ArgLys: 3.825 ± 0.739
5.476ArgLeu: 5.476 ± 0.838
1.391ArgMet: 1.391 ± 0.37
1.739ArgAsn: 1.739 ± 0.472
1.13ArgPro: 1.13 ± 0.416
1.304ArgGln: 1.304 ± 0.411
1.739ArgArg: 1.739 ± 0.509
2.695ArgSer: 2.695 ± 0.476
2.086ArgThr: 2.086 ± 0.535
2.434ArgVal: 2.434 ± 0.459
0.261ArgTrp: 0.261 ± 0.17
1.652ArgTyr: 1.652 ± 0.371
0.0ArgXaa: 0.0 ± 0.0
Ser
5.65SerAla: 5.65 ± 1.582
0.348SerCys: 0.348 ± 0.2
3.564SerAsp: 3.564 ± 0.452
4.172SerGlu: 4.172 ± 0.771
2.608SerPhe: 2.608 ± 0.546
3.738SerGly: 3.738 ± 0.642
0.522SerHis: 0.522 ± 0.216
4.086SerIle: 4.086 ± 0.51
3.999SerLys: 3.999 ± 0.76
4.52SerLeu: 4.52 ± 0.784
1.825SerMet: 1.825 ± 0.502
3.303SerAsn: 3.303 ± 0.819
1.391SerPro: 1.391 ± 0.305
2.782SerGln: 2.782 ± 0.453
1.652SerArg: 1.652 ± 0.361
3.477SerSer: 3.477 ± 0.911
3.999SerThr: 3.999 ± 0.886
3.825SerVal: 3.825 ± 0.548
1.391SerTrp: 1.391 ± 0.262
1.825SerTyr: 1.825 ± 0.389
0.0SerXaa: 0.0 ± 0.0
Thr
5.129ThrAla: 5.129 ± 0.939
0.174ThrCys: 0.174 ± 0.094
3.738ThrAsp: 3.738 ± 0.622
5.042ThrGlu: 5.042 ± 0.741
2.434ThrPhe: 2.434 ± 0.568
5.129ThrGly: 5.129 ± 0.785
0.522ThrHis: 0.522 ± 0.219
4.086ThrIle: 4.086 ± 0.713
3.39ThrLys: 3.39 ± 0.654
4.346ThrLeu: 4.346 ± 0.584
1.391ThrMet: 1.391 ± 0.595
4.086ThrAsn: 4.086 ± 0.878
1.565ThrPro: 1.565 ± 0.36
2.782ThrGln: 2.782 ± 0.526
2.434ThrArg: 2.434 ± 0.464
3.129ThrSer: 3.129 ± 0.949
4.346ThrThr: 4.346 ± 0.846
4.346ThrVal: 4.346 ± 0.539
0.348ThrTrp: 0.348 ± 0.167
1.999ThrTyr: 1.999 ± 0.558
0.0ThrXaa: 0.0 ± 0.0
Val
4.259ValAla: 4.259 ± 0.698
0.261ValCys: 0.261 ± 0.139
4.259ValAsp: 4.259 ± 0.521
4.607ValGlu: 4.607 ± 0.765
1.565ValPhe: 1.565 ± 0.364
3.999ValGly: 3.999 ± 0.672
1.217ValHis: 1.217 ± 0.389
3.825ValIle: 3.825 ± 0.634
4.086ValLys: 4.086 ± 0.564
5.737ValLeu: 5.737 ± 0.742
1.391ValMet: 1.391 ± 0.393
3.39ValAsn: 3.39 ± 0.524
1.391ValPro: 1.391 ± 0.306
2.434ValGln: 2.434 ± 0.474
2.608ValArg: 2.608 ± 0.542
4.433ValSer: 4.433 ± 0.725
3.999ValThr: 3.999 ± 0.557
3.999ValVal: 3.999 ± 0.875
0.695ValTrp: 0.695 ± 0.222
1.739ValTyr: 1.739 ± 0.513
0.0ValXaa: 0.0 ± 0.0
Trp
0.956TrpAla: 0.956 ± 0.356
0.174TrpCys: 0.174 ± 0.113
1.304TrpAsp: 1.304 ± 0.388
0.956TrpGlu: 0.956 ± 0.231
0.608TrpPhe: 0.608 ± 0.219
0.608TrpGly: 0.608 ± 0.254
0.087TrpHis: 0.087 ± 0.09
0.695TrpIle: 0.695 ± 0.247
0.956TrpLys: 0.956 ± 0.257
1.478TrpLeu: 1.478 ± 0.371
0.087TrpMet: 0.087 ± 0.081
0.869TrpAsn: 0.869 ± 0.353
0.0TrpPro: 0.0 ± 0.0
0.348TrpGln: 0.348 ± 0.207
0.608TrpArg: 0.608 ± 0.231
0.782TrpSer: 0.782 ± 0.213
0.435TrpThr: 0.435 ± 0.193
0.869TrpVal: 0.869 ± 0.265
0.0TrpTrp: 0.0 ± 0.0
0.348TrpTyr: 0.348 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.652TyrAla: 1.652 ± 0.418
0.435TyrCys: 0.435 ± 0.191
1.652TyrAsp: 1.652 ± 0.463
2.782TyrGlu: 2.782 ± 0.576
1.739TyrPhe: 1.739 ± 0.415
2.521TyrGly: 2.521 ± 0.6
0.435TyrHis: 0.435 ± 0.197
2.434TyrIle: 2.434 ± 0.496
2.955TyrLys: 2.955 ± 0.52
2.869TyrLeu: 2.869 ± 0.586
0.522TyrMet: 0.522 ± 0.187
1.825TyrAsn: 1.825 ± 0.466
0.695TyrPro: 0.695 ± 0.253
2.26TyrGln: 2.26 ± 0.433
2.347TyrArg: 2.347 ± 0.563
1.739TyrSer: 1.739 ± 0.295
2.608TyrThr: 2.608 ± 0.386
2.26TyrVal: 2.26 ± 0.509
0.608TyrTrp: 0.608 ± 0.216
1.739TyrTyr: 1.739 ± 0.625
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski