Amino acid dipepetide frequency for Sanxia picorna-like virus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.792AlaAla: 9.792 ± 1.258
1.224AlaCys: 1.224 ± 0.662
2.04AlaAsp: 2.04 ± 0.243
4.08AlaGlu: 4.08 ± 0.486
7.752AlaPhe: 7.752 ± 0.519
4.488AlaGly: 4.488 ± 1.612
2.856AlaHis: 2.856 ± 0.872
5.712AlaIle: 5.712 ± 0.397
3.672AlaLys: 3.672 ± 0.64
8.568AlaLeu: 8.568 ± 0.078
0.408AlaMet: 0.408 ± 0.221
1.632AlaAsn: 1.632 ± 1.137
6.12AlaPro: 6.12 ± 0.618
3.264AlaGln: 3.264 ± 0.928
4.488AlaArg: 4.488 ± 0.408
5.712AlaSer: 5.712 ± 0.397
8.976AlaThr: 8.976 ± 0.816
8.976AlaVal: 8.976 ± 0.816
0.816AlaTrp: 0.816 ± 0.442
3.264AlaTyr: 3.264 ± 1.601
0.0AlaXaa: 0.0 ± 0.0
Cys
1.224CysAla: 1.224 ± 0.011
0.816CysCys: 0.816 ± 0.232
0.0CysAsp: 0.0 ± 0.0
0.408CysGlu: 0.408 ± 0.221
1.632CysPhe: 1.632 ± 0.883
0.408CysGly: 0.408 ± 0.221
0.0CysHis: 0.0 ± 0.0
1.224CysIle: 1.224 ± 0.011
1.224CysLys: 1.224 ± 0.662
2.04CysLeu: 2.04 ± 0.917
0.408CysMet: 0.408 ± 0.221
0.408CysAsn: 0.408 ± 0.453
0.816CysPro: 0.816 ± 0.442
0.0CysGln: 0.0 ± 0.0
0.408CysArg: 0.408 ± 0.221
0.408CysSer: 0.408 ± 0.221
0.816CysThr: 0.816 ± 0.905
1.224CysVal: 1.224 ± 0.685
0.0CysTrp: 0.0 ± 0.0
0.816CysTyr: 0.816 ± 0.905
0.0CysXaa: 0.0 ± 0.0
Asp
3.672AspAla: 3.672 ± 0.707
1.224AspCys: 1.224 ± 0.011
3.264AspAsp: 3.264 ± 1.093
3.264AspGlu: 3.264 ± 1.093
4.488AspPhe: 4.488 ± 0.939
2.856AspGly: 2.856 ± 0.199
0.816AspHis: 0.816 ± 0.232
4.08AspIle: 4.08 ± 0.861
0.408AspLys: 0.408 ± 0.221
2.856AspLeu: 2.856 ± 0.199
1.224AspMet: 1.224 ± 0.011
4.488AspAsn: 4.488 ± 1.082
1.224AspPro: 1.224 ± 0.685
0.0AspGln: 0.0 ± 0.0
2.04AspArg: 2.04 ± 0.43
2.448AspSer: 2.448 ± 0.022
2.04AspThr: 2.04 ± 0.243
4.08AspVal: 4.08 ± 0.486
0.408AspTrp: 0.408 ± 0.221
0.408AspTyr: 0.408 ± 0.221
0.0AspXaa: 0.0 ± 0.0
Glu
4.488GluAla: 4.488 ± 1.082
0.0GluCys: 0.0 ± 0.0
2.04GluAsp: 2.04 ± 1.104
3.264GluGlu: 3.264 ± 0.419
1.632GluPhe: 1.632 ± 0.883
1.632GluGly: 1.632 ± 0.21
0.816GluHis: 0.816 ± 0.232
2.856GluIle: 2.856 ± 0.872
2.04GluLys: 2.04 ± 1.104
6.528GluLeu: 6.528 ± 1.512
0.816GluMet: 0.816 ± 0.905
1.224GluAsn: 1.224 ± 0.011
2.04GluPro: 2.04 ± 0.243
1.632GluGln: 1.632 ± 0.464
4.896GluArg: 4.896 ± 1.976
5.304GluSer: 5.304 ± 0.85
3.672GluThr: 3.672 ± 0.64
2.448GluVal: 2.448 ± 0.696
0.408GluTrp: 0.408 ± 0.221
2.04GluTyr: 2.04 ± 1.104
0.0GluXaa: 0.0 ± 0.0
Phe
5.712PheAla: 5.712 ± 0.397
0.408PheCys: 0.408 ± 0.221
1.224PheAsp: 1.224 ± 0.685
1.224PheGlu: 1.224 ± 0.662
2.04PhePhe: 2.04 ± 0.243
4.896PheGly: 4.896 ± 1.302
0.408PheHis: 0.408 ± 0.453
2.856PheIle: 2.856 ± 0.872
3.264PheLys: 3.264 ± 0.254
2.448PheLeu: 2.448 ± 1.325
1.224PheMet: 1.224 ± 0.662
2.856PheAsn: 2.856 ± 0.475
2.856PhePro: 2.856 ± 0.475
0.816PheGln: 0.816 ± 0.232
3.672PheArg: 3.672 ± 0.707
3.264PheSer: 3.264 ± 0.928
3.264PheThr: 3.264 ± 0.419
4.08PheVal: 4.08 ± 1.16
0.408PheTrp: 0.408 ± 0.221
2.04PheTyr: 2.04 ± 0.43
0.0PheXaa: 0.0 ± 0.0
Gly
4.488GlyAla: 4.488 ± 1.082
0.408GlyCys: 0.408 ± 0.453
4.896GlyAsp: 4.896 ± 1.976
1.632GlyGlu: 1.632 ± 0.883
2.856GlyPhe: 2.856 ± 0.199
4.488GlyGly: 4.488 ± 0.939
0.816GlyHis: 0.816 ± 0.232
3.672GlyIle: 3.672 ± 1.314
3.672GlyLys: 3.672 ± 1.314
4.896GlyLeu: 4.896 ± 1.392
0.408GlyMet: 0.408 ± 0.221
2.04GlyAsn: 2.04 ± 0.243
3.264GlyPro: 3.264 ± 0.928
1.632GlyGln: 1.632 ± 0.21
1.632GlyArg: 1.632 ± 0.464
4.896GlySer: 4.896 ± 1.302
4.08GlyThr: 4.08 ± 3.18
3.264GlyVal: 3.264 ± 0.419
0.0GlyTrp: 0.0 ± 0.0
2.856GlyTyr: 2.856 ± 0.475
0.0GlyXaa: 0.0 ± 0.0
His
1.632HisAla: 1.632 ± 0.464
0.816HisCys: 0.816 ± 0.905
0.816HisAsp: 0.816 ± 0.232
0.816HisGlu: 0.816 ± 0.442
2.04HisPhe: 2.04 ± 0.243
1.224HisGly: 1.224 ± 0.011
0.408HisHis: 0.408 ± 0.453
2.04HisIle: 2.04 ± 0.43
1.632HisLys: 1.632 ± 0.883
2.448HisLeu: 2.448 ± 0.022
1.224HisMet: 1.224 ± 0.662
1.224HisAsn: 1.224 ± 0.011
0.816HisPro: 0.816 ± 0.442
0.408HisGln: 0.408 ± 0.221
0.816HisArg: 0.816 ± 0.232
2.04HisSer: 2.04 ± 0.243
3.264HisThr: 3.264 ± 0.419
1.632HisVal: 1.632 ± 0.464
0.816HisTrp: 0.816 ± 0.905
1.224HisTyr: 1.224 ± 0.685
0.0HisXaa: 0.0 ± 0.0
Ile
5.712IleAla: 5.712 ± 0.95
0.0IleCys: 0.0 ± 0.0
2.856IleAsp: 2.856 ± 0.199
4.08IleGlu: 4.08 ± 2.208
2.448IlePhe: 2.448 ± 0.651
3.672IleGly: 3.672 ± 0.64
0.816IleHis: 0.816 ± 0.232
2.04IleIle: 2.04 ± 0.43
3.672IleLys: 3.672 ± 1.314
2.04IleLeu: 2.04 ± 0.243
2.04IleMet: 2.04 ± 1.104
2.856IleAsn: 2.856 ± 0.872
3.672IlePro: 3.672 ± 2.727
0.408IleGln: 0.408 ± 0.453
2.856IleArg: 2.856 ± 0.475
2.448IleSer: 2.448 ± 0.022
4.896IleThr: 4.896 ± 0.718
2.856IleVal: 2.856 ± 0.199
0.408IleTrp: 0.408 ± 0.221
1.224IleTyr: 1.224 ± 0.662
0.0IleXaa: 0.0 ± 0.0
Lys
3.264LysAla: 3.264 ± 0.419
0.408LysCys: 0.408 ± 0.221
2.04LysAsp: 2.04 ± 0.243
3.672LysGlu: 3.672 ± 1.314
2.448LysPhe: 2.448 ± 0.651
2.04LysGly: 2.04 ± 1.104
2.448LysHis: 2.448 ± 1.325
2.448LysIle: 2.448 ± 1.325
3.264LysLys: 3.264 ± 1.766
5.712LysLeu: 5.712 ± 0.397
2.04LysMet: 2.04 ± 0.243
1.632LysAsn: 1.632 ± 0.464
2.856LysPro: 2.856 ± 0.872
1.632LysGln: 1.632 ± 0.21
2.448LysArg: 2.448 ± 1.325
3.264LysSer: 3.264 ± 1.766
4.488LysThr: 4.488 ± 1.755
4.08LysVal: 4.08 ± 1.534
0.408LysTrp: 0.408 ± 0.221
0.816LysTyr: 0.816 ± 0.442
0.0LysXaa: 0.0 ± 0.0
Leu
7.344LeuAla: 7.344 ± 0.067
2.04LeuCys: 2.04 ± 0.43
5.712LeuAsp: 5.712 ± 1.071
6.12LeuGlu: 6.12 ± 1.291
1.632LeuPhe: 1.632 ± 0.21
4.896LeuGly: 4.896 ± 2.065
2.04LeuHis: 2.04 ± 1.104
4.488LeuIle: 4.488 ± 0.265
4.08LeuLys: 4.08 ± 0.861
4.896LeuLeu: 4.896 ± 1.392
1.224LeuMet: 1.224 ± 0.662
2.04LeuAsn: 2.04 ± 0.243
4.488LeuPro: 4.488 ± 2.286
0.816LeuGln: 0.816 ± 0.232
5.304LeuArg: 5.304 ± 0.176
7.344LeuSer: 7.344 ± 0.74
5.304LeuThr: 5.304 ± 2.518
6.936LeuVal: 6.936 ± 0.961
1.632LeuTrp: 1.632 ± 0.883
2.856LeuTyr: 2.856 ± 0.199
0.0LeuXaa: 0.0 ± 0.0
Met
3.672MetAla: 3.672 ± 0.707
0.408MetCys: 0.408 ± 0.453
1.224MetAsp: 1.224 ± 0.011
0.816MetGlu: 0.816 ± 0.905
0.408MetPhe: 0.408 ± 0.453
0.408MetGly: 0.408 ± 0.221
1.224MetHis: 1.224 ± 1.358
1.224MetIle: 1.224 ± 0.662
0.816MetLys: 0.816 ± 0.442
1.224MetLeu: 1.224 ± 0.011
0.0MetMet: 0.0 ± 0.0
0.408MetAsn: 0.408 ± 0.221
1.224MetPro: 1.224 ± 0.685
0.816MetGln: 0.816 ± 0.442
1.632MetArg: 1.632 ± 0.883
1.632MetSer: 1.632 ± 0.464
2.448MetThr: 2.448 ± 1.325
2.04MetVal: 2.04 ± 0.43
0.408MetTrp: 0.408 ± 0.453
1.224MetTyr: 1.224 ± 0.662
0.0MetXaa: 0.0 ± 0.0
Asn
4.896AsnAla: 4.896 ± 1.392
0.408AsnCys: 0.408 ± 0.221
1.224AsnAsp: 1.224 ± 0.011
1.224AsnGlu: 1.224 ± 0.685
2.04AsnPhe: 2.04 ± 0.917
2.856AsnGly: 2.856 ± 0.872
0.408AsnHis: 0.408 ± 0.453
2.04AsnIle: 2.04 ± 0.243
3.672AsnLys: 3.672 ± 1.314
2.448AsnLeu: 2.448 ± 0.696
1.224AsnMet: 1.224 ± 0.011
2.856AsnAsn: 2.856 ± 0.199
1.632AsnPro: 1.632 ± 1.137
0.816AsnGln: 0.816 ± 0.442
2.448AsnArg: 2.448 ± 0.651
1.632AsnSer: 1.632 ± 0.21
4.08AsnThr: 4.08 ± 1.16
5.304AsnVal: 5.304 ± 1.844
0.408AsnTrp: 0.408 ± 0.453
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.712ProAla: 5.712 ± 0.276
0.408ProCys: 0.408 ± 0.453
2.448ProAsp: 2.448 ± 0.696
3.672ProGlu: 3.672 ± 1.314
2.448ProPhe: 2.448 ± 0.022
2.856ProGly: 2.856 ± 0.199
2.448ProHis: 2.448 ± 2.043
0.816ProIle: 0.816 ± 0.905
1.224ProLys: 1.224 ± 0.685
6.936ProLeu: 6.936 ± 1.635
2.448ProMet: 2.448 ± 0.696
1.224ProAsn: 1.224 ± 0.685
4.488ProPro: 4.488 ± 4.306
1.632ProGln: 1.632 ± 1.137
2.448ProArg: 2.448 ± 0.651
1.224ProSer: 1.224 ± 0.685
4.08ProThr: 4.08 ± 1.16
6.528ProVal: 6.528 ± 1.182
0.816ProTrp: 0.816 ± 0.442
1.632ProTyr: 1.632 ± 0.21
0.0ProXaa: 0.0 ± 0.0
Gln
3.264GlnAla: 3.264 ± 0.419
0.0GlnCys: 0.0 ± 0.0
1.224GlnAsp: 1.224 ± 0.011
2.04GlnGlu: 2.04 ± 0.43
0.0GlnPhe: 0.0 ± 0.0
4.08GlnGly: 4.08 ± 1.534
0.816GlnHis: 0.816 ± 0.232
0.0GlnIle: 0.0 ± 0.0
0.816GlnLys: 0.816 ± 0.442
2.856GlnLeu: 2.856 ± 1.822
0.0GlnMet: 0.0 ± 0.0
0.816GlnAsn: 0.816 ± 0.232
2.448GlnPro: 2.448 ± 0.696
1.224GlnGln: 1.224 ± 0.662
2.448GlnArg: 2.448 ± 0.022
4.08GlnSer: 4.08 ± 1.16
1.632GlnThr: 1.632 ± 0.883
1.632GlnVal: 1.632 ± 0.464
0.408GlnTrp: 0.408 ± 0.221
0.816GlnTyr: 0.816 ± 0.442
0.0GlnXaa: 0.0 ± 0.0
Arg
2.448ArgAla: 2.448 ± 0.651
0.408ArgCys: 0.408 ± 0.221
3.672ArgAsp: 3.672 ± 0.033
3.672ArgGlu: 3.672 ± 1.314
2.856ArgPhe: 2.856 ± 0.199
1.632ArgGly: 1.632 ± 1.137
2.448ArgHis: 2.448 ± 1.325
3.264ArgIle: 3.264 ± 0.419
4.488ArgLys: 4.488 ± 1.755
3.264ArgLeu: 3.264 ± 0.254
2.04ArgMet: 2.04 ± 0.43
3.672ArgAsn: 3.672 ± 0.707
4.488ArgPro: 4.488 ± 0.408
2.856ArgGln: 2.856 ± 0.872
4.488ArgArg: 4.488 ± 1.082
2.856ArgSer: 2.856 ± 0.872
3.672ArgThr: 3.672 ± 0.64
4.08ArgVal: 4.08 ± 0.861
0.408ArgTrp: 0.408 ± 0.221
1.632ArgTyr: 1.632 ± 1.137
0.0ArgXaa: 0.0 ± 0.0
Ser
8.568SerAla: 8.568 ± 2.616
1.224SerCys: 1.224 ± 0.685
3.264SerAsp: 3.264 ± 0.254
3.672SerGlu: 3.672 ± 1.38
2.04SerPhe: 2.04 ± 0.43
6.12SerGly: 6.12 ± 0.729
1.224SerHis: 1.224 ± 0.685
4.896SerIle: 4.896 ± 2.065
3.672SerLys: 3.672 ± 1.314
5.304SerLeu: 5.304 ± 0.85
1.632SerMet: 1.632 ± 1.137
2.04SerAsn: 2.04 ± 0.43
2.04SerPro: 2.04 ± 1.59
2.448SerGln: 2.448 ± 0.651
4.08SerArg: 4.08 ± 1.16
3.672SerSer: 3.672 ± 0.707
4.488SerThr: 4.488 ± 0.939
4.488SerVal: 4.488 ± 1.082
1.224SerTrp: 1.224 ± 0.662
1.224SerTyr: 1.224 ± 0.685
0.0SerXaa: 0.0 ± 0.0
Thr
6.936ThrAla: 6.936 ± 2.982
1.224ThrCys: 1.224 ± 0.662
2.04ThrAsp: 2.04 ± 0.243
2.04ThrGlu: 2.04 ± 0.243
4.08ThrPhe: 4.08 ± 0.486
2.04ThrGly: 2.04 ± 0.243
2.04ThrHis: 2.04 ± 0.43
2.856ThrIle: 2.856 ± 0.475
2.448ThrLys: 2.448 ± 0.651
6.936ThrLeu: 6.936 ± 0.961
2.04ThrMet: 2.04 ± 1.155
5.304ThrAsn: 5.304 ± 1.844
5.304ThrPro: 5.304 ± 0.497
6.936ThrGln: 6.936 ± 0.386
2.448ThrArg: 2.448 ± 0.022
6.12ThrSer: 6.12 ± 1.403
6.936ThrThr: 6.936 ± 3.655
5.712ThrVal: 5.712 ± 1.071
0.408ThrTrp: 0.408 ± 0.221
4.488ThrTyr: 4.488 ± 0.265
0.0ThrXaa: 0.0 ± 0.0
Val
6.936ValAla: 6.936 ± 1.733
2.448ValCys: 2.448 ± 0.696
2.856ValAsp: 2.856 ± 1.148
2.448ValGlu: 2.448 ± 0.651
3.264ValPhe: 3.264 ± 0.419
2.448ValGly: 2.448 ± 0.651
3.672ValHis: 3.672 ± 0.033
2.04ValIle: 2.04 ± 0.43
4.08ValLys: 4.08 ± 0.861
6.936ValLeu: 6.936 ± 1.733
2.04ValMet: 2.04 ± 0.243
3.264ValAsn: 3.264 ± 1.601
5.304ValPro: 5.304 ± 0.497
2.04ValGln: 2.04 ± 0.243
6.12ValArg: 6.12 ± 1.965
5.712ValSer: 5.712 ± 3.644
5.304ValThr: 5.304 ± 2.518
7.344ValVal: 7.344 ± 0.067
2.04ValTrp: 2.04 ± 0.43
3.672ValTyr: 3.672 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
0.816TrpAla: 0.816 ± 0.442
0.408TrpCys: 0.408 ± 0.221
0.0TrpAsp: 0.0 ± 0.0
0.816TrpGlu: 0.816 ± 0.442
1.224TrpPhe: 1.224 ± 0.662
0.0TrpGly: 0.0 ± 0.0
1.224TrpHis: 1.224 ± 0.662
0.408TrpIle: 0.408 ± 0.221
1.224TrpLys: 1.224 ± 0.662
1.632TrpLeu: 1.632 ± 0.464
0.0TrpMet: 0.0 ± 0.0
0.408TrpAsn: 0.408 ± 0.221
0.0TrpPro: 0.0 ± 0.0
0.816TrpGln: 0.816 ± 0.232
0.408TrpArg: 0.408 ± 0.453
0.816TrpSer: 0.816 ± 0.442
0.408TrpThr: 0.408 ± 0.221
0.408TrpVal: 0.408 ± 0.221
0.0TrpTrp: 0.0 ± 0.0
1.224TrpTyr: 1.224 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.264TyrAla: 3.264 ± 1.601
0.0TyrCys: 0.0 ± 0.0
2.448TyrAsp: 2.448 ± 0.651
0.816TyrGlu: 0.816 ± 0.442
1.632TyrPhe: 1.632 ± 0.464
2.856TyrGly: 2.856 ± 0.199
0.408TyrHis: 0.408 ± 0.453
2.04TyrIle: 2.04 ± 1.59
2.04TyrLys: 2.04 ± 0.43
1.224TyrLeu: 1.224 ± 0.011
0.408TyrMet: 0.408 ± 0.184
1.224TyrAsn: 1.224 ± 0.011
0.408TyrPro: 0.408 ± 0.221
0.408TyrGln: 0.408 ± 0.221
3.264TyrArg: 3.264 ± 1.766
2.448TyrSer: 2.448 ± 0.022
4.896TyrThr: 4.896 ± 1.392
2.856TyrVal: 2.856 ± 0.475
0.816TyrTrp: 0.816 ± 0.442
0.408TyrTyr: 0.408 ± 0.453
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski